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EC Tree
IUBMB Comments The enzyme is involved in the biosynthesis of the linker region of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotypes O8, O9 and O9a.
The enzyme appears in viruses and cellular organisms
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WbdC
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GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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GDP-alpha-D-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase (configuration-retaining)
The enzyme is involved in the biosynthesis of the linker region of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotypes O8, O9 and O9a.
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GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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brenda
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brenda
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brenda
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brenda
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WBPZ_PSEAE
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
381
0
43440
Swiss-Prot
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E275A
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the mutant shows a drastic reduction in activity
E283A
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the mutant shows about wild type activity
E275A
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the mutant shows a drastic reduction in activity
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E283A
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the mutant shows about wild type activity
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amylose resin column chromatography
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expressed in Escherichia coli Top10 cells
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Greenfield, L.; Richards, M.; Li, J.; Wakarchuk, W.; Lowary, T.; Whitfield, C.
Biosynthesis of the polymannose lipopolysaccharide O-antigens from Escherichia coli serotypes O8 and O9a requires a unique combination of single- and multiple-active site mannosyltransferases
J. Biol. Chem.
287
35078-35091
2012
Escherichia coli, Escherichia coli CWG636, Escherichia coli CWG634
brenda
Greenfield, L.; Richards, M.; Vinogradov, E.; Wakarchuk, W.; Lowary, T.; Whitfield, C.
Domain organization of the polymerizing mannosyltransferases involved in synthesis of the Escherichia coli O8 and O9a lipopolysaccharide O-antigens
J. Biol. Chem.
287
38135-38149
2012
Escherichia coli, Escherichia coli CWG634
brenda
Kido, N.; Sugiyama, T.; Yokochi, T.; Kobayashi, H.; Okawa, Y.
Synthesis of Escherichia coli O9a polysaccharide requires the participation of two domains of WbdA, a mannosyltransferase encoded within the wb gene cluster
Mol. Microbiol.
27
1213-1221
1998
Escherichia coli
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