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Information on EC 2.4.1.318 - demethyllactenocin mycarosyltransferase
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EC Tree
2.4.1.318 demethyllactenocin mycarosyltransferaseIUBMB Comments
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
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Word Map
- 2.4.1.318
- tomato
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curl
- bemisia
- whitefly
- tabaci
- begomovirus
-
stunt
- geminiviridae
- geminiviruses
- lycopersicum
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israel
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sardinia
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gennadius
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viruliferous
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monopartite
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florida
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tylcd
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dominican
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phytopathology
- aleyrodidae
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symptomless
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whitefly-transmitted
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greenhouses
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rojas
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nonanucleotide
- pimpinellifolium
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agroinoculation
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virus-resistant
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promega
- synthesis
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madison
- habrochaites
-
interveinal
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crumple
- chilense
- betasatellite
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non-viruliferous
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wyatt
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pgem-t
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sinaloa
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tomato-infecting
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silverleaf
The enzyme appears in viruses and cellular organisms
Synonyms
tylcv, mycarosyltransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
tylC5
tylCV
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
dTDP-beta-L-mycarose:demethyllactenocin 4'-O-alpha-L-mycarosyltransferase
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
-
-
?
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
dTDP-beta-L-mycarose i.e. dTDP-2,6-dideoxy-3-C-methyl-beta-L-ribo-hexose. demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside
-
-
?
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
-
-
?
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
dTDP-beta-L-mycarose i.e. dTDP-2,6-dideoxy-3-C-methyl-beta-L-ribo-hexose. demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
-
-
?
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Anemia, Hypochromic
Molecular dissection of distinct symptoms induced by tomato chlorosis virus and tomato yellow leaf curl virus based on comparative transcriptome analysis.
Coinfection
Coinfection by Two Begomoviruses Aggravates Plant Symptoms But Does Not Influence the Performance and Preference of Insect Vector Bemisia tabaci (Hemiptera: Aleyrodidae).
Coinfection
Detection of Satellite DNA Beta in Tomato Plants with Tomato Yellow Leaf Curl Disease in Jordan.
Coinfection
First Report of Tobacco as a Natural Host of Tomato yellow leaf curl virus in Spain.
Coinfection
First Report of Tomato chlorosis virus Infecting Tomato in Single and Mixed Infections with Tomato yellow leaf curl virus in Cuba.
Coinfection
First Report of Tomato yellow leaf curl virus Co-infecting Pepper with Tomato chino La Paz virus in Baja California Sur, Mexico.
Coinfection
First Report of Tomato yellow leaf curl virus Infecting Tomato, Tomatillo, and Peppers in Guatemala
Coinfection
First Report of Tomato yellow leaf curl virus Infecting Tomato, Tomatillo, and Peppers in Guatemala.
Coinfection
First Report of Tomato Yellow Leaf Curl Virus-Israel Species Infecting Tomato, Pepper and Bean in Tunisia
Coinfection
Pathogenicity and insect transmission of a begomovirus complex between tomato yellow leaf curl virus and Ageratum yellow vein betasatellite.
Coinfection
Synergistic Effects of a Tomato chlorosis virus and Tomato yellow leaf curl virus Mixed Infection on Host Tomato Plants and the Whitefly Vector.
Coinfection
The Global Dimension of Tomato Yellow Leaf Curl Disease: Current Status and Breeding Perspectives.
Coinfection
Three years survey of Tomato yellow leaf curl Sardinia virus reservoir weed hosts in southern Italy.
Coinfection
Tomato yellow leaf curl virus resistance by Ty-1 involves increased cytosine methylation of viral genomes and is compromised by cucumber mosaic virus infection.
Coinfection
Transcriptome Profiling of the Whitefly Bemisia tabaci MED in Response to Single Infection of Tomato yellow leaf curl virus, Tomato chlorosis virus, and Their Co-infection.
