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Information on EC 2.4.1.214 - glycoprotein 3-alpha-L-fucosyltransferase
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2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferaseIUBMB Comments
Requires Mn2+. The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue. This enzyme catalyses a reaction similar to that of EC 2.4.1.68, glycoprotein 6-alpha-L-fucosyltransferase, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,3-linkage rather than an alpha1,6-linkage. The {iupac/misc/glycp#3.5::N-glycan} products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea).
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Word Map
- 2.4.1.214
-
lewis
-
sialylated
-
fucosylated
- selectins
-
p-selectin
-
fucts
-
alpha1,3-fucosylated
- psgl-1
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fuc-tiv
- ligand-1
-
alpha1,3fucosyltransferases
- n-acetyllactosamine
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polylactosamine
-
sialyl-lewis
-
alpha2,3-sialylated
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anti-horseradish
- beta1,2-xylosyltransferase
-
selectin-dependent
-
skin-homing
- lacto-n-neotetraose
- st3gal
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alpha2,3-sialyltransferase
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counterreceptors
- lacto-n-tetraose
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sialyl-lex
-
lewis-type
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meca-79
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alpha1,3-fucose
- fuct-iii
- alpha1,3/4-fucosyltransferases
- synthesis
- drug development
- pharmacology
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
+
=
+
+
=
+
Synonyms
fuct-vii, fuc-tvii, alpha1,3-fucosyltransferase, fuct-iv, fucosyltransferase vii, fut11, fucta, alpha(1,3)fucosyltransferase, alpha3-fucosyltransferase, fuct vii, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alpha(1,3)-fucosyltransferase-VII
alpha1,3-fucosyltransferase
AtFUT11
-
-
-
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core alpha-(1,3)-fucosyltransferase
-
-
-
-
core alpha1,3-fucosyltransferase
Fuc-T C3
-
-
-
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fucosyltransferase VII
FucT
FucT 115
FucT 45
FucT-IV
FucT-VII
FucT1
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-
-
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FucTA
FucTC
FUT11
Fut9
GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuca1-6GlcNAc)-Asn-peptide) alpha1-3-fucosyltransferase
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-
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GDP-L-fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase
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-
-
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GDP-L-fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase
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-
-
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FucTA
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-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
GDP-beta-L-fucose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = GDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]-L-asparaginyl-[protein]
GDP-beta-L-fucose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = GDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]-L-asparaginyl-[protein]
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-
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GDP-beta-L-fucose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = GDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]-L-asparaginyl-[protein]
the enzyme contains the conserved alpha 1,3 FucT motif, which is crucial for activity and nucleotide sugar binding
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
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-
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-
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SYSTEMATIC NAME
IUBMB Comments
GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase
Requires Mn2+. The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue. This enzyme catalyses a reaction similar to that of EC 2.4.1.68, glycoprotein 6-alpha-L-fucosyltransferase, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,3-linkage rather than an alpha1,6-linkage. The {iupac/misc/glycp#3.5::N-glycan} products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea).
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CAS REGISTRY NUMBER
COMMENTARY
68247-53-0
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GDP-alpha-L-fucose + Galbeta1-4GlcNAc-R
GDP + Galbeta1-4[Fucalpha1-3]GlcNAc-R
-
-
-
-
ir
GDP-alpha-L-fucose + NeuAcalpha2-3Galbeta1-3GlcNAcbeta-R
GDP + NeuAcalpha2-3Galbeta1-3[Fucalpha1-3]GlcNAcbeta-R
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4% of the activity with NeuAcalpha2-3Galbeta1-4GlcNAc-R
-
-
?
GDP-alpha-L-fucose + NeuAcalpha2-3Galbeta1-4GlcNAc
GDP + NeuAcalpha2-3Galbeta1-4[Fucalpha1-3]GlcNAc
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28% of the activity with NeuAcalpha2-3Galbeta1-4GlcNAc-R
-
-
?
