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EC Tree
IUBMB Comments Involved in the synthesis of several different major classes of glycosphingolipids.
The taxonomic range for the selected organisms is: Homo sapiens The enzyme appears in selected viruses and cellular organisms
Synonyms
laccer synthase, b4galt6, beta4galt5, udp-gal:glucosylceramide beta-1,4-galactosyltransferase, lac-cer synthase, beta-1,4-galactosyltransferase v,
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lactosylceramide synthase
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UDP-galactose:GlcCer, beta1-4 galactosyltransferase
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UDPgalactose:glucosylceramide beta1->4-galactosyltransferase
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UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase
Involved in the synthesis of several different major classes of glycosphingolipids.
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UDP-galactose + beta-D-glucosyl-(1<->1)-ceramide
UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
UDP-galactose + ceramide
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UDP-galactose + galactosylceramide
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UDP-galactose + GlcNAc-beta-(1->3)-Gal-beta-(1->4)-Glc-beta-(1<->1)-Cer
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UDP-galactose + lactosylceramide
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UDP-galactose + beta-D-glucosyl-(1<->1)-ceramide
UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
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UDP-galactose + beta-D-glucosyl-(1<->1)-ceramide
UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
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the enzyme is involved in the synthesis of several different major classes of glycosphingolipids
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UDP-galactose + beta-D-glucosyl-(1<->1)-ceramide
UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
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the enzyme is involved in the synthesis of several different major classes of glycosphingolipids
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Mg2+
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the enzyme is inactive without added metal ions. Maximal activity is obtained in the presence of 1.0 mM Mn2+/Mg2+ (1:1)
Mn2+
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optimum activity is obtained in the presence of 1.0 mM Mn2+/Mg2+ (1:1)
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Cutscum
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maximal activity in a detergent mixture, Triton X-100/Cutscum (1:2, v/v), 0.1 mg/ml
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Triton X-100
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maximal activity in a detergent mixture, Triton X-100/Cutscum (1:2, v/v), 0.1 mg/ml
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Astrocytoma
Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line.
Atherosclerosis
Platelet derived growth factor recruits lactosylceramide to induce cell proliferation in UDP Gal:GlcCer: beta1 --> 4Galactosyltransferase (GalT-V) mutant Chinese hamster ovary cells.
Colonic Neoplasms
VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo.
Glioblastoma
Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line.
Lymphoma
Selenium reduces enterohemorrhagic Escherichia coli O157:H7 verotoxin production and globotriaosylceramide receptor expression on host cells.
Melanoma
Human melanoma and Chinese hamster ovary cells galactosylate n-alkyl-beta-glucosides using UDP gal:GlcNAc beta 1,4 galactosyltransferase.
Melanoma
Positive regulation of tumor necrosis factor-alpha by ganglioside GM3 through Akt in mouse melanoma B16 cells.
Melanoma, Experimental
Expression machinery of GM4: the excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GM4 synthesis in mammalian cells.
Neoplasms
Correlated gene expression between beta-1,4-galactosyltransferase V and N-acetylglucosaminyltransferase V in human cancer cell lines.
Neoplasms
Platelet derived growth factor recruits lactosylceramide to induce cell proliferation in UDP Gal:GlcCer: beta1 --> 4Galactosyltransferase (GalT-V) mutant Chinese hamster ovary cells.
Neoplasms
Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells.
Neoplasms
The Yin and Yang of lactosylceramide metabolism: Implications in cell function.
Neoplasms
Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1.
Neuroblastoma
Trichothecenes induce accumulation of glucosylceramide in neural cells by interfering with lactosylceramide synthase activity.
Neuroinflammatory Diseases
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
Pectus Carinatum
Skeletal dysplasia, global developmental delay, and multiple congenital anomalies in a 5-year-old boy-Report of the second family with B3GAT3 mutation and expansion of the phenotype.
Polycystic Kidney Diseases
The Yin and Yang of lactosylceramide metabolism: Implications in cell function.
Refractive Errors
Skeletal dysplasia, global developmental delay, and multiple congenital anomalies in a 5-year-old boy-Report of the second family with B3GAT3 mutation and expansion of the phenotype.
Skin Abnormalities
Skeletal dysplasia, global developmental delay, and multiple congenital anomalies in a 5-year-old boy-Report of the second family with B3GAT3 mutation and expansion of the phenotype.
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0.003
beta-D-glucosyl-(1<->1)-ceramide
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pH 6.8, 37°C
0.0005
UDP-galactose
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pH 6.8, 37°C
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0.0613
recombinant enzyme, pH and temperature not specified in the publication
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4.55
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isoelectric focusing
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SwissProt
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high expression
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high expression
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low axpression
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low axpression
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low axpression
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low axpression
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from normal and familial hypercholesterolemic homozygotes. Urinary proximal tubular cells from familial hypercholesterolemic homozygous patients contain glucosylceramide beta-1,4-galactosyltransferase activity 35% higher as compared to control cells
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physiological function
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elevated glucosylceramide beta-1,4-galactosyltransferase activity may contribute to the storage of lactosylceramide urinary proximal tubular cells from familial hypercholesterolemic patients
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B4GT6_HUMAN
382
1
44914
Swiss-Prot
Secretory Pathway (Reliability: 4 )
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B4GALT5 gene/protein expression is specifically increased in human colorectal cancer
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medicine
B4GALT5 gene/protein expression is specifically increased in human colorectal cancer tumors, with a concomitant increase in its enzymatic activity, and product lactosylceramide, and increased dihydrosphingolipid metabolites. Inhibition of glycosphingolipid synthesis by the synthetic ceramide analog, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol, concurrently inhibits colorectal cancer cell proliferation, as well as B4GALT5 mass and several glycosphingolipid levels
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Takizawa, M.; Nomura, T.; Wakisaka, E.; Yoshizuka, N.; Aoki, J.; Arai, H.; Inoue, K.; Hattori, M.; Matsuo, N.
cDNA cloning and expression of human lactosylceramide synthase
Biochim. Biophys. Acta
1438
301-304
1999
Homo sapiens (Q9UBX8)
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Chatterjee, S.; Castiglione, E.
UDPgalactose:glucosylceramide beta1->4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes
Biochim. Biophys. Acta
923
136-142
1987
Homo sapiens
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Chatterjee, S.; Ghosh, N.; Khurana, S.
Purification of uridine diphosphate-galactose:glucosyl ceramide, beta1-4 galactosyltransferase from human kidney
J. Biol. Chem.
267
7148-7153
1992
Homo sapiens
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Chatterjee, S.B.; Hou, J.; Bandaru, V.V.R.; Pezhouh, M.K.; Syed Rifat Mannan, A.A.; Sharma, R.
Lactosylceramide synthase beta-1,4-GalT-V A novel target for the diagnosis and therapy of human colorectal cancer
Biochem. Biophys. Res. Commun.
508
380-386
2019
Homo sapiens (O43286)
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