Coinfection
Whitefly-mediated transmission and subsequent acquisition of highly similar and naturally occurring Tomato yellow leaf curl virus variants.
Coinfection
Within-host dynamics of the emergence of tomato yellow leaf curl virus recombinants.
Infections
A common set of developmental miRNAs are upregulated in Nicotiana benthamiana by diverse begomoviruses.
Infections
A developmentally regulated lipocalin-like gene is overexpressed in Tomato yellow leaf curl virus-resistant tomato plants upon virus inoculation, and its silencing abolishes resistance.
Infections
A novel plant protein-disulfide isomerase participates in resistance response against the TYLCV in tomato.
Infections
A novel synthetic quantification standard including virus and internal report targets: application for the detection and quantification of emerging begomoviruses on tomato.
Infections
A simple, efficient agroinoculation soaking procedure for Tomato yellow leaf curl virus
Infections
Accumulation and transmission of alphasatellite, betasatellite and tomato yellow leaf curl virus in susceptible and Ty-1-resistant tomato plants.
Infections
Amino Acid Utilization May Explain Why Bemisia tabaci Q and B Differ in Their Performance on Plants Infected by the Tomato yellow leaf curl virus.
Infections
AP2/ERF Transcription Factors Involved in Response to Tomato Yellow Leaf Curly Virus in Tomato.
Infections
Application of Whole Genome Resequencing in Mapping of a Tomato Yellow Leaf Curl Virus Resistance Gene.
Infections
Bemisia tabaci Vesicle-Associated Membrane Protein 2 Interacts with Begomoviruses and Plays a Role in Virus Acquisition.
Infections
Capsicum Species: Symptomless Hosts and Reservoirs of Tomato yellow leaf curl virus.
Infections
Capsicum species: symptomless hosts and reservoirs of Tomato yellow leaf curl virus.
Infections
Clay nanosheet-mediated delivery of recombinant plasmids expressing artificial miRNAs via leaf spray to prevent infection by plant DNA viruses.
Infections
Comparative Analyses of Tomato yellow leaf curl virus C4 Protein-Interacting Host Proteins in Healthy and Infected Tomato Tissues.
Infections
Comparative proteomic analysis provides new insight into differential transmission of two begomoviruses by a whitefly.
Infections
Comparative proteomic analysis provides novel insight into the interaction between resistant vs susceptible tomato cultivars and TYLCV infection.
Infections
Comparative transcriptome profiling of a resistant vs. susceptible tomato (Solanum lycopersicum) cultivar in response to infection by tomato yellow leaf curl virus.
Infections
Corrigendum: Genome-wide analysis of tomato long non-coding RNAs and identification as endogenous target mimic for microRNA in response to TYLCV infection.
Infections
Detection of Satellite DNA Beta in Tomato Plants with Tomato Yellow Leaf Curl Disease in Jordan.
Infections
Development and Application of Gene-Specific Markers for Tomato Yellow Leaf Curl Virus Resistance in Both Field and Artificial Infections.
Infections
Development of a method to rapidly assess resistance/susceptibility of Micro-Tom tomatoes to Tomato yellow leaf curl virus via agroinoculation of cotyledons.
Infections
Effects of Isaria fumosorosea on TYLCV (Tomato Yellow Leaf Curl Virus) Accumulation and Transmitting Capacity of Bemisia tabaci.
Infections
Effects of plant virus and its insect vector on Encarsia formosa, a biocontrol agent of whiteflies.
Infections
Elevated O? and TYLCV Infection Reduce the Suitability of Tomato as a Host for the Whitefly Bemisia tabaci.
Infections
Engineering resistance against tomato yellow leaf curl virus (TYLCV) using antisense RNA.
Infections
Evaluating Acylsugars-Mediated Resistance in Tomato against Bemisia tabaci and Transmission of Tomato Yellow Leaf Curl Virus.
