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(n-acetylneuraminyl)-galactosylglucosylceramide n-acetylgalactosaminyltransferase deficiency
Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting.
Abortion, Spontaneous
Two Thai Burmese descendants with A4GALT*01N.21, p phenotype, and anti-PP1Pk.
Acute Kidney Injury
Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.
Acute Kidney Injury
Lose the lipid: renoprotection conferred by Gb3 synthase knockout.
Adenocarcinoma of Lung
An increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells.
Adenocarcinoma of Lung
Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells.
Alzheimer Disease
PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.
Bone Diseases
Effect of miglustat on bone disease in adults with type 1 Gaucher disease: a pooled analysis of three multinational, open-label studies.
Brain Ischemia
Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning.
Breast Neoplasms
Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer.
Breast Neoplasms
Ceramide Glycosylation by Glucosylceramide Synthase Selectively Maintains the Properties of Breast Cancer Stem Cells.
Breast Neoplasms
Co-suppression of MDR1 (multidrug resistance 1) and GCS (glucosylceramide synthase) restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi).
Breast Neoplasms
Doxorubicin influences the expression of glucosylceramide synthase in invasive ductal breast cancer.
Breast Neoplasms
Evaluation of anticancer agents using flow cytometry analysis of cancer stem cells.
Breast Neoplasms
Expression of glucosylceramide synthase in invasive ductal breast cancer may be correlated with high estrogen receptor status and low HER-2 status.
Breast Neoplasms
Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.
Breast Neoplasms
Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs.
Breast Neoplasms
Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma.
Breast Neoplasms
Lactoferricin-induced apoptosis in estrogen-nonresponsive MDA-MB-435 breast cancer cells is enhanced by C6 ceramide or tamoxifen.
Breast Neoplasms
MDR1 (multidrug resistence 1) can regulate GCS (glucosylceramide synthase) in breast cancer cells.
Breast Neoplasms
Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.
Breast Neoplasms
Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.
Breast Neoplasms
P-glycoprotein modulates ceramide-mediated sensitivity of human breast cancer cells to tubulin-binding anticancer drugs.
Breast Neoplasms
Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer.
Breast Neoplasms
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Breast Neoplasms
Suppression of glucosylceramide synthase by RNA interference reverses multidrug resistance in human breast cancer cells.
Breast Neoplasms
Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs.
Breast Neoplasms
The opposite effects of doxorubicin on bone marrow stem cells versus breast cancer stem cells depend on glucosylceramide synthase.
Breast Neoplasms
The roles of antiapoptotic sphingosine kinase-1 and glucosylceramide genes in drug induced cell death of MCF-7 breast cancer cells.
Breast Neoplasms
[Construction of glucosylceramide synthase-specific siRNA expression vector and its efficiency in reversal of drug resistance in breast carcinoma cells]
Breast Neoplasms
[Effects of artificial microRNA targeting glucosylceramide synthase on drug sensitivity of breast cancer cells].
Breast Neoplasms
[Investigation on the relationship between multidrug resistance and expression of glucosylceramide synthase in human breast carcinoma cells]
Carcinoma
Effect of verapamil in the reversal of doxorubicin chemotherapy resistance in advanced gastric cancer.
Carcinoma
Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action.
Carcinoma, Hepatocellular
Differential chemosensitizing effect of two glucosylceramide synthase inhibitors in hepatoma cells.
Carcinoma, Hepatocellular
Glucosylceramide synthase inhibitors D-PDMP and D-EtDO-P4 decrease the GM3 ganglioside level, differ in their effects on insulin receptor autophosphorylation but increase Akt1 kinase phosphorylation in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma.
Carcinoma, Lewis Lung
Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action.
Carcinoma, Non-Small-Cell Lung
Overexpression of glucosylceramide synthase and its significance in the clinical outcome of non-small cell lung cancer.
Carcinoma, Renal Cell
Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies.
Carcinoma, Squamous Cell
Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.
Cataplexy
Treatment of cataplexy in Niemann-Pick disease type C with the use of miglustat.
Cholera
Transition of mesenchymal and epithelial cancer cells depends on ?1-4 galactosyltransferase-mediated glycosphingolipids.