GDP-alpha-L-fucose + NeuAcalpha2-3Galbeta1-4GlcNAcbeta-R
GDP + NeuAcalpha2-3Galbeta1-4[Fucalpha1-3]GlcNAcbeta-R
-
best substrate
-
-
?
GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-L-Asn
GDP + (1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-glucosaminyl-L-Asn
-
-
-
-
?
GDP-beta-L-fucose + GlcNAc-beta-(1->2)-Man-alpha-(1->6)-[GlcNAc-beta-(1->2)-Man-alpha-(1->3)]-Man-beta-(1->4)-GlcNAc-beta-(1->4)-[(Fuc-alpha-(1->6)]-GlcNAc-beta-(1->)-N?Asn?peptide
GDP + GlcNAc-beta-(1->2)-Man-alpha-(1->6)-[GlcNAc-beta-(1->2)-Man-alpha-(1->3)]-Man-beta-(1->4)-GlcNAc-beta-(1->4)-[(Fuc-alpha-(1->6)]-[(Fuc-alpha-(1->3)]-GlcNAc-beta-(1->)-N?Asn?peptide
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1-2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)(Fucalpha(1->3))GlcNAc
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)(ucalpha(1->6)G)cNAcbeta(1->)N-Asn-peptide(NAc)
?
-
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)]GlcNAc
-
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
GDP-beta-L-fucose + Manalpha(1->6)(Manalpha(1->3))Manalpha(1->6)(Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + Manalpha(1->6)(Manalpha(1->3))Manalpha(1->6)(Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)[Fucalpha(1->3)]GlcNAc
-
-
-
?
GDP-beta-L-fucose + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
-
-
-
?
GDP-fucose + alpha1-acid glycoprotein
GDP + alpha1-3 fucosylated glycoprotein
-
the activity of the LEC11 cells enzyme is considerably higher than the activity of the LEC12 cells enzyme
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?
GDP-fucose + asialo-alpha1-acid glycoprotein
GDP + alpha1-3 fucosylated glycoprotein
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-
-
?
GDP-fucose + asialo/agalacto-glycopeptide-F2
GDP + alpha1-3-fucosylated glycopeptide
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asialo/agalacto-glycopeptide-F2: from human fibrinogen
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?
GDP-fucose + asialo/agalacto-glycopeptide-IgGF6
GDP + alpha1-3-fucosylated glycopeptide
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asialo/agalacto-glycopeptide-IgGF6: from core alpha1-6-fucosylated human IgG
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?
GDP-fucose + asialofetuin
GDP + alpha1-3 fucosylated glycoprotein
-
-
-
?
GDP-fucose + asialotransferrin
GDP + alpha1-3 fucosylated glycoprotein
-
-
-
?
GDP-fucose + bisected agalacto-glycopeptide-IgGF6
GDP + alpha1-3-fucosylated glycopeptide
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-
-
?
GDP-fucose + dabsylated-GalGal-peptide
GDP + alpha1-3-fucosylated peptide
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0.7% relative activity with recombinant enzyme
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?
GDP-fucose + dabsylated-GalGn-peptide
GDP + alpha1-3-fucosylated peptide
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50% relative activity with recombinant enzyme
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?
GDP-fucose + dansyl-GnGnF6
GDP + alpha1-3-fucosylated glycopeptide
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prefucosylation of GnGn with chicken heart extract results in a superior conversion of GnGnF6 by FucTA than with GnGn, 100% relative conversion
-
?
GDP-fucose + dansylated mono-beta1,3-galactosylated glycopeptide
GDP + alpha1-3-fucosylated glycopeptide
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FucTA gene
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?
GDP-fucose + fetuin
GDP + alpha1-3 fucosylated glycoprotein
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the activity of the LEC11 cells enzyme is considerably higher than the activity of the LEC12 cells enzyme
-
?
