The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains.
The expected taxonomic range for this enzyme is: Salmonella enterica
The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains.
Substrates: group C2 transferase RfbZ can transfer mannose only to Gal-PP1-decaprenol, not to decaprenol phosphate or Man-Gal-PP1-decaprenol Products: -
the transferases of O antigen synthesis act in sequence in the assembly of a particular repeating unit and cannot function until completion of the previous step
in Salmonella group C2, the rfb (O antigen) gene cluster differs from that of group B. The O antigens of groups C2 and B have the same sugars but differ in structure. A block of seven open reading frames is unique to group C2 which encode the O antigen polymerase (RfbC) and the transferases responsible for assembly of the group C2 O antigen
comparison of the Rfb gene cluster of group B strain LT2 and group D strain Ty2 reveals an 11.8 kb central region of limited similarity flanked by regions of high similarity in group C2 strain M67. Expression of the genes from the central region confer a group C2 O-antigen structure on a Salmonella LT2 partial deletion strain
in Salmonella group C2, the rfb (O antigen) gene cluster differs from that of group B. The O antigens of groups C2 and B have the same sugars but differ in structure. A block of seven open reading frames is unique to group C2 which encode the O antigen polymerase (RfbC) and the transferases responsible for assembly of the group C2 O antigen
comparison of the Rfb gene cluster of group B strain LT2 and group D strain Ty2 reveals an 11.8 kb central region of limited similarity flanked by regions of high similarity in group C2 strain M67. Expression of the genes from the central region confer a group C2 O-antigen structure on a Salmonella LT2 partial deletion strain
construction of bivalent vaccines for preventing both Salmonella typhimurium and Salmonella newport infections by using the aspartate semialdehyde dehydrogenase-based balanced-lethal vector-host system. The constructed plasmid pCZ11 carrying a subset of the Salmonella newport O-antigen gene cluster including the wzx-wbaR-wbaL-wbaQ-wzy-wbaW-wbaZ genes is introduced into Salmonella typhimurium. Upon deletion of the crp gene for attenuation purposes, BALB/c mice are orally immunized with the strains. Compared with a mock immunization, immunization with the vaccine strains induces significant serum IgG responses against both Salmonella typhimurium and Salmonella newport lipopolysaccharide
Liu, D.; Haase, A.; Lindqvist, L.; Lindberg, A.; Reeves, P.
Glycosyl transferases of O-antigen biosynthesis in Salmonella enterica Identification and characterization of transferase genes of groups B, C2, and E1
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