Colonic Neoplasms
Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells.
Colorectal Neoplasms
Expression and significance of glucosylceramide synthase in colorectal carcinoma tissues.
Cysts
Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease.
Diabetes Mellitus
The design and clinical development of inhibitors of glycosphingolipid synthesis: will invention be the mother of necessity?
Diabetes Mellitus, Type 2
Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.
Diabetes Mellitus, Type 2
Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars.
Diabetes Mellitus, Type 2
Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.
Diabetes Mellitus, Type 2
Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice.
Diabetes Mellitus, Type 2
The design and clinical development of inhibitors of glycosphingolipid synthesis: will invention be the mother of necessity?
Fabry Disease
Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease.
Fabry Disease
Glucosylceramide synthase inhibition with lucerastat lowers globotriaosylceramide and lysosome staining in cultured fibroblasts from Fabry patients with different mutation types.
Fabry Disease
Glycosphingolipid depletion in fabry disease lymphoblasts with potent inhibitors of glucosylceramide synthase.
Fabry Disease
Lucerastat, an Iminosugar for Substrate Reduction Therapy: Pharmacokinetics, Tolerability, and Safety in Subjects With Mild, Moderate, and Severe Renal Function Impairment.
Fabry Disease
Lucerastat, an Iminosugar for Substrate Reduction Therapy: Tolerability, Pharmacodynamics, and Pharmacokinetics in Patients With Fabry Disease on Enzyme Replacement.
Fabry Disease
Lucerastat, an iminosugar with potential as substrate reduction therapy for glycolipid storage disorders: safety, tolerability, and pharmacokinetics in healthy subjects.
Fabry Disease
Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation.
Fabry Disease
The effect of the glucosylceramide synthase inhibitor lucerastat on cardiac repolarization: results from a thorough QT study in healthy subjects.
Fatty Liver
Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice.
Fatty Liver
Sphingolipids and hepatic steatosis.
Gaucher Disease
A new brain-penetrant glucosylceramide synthase inhibitor as potential Therapeutics for Gaucher disease.
Gaucher Disease
A Phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1.
Gaucher Disease
A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease.
Gaucher Disease
Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.
Gaucher Disease
Carcinogenicity testing of eliglustat in mice and rats.
Gaucher Disease
Characterization of Variants in the Glucosylceramide Synthase Gene and their Association with Type 1 Gaucher Disease Severity.
Gaucher Disease
CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease.
Gaucher Disease
Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.
Gaucher Disease
Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells.
Gaucher Disease
Effects of paroxetine, ketoconazole, and rifampin on the metabolism of eliglustat, an oral substrate reduction therapy for Gaucher disease type 1.
Gaucher Disease
Eliglustat prevents Shiga toxin 2 cytotoxic effects in human renal tubular epithelial cells.
Gaucher Disease
ELIGLUSTAT TARTRATE: Glucosylceramide Synthase Inhibitor Treatment of Type 1 Gaucher Disease.
Gaucher Disease
Eliglustat: first global approval.
Gaucher Disease
Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing.
Gaucher Disease
Exploiting Gangliosides for the Therapy of Ewing's Sarcoma and H3K27M-Mutant Diffuse Midline Glioma.
Gaucher Disease
Lucerastat, an iminosugar with potential as substrate reduction therapy for glycolipid storage disorders: safety, tolerability, and pharmacokinetics in healthy subjects.
Gaucher Disease
Management and monitoring recommendations for the use of eliglustat in adults with type 1 Gaucher disease in Europe.
Gaucher Disease
Miglustat as a therapeutic agent: prospects and caveats.
Gaucher Disease
Optimization of Eliglustat-Based Glucosylceramide Synthase Inhibitors as Substrate Reduction Therapy for Gaucher Disease Type 3.
Gaucher Disease
Polymorphisms in glucosylceramide (glucocerebroside) synthase and the Gaucher disease phenotype.
Gaucher Disease
Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain.
Gaucher Disease
Real-world clinical experience with long-term miglustat maintenance therapy in type 1 Gaucher disease: the ZAGAL project.