GDP-fucose + Galbeta1-4GlcNAcalpha-p-nitrophenol
Galbeta1-4(Fucalpha1-3)GlcNAcalpha-p-nitrophenol
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CFET-3 required no cations, CFET-4 required divalent cations
-
-
?
GDP-fucose + Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc
GDP + Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc
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CFET-3 required no cations, CFET-4 required divalent cations
-
-
?
GDP-fucose + GalGal-N-glycan
GDP + alpha1-3-fucosylated GalGal-N-glycan
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4.6% relative conversion, FucTA gene
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?
GDP-fucose + GalGalF6-N-glycan
GDP + alpha1-3-fucosylated GalGalF6-N-glycan
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19.8% relative conversion, FucTA gene
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?
GDP-fucose + GalNAcbeta1-4GlcNAcbeta1-3Galbeta1-4Glc
GalNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc
-
LDNT, CFET-2
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcbeta1-Asn
-
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn
-
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-3[Manalpha1-3(Manalpha1-6)Manalpha1-6]Manbeta1-4-GlcNAcbeta1-4GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2-Manalpha1-3[Manalpha1-3(Manalpha1-6)Manalpha1-6]Manbeta1-4-GlcNAcbeta1-4 (Fucalpha1-3)GlcNAcbeta1-Asn
-
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-N-Asn-peptide(Nac)
GDP + GlcNAcbeta1-2-Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcbeta1-N-Asn-peptide(Nac)
-
-
the product shows a difucosylated structure with two Fuc residues at the Asn-bound GlcNAc residue, 40% yield
?
GDP-fucose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)[Fucalpha1-6]GlcNAcbeta1-Asn
-
difucosylated glycan structure
-
?
GDP-fucose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn
-
-
-
?
GDP-fucose + GnGn-oligosaccharide
GDP + alpha1-3 fucosylated GnGn-oligosaccharide
-
93% relative activity of pure enzyme
-
?
GDP-fucose + GnGn-peptide
GDP + alpha1-3 fucosylated peptide
-
100% relative activity of pure enzyme and of crude extract
-
?
GDP-fucose + GnGn-peptide
GDP + alpha1-3-fucosylated peptide
-
100% relative activity with recombinant enzyme
-
?
GDP-fucose + GnGnF6-oligosaccharide
GDP + alpha1-3 fucosylated oligosaccharide
-
95% relative activity of pure enzyme
-
?
GDP-fucose + M5Gn-Asn
GDP + alpha1-3-fucosylated M5Gn-Asn
-
71% relative activity with recombinant enzyme
-
?
GDP-fucose + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn
Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcb1-Asn
-
CFET-1
-
-
?
GDP-fucose + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAcbeta1-Asn
GDP + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn
-
CFET-1, Nglycan pentasaccharide core acceptor as substrate
-
-
?
GDP-fucose + N-acetyllactosamine
GDP + 3-fucosyl-N-acetyllactosamine
-
-
-
?
GDP-fucose + N-[2-(2-pyridylamino)ethyl]-succinamic acid-labeled biantennary oligosaccharides
GDP + ?
-
-
-
?
GDP-fucose + transferrin
GDP + alpha1-3 fucosylated glycoprotein
-
-
-
?
GDP-L-Fuc + asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan
L-fucose alpha-1,3-bound to asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan + GDP
-
-
-
?
GDP-L-fucose + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,6)GlcNAc
GDP + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)(Fucalpha1,6)GlcNAc
-
preferred substrate
-
-
?
GDP-L-fucose + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4GlcNAc
GDP + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)GlcNAc
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
GDP-L-Gal + asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan
L-galactose bound to asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan + GDP
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
-
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
-
-
-
?
GDP-fucose + dabsyl-GnGn-peptide
GDP + alpha1-3-fucosylated dabsyl-GnGn-peptide
-
FucTA gene, dabsylated glycopeptide derived from fibrin carrying a GnGn oligosaccharide
-
?
