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Information on EC 2.4.1.206 - lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase and Organism(s) Rattus norvegicus and UniProt Accession Q99NB2

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This record set is specific for:
Rattus norvegicus
UNIPROT: Q99NB2 not found.
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Word Map
  • 2.4.1.206
  • udp-3hglcnac
  • beta-1,6-glcnac
  • exostoses
  • lacto-series
  • sggls
  • lc3cer
  • medicine
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
glcnac transferase, beta3gn-t5, beta3gn-t2, lc3 synthase, lactosylceramide n-acetylglucosaminyltransferase, beta3gnt5, la2 synthase, lc3 synthase/bgn-t5, beta1-3-n-acetylglucosaminyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
lactotriaosylceramide synthase
-
UDP-GlcNAc:lactosylceramide beta1,3-N-acetylglucosaminyltransferase
-
acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-lactosylceramide beta-
-
-
-
-
beta1-3-N-acetylglucosaminyltransferase
-
-
-
-
LA2 synthase
-
-
-
-
lactosylceramide beta-acetylglucosaminyltransferase
-
-
-
-
lactosylceramide: N-acetylglucosaminyltransferase
-
-
uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
83682-80-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide
UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
show the reaction diagram
-
-
?
UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide
UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
show the reaction diagram
UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-phenyl-C14H29
UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-phenyl-C14H29
show the reaction diagram
-
synthetic substrate, 75% specific activity compared to lactosylceramide
-
?
UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-glucosamine + lactosylceramide
UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-glucosamine + lactosylceramide
UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
78% activity compared to Mn2+
Cu2+
-
4% activity compared to Mn2+
Hg2+
-
4% activity compared to Mn2+
Mg2+
-
40% activity compared to Mn2+
Mn2+
-
absolute requirement
Zn2+
-
11% activity compared to Mn2+
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CHAPS
-
41% stimulation compared to Triton CF-54
deoxycholate
-
8% stimulation compared to Triton CF-54
octyl-beta-D-glucopyranoside
-
46% stimulation compared to Triton CF-54
sodium taurocholate
-
25% stimulation compared to Triton CF-54
taurodeoxycholate
-
11% stimulation compared to Triton CF-54
Triton CF-54
-
stimulation, maximal at 0.4%
Triton X-100
-
89% stimulation compared to Triton CF-54
Tween 20
-
38% stimulation compared to Triton CF-54
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.021
D-galactosyl-1,4-beta-D-glucosylceramide
-
cerebellum microsomes
0.035
D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
cerebellum microsomes
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00000009
-
granule cells, 14 days old
0.0000001
-
cerebellum homogenate of 3 days old organisms
0.00000015
-
granule cells, 3 days old
0.00000042
-
cerebellum homogenate of 14 days old organisms
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8 - 7.4
-
cacodylate buffer
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
not a full length clone
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
B3GN5_RAT
377
1
44131
Swiss-Prot
Secretory Pathway (Reliability: 3)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial sequence, not a full length clone, DNA sequence determination
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chou, D.K.H.; Jungalwala, F.B.
N-acetylglucosaminyltransferase regulates the expression of neolactoglycolipids including sulfoglucuronylglycolipids in the developing nervous system
J. Biol. Chem.
268
21727-21733
1993
Rattus norvegicus
Manually annotated by BRENDA team
Chou, D.K.H.; Jungalwala, F.B.
N-acetylglucosaminyl Transferase regulates the expression of sulfoglucuronyl glycolipids in specific cell types in cerebellum during development
J. Biol. Chem.
271
28868-28874
1996
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Togayachi, A.; Akashima, T.; Ookubo, R.; Kudo, T.; Nishihara, S.; Iwasaki, H.; Natsume, A.; Mio, H.; Inokuchi, J.i.; Irimura, T.; Sasaki, K.; Narimatsu, H.
Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T5), an essential enzyme for the expression of HNK-1 and lewis X epitopes on glycolipids
J. Biol. Chem.
276
22032-22040
2001
Homo sapiens (Q9BYG0), Homo sapiens, Rattus norvegicus, Rattus norvegicus (Q99NB2)
Manually annotated by BRENDA team