Gaucher Disease
RNAi-mediated inhibition of the glucosylceramide synthase (GCS) gene: A preliminary study towards a therapeutic strategy for Gaucher disease and other glycosphingolipid storage diseases.
Gaucher Disease
Safety, Tolerability, and Pharmacokinetics of Eliglustat Tartrate (Genz-112638) After Single Doses, Multiple Doses, and Food in Healthy Volunteers.
Gaucher Disease
Short-term effect of miglustat in every day clinical use in treatment-naïve or previously treated patients with type 1 Gaucher's disease.
Gaucher Disease
Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease.
Gaucher Disease
Substrate reduction therapy with miglustat for type 1 Gaucher disease: A retrospective analysis from a single institution.
Gaucher Disease
Systemic delivery of a glucosylceramide synthase inhibitor reduces CNS substrates and increases lifespan in a mouse model of type 2 Gaucher disease.
Gaucher Disease
The pharmacokinetics and tissue distribution of the glucosylceramide synthase inhibitor miglustat in the rat.
Gaucher Disease
Treatment of cataplexy in Niemann-Pick disease type C with the use of miglustat.
Gaucher Disease
Treatment of Niemann-Pick disease type C in two children with miglustat: initial responses and maintenance of effects over 1 year.
Glioblastoma
Glucosylceramide synthase protects glioblastoma cells against autophagic and apoptotic death induced by temozolomide and Paclitaxel.
Glioblastoma
Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma.
Glioma
Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells.
Head and Neck Neoplasms
Inhibition of Glucosylceramide Synthase Sensitizes Head and Neck Cancer to Cisplatin.
Hyperglycemia
Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells.
Infarction, Middle Cerebral Artery
Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning.
Infections
Glucosylceramide synthase maintains influenza virus entry and infection.
Infections
Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5.
Infections
Surface localization of glucosylceramide during Cryptococcus neoformans infection allows targeting as a potential antifungal.
Infertility, Male
Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting.
Influenza, Human
Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and influenza virus.
Influenza, Human
Glucosylceramide synthase maintains influenza virus entry and infection.
Insulin Resistance
Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.
Insulin Resistance
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity.
Insulin Resistance
Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice.
Insulin Resistance
The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.
Kidney Diseases, Cystic
Abnormalities of glycosphingolipid, sulfatide, and ceramide in the polycystic (cpk/cpk) mouse.
lactosylceramide 4-alpha-galactosyltransferase deficiency
1-O-Acylceramides are natural components of human and mouse epidermis.
lactosylceramide 4-alpha-galactosyltransferase deficiency
Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.
lactosylceramide 4-alpha-galactosyltransferase deficiency
Glucosylceramide synthase deficiency in the heart compromises ?1-adrenergic receptor trafficking.
Leukemia
Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity.
Leukemia
Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and tetrandrine on the reversion of multidrug resistance in K562/A02 cells.
Leukemia
Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells: implication in the sensitivity to verotoxins.
Leukemia
Fludarabine-resistance associates with ceramide metabolism and leukemia stem cell development in chronic lymphocytic leukemia.
Leukemia
GCS induces multidrug resistance by regulating apoptosis-related genes in K562/AO2 cell line.
Leukemia
Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity.
Leukemia
Glucosylceramide synthase promotes Bcl-2 expression via the ERK signaling pathway in the K562/A02 leukemia drug-resistant cell line.
Leukemia
Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins.
Leukemia
Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells.
Leukemia
Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia.
Leukemia
Targeting glucosylceramide synthase synergizes with C(6)-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia.
Leukemia
The effect of glucosylceramide synthase on P-glycoprotein function in K562/AO2 leukemia drug-resistance cell line.
Leukemia
[Effect of glucosylceramide synthase on P-gp expression by ERK signal transduction pathway in leukemia multi-drug resistance cell line].
Leukemia
[Effect of PDMP, a glucosylceramide synthase inhibitor, on reversion of daunorubicin resistance in human leukemia cell line K562/A02]
Leukemia
[NF-? B mediates the effect of glucosylceramide synthase on P-glycoprotein modulation in a drug-resistance leukemia cell line].
Leukemia
[Relation between glucosylceramide synthase and multidrug resistance in leukemia cells]
Leukemia
[Study on the correlation of GCS and MDR1 genes in inducing multidrug resistance in human K562/A02 cell line]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation.
