Reference on EC 2.4.1.227 - undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mengin-Lecreulx, D.; Textier, L.; Rousseau, M.; van Heijenoort, J.
The murG gene of Escherichia coli codes for the UDP-N-acetylglucosamine:N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase involved in the membrane steps of peptidoglycan synthesis
J. Bacteriol.
173
4625-4636
1991
Escherichia coli
Ha, S.; Chang, E.; Lo, M.C.; Men, H.; Park, P.; Ge, M.; Walker, S.
The kinetik characterization of Escherichia coli MurG using synthetic substrate analogues
J. Am. Chem. Soc.
121
84158426
1999
Escherichia coli
-
Branstrom, A.A.; Midha, S.; Longley, C.B.; Han, K.; Baizman, E.R.; Axelrod, H.R.
Assay for identification of inhibitors for bacterial MraY translocase or MurG transferase
Anal. Biochem.
280
315-319
2000
Escherichia coli, Escherichia coli OV58-pUG18
Cudic, P.; Behenna, D.C.; Yu, M.K.; Kruger, R.G.; Szewczuk, L.M.; McCafferty, D.G.
Synthesis of P1-citronellyl-P2-alpha-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG
Bioorg. Med. chem. Lett.
11
3107-3110
2001
Escherichia coli
Men, H.; Park, P.; Walker, S.
Substrate synthesis and activity assay for MurG
J. Am. Chem. Soc.
120
2484-2485
1998
Escherichia coli
-
Ha, S.; Gross.B.; Walker, S.
E. coli MurG: A paradigm for a superfamily of glycosyltransferases
Curr. Drug Targets Infect. Disord.
1
201-213
2001
Escherichia coli
Chen, L.; Men, H.; Ha, S.; Ye, X.Y.; Brunner, L.; Hu, Y.; Walker, S.
Intrinsic lipid preferences and kinetic mechanism of Escherichia coli MuG
Biochemistry
41
6824-6833
2002
Escherichia coli
Hu, Y.; Chen, L.; Ha, S.; Gross, B.; Falcone, B.; Walker, D.; Mokhtarzadeh, M.; Walker, S.
Crystal structure of the MurG: UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases
Proc. Natl. Acad. Sci. USA
100
845-849
2003
Escherichia coli (P17443)
Auger, G.; van Heijenoort, J.; Mengin-Lecreulx, D.; Blanot, D.
A MurG assay which utilises a synthetic analogue of lipid I
FEMS Microbiol. Lett.
219
115-119
2003
Escherichia coli
Ravishankar, S.; Kumar, V.P.; Chandrakala, B.; Jha, R.K.; Solapure, S.M.; De Sousa, S.M.
Scintillation proximity assay for inhibitors of Escherichia coli MurG and, optionally, MraY
Antimicrob. Agents Chemother.
49
1410-1418
2005
Escherichia coli
Liu, H.; Ritter, T.K.; Sadamoto, R.; Sears, P.S.; Wu, M.; Wong, C.H.
Acceptor specificity and inhibition of the bacterial cell-wall glycosyltransferase MurG
Chembiochem
4
603-609
2003
Escherichia coli
van den Brink-van der Laan, E.; Boots, J.W.P.; Spelbrink, R.E.J.; Kool, G.M.; Breukink, E.; Killian, J.A.; de Kruijff, B.
Membrane interaction of the glycosyltransferase MurG: A special role for cardiolipin
J. Bacteriol.
185
3773-3779
2003
Escherichia coli
Love, K.R.; Swoboda, J.G.; Noren, C.J.; Walker, S.
Enabling glycosyltransferase evolution: a facile substrate-attachment strategy for phage-display enzyme evolution
Chembiochem
7
753-756
2006
Escherichia coli
Mohammadi, T.; Karczmarek, A.; Crouvoisier, M.; Bouhss, A.; Mengin-Lecreulx, D.; den Blaauwen, T.
The essential peptidoglycan glycosyltransferase MurG forms a complex with proteins involved in lateral envelope growth as well as with proteins involved in cell division in Escherichia coli
Mol. Microbiol.
