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Information on EC 2.4.1.217 - mannosyl-3-phosphoglycerate synthase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.217 mannosyl-3-phosphoglycerate synthase
IUBMB Comments
Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.
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Word Map
  • 2.4.1.217
  • mannosylglycerate
  • cavernous
  • d-3-phosphoglycerate
  • intracavernosal
  • osmoadaptation
  • rhodothermus
  • bioprostheses
  • patient-prosthesis
  • neurography
  • thermoadaptation
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
mpgs, mpg synthase, mannosyl-3-phosphoglycerate synthase/phosphatase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate
show the reaction diagram
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