Leukemia, Myeloid, Acute
P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway.
Leukemia, Promyelocytic, Acute
Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity.
Liver Diseases
Correction of cilia structure and function alleviates multi-organ pathology in Bardet-Biedl syndrome mice.
Liver Diseases
The role of glucosylceramide and glucosylceramide synthase in liver disease: from bench to bedside - Review.
Lung Neoplasms
Overexpression of glucosylceramide synthase and its significance in the clinical outcome of non-small cell lung cancer.
Lung Neoplasms
Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells.
Lymphoma, B-Cell
Mechanism of the reversal effect of mifepristone on drug resistance of the human cervical cancer cell line HeLa/MMC.
Lysosomal Storage Diseases
Systemic delivery of a glucosylceramide synthase inhibitor reduces CNS substrates and increases lifespan in a mouse model of type 2 Gaucher disease.
Medulloblastoma
Synthesis, shedding, and intercellular transfer of human medulloblastoma gangliosides: abrogation by a new inhibitor of glucosylceramide synthase.
Melanoma
Crucial role of glucosylceramide synthase in the regulation of stem cell-like cancer cells in B16F10 murine melanoma.
Melanoma
Influence of cellular ganglioside depletion on tumor formation.
Melanoma
Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase.
Melanoma
The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs.
Melanoma
Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formation.
Mesothelioma
Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells.
Mesothelioma, Malignant
Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells.
Neoplasm Metastasis
Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action.
Neoplasms
3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells.
Neoplasms
A new mixed-backbone oligonucleotide against glucosylceramide synthase Sensitizes multidrug-resistant tumors to apoptosis.
Neoplasms
Alteration of Ceramide 1-O-Functionalization as a Promising Approach for Cancer Therapy.
Neoplasms
Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer.
Neoplasms
Are Glucosylceramide-Related Sphingolipids Involved in the Increased Risk for Cancer in Gaucher Disease Patients? Review and Hypotheses.
Neoplasms
Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.
Neoplasms
Ceramide mediates tumor-induced dendritic cell apoptosis.
Neoplasms
Ceramide synthesis and metabolism as a target for cancer therapy.
Neoplasms
Colony-stimulating factor-1 antibody reverses chemoresistance in human mcf-7 breast cancer xenografts.
Neoplasms
Crucial role of glucosylceramide synthase in the regulation of stem cell-like cancer cells in B16F10 murine melanoma.
Neoplasms
Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines.
Neoplasms
Degradation of NF-kappa B in T cells by gangliosides expressed on renal cell carcinomas.
Neoplasms
Differential influence of the tumour-specific non-human sialic acid containing GM3 ganglioside on CD4+CD25- effector and naturally occurring CD4+CD25+ regulatory T cells function.
Neoplasms
Expression of glucosylceramide synthase in invasive ductal breast cancer may be correlated with high estrogen receptor status and low HER-2 status.
Neoplasms
Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells: implication in the sensitivity to verotoxins.
Neoplasms
Glucose availability and glycolytic metabolism dictate glycosphingolipid levels.
Neoplasms
Glucosylceramidases and malignancies in mammals.
Neoplasms
Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs.
Neoplasms
Glucosylceramide synthase promotes Bcl-2 expression via the ERK signaling pathway in the K562/A02 leukemia drug-resistant cell line.
Neoplasms
Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.
Neoplasms
Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma.
Neoplasms
Glycolipid composition in bladder tumor: a crucial role of GM3 ganglioside in tumor invasion.
Neoplasms
Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies.
Neoplasms
Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action.
Neoplasms
Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.
Neoplasms
Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells.
Neoplasms
Inhibition of Glucosylceramide Synthase Sensitizes Head and Neck Cancer to Cisplatin.
Neoplasms
Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase.
Neoplasms
Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin.
Neoplasms
Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer.
Neoplasms
New Insights on Glucosylceramide Synthase in Cancer Drug Resistance and Myelosuppression.
Neoplasms
Novel mechanisms of action of classical chemotherapeutic agents on sphingolipid pathways.
Neoplasms
Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.
