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Information on EC 2.4.1.177 - cinnamate beta-D-glucosyltransferase
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EC Tree
2.4.1.177 cinnamate beta-D-glucosyltransferaseIUBMB Comments
4-Coumarate, 2-coumarate, benzoate, feruloate and caffeate can also act as acceptors, but more slowly. Involved in the biosynthesis of chlorogenic acid in the root of the sweet potato, Ipomoea batatas.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
fagt2, udp-glucose:cinnamate glucosyltransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
FaGT2
UDPG:t-cinnamate glucosyltransferase
-
-
-
-
uridine diphosphoglucose-cinnamate glucosyltransferase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-glucose + trans-cinnamate = UDP + trans-cinnamoyl beta-D-glucoside
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:trans-cinnamate beta-D-glucosyltransferase
4-Coumarate, 2-coumarate, benzoate, feruloate and caffeate can also act as acceptors, but more slowly. Involved in the biosynthesis of chlorogenic acid in the root of the sweet potato, Ipomoea batatas.
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CAS REGISTRY NUMBER
COMMENTARY
83744-95-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,4,5-trichlorophenol + UDP-glucose
?
-
225% of the activity with cinnamic acid
-
-
?
3,4-dimethoxycinnamic acid + UDP-glucose
UDP + 3,4-dimethoxycinnamoyl-beta-D-glucoside
-
-
-
?
3,5-dichloro-4-hydroxybenzoic acid + UDP-glucose
?
-
102% of the activity with cinnamic acid
-
-
?
3-aminobenzoic acid + UDP-glucose
UDP + 3-aminobenzoyl-beta-D-glucoside
-
-
-
?
3-hydroxybenzoic acid + UDP-glucose
UDP + 1-O-(3-hydroxybenzoyl)-beta-D-glucopyranose
-
-
-
?
4-aminobenzoic acid + UDP-glucose
UDP + 4-aminobenzoyl-beta-D-glucoside
-
-
-
?
4-chlorocinnamic acid + UDP-glucose
?
-
56% of the activity with cinnamic acid
-
-
?
5-hydroxyferulic acid + UDP-glucose
UDP + 5-hydroxyferuloyl-beta-D-glucoside
-
-
-
?
anthranilic acid + UDP-glucose
?
-
11% of the activity with cinnamic acid
-
-
?
caffeic acid + UDP-glucose
UDP + caffeoyl-beta-D-glucoside
-
-
-
?
ferulic acid + UDP-glucose
UDP + feruloyl-beta-D-glucoside
-
-
-
?
nicotinic acid + UDP-glucose
?
-
5% of the activity with cinnamic acid
-
-
?
p-coumaric acid + UDP-glucose
UDP + p-coumaroyl-beta-D-glucoside
-
-
-
?
p-hydroxybenzoic acid + UDP-glucose
UDP + 4-hydroxybenzoyl-beta-D-glucoside
-
-
-
?
phenylbutyric acid + UDP-glucose
UDP + phenylbutyryl-beta-D-glucoside
-
-
-
?
phenylpropionic acid + UDP-glucose
UDP + phenylpropionyl-beta-D-glucoside
-
-
-
?
sinapic acid + UDP-glucose
UDP + sinapoyl-beta-D-glucoside
-
-
-
?
sorbic acid + UDP-glucose
?
-
126% of the activity with cinnamic acid
-
-
?
trans-2-hexenoic acid + UDP-glucose
?
-
12% of the activity with cinnamic acid
-
-
?
trans-3-(2-furyl)acrylic acid + UDP-glucose
?
-
94% of the activity with cinnamic acid
-
-
?
trans-3-(3-pyridyl)acrylic acid + UDP-glucose
?
-
9% of the activity with cinnamic acid
-
-
?
UDP-alpha-D-glucose + caffeate
UDP + 1-O-caffeoyl-beta-D-glucose
-
glucosylation at 15% the rate of cinnamate
-
-
?
UDP-alpha-D-glucose + quercetin
UDP + quercetin 3-O-beta-D-glucoside
-
-
-
-
?
UDP-glucose + 2,3-dimethoxybenzyl alcohol
UDP + 2,3-dimethoxybenzyl beta-D-glucoside
Verbesina caracasana
-
-
-
?
