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IUBMB Comments The enzyme, found in Mycobacteria , can also use UDP-α-D -glucose with much lower catalytic efficiency.
Synonyms glgM ,
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glgA
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glgM
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ADP-alpha-D-glucose + alpha-D-glucose-1-phosphate = ADP + alpha-maltose-1-phosphate
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MetaCyc
glycogen biosynthesis III (from alpha-maltose 1-phosphate)
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ADP-alpha-D-glucose:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (configuration-retaining)
The enzyme, found in Mycobacteria, can also use UDP-alpha-D-glucose with much lower catalytic efficiency.
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ADP-alpha-D-glucose + alpha-D-glucose-1-phosphate
ADP + alpha-maltose-1-phosphate
additional information
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ADP-alpha-D-glucose + alpha-D-glucose-1-phosphate
ADP + alpha-maltose-1-phosphate
Substrates: -
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ADP-alpha-D-glucose + alpha-D-glucose-1-phosphate
ADP + alpha-maltose-1-phosphate
Substrates: -
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additional information
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Substrates: enzyme follows a ternary complex mechanism, whereby ADP-glucose binds to the enzyme before D-glucose 1-phosphate. GlgM shows no detecable glycogen synthase activity
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additional information
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Substrates: enzyme follows a ternary complex mechanism, whereby ADP-glucose binds to the enzyme before D-glucose 1-phosphate. GlgM shows no detecable glycogen synthase activity
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ADP-alpha-D-glucose + alpha-D-glucose-1-phosphate
ADP + alpha-maltose-1-phosphate
ADP-alpha-D-glucose + alpha-D-glucose-1-phosphate
ADP + alpha-maltose-1-phosphate
Substrates: -
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ADP-alpha-D-glucose + alpha-D-glucose-1-phosphate
ADP + alpha-maltose-1-phosphate
Substrates: -
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alpha-D-glucose-1-phosphate
substrate inhibition
D-glucose 1-phosphate
substrate inhibition above 4 mM
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0.046 - 0.145
ADP-alpha-D-glucose
0.578 - 0.816
alpha-D-glucose-1-phosphate
0.046
ADP-alpha-D-glucose
with 4.0 mM alpha-D-glucose-1-phosphate, at pH 7.0 and 37°C
0.063
ADP-alpha-D-glucose
with 2.5 mM alpha-D-glucose-1-phosphate, at pH 7.0 and 37°C
0.121
ADP-alpha-D-glucose
with 1.0 mM alpha-D-glucose-1-phosphate, at pH 7.0 and 37°C
0.145
ADP-alpha-D-glucose
with 0.25 mM alpha-D-glucose-1-phosphate, at pH 7.0 and 37°C
0.578
alpha-D-glucose-1-phosphate
with 0.5 mM ADP-alpha-D-glucose, at pH 7.0 and 37°C
0.695
alpha-D-glucose-1-phosphate
with 4.0 mM ADP-alpha-D-glucose, at pH 7.0 and 37°C
0.816
alpha-D-glucose-1-phosphate
with 0.1 mM ADP-alpha-D-glucose, at pH 7.0 and 37°C
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15.4 - 29.2
ADP-alpha-D-glucose
39 - 97.9
alpha-D-glucose-1-phosphate
15.4
ADP-alpha-D-glucose
with 4.0 mM alpha-D-glucose-1-phosphate, at pH 7.0 and 37°C
19.8
ADP-alpha-D-glucose
with 2.5 mM alpha-D-glucose-1-phosphate, at pH 7.0 and 37°C
20
ADP-alpha-D-glucose
with 0.25 mM alpha-D-glucose-1-phosphate, at pH 7.0 and 37°C
29.2
ADP-alpha-D-glucose
with 1.0 mM alpha-D-glucose-1-phosphate, at pH 7.0 and 37°C
39
alpha-D-glucose-1-phosphate
with 0.1 mM ADP-alpha-D-glucose, at pH 7.0 and 37°C
80.6
alpha-D-glucose-1-phosphate
with 4.0 mM ADP-alpha-D-glucose, at pH 7.0 and 37°C
97.9
alpha-D-glucose-1-phosphate
with 0.5 mM ADP-alpha-D-glucose, at pH 7.0 and 37°C
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0.578 - 1.45
alpha-D-glucose-1-phosphate
0.578
alpha-D-glucose-1-phosphate
with 0.5 mM ADP-alpha-D-glucose, at pH 7.0 and 37°C
0.895
alpha-D-glucose-1-phosphate
with 4.0 mM ADP-alpha-D-glucose, at pH 7.0 and 37°C
1.45
alpha-D-glucose-1-phosphate
with 0.1 mM ADP-alpha-D-glucose, at pH 7.0 and 37°C
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UniProt
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UniProt
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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GLGM_MYCS2
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
387
0
41679
Swiss-Prot
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GLGM_MYCTO
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
387
0
41533
Swiss-Prot
other Location (Reliability: 3 )
GLGM_MYCTU
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
387
0
41533
Swiss-Prot
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structure at 1.9 A resolution. GlgM shares a GT-B fold with bacterial glycogen synthases
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HisTrap column chromatography and Superdex 200 gel filtration
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expressed in Mycobaterium smegmatis mc2155
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Koliwer-Brandl, H.; Syson, K.; van de Weerd, R.; Chandra, G.; Appelmelk, B.; Alber, M.; Ioerger, T.; Jacobs, W.J.; Geurtsen, J.; Bornemann, S.; Kalscheuer, R.
Metabolic network for the biosynthesis of intra- and extracellular alpha-glucans required for virulence of Mycobacterium tuberculosis
PLoS Pathog.
12
e1005768
2016
Mycobacterium tuberculosis (P9WMZ1), Mycobacterium tuberculosis H37Rv (P9WMZ1)
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Syson, K.; Stevenson, C.; Lawson, D.; Bornemann, S.
Structure of the Mycobacterium smegmatis alpha-maltose-1-phosphate synthase GlgM
Acta Crystallogr. Sect. F
76
175-181
2020
Mycolicibacterium smegmatis (A0R2E2), Mycolicibacterium smegmatis ATCC 700084 (A0R2E2)
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