Neoplasms
Overexpression of glucosylceramide synthase and its significance in the clinical outcome of non-small cell lung cancer.
Neoplasms
Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.
Neoplasms
PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy.
Neoplasms
Prognostic value of glucosylceramide synthase and P-glycoprotein expression in oral cavity cancer.
Neoplasms
Rationales for cancer chemotherapy with PDMP, a specific inhibitor of glucosylceramide synthase.
Neoplasms
Re-configuration of sphingolipid metabolism by oncogenic transformation.
Neoplasms
Sphingolipid metabolism enzymes as targets for anticancer therapy.
Neoplasms
Sphingolipids and response to chemotherapy.
Neoplasms
Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.
Neoplasms
Suppression of glucosylceramide synthase by RNA interference reverses multidrug resistance in human breast cancer cells.
Neoplasms
Suppression of Glucosylceramide Synthase Restores p53-Dependent Apoptosis in Mutant p53 Cancer Cells.
Neoplasms
Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.
Neoplasms
Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells.
Neoplasms
Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer.
Neoplasms
Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formation.
Neoplasms
Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance.
Neoplasms
Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model.
Neoplasms
[Expression of glucosylceramide synthase mRNA in vincristine-resistant KBV200 cell line in association with multidrug resistance]
Neuroblastoma
Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells.
Neuroblastoma
Effects of an inhibitor of glucosylceramide synthase on glycosphingolipid synthesis and neurite outgrowth in murine neuroblastoma cell lines.
Neuroblastoma
Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.
Neuroblastoma
[Effect of endogeneous gangliosides on integrin alpha2beta1-mediated adhesion of neuroblastoma cells to collagen]
Neurologic Manifestations
Impact of miglustat on evolution of atypical presentation of late-infantile-onset Niemann-Pick disease type C with early cognitive impairment, behavioral dysfunction, epilepsy, ophthalmoplegia, and cerebellar involvement: a case report.
Niemann-Pick Disease, Type C
Cholesterol-dependent increases in glucosylceramide synthase activity in Niemann-Pick disease type C model cells: Abnormal trafficking of endogenously formed ceramide metabolites by inhibition of the enzyme.
Niemann-Pick Disease, Type C
Impact of miglustat on evolution of atypical presentation of late-infantile-onset Niemann-Pick disease type C with early cognitive impairment, behavioral dysfunction, epilepsy, ophthalmoplegia, and cerebellar involvement: a case report.
Niemann-Pick Diseases
Cholesterol-dependent increases in glucosylceramide synthase activity in Niemann-Pick disease type C model cells: Abnormal trafficking of endogenously formed ceramide metabolites by inhibition of the enzyme.
Niemann-Pick Diseases
Impact of miglustat on evolution of atypical presentation of late-infantile-onset Niemann-Pick disease type C with early cognitive impairment, behavioral dysfunction, epilepsy, ophthalmoplegia, and cerebellar involvement: a case report.
Obesity
Correction of cilia structure and function alleviates multi-organ pathology in Bardet-Biedl syndrome mice.
Osteosarcoma
Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5.
Ovarian Neoplasms
[Mifepristone modulates glucosylceramide synthase expression and reverse multidrug resistance in ovarian cancer cells.]
Pancreatic Neoplasms
The glucosylceramide synthase inhibitor PDMP sensitizes pancreatic cancer cells to MEK/ERK inhibitor AZD-6244.
Polycystic Kidney Diseases
Glycosphingolipid metabolism and polycystic kidney disease.
Polycystic Kidney Diseases
The design and clinical development of inhibitors of glycosphingolipid synthesis: will invention be the mother of necessity?
Polycystic Kidney, Autosomal Dominant
Glycosphingolipid metabolism and polycystic kidney disease.
Retinal Degeneration
Correction of cilia structure and function alleviates multi-organ pathology in Bardet-Biedl syndrome mice.
Sandhoff Disease
Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease.
Sandhoff Disease
Substrate Reduction Therapy for Sandhoff Disease through Inhibition of Glucosylceramide Synthase Activity.
Stomach Ulcer
Attenuation of Acetic Acid-Induced Gastric Ulcer Formation in Rats by Glucosylceramide Synthase Inhibitors.
