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Information on EC 2.4.1.376 - EGF-domain serine glucosyltransferase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.376 EGF-domain serine glucosyltransferase
IUBMB Comments
The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains. Glycosylation takes place at the serine in the C-X-S-X-P-C motif. The enzyme is bifunctional also being active with UDP-alpha-xylose as donor (EC 2.4.2.63, EGF-domain serine xylosyltransferase). When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
[protein with EGF-like domain]-L-serine
=
+
[protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine
Synonyms
Poglut, POGLUT1, POGLUT2, POGLUT3, protein O-glucosyltransferase, protein O-glucosyltransferase 1, protein O-glycosyltransferase, protein-O-glucosyltransferase 1, Rumi, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine
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PATHWAY SOURCE
PATHWAYS
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