Information on EC 2.4.1.370 - inositol phosphorylceramide mannosyltransferase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.370 inositol phosphorylceramide mannosyltransferase
IUBMB Comments
The simplest complex sphingolipid of yeast, inositol-phospho-alpha-hydroxyphytoceramide (IPC), is usually mannosylated to yield mannosyl-inositol-phospho-alpha hydroxyphytoceramide (MIPC). The enzyme is located in the Golgi apparatus, and utilizes GDP-mannose as the mannosyl group donor. It consists of a catalytic subunit (SUR1 or CSH1) and a regulatory subunit (CSG2).
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide
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a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide
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Synonyms
BCL21, Csg1, Csg1p, CSH1, Csh1p, SUR1, YBR161w, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-alpha-D-mannose + a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide = a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide + GDP
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PATHWAY SOURCE
PATHWAYS
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