Infections
Female-Biased Symbionts and Tomato Yellow Leaf Curl Virus Infections in Bemisia tabaci.
Infections
First Report of Capsicum annuum Plants Infected by Tomato Yellow Leaf Curl Virus.
Infections
First report of Capsicum annuum plants infected by tomato yellow leaf curl virus.
Infections
First Report of Tobacco as a Natural Host of Tomato yellow leaf curl virus in Spain.
Infections
First Report of Tomato yellow leaf curl virus Infecting Common Bean (Phaseolus vulgaris) in Greece.
Infections
First Report of Tomato yellow leaf curl virus Infecting Eustoma (Eustoma grandiflorum) in Korea.
Infections
First Report of Tomato yellow leaf curl virus Infecting Tomato, Tomatillo, and Peppers in Guatemala
Infections
First Report of Tomato yellow leaf curl virus Infecting Tomato, Tomatillo, and Peppers in Guatemala.
Infections
First Report of Tomato Yellow Leaf Curl Virus-Is in Spain: Coexistence of Two Different Geminiviruses in the Same Epidemic Outbreak.
Infections
Flue-cured tobacco confirmed as a reservoir host plant for Tomato yellow leaf curl virus by agro-inoculation and Bemisia tabaci MED-mediated transmission.
Infections
Functional analysis of proteins involved in movement of the monopartite begomovirus, Tomato yellow leaf curl virus.
Infections
Generation of plants resistant to tomato yellow leaf curl virus by using artificial zinc-finger proteins.
Infections
Genetic diversity, host range, and distribution of tomato yellow leaf curl virus in Iran.
Infections
Genome-wide analysis of bHLH transcription factor and involvement in the infection by yellow leaf curl virus in tomato ( Solanum lycopersicum ).
Infections
Genome-wide analysis of tomato long non-coding RNAs and identification as endogenous target mimic for microRNA in response to TYLCV infection.
Infections
Genome-wide identification of long non-coding RNAs in tomato plants irradiated by neutrons followed by infection with Tomato yellow leaf curl virus.
Infections
Host GRXC6 restricts Tomato yellow leaf curl virus infection by inhibiting the nuclear export of the V2 protein.
Infections
Identification of Tomato yellow leaf curl virus Naturally Infecting Common Bean in Japan.
Infections
Inheritance of Tomato yellow leaf curl virus Resistance Derived from Solanum pimpinellifolium UPV16991
Infections
Inheritance of Tomato yellow leaf curl virus Resistance Derived from Solanum pimpinellifolium UPV16991.
Infections
Inhibition of Binding of Tomato Yellow Leaf Curl Virus Rep to its Replication Origin by Artificial Zinc-Finger Protein.
Infections
Insecticidal Effects on the Spatial Progression of Tomato Yellow Leaf Curl Virus and Movement of Its Whitefly Vector in Tomato.
Infections
Intron-hairpin RNA derived from replication associated protein C1 gene confers immunity to tomato yellow leaf curl virus infection in transgenic tomato plants.
Infections
Lamium amplexicaule (Lamiaceae): a weed reservoir for tomato yellow leaf curl virus (TYLCV) in Korea.
Infections
Lanai: A small, fast growing tomato variety is an excellent model system for studying geminiviruses.
Infections
Manipulation of Host Quality and Defense by a Plant Virus Improves Performance of Whitefly Vectors.
Infections
Members of WRKY Group III transcription factors are important in TYLCV defense signaling pathway in tomato (Solanum lycopersicum).
Infections
Monitoring the dynamics of emergence of a non-canonical recombinant of Tomato yellow leaf curl virus and displacement of its parental viruses in tomato.
Infections
Multiple forms of vector manipulation by a plant-infecting virus: Bemisia tabaci and tomato yellow leaf curl virus.
Infections
Pathogenicity and insect transmission of a begomovirus complex between tomato yellow leaf curl virus and Ageratum yellow vein betasatellite.