Synucleinopathies
A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
Synucleinopathies
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.
Teratocarcinoma
A single point mutation in the gene encoding Gb3/CD77 synthase causes a rare inherited polyagglutination syndrome.
Thyroid Cancer, Papillary
Upregulation of glucosylceramide synthase protein in papillary thyroid carcinoma.
Triple Negative Breast Neoplasms
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Urinary Bladder Neoplasms
Up-regulation of glucosylceramide synthase in urinary bladder neoplasms.
Uterine Cervical Neoplasms
Resistance to the antiproliferative effect induced by a short-chain ceramide is associated with an increase of glucosylceramide synthase, P-glycoprotein, and multidrug-resistance gene-1 in cervical cancer cells.
Virus Diseases
Glucosylceramide synthase maintains influenza virus entry and infection.
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Bailly, P.; Piller, F.; Cartron, J.P.; Leroy, Y.; Fournet, B.
Identification of UDP-galactose:lactose (lactosylceramide) alpha-4 and beta-3 galactosyltransferases in human kidney
Biochem. Biophys. Res. Commun.
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84-91
1986
Homo sapiens
brenda
Iizuka, S.; Chen, S.H.; Yoshida, A.
Studies on the human blood group P system: an existence of UDP-Gal: lactosylceramide alpha 1 -> 4 galactosyltransferase in the small p type cells
Biochem. Biophys. Res. Commun.
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1187-1195
1986
Homo sapiens
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Chen, C.; Fenderson, B.A.; Andrews, P.W.; Hakomori, S.
Glycolipid glycosyltransferases in human embryonal carcinoma cells during retinoic acid induced differentiation
Biochemistry
28
2229-2238
1989
Homo sapiens
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Stults, C.L.M.; Larsen, R.D.; Macher, B.A.
alpha-1,4Galactosyltransferase activity and Gbeta3Cer expression in human leukemia/lymphoma cell lines
Glycoconj. J.
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680-689
1995
Homo sapiens
brenda
Kojima, Y.; Fukumoto, S.; Furukawa, K.; Okajima, T.; Wiels, J.; Yokoyama, K.; Suzuki, Y.; Urano, T.; Ohta, M.; Furukawa, K.
Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of Globo series glycosphingolipids
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2000
Homo sapiens
brenda
Steffensen, R.; Carlier, K.; Wiels, J.; Levery, S.B.; Stroud, M.; Cedergren, B.; Sojka, B.N.; Bennett, E.P.; Jersild, C.; Clausen, H.
Cloning and expression of the histo-blood group Pk UDP-galactose: Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase. Molecular genetic basis of the p phenotype
J. Biol. Chem.
275
16723-16729
2000
Homo sapiens (Q9NPC4), Homo sapiens
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Iwamura, K.; Furukawa, K.; Uchikawa, M.; Sojka, B.N.; Kojima, Y.; Wiels, J.; Shiku, H.; Urano, T.; Furukawa, K.
The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene: a clue to the solution of the P1/P2/p puzzle
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44429-44438
2003
Homo sapiens
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Okuda, T.; Nakayama, K.I.
Identification and characterization of the human Gb3/CD77 synthase gene promoter
Glycobiology
18
1028-1035
2008
Homo sapiens
brenda
Schweppe, C.H.; Bielaszewska, M.; Pohlentz, G.; Friedrich, A.W.; Buentemeyer, H.; Alexander Schmidt, M.; Kim, K.S.; Peter-Katalini?, J.; Karch, H.; Muething, J.
Glycosphingolipids in vascular endothelial cells: relationship of heterogeneity in Gb3Cer/CD77 receptor expression with differential Shiga toxin 1 cytotoxicity
Glycoconj. J.
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2008
Homo sapiens (Q9NPC4), Homo sapiens
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Shin, I.S.; Ishii, S.; Shin, J.S.; Sung, K.I.; Park, B.S.; Jang, H.Y.; Kim, B.W.
Globotriaosylceramide (Gb3) content in HeLa cells is correlated to Shiga toxin-induced cytotoxicity and Gb3 synthase expression
BMB Rep.
