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Information on EC 2.4.1.312 - protein O-mannose beta-1,4-N-acetylglucosaminyltransferase

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IUBMB Comments
The human protein is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
GTDC2, O-mannose beta-1,4-N-acetylglucosaminyltransferase, POMGNT2, protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2, protein O-mannose beta1,4-N-acetylglucosaminyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] = UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]
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