UDP-glucose + 2,4-dimethoxybenzyl alcohol
UDP + 2,4-dimethoxybenzyl beta-D-glucose
Verbesina caracasana
-
-
-
?
UDP-glucose + 2,4-dimethoxycinnamate
UDP + 2,4-dimethoxycinnamoyl beta-D-glucoside
Verbesina caracasana
-
-
-
?
UDP-glucose + 2,5-dimethoxybenzyl alcohol
UDP + 2,5-dimethoxybenzyl beta-D-glucose
Verbesina caracasana
-
-
-
?
UDP-glucose + 2,5-dimethoxycinnamate
UDP + 2,5-dimethoxycinnamoyl beta-D-glucose
Verbesina caracasana
-
-
-
?
UDP-glucose + 2,6-dimethoxycinnamate
UDP + 2,6-dimethoxycinnamoyl beta-D-glucoside
Verbesina caracasana
-
-
-
?
UDP-glucose + 2-methoxycinnamate
UDP + 2-methoxycinnamoyl beta-D-glucoside
Verbesina caracasana
-
-
-
?
UDP-glucose + 3,4,5-trimethoxycinnamate
UDP + 3,4,5-trimethoxycinnamoyl beta-D-glucoside
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glucosylation at 84% the rate of 4-methoxycinnamate
-
-
?
UDP-glucose + 3,4-dimethoxybenzyl alcohol
UDP + 3,4-dimethoxybenzyl beta-D-glucose
Verbesina caracasana
-
-
-
?
UDP-glucose + 3,5-dimethoxycinnamate
UDP + 3,5-dimethoxycinnamoyl beta-D-glucoside
Verbesina caracasana
-
-
-
?
UDP-glucose + 3-methoxycinnamate
UDP + 3-methoxycinnamoyl beta-D-glucoside
-
glucosylation at 52% the rate of 4-methoxycinnamate
-
-
?
UDP-glucose + 4-hydroxy-3-methoxycinnamate
UDP + 4-hydroxy-3-methoxycinnamoyl beta-D-glucoside
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glucosylation at 35% the rate of cinnamate
-
-
?
UDP-glucose + benzoate
UDP + benzoyl-beta-D-glucoside
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glucosylation at 71% the rate of cinnamate
-
-
?
UDP-glucose + isoferulic acid
UDP + isoferuloyl beta-D-glucose
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glucosylation at 46% the rate of 4-methoxycinnamate
-
-
?
UDP-glucose + o-coumarate
UDP + o-coumaroyl beta-D-glucose
-
glucosylation at 52% the rate of cinnamate
-
-
?
UDP-glucose + p-coumaric acid
UDP + p-coumaroyl beta-D-glucose
-
-
-
-
?
UDP-glucose + sinapic acid
UDP + sinapoyl beta-D-glucose
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glucosylation at 6.5% the rate of 4-methoxycinnamate
-
-
?
vanillic acid + UDP-glucose
UDP + vannilyl-beta-D-glucoside
-
-
-
?
cinnamic acid + UDP-glucose
UDP + cinnamoyl-beta-D-glucoside
-
-
-
?
cinnamic acid + UDP-glucose
UDP + cinnamoyl-beta-D-glucoside
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100% of activity
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
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best substrate
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
-
best substrate
trans-isomer
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
-
trans-cinnamate
trans-isomer
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
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involved in biosynthesis of chlorogenic acid in root of Ipomoea batatas
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
-
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
-
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
-
-
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
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glucosylation at 8% the rate of 4-methoxycinnamate
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-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
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enzyme of benzoate metabolism
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-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
-
-
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
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enzyme of benzoate metabolism
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
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glucosylation at 8% the rate of 4-methoxycinnamate
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
-
enzyme of benzoate metabolism
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
Verbesina caracasana
-
-
-
-
?
UDP-alpha-D-glucose + ferulate
UDP + 1-O-feruloyl-beta-D-glucose
-
glucosylation at 27% the rate of cinnamate
-
-
?
UDP-alpha-D-glucose + ferulate
UDP + 1-O-feruloyl-beta-D-glucose
-
glucosylation 26% the rate of 4-methoxycinnamate
-
-
?