GDP-fucose + dabsyl-GnGn-peptide
GDP + alpha1-3-fucosylated dabsyl-GnGn-peptide
-
GnGn is the most suitable substrate for FucTA
-
?
GDP-fucose + dansyl-GnGn
GDP + alpha1-3-fucosylated glycopeptide
-
FucTA gene, dansylated glycopeptide derived from IgG, 40% relative conversion
-
?
GDP-fucose + dansyl-GnGn
GDP + alpha1-3-fucosylated glycopeptide
-
-
-
?
GDP-fucose + GnGnF6-peptide
GDP + alpha1-3-fucosylated GnGnF6-peptide
-
87% relative activity with recombinant enzyme
-
?
GDP-fucose + GnGnF6-peptide
GDP + alpha1-3-fucosylated GnGnF6-peptide
-
99% relative activity of pure enzyme and 70% relative activity of crude extract
-
?
GDP-fucose + N-acetyllactosamine
GDP + Galbeta1-4(Fucalpha1-3)GlcNAc
-
FucT involved in production of the Lewis x trisaccharide, the major component of the bacterias lipopolysaccharides
-
-
?
GDP-fucose + N-acetyllactosamine
GDP + Galbeta1-4(Fucalpha1-3)GlcNAc
-
FucT involved in production of the Lewis x trisaccharide, the major component of the bacterias lipopolysaccharides
-
-
?
GDP-L-fucose + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4GlcNAc
GDP + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)GlcNAc
-
-
-
-
?
GDP-L-fucose + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4GlcNAc
GDP + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)GlcNAc
Schistosoma sp.
-
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
additional information
?
-
substrate specificity of FucTA of Apis mellifera is similar to Drosophila melanogaster FucTA
-
-
?
additional information
?
-
-
FucTA gene, amongst the dansyl glycopeptides tested, only those with one free non-reducing terminal N-acetyl-glucosamine residue act as substrates: specifically GnGn lacking one GlcNAc, GnGn substituted with one galactose residue or GnGn substituted with one Lewis-a epitope
-
-
?
additional information
?
-
-
the core alpha1-3-fucosyltransferases are involved in the synthesis of glycans specific to plants and invertebrates which are known to be immunogenic and allergenic
-
-
?
additional information
?
-
-
the enzyme is able to fucosylate N-glycan structures of human transferrin in vitro
-
-
?
additional information
?
-
-
alpha1-6-fucosylated glycans are better substrates than beta-1-4-galactosylated glycans, FucTA gene
-
-
?
additional information
?
-
-
substrate specificity, no activity with GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)GlcNAc, the recombinant enzyme accepts core alpha1,6-fucosylated glycans as substrates for core alpha1,3-fucosylation prior Lewis-type fucosylation, strict order of fucosylation events, overview
-
-
?
additional information
?
-
-
alpha1,3-fucosylation by FucT-VII is a step in the biosynthesis of Lewis X antigen, FucT-VII stimulates the growth of hepatocarcinoma cells via the cyclin-dependent kinase inhibitor p27Kip1, phosphorylation of the Rb protein is involved, signaling pathway overview
-
-
?
additional information
?
-
-
FucT-IV and FucT-VII are responsible for generation of sialylated Lewis X, i.e. sLex, FucT-VII being the major enzyme form in selectin ligand activity regulating leukocyte recruitment and lymphocyte homing into lymph nodes, FucT-IV and FucT-VII are both involved in conferring L-, P- and E-selectin binding activities to P-selectin glycoprotein ligand-1, i.e. PSGL-1, in humans, overview, FucT-IV and FucT-VII show cooperation in recruitment of selectin-expressing cells on PSGL-1 and in regulating cell rolling velocity and stability
-
-
?
additional information
?
