Information on EC 2.4.1.246 - mannosylfructose-phosphate synthase

for references in articles please use BRENDA:EC2.4.1.246
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The expected taxonomic range for this enzyme is: Agrobacterium tumefaciens

EC NUMBER
COMMENTARY hide
2.4.1.246
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RECOMMENDED NAME
GeneOntology No.
mannosylfructose-phosphate synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-mannose + D-fructose 6-phosphate = GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
mannosylfructose biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
GDP-mannose:D-fructose-6-phosphate 2-alpha-D-mannosyltransferase
This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ or Mn2+ for activity. GDP-mannose can be replaced by ADP-mannose but with a concomitant decrease in activity. The product of this reaction is dephosphorylated by EC 3.1.3.79 (mannosylfructose-phosphate phosphatase) to form the non-reducing disaccharide mannosylfructose, which is the major endogenous osmolyte produced by several alpha-proteobacteria in response to osmotic stress. The F in the product name is used to indicate that the fructose residue of sucrose carries the substituent.
CAS REGISTRY NUMBER
COMMENTARY hide
92480-04-1
not distinguished from EC 2.4.1.167
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Agrobacterium tumefaciens C58 / ATCC 33970
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Uniprot
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GDP-mannose + D-fructose 6-phosphate
GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate
show the reaction diagram
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?
Show AA Sequence (523 entries)
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