65
1106-1121
2007
Escherichia coli
Crouvoisier, M.; Auger, G.; Blanot, D.; Mengin-Lecreulx, D.
Role of the amino acid invariants in the active site of MurG as evaluated by site-directed mutagenesis
Biochimie
89
1498-1508
2007
Escherichia coli (P17443)
Bouhss, A.; Trunkfield, A.; Bugg, T.; Mengin-Lecreulx, D.
The biosynthesis of peptidoglycan lipid-linked intermediates
FEMS Microbiol. Rev.
32
208-233
2008
Escherichia coli
Trunkfield, A.E.; Gurcha, S.S.; Besra, G.S.; Bugg, T.D.
Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics
Bioorg. Med. Chem.
18
2651-2663
2010
Escherichia coli
Michaelis, A.M.; Gitai, Z.
Dynamic polar sequestration of excess MurG may regulate enzymatic function
J. Bacteriol.
192
4597-4605
2010
Escherichia coli
Ezhilarasan, V.; Sharma, O.; Pan, A.
In silico identification of potential drug targets in Clostridium difficile R20291: modeling and virtual screening analysis of a candidate enzyme MurG
Med. Chem. Res.
22
2692-2705
2012
Clostridioides difficile, Clostridioides difficile R20291
-
Brown, K.; Vial, S.C.; Dedi, N.; Westcott, J.; Scally, S.; Bugg, T.D.; Charlton, P.A.; Cheetham, G.M.
Crystal structure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex
Protein Pept. Lett.
20
1002-1008
2013
Pseudomonas aeruginosa (Q9HW01)
Mann, P.A.; Mueller, A.; Xiao, L.; Pereira, P.M.; Yang, C.; Ho Lee, S.; Wang, H.; Trzeciak, J.; Schneeweis, J.; Dos Santos, M.M.; Murgolo, N.; She, X.; Gill, C.; Balibar, C.J.; Labroli, M.; Su, J.; Flattery, A.; Sherborne, B.; Maier, R.; Tan, C.M.; Black, T.; Onder, K.; Kargman, S.; Monsma, F.J.; Pinho, M.G.; Schneider, T.; Roemer, T.
Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG
ACS Chem. Biol.
8
2442-2451
2013
Staphylococcus aureus
Gifford, S.M.; Meyer, P.
Enzyme function is regulated by its localization
Comput. Biol. Chem.
59 Pt B
113-122
2015
Bacillus subtilis
Egan, A.J.; Biboy, J.; vant Veer, I.; Breukink, E.; Vollmer, W.
Activities and regulation of peptidoglycan synthases
Philos. Trans. R. Soc. Lond. B Biol. Sci.
370
20150031
2015
Escherichia coli, Micrococcus flavus
Mitachi, K.; Yun, H.; Gillman, C.; Skorupinska-Tudek, K.; Swiezewska, E.; Clemons, W.; Kurosu, M.
Substrate tolerance of bacterial glycosyltransferase MurG novel fluorescence-based assays
ACS Infect. Dis.
6
1501-1516
2019
Mycolicibacterium smegmatis, Hydrogenivirga sp. 128-5-R1-1 (A8US35), Mycolicibacterium smegmatis ATCC 607
Nishimoto, M.
Large scale production of lacto-N-biose I, a building block of type I human milk oligosaccharides, using sugar phosphorylases
Biosci. Biotechnol. Biochem.
84
17-24
2020
Escherichia coli
Amera, G.M.; Khan, R.J.; Pathak, A.; Jha, R.K.; Muthukumaran, J.; Singh, A.K.
Screening of promising molecules against MurG as drug target in multi-drug-resistant-Acinetobacter baumannii - insights from comparative protein modeling, molecular docking and molecular dynamics simulation
J. Biomol. Struct. Dyn.
2019
1-23
2019
Acinetobacter baumannii (B0V9F5), Acinetobacter baumannii AYE (B0V9F5)
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