UDP-glucose + 2-coumarate
UDP + 2-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 2-coumarate
UDP + 2-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3,4-dimethoxycinnamate
UDP + 3,4-dimethoxycinnamoyl beta-D-glucose
-
glucosylation at 78% the rate of 4-methoxycinnamate
-
-
?
UDP-glucose + 3,4-dimethoxycinnamate
UDP + 3,4-dimethoxycinnamoyl beta-D-glucose
-
glucosylation at 78% the rate of 4-methoxycinnamate
-
-
?
UDP-glucose + 3,4-dimethoxycinnamate
UDP + 3,4-dimethoxycinnamoyl beta-D-glucose
Verbesina caracasana
-
-
-
?
UDP-glucose + 3,4-dimethoxycinnamate
UDP + 3,4-dimethoxycinnamoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3,4-dimethoxycinnamate
UDP + 3,4-dimethoxycinnamoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3,4-dimethoxycinnamate
UDP + 3,4-dimethoxycinnamoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3-coumarate
UDP + 3-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3-coumarate
UDP + 3-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3-hydroxybenzoate
UDP + 3-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3-hydroxybenzoate
UDP + 3-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3-hydroxybenzoate
UDP + 3-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-coumarate
UDP + 4-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-coumarate
UDP + 4-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-hydroxybenzoate
UDP + 4-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-hydroxybenzoate
UDP + 4-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-hydroxybenzoate
UDP + 4-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-methoxycinnamate
UDP + 4-methoxycinnamoyl beta-D-glucose
-
best substrate
-
-
?
UDP-glucose + 4-methoxycinnamate
UDP + 4-methoxycinnamoyl beta-D-glucose
-
best substrate
-
-
?
UDP-glucose + caffeate
UDP + caffeoyl beta-D-glucoside
-
-
-
?
UDP-glucose + ferulate
UDP + feruloyl beta-D-glucoside
-
-
-
?
UDP-glucose + gallate
UDP + galloyl beta-D-glucoside
-
-
-
?
UDP-glucose + gentisate
UDP + gentisoyl beta-D-glucoside
-
-
-
?
UDP-glucose + p-coumarate
UDP + p-coumaroyl-D-glucose
-
the glucosyl-group is introduced exclusively into the carboxyl-group
-
?
UDP-glucose + p-coumarate
UDP + p-coumaroyl-D-glucose
-
glucosylation at 57% the rate of cinnamate
-
?
UDP-glucose + p-coumarate
UDP + p-coumaroyl-D-glucose
-
glucosylation at 43% the rate of 4-methoxycinnamate
-
-
?
UDP-glucose + p-coumarate
UDP + p-coumaroyl-D-glucose
-
glucosylation at 43% the rate of 4-methoxycinnamate
-
-
?
UDP-glucose + protocatechuate
UDP + protocatechuoyl beta-D-glucoside
-
-
-
?
UDP-glucose + protocatechuate
UDP + protocatechuoyl beta-D-glucoside
-
-
-
?
UDP-glucose + protocatechuate
UDP + protocatechuoyl beta-D-glucoside
-
-
-
?
UDP-glucose + salicylate
UDP + salicoyl beta-D-glucoside
-
-
-
?
UDP-glucose + sinapate
UDP + sinapoyl beta-D-glucoside
-
-
-
?
UDP-glucose + sorbate
UDP + sorboyl beta-D-glucoside
-
-
-
?
UDP-glucose + syringate
UDP + syringoyl beta-D-glucoside
-
-
-
?
UDP-glucose + trans-cinnamate
UDP + trans-cinnamoyl beta-D-glucoside
-
-
-
?
UDP-glucose + trans-cinnamate
UDP + trans-cinnamoyl beta-D-glucoside
-
-
-
?
UDP-glucose + trans-cinnamate
UDP + trans-cinnamoyl beta-D-glucoside
-
-
-
?
UDP-glucose + trans-cinnamate
UDP + trans-cinnamoyl beta-D-glucoside
-
-
-
-
?
UDP-glucose + trans-cinnamate
UDP + trans-cinnamoyl beta-D-glucoside
-
-
-
?
UDP-glucose + vanillate
UDP + vanilloyl beta-D-glucoside
-
-
-
?
additional information
?
-
the enzyme shows substrate promiscuity as it forms glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids. Substrate specificity, overview
-
-
-
additional information
?
