Information on EC - alpha,alpha-trehalose synthase

for references in articles please use BRENDA:EC2.4.1.245
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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
       alpha,alpha-trehalose synthase
IUBMB Comments
Requires Mg2+ for maximal activity . The enzyme-catalysed reaction is reversible . In the reverse direction to that shown above, the enzyme is specific for alpha,alpha-trehalose as substrate, as it cannot use alpha- or beta-paranitrophenyl glucosides, maltose, sucrose, lactose or cellobiose . While the enzymes from the thermophilic bacterium Rubrobacter xylanophilus and the hyperthermophilic archaeon Pyrococcus horikoshii can use ADP-, UDP- and GDP-alpha-D-glucose to the same extent [2,3], that from the hyperthermophilic archaeon Thermococcus litoralis has a marked preference for ADP-alpha-D-glucose and that from the hyperthermophilic archaeon Thermoproteus tenax has a marked preference for UDP-alpha-D-glucose .
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
PH1035, TaTS, TmTreT, trehalose glycosyltransferring synthase, Trehalose synthase, TreT, more
NDP-alpha-D-glucose + D-glucose = alpha,alpha-trehalose + NDP
show the reaction diagram
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