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310-314
2009
Homo sapiens
brenda
Okuda, T.; Furukawa, K.; Nakayama, K.
A novel, promoter-based, target-specific assay identifies 2-deoxy-D-glucose as an inhibitor of globotriaosylceramide biosynthesis
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276
5191-5202
2009
Homo sapiens
brenda
Ramkumar, S.; Sakac, D.; Binnington, B.; Branch, D.R.; Lingwood, C.A.
Induction of HIV-1 resistance: cell susceptibility to infection is an inverse function of globotriaosyl ceramide levels
Glycobiology
19
76-82
2009
Homo sapiens
brenda
Shiozuka, C.; Taguchi, A.; Matsuda, J.; Noguchi, Y.; Kunieda, T.; Uchio-Yamada, K.; Yoshioka, H.; Hamanaka, R.; Yano, S.; Yokoyama, S.; Mannen, K.; Kulkarni, A.B.; Furukawa, K.; Ishii, S.
Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease
J. Biochem.
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161-170
2011
Homo sapiens
brenda
Yamaji, T.; Nishikawa, K.; Hanada, K.
Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis
J. Biol. Chem.
285
35505-35518
2010
Homo sapiens
brenda
Suchanowska, A.; Kaczmarek, R.; Duk, M.; Lukasiewicz, J.; Smolarek, D.; Majorczyk, E.; Jaskiewicz, E.; Laskowska, A.; Wasniowska, K.; Grodecka, M.; Lisowska, E.; Czerwinski, M.
A single point mutation in the gene encoding Gb3/CD77 synthase causes a rare inherited polyagglutination syndrome
J. Biol. Chem.
287
38220-38230
2012
Homo sapiens (Q9NPC4), Homo sapiens
brenda
Kaczmarek, R.; Duk, M.; Szymczak, K.; Korchagina, E.; Tyborowska, J.; Mikolajczyk, K.; Bovin, N.; Szewczyk, B.; Jaskiewicz, E.; Czerwinski, M.
Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating Pk, P1 and NOR blood group antigens
Biochem. Biophys. Res. Commun.
470
168-174
2016
Homo sapiens (Q9NPC4), Homo sapiens
brenda
Tyler, A.; Johansson, A.; Karlsson, T.; Gudey, S.K.; Braennstroem, T.; Grankvist, K.; Behnam-Motlagh, P.
Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells
Exp. Cell Res.
336
23-32
2015
Homo sapiens
brenda
Jacob, F.; Alam, S.; Konantz, M.; Liang, C.Y.; Kohler, R.S.; Everest-Dass, A.V.; Huang, Y.L.; Rimmer, N.; Fedier, A.; Schoetzau, A.; Lopez, M.N.; Packer, N.H.; Lengerke, C.; Heinzelmann-Schwarz, V.
Transition of mesenchymal and epithelial cancer cells depends on alpha1-4 galactosyltransferase-mediated glycosphingolipids
Cancer Res.
78
2952-2965
2018
Homo sapiens (Q9NPC4)
brenda
Kaczmarek, R.; Mikolajewicz, K.; Szymczak, K.; Duk, M.; Majorczyk, E.; Krop-Watorek, A.; Buczkowska, A.; Czerwinski, M.
Evaluation of an amino acid residue critical for the specificity and activity of human Gb3/CD77 synthase
Glycoconj. J.
33
963-973
2016
Homo sapiens (Q9NPC4), Homo sapiens
brenda
Lv, X.; Chen, Y.; Luo, Y.; Li, L.; Wang, H.
The synonymous 903C>G mutation in the alpha 1,4-galactosyltransferase gene in a Chinese woman with habitual abortion A case report
Medicine (Baltimore)
98
e16361
2019
Homo sapiens (Q9NPC4), Homo sapiens
brenda
Kaczmarek, R.; Szymczak-Kulus, K.; Bereznicka, A.; Mikolajczyk, K.; Duk, M.; Majorczyk, E.; Krop-Watorek, A.; Klausa, E.; Skowronska, J.; Michalewska, B.; Brojer, E.; Czerwinski, M.
Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system
PLoS ONE
13
e0196627
2018
Homo sapiens (Q9NPC4), Homo sapiens
brenda