-
only compounds containing a carboxylic group and an aromatic ring structure are accepted as substrates. Substituents at the aromatic ring are tolerated as long as they are not located in the ortho position.
-
-
?
additional information
?
-
-
only compounds containing a carboxylic group and an aromatic ring structure are accepted as substrates. Substituents at the aromatic ring are tolerated as long as they are not located in the ortho position.
-
-
?
additional information
?
-
-
catalyzes the formation of cinnamic acid and p-coumaric acid glucose esters during strawberry fruit ripening, experimental results suggest that FaGT2 is involved in the detoxification of xenobiotics in accordance to its induction by oxidative stress
-
-
?
additional information
?
-
-
most of the substrates also tested in plants by injecting the substance into fresh ripe strawberries
-
-
?
additional information
?
-
the enzyme shows substrate promiscuity as it forms glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids
-
-
-
additional information
?
-
-
the enzyme shows substrate promiscuity as it forms glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids
-
-
-
additional information
?
-
the enzyme shows substrate promiscuity as it forms glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids
-
-
-
additional information
?
-
the enzyme shows substrate promiscuity as it forms glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids
-
-
-
additional information
?
-
-
the enzyme shows substrate promiscuity as it forms glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids
-
-
-
additional information
?
-
the enzyme shows substrate promiscuity as it forms glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids. Substrate specificity, overview
-
-
-
additional information
?
-
the enzyme shows substrate promiscuity as it forms glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids. Substrate specificity, overview
-
-
-
additional information
?
-
-
the enzyme shows substrate promiscuity as it forms glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids. Substrate specificity, overview
-
-
-
additional information
?
-
the enzyme shows substrate promiscuity as it forms glucose esters of a variety of (hydroxyl)benzoic and (hydroxyl)cinnamic acids. Substrate specificity, overview
-
-
-
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
catalyzes the formation of cinnamic acid and p-coumaric acid glucose esters during strawberry fruit ripening, experimental results suggest that FaGT2 is involved in the detoxification of xenobiotics in accordance to its induction by oxidative stress
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
-
involved in biosynthesis of chlorogenic acid in root of Ipomoea batatas
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
-
enzyme of benzoate metabolism
-
-
?
UDP-alpha-D-glucose + cinnamate
UDP + 1-O-cinnamoyl-beta-D-glucose
-
enzyme of benzoate metabolism
-
-
?
UDP-glucose + 2-coumarate
UDP + 2-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 2-coumarate
UDP + 2-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3,4-dimethoxycinnamate
UDP + 3,4-dimethoxycinnamoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3,4-dimethoxycinnamate
UDP + 3,4-dimethoxycinnamoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3,4-dimethoxycinnamate
UDP + 3,4-dimethoxycinnamoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3-coumarate
UDP + 3-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3-coumarate
UDP + 3-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3-hydroxybenzoate
UDP + 3-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3-hydroxybenzoate
UDP + 3-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 3-hydroxybenzoate
UDP + 3-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-coumarate
UDP + 4-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-coumarate
UDP + 4-coumaroyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-hydroxybenzoate
UDP + 4-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-hydroxybenzoate
UDP + 4-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + 4-hydroxybenzoate
UDP + 4-hydroxybenzoyl beta-D-glucoside
-
-
-
?
UDP-glucose + caffeate
UDP + caffeoyl beta-D-glucoside
-
-
-
?
UDP-glucose + ferulate
UDP + feruloyl beta-D-glucoside
-
-
-
?
UDP-glucose + gallate
UDP + galloyl beta-D-glucoside
-
-
-
?
UDP-glucose + gentisate
UDP + gentisoyl beta-D-glucoside
-
-
-
?
UDP-glucose + protocatechuate
UDP + protocatechuoyl beta-D-glucoside
-
-
-
?
UDP-glucose + protocatechuate
UDP + protocatechuoyl beta-D-glucoside
-
-
-
?
UDP-glucose + protocatechuate
UDP + protocatechuoyl beta-D-glucoside
-
-
-
?
UDP-glucose + salicylate
UDP + salicoyl beta-D-glucoside
-
-
-
?
UDP-glucose + sinapate
UDP + sinapoyl beta-D-glucoside