-
-
FucT-VII is essential for biosynthesis of selectin binding ligands in T-cells, H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells via the Raf-MEK-ERK pathway, but induction of FucT-VII requires the concomitant activation of at least 3 different signaling pathways, overview
-
-
?
additional information
?
-
-
sialyl Lewis X biosynthesis is mediated by alpha1-3 fucosyltransferase-VIIS, the enzyme is essential for biosynthesis of P- and E-selectin binding ligands in T-cells
-
-
?
additional information
?
-
-
the enzyme is essential for biosynthesis of selectin binding ligands in T-cells
-
-
?
additional information
?
-
-
the enzyme is responsible for the generation of functional P- and E-selectin ligands
-
-
?
additional information
?
-
-
the enzyme synthesizes functional selectin ligands on the surface of leukocytes
-
-
?
additional information
?
-
-
development of a sensitive cell-based assay system to monitor FucT-VII mediated sialyl Lewis biosynthesis
-
-
?
additional information
?
-
-
poorly active with Galbeta1-4GlcNAc-O-(CH2)8-COOCH3, Fucalpha1-2Galbeta1-4GlcNAcbeta-R, Galbeta1-3GlcNAcbeta-R, and Fucalpha1-2Galbeta1-3GlcNAcbeta-R
-
-
?
additional information
?
-
-
substrate specificities of wild-type and alpha 1,3 FucT motif mutants, overview
-
-
?
additional information
?
-
-
compounds lacking the peptide-linked GlNAc or outer arm GlcNAc do not serve as acceptors
-
-
?
additional information
?
-
-
the enzyme functions in the synthesis of core alpha1-3-fucosylated complex-type glycans
-
-
?
additional information
?
-
-
Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T-cell trafficking to lymph nodes
-
-
?
additional information
?
-
-
FucT-IV E- and P-selectin ligand precursors to give mature E- and P-selectin ligands, 3-alpha-fucosylates FucT-VII 3-alpha-fucosylates P-selectin ligand precursors to give mature P-selectin ligands that are essential for control of frequency of and all interaction related to leukocyte rolling, overview, FucT-IV and FucT-VII show overlapping activities in the immunosurveillance of the skin
-
-
?
additional information
?
-
-
the enzyme performs Lewis X carbohydrate structure synthesis on oligosaccharides, polylactosamine chains, and glycolipids in the brain with high alpha1,3-fucosyltransferase activity
-
-
?
additional information
?
-
Schistosoma sp.
-
the native enzyme accepts core alpha1,6-fucosylated glycans as substrates for core alpha1,3-fucosylation prior Lewis-type fucosylation, strict order of fucosylation events, overview
-
-
?
additional information
?
-
-
the enzyme acts upon N-glycopeptides and related oligosaccharides with the glycan structure GlcNAc2Man3GlcNAc2, no transfer to N-glycans is observed when the terminal GlcNAc residues are either absent or substituted with galactose, N-acetyllactosamine, lacto-N-biose and N-acetylchito-oligosaccharides do not function as acceptors for the enzyme
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GDP-alpha-L-fucose + Galbeta1-4GlcNAc-R
GDP + Galbeta1-4[Fucalpha1-3]GlcNAc-R
-
-
-
-
ir
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1-2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)(Fucalpha(1->3))GlcNAc
-
-
-
?
GDP-beta-L-fucose + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
additional information
?
-
-
the core alpha1-3-fucosyltransferases are involved in the synthesis of glycans specific to plants and invertebrates which are known to be immunogenic and allergenic
-
-
?
additional information
?
-
-
alpha1,3-fucosylation by FucT-VII is a step in the biosynthesis of Lewis X antigen, FucT-VII stimulates the growth of hepatocarcinoma cells via the cyclin-dependent kinase inhibitor p27Kip1, phosphorylation of the Rb protein is involved, signaling pathway overview
-
-
?
additional information
?
