Disease on EC 2.4.1.221 - peptide-O-fucosyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
poFUT1 promotes endometrial decidualization by enhancing the O-fucosylation of Notch1.
poFUT1 promotes uterine angiogenesis and vascular remodeling via enhancing the O-fucosylation on uPA.
Progesterone promotes embryo adhesion by upregulating c-Fos/c-Jun transcription factor-mediate poFUT1 expression.
Abortion, Threatened
LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface.
Adenocarcinoma
POFUT1 as a Promising Novel Biomarker of Colorectal Cancer.
Adenoma
Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression.
Breast Neoplasms
Overexpression of Pofut1 and activated Notch1 may be associated with poor prognosis in breast cancer.
Carcinogenesis
PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.
Carcinoma
Bioinformatics insight into glycosyltransferase gene expression in gastric cancer: POFUT1 is a potential biomarker.
Protein O-fucosyltransferase 1: A potential diagnostic marker and therapeutic target for human oral cancer.
Carcinoma, Ductal
Overexpression of Pofut1 and activated Notch1 may be associated with poor prognosis in breast cancer.
Carcinoma, Hepatocellular
Author Correction: Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.
Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.
Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway.
Carcinoma, Squamous Cell
Protein O-fucosyltransferase 1: A potential diagnostic marker and therapeutic target for human oral cancer.
Colorectal Neoplasms
Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer.
PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.
POFUT1 as a Promising Novel Biomarker of Colorectal Cancer.
POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling.
Weighted gene coexpression analysis indicates that PLAGL2 and POFUT1 are related to the differential features of proximal and distal colorectal cancer.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Analyzing the Effects of O-Fucosylation on Secretion of ADAMTS Proteins Using Cell-Based Assays.
Enterocolitis
Intestinal deletion of Pofut1 in the mouse inactivates notch signaling and causes enterocolitis.
Esophageal Neoplasms
Upregulation of Fucosyltransferase 3, 8 and protein O-Fucosyltransferase 1, 2 genes in esophageal cancer stem-like cells (CSLCs).
Glioblastoma
Histology-based expression profiling yields novel prognostic markers in human glioblastoma.
Glioma
Focused microarray analysis of glyco-gene expression in human glioblastomas.
Heart Failure
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.
Hidradenitis
Novel POFUT1 mutation associated with hidradenitis suppurativa-Dowling-Degos disease firm up a role for Notch signalling in the pathogenesis of this disorder.
Novel POFUT1 mutation associated with hidradenitis suppurativa-Dowling-Degos disease firm up a role for Notch signalling in the pathogenesis of this disorder: reply from the authors.
Hidradenitis Suppurativa
A new nonsense mutation in the POGLUT1 gene in two sisters with Dowling-Degos disease.
A novel mutation in POFUT1 gene associated with Dowling-Degos disease and hidradenitis suppurativa.
Hyperpigmentation
Phenotypic expansion of POFUT1 loss of function mutations in a disorder featuring segmental dyspigmentation with eczematous and folliculo-centric lesions.
Variant in human POFUT1 reduces enzymatic activity and likely causes a recessive microcephaly, global developmental delay with cardiac and vascular features.
Hypopigmentation
Mutations in POFUT1, Encoding Protein O-fucosyltransferase 1, Cause Generalized Dowling-Degos Disease.
Infections
Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts.
Protein O-Fucosyltransferase 2 Is Not Essential for Plasmodium berghei Development.
Protein O-fucosyltransferase 2-mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection.
Liver Diseases
Variant in human POFUT1 reduces enzymatic activity and likely causes a recessive microcephaly, global developmental delay with cardiac and vascular features.
Lung Neoplasms
Fucosylation genes as circulating biomarkers for lung cancer.
Malaria
Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts.
Protein O-Fucosyltransferase 2 Is Not Essential for Plasmodium berghei Development.
Malignant Atrophic Papulosis
Variant in human POFUT1 reduces enzymatic activity and likely causes a recessive microcephaly, global developmental delay with cardiac and vascular features.
Microcephaly
Variant in human POFUT1 reduces enzymatic activity and likely causes a recessive microcephaly, global developmental delay with cardiac and vascular features.
Mouth Neoplasms
Protein O-fucosyltransferase 1: A potential diagnostic marker and therapeutic target for human oral cancer.
Myocardial Infarction
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.
Neoplasm Metastasis
Author Correction: Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.
Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.
Overexpression of Pofut1 and activated Notch1 may be associated with poor prognosis in breast cancer.
Neoplasms
Bioinformatics insight into glycosyltransferase gene expression in gastric cancer: POFUT1 is a potential biomarker.
Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.
Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling.
Fucosylation genes as circulating biomarkers for lung cancer.
Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer.
Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.
Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression.
Overexpression of Pofut1 and activated Notch1 may be associated with poor prognosis in breast cancer.
PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.
POFUT1 and PLAGL2 gene pair linked by a bidirectional promoter: the two in one of tumour progression in colorectal cancer?
POFUT1 as a Promising Novel Biomarker of Colorectal Cancer.
POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling.
Protein O-fucosyltransferase 1: A potential diagnostic marker and therapeutic target for human oral cancer.
Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.
Upregulation of Fucosyltransferase 3, 8 and protein O-Fucosyltransferase 1, 2 genes in esophageal cancer stem-like cells (CSLCs).
Weighted gene coexpression analysis indicates that PLAGL2 and POFUT1 are related to the differential features of proximal and distal colorectal cancer.
peptide-o-fucosyltransferase deficiency
POFUT1 is dispensable for structure, function and survival of mouse podocytes.
Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of notch receptor ligand interactions.
Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1.
Skin Diseases
Phenotypic expansion of POFUT1 loss of function mutations in a disorder featuring segmental dyspigmentation with eczematous and folliculo-centric lesions.
Stomach Neoplasms
Bioinformatics insight into glycosyltransferase gene expression in gastric cancer: POFUT1 is a potential biomarker.
Teratoma
O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.