Infections
Proteomic Analyses of Whitefly-Begomovirus Interactions Reveal the Inhibitory Role of Tumorous Imaginal Discs in Viral Retention.
Infections
Re-analysis of long non-coding RNAs and prediction of circRNAs reveal their novel roles in susceptible tomato following TYLCV infection.
Infections
Recent Emergence of the Mild Strain of Tomato yellow leaf curl virus as a Cause of Tomato Yellow Leaf Curl Disease of Processing Tomatoes (Solanum lycopersicon) in the Dominican Republic.
Infections
Recruitment of the host plant heat shock protein 70 by Tomato yellow leaf curl virus coat protein is required for virus infection.
Infections
Resistance to tomato yellow leaf curl geminivirus in Nicotiana benthamiana plants transformed with a truncated viral C1 gene.
Infections
Revisiting Seed Transmission of the Type Strain of Tomato yellow leaf curl virus in Tomato Plants.
Infections
RNA interference-based resistance in transgenic tomato plants against Tomato yellow leaf curl virus-Oman (TYLCV-OM) and its associated betasatellite.
Infections
Salicylic acid-induced differential resistance to the Tomato yellow leaf curl virus among resistant and susceptible tomato cultivars.
Infections
Screening Common Bean (Phaseolus vulgaris) for Resistance to Tomato yellow leaf curl virus.
Infections
Screening common bean (Phaseolus vulgaris) for resistance to Tomato yellow leaf curl virus.
Infections
Seed Transmission of Tomato yellow leaf curl virus in White Soybean (Glycine max).
Infections
Six NAC transcription factors involved in response to TYLCV infection in resistant and susceptible tomato cultivars.
Infections
SlMAPK3 enhances tolerance to tomato yellow leaf curl virus (TYLCV) by regulating salicylic acid and jasmonic acid signaling in tomato (Solanum lycopersicum).
Infections
The autophagy pathway participates in resistance to tomato yellow leaf curl virus infection in whiteflies.
Infections
The capsid protein of tomato yellow leaf curl virus binds cooperatively to single-stranded DNA.
Infections
The Combined Effect of Elevated O3 Levels and TYLCV Infection Increases the Fitness of Bemisia tabaci Mediterranean on Tomato Plants.
Infections
The six Tomato yellow leaf curl virus genes expressed individually in tomato induce different levels of plant stress response attenuation.
Infections
The Tomato yellow leaf curl virus V2 protein forms aggregates depending on the cytoskeleton integrity and binds viral genomic DNA.
Infections
Tomato plant cell death induced by inhibition of HSP90 is alleviated by Tomato yellow leaf curl virus infection.
Infections
Tomato yellow leaf curl virus alters the host preferences of its vector Bemisia tabaci.
Infections
Tomato yellow leaf curl virus can be acquired and transmitted by Bemisia tabaci (Gennadius) from tomato fruit
Infections
Tomato yellow leaf curl virus Can Be Acquired and Transmitted by Bemisia tabaci (Gennadius) from Tomato Fruit.
Infections
Tomato yellow leaf curl virus differentially influences plant defence responses to a vector and a non-vector herbivore.
Infections
Tomato yellow leaf curl virus in the Dominican Republic: Characterization of an Infectious Clone, Virus Monitoring in Whiteflies, and Identification of Reservoir Hosts.
Infections
Tomato yellow leaf curl virus in the Dominican Republic: characterization of an infectious clone, virus monitoring in whiteflies, and identification of reservoir hosts.
Infections
Tomato Yellow Leaf Curl Virus Infection Alters Bemisia tabaci MED (Hemiptera: Aleyrodidae) Vulnerability to Flupyradifurone.
Infections
Tomato yellow leaf curl virus intergenic siRNAs target a host long noncoding RNA to modulate disease symptoms.
Infections
Tomato yellow leaf curl virus Resistant Tomatoes Show Resistance to Tomato curly stunt virus.