-
-
FucT-IV and FucT-VII are responsible for generation of sialylated Lewis X, i.e. sLex, FucT-VII being the major enzyme form in selectin ligand activity regulating leukocyte recruitment and lymphocyte homing into lymph nodes, FucT-IV and FucT-VII are both involved in conferring L-, P- and E-selectin binding activities to P-selectin glycoprotein ligand-1, i.e. PSGL-1, in humans, overview, FucT-IV and FucT-VII show cooperation in recruitment of selectin-expressing cells on PSGL-1 and in regulating cell rolling velocity and stability
-
-
?
additional information
?
-
-
FucT-VII is essential for biosynthesis of selectin binding ligands in T-cells, H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells via the Raf-MEK-ERK pathway, but induction of FucT-VII requires the concomitant activation of at least 3 different signaling pathways, overview
-
-
?
additional information
?
-
-
sialyl Lewis X biosynthesis is mediated by alpha1-3 fucosyltransferase-VIIS, the enzyme is essential for biosynthesis of P- and E-selectin binding ligands in T-cells
-
-
?
additional information
?
-
-
the enzyme is essential for biosynthesis of selectin binding ligands in T-cells
-
-
?
additional information
?
-
-
the enzyme is responsible for the generation of functional P- and E-selectin ligands
-
-
?
additional information
?
-
-
the enzyme synthesizes functional selectin ligands on the surface of leukocytes
-
-
?
additional information
?
-
-
the enzyme functions in the synthesis of core alpha1-3-fucosylated complex-type glycans
-
-
?
additional information
?
-
-
Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T-cell trafficking to lymph nodes
-
-
?
additional information
?
-
-
FucT-IV E- and P-selectin ligand precursors to give mature E- and P-selectin ligands, 3-alpha-fucosylates FucT-VII 3-alpha-fucosylates P-selectin ligand precursors to give mature P-selectin ligands that are essential for control of frequency of and all interaction related to leukocyte rolling, overview, FucT-IV and FucT-VII show overlapping activities in the immunosurveillance of the skin
-
-
?
additional information
?
-
-
the enzyme performs Lewis X carbohydrate structure synthesis on oligosaccharides, polylactosamine chains, and glycolipids in the brain with high alpha1,3-fucosyltransferase activity
-
-
?
additional information
?
-
Schistosoma sp.
-
the native enzyme accepts core alpha1,6-fucosylated glycans as substrates for core alpha1,3-fucosylation prior Lewis-type fucosylation, strict order of fucosylation events, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Co2+
Mg2+
Mn2+
Ni2+
Zn2+
additional information
Ca2+
the enzyme is also active in the presence of Mg2+, Co2+, Ni2+ and Ca2+
Ca2+
the enzyme is also active in the presence of Mg2+, Co2+, Ni2+ and Ca2+
Co2+
the enzyme is also active in the presence of Mg2+, Co2+, Ni2+ and Ca2+
Co2+
the enzyme is also active in the presence of Mg2+, Co2+, Ni2+ and Ca2+
Mg2+
the enzyme is also active in the presence of Mg2+, Co2+, Ni2+ and Ca2+
Mg2+
the enzyme is also active in the presence of Mg2+, Co2+, Ni2+ and Ca2+
Ni2+
the enzyme is also active in the presence of Mg2+, Co2+, Ni2+ and Ca2+
Ni2+
the enzyme is also active in the presence of Mg2+, Co2+, Ni2+ and Ca2+
additional information
Zn2+ and Cu2+ ions do not activate the enzyme
additional information
Zn2+ and Cu2+ ions do not activate the enzyme
additional information
-
Zn2+ and Cu2+ ions do not activate the enzyme
additional information
-
activation by divalent cations in descending order: Mn2+, Mg2+, Ca2+, Co2+, while Ni2+ has no effect on the enzyme activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ca2+
about 45% residual activity at 10 mM; about 75% residual activity at 10 mM
Co2+
about 30% residual activity at 10 mM; about 35% residual activity at 10 mM
EDTA