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Information on EC 2.4.1.244 - N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase

for references in articles please use BRENDA:EC2.4.1.244
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IUBMB Comments
The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end. The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme-characterization experiments. Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
b4galnt3, beta4galnac-t3, beta4galnactb, beta1,4-n-acetylgalactosaminyltransferase iii, beta1,4-n-acetylgalactosaminyltransferase-iii, beta4galnac-t4, beta1,4-n-acetylgalactosaminyltransferases, beta1,4-n-acetylgalactosaminyltransferase ii, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
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PATHWAY SOURCE
PATHWAYS
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