Infections
Tomato yellow leaf curl virus resistant tomatoes show resistance to Tomato curly stunt virus.
Infections
Tomato Yellow Leaf Curl Virus V2 Interacts with Host Histone Deacetylase 6 To Suppress Methylation-Mediated Transcriptional Gene Silencing in Plants.
Infections
Tomato Yellow Leaf Curl Virus V2 Protein Plays a Critical Role in the Nuclear Export of V1 Protein and Viral Systemic Infection.
Infections
Tomato Yellow Leaf Curl Virus-Resistant and -Susceptible Tomato Genotypes Similarly Impact the Virus Population Genetics.
Infections
Towards area wide management of insect vectored viruses of tomatoes in the Bowen district.
Infections
Transcriptional reprogramming caused by the geminivirus Tomato yellow leaf curl virus in local or systemic infections in Nicotiana benthamiana.
Infections
Transcriptome profiles of tomato plants after neutron irradiation and infection with TYLCV.
Infections
Transcriptome Profiling of the Whitefly Bemisia tabaci MED in Response to Single Infection of Tomato yellow leaf curl virus, Tomato chlorosis virus, and Their Co-infection.
Infections
Transcriptome profiling of whitefly guts in response to Tomato yellow leaf curl virus infection.
Infections
Ty-1, a universal resistance gene against geminiviruses that is compromised by co-replication of a betasatellite.
Infections
Virus Accumulation and Whitefly Performance Modulate the Role of Alternate Host Species as Inoculum Sources of Tomato Yellow Leaf Curl Virus.
Infections
Virus infection of a weed increases vector attraction to and vector fitness on the weed.
Infections
Water Balance, Hormone Homeostasis, and Sugar Signaling Are All Involved in Tomato Resistance to Tomato Yellow Leaf Curl Virus.
Metrorrhagia
Differentiation of Tomato yellow leaf curl virus and Tomato yellow leaf curl Sardinia virus using real-time TaqMan PCR.
Mycoses
Effects of Isaria fumosorosea on TYLCV (Tomato Yellow Leaf Curl Virus) Accumulation and Transmitting Capacity of Bemisia tabaci.
Virus Diseases
Comparative Analyses of Tomato yellow leaf curl virus C4 Protein-Interacting Host Proteins in Healthy and Infected Tomato Tissues.
Virus Diseases
Resistance to tomato yellow leaf curl geminivirus in Nicotiana benthamiana plants transformed with a truncated viral C1 gene.
Virus Diseases
The six Tomato yellow leaf curl virus genes expressed individually in tomato induce different levels of plant stress response attenuation.
Virus Diseases
Tomato yellow leaf curl virus intergenic siRNAs target a host long noncoding RNA to modulate disease symptoms.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
physiological function
the disruption of the tylCV gene results in the accumulation of desmycosin, the direct precursor of tilmicosin
physiological function
-
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
-
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A0A645DAN2_9ZZZZ
357
0
40890
TrEMBL
other Location (Reliability: 1)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
synthesis
the disruption of the tylCV gene results in the accumulation of desmycosin, the direct precursor of tilmicosin. After optimization of the culture conditions, the yield of desmycosin reaches 7.3 g/l in a 5 l jar fermentor
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bate, N.; Butler, A.R.; Smith, I.P.; Cundliffe, E.
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin
Microbiology
146
139-146
2000
Streptomyces fradiae (Q9XC67), Streptomyces fradiae, Streptomyces fradiae T59235 (Q9XC67)
brenda
Min, Y.; Lv, H.; Zheng, Y.
Fusion PCR-targeted tylCV gene deletion of Streptomyces fradiae for producing desmycosin, the direct precursor of tilmicosin
Process Biochem.
42
729-733
2007
Streptomyces fradiae (Q9XC67)
-
brenda
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Release 2023.1 (January 2023)
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