The enzyme, characterized from Leishmania parasites, is involved in synthesis of mannogen, a β-(1→2)-mannan oligosaccharide used by the organisms as a carbohydrate reserve.
The expected taxonomic range for this enzyme is: Leishmania mexicana
The enzyme, characterized from Leishmania parasites, is involved in synthesis of mannogen, a beta-(1->2)-mannan oligosaccharide used by the organisms as a carbohydrate reserve.
Substrates: MTP1 alone produces hyper-elongated mannogen oligomers (DP >60), while expression of MTP2 results in synthesis of a restricted pool of short mannogen oligomers (DP 2-10). Co-expression of both MTP1 and 2 results in an intermediate mannogen profile containing both short and long mannogen oligomers (DP 4 to >60) Products: -
enzyme catalyzes both the sugar nucleotide-dependent biosynthesis and phosphorolytic turnover of mannogen, glycosyltransferase family 108. Isoforms MTP1 and 2 function primarily as GDPMan-dependent beta-1,2-mannosyltransferases. Parasites lacking isoforms Mtp1-7 do not induce lesions or proliferate in highly susceptible BALB/c mice. Expression of MTP1 alone or MTP1/MTP2 together in the absence of phosphorolytic Mtps exacerbates the loss of virulence phenotype, with no recovery of parasites from tissue biopsies. The mutant lacking Mtp2 does not induce lesions in BALB/c mice even when a high inoculum is used
show
top
