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Information on EC 2.4.1.198 - phosphatidylinositol N-acetylglucosaminyltransferase

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IUBMB Comments
Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
pig-a, gpi-gnt, dscr5, gpi-n-acetylglucosaminyltransferase, gpi19, gpi-glcnac transferase, phosphatidylinositol n-acetylglucosaminyltransferase, gpi15, phosphatidylinositol n-acetylglucosaminyltransferase subunit a, afpig-a, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
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In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.
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