Disease on EC 2.4.1.226 - N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
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DISEASE 
TITLE OF PUBLICATION
LINK TO PUBMED
Atherosclerosis
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
Atherosclerosis
Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
Atherosclerosis
Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis.
Brachydactyly
A FURTHER PATIENT OF PURE 15q DELETION: CLINICAL AND MOLECULAR CYTOGENETIC FINDINGS.
Brachydactyly
A novel CHSY1 gene mutation underlies Temtamy preaxial brachydactyly syndrome in a Pakistani family.
Brachydactyly
Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning.
Brachydactyly
Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling.
Brachydactyly
Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling.
Carcinogenesis
CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NF?B and/or caspase-3/7 signaling pathway.
Carcinoma, Hepatocellular
CHSY1 promotes aggressive phenotypes of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway.
Colorectal Neoplasms
Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.
Colorectal Neoplasms
CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NF?B and/or caspase-3/7 signaling pathway.
Craniofacial Abnormalities
Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.
Encephalomyelitis
Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type.
Encephalomyelitis, Autoimmune, Experimental
Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type.
Glioblastoma
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability.
Glioblastoma
Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling.
Glioma
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability.
Glioma
Tumor-dependent effects of proteoglycans and various glycosaminoglycan synthesizing enzymes and sulfotransferases on patients' outcome.
Hearing Loss
Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling.
Intervertebral Disc Degeneration
Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.
Joint Instability
Chondroitin Sulfate N-acetylgalactosaminylTransferase-1 (CSGalNAcT-1) Deficiency Results in a Mild Skeletal Dysplasia and Joint Laxity.
Lymphoma, B-Cell
CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NF?B and/or caspase-3/7 signaling pathway.
Melanoma
The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.
Multiple Sclerosis
Chondroitin sulfate ?-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism: Association with progression of multiple sclerosis.
Neoplasm Metastasis
CHSY1 promotes aggressive phenotypes of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway.
Neoplasms
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability.
Neoplasms
Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance.
Neoplasms
CHSY1 is upregulated and acts as tumor promotor in gastric cancer through regulating cell proliferation, apoptosis, and migration.
Neoplasms
CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NF?B and/or caspase-3/7 signaling pathway.
Neoplasms
CHSY1 promotes aggressive phenotypes of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway.
Neurofibrosarcoma
Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance.
Sarcoma
Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance.
Spinal Cord Injuries
Chondroitin sulfate ?-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism: Association with progression of multiple sclerosis.
Spinal Cord Injuries
Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury.
Stomach Neoplasms
CHSY1 is upregulated and acts as tumor promotor in gastric cancer through regulating cell proliferation, apoptosis, and migration.
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