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Information on EC 2.4.1.173 - sterol 3beta-glucosyltransferase
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EC Tree
2.4.1.173 sterol 3beta-glucosyltransferaseIUBMB Comments
Not identical with EC 2.4.1.192 (nuatigenin 3beta-glucosyltransferase) or EC 2.4.1.193 (sarsapogenin 3beta-glucosyltransferase).
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Word Map
- 2.4.1.173
- glucoside
-
steryl
-
glucosylation
-
pexophagy
- somnifera
-
withania
-
glucosyltransferases
-
withanolide
- stigmasterol
- synthesis
- sitosterol
-
3beta-hydroxy
- orbiculare
-
udp-glucose-dependent
- udpase
-
withaferin
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
sterol glucosyltransferase, atg26, ugt80b1, ugt80a2, sgtl1, ugt51, udpg-sgtase, sterol glycosyltransferase, sgtl2, udp-glucose:sterol glucosyltransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Atg26
autophagy-related protein 26
ScAtg26
multidomain protein which possesses pleckstrin homology, GRAM (glucosyltransferase, Rab-like GTPase activators, and myotubularins), and catalytic UDP-glucosyl transferase, domains
SGT
SGT1
SGT2
SGTL1
sterol glucosyltransferase
-
-
-
-
sterol glucosyltransferase Ugt51/Paz4
sterol glycosyltransferase
sterol-beta-D-glucosyltransferase
-
-
-
-
sterol:UDPG glucosyltransferase
-
-
-
-
UDP-Glc:sterol glucosyltransferase 80B1
UDP-glucose sterol glucosyltransferase
UDP-glucose sterol glycosyltransferase
-
UDP-glucose-sterol beta-glucosyltransferase
-
-
-
-
UDP-glucose-sterol glucosyltransferase
-
-
-
-
UDP-glucose:sterol glucosyltransferase
UDP-glycosyltransferase 51
UDPG-SGTase
UDPG:sterol glucosyltransferase
-
-
-
-
UDPglucose:sterol glucosyltransferase
-
-
-
-
Ugt51
Ugt51/Paz4
UGT713B1
UGT80A2
UGT80B1
uridine diphosphoglucose-poriferasterol glucosyltransferase
-
-
-
-
uridine diphosphoglucose-sterol glucosyltransferase
-
-
-
-
SGTL1
gene encoding a member of the sterol glucosyltransferase in Withania somnifera
UDP-glucose:sterol glucosyltransferase
-
UDPG-SGTase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
-
,
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:sterol 3-O-beta-D-glucosyltransferase
Not identical with EC 2.4.1.192 (nuatigenin 3beta-glucosyltransferase) or EC 2.4.1.193 (sarsapogenin 3beta-glucosyltransferase).
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CAS REGISTRY NUMBER
COMMENTARY
123940-38-5
-
9075-00-7
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(22S,25S)-5alpha-solanidanin-3beta-ol + UDP-glucose
?
-
demissidine 1.4% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
(22S,25S)-epoxy-furost-5-en-3beta,26-diol + UDP-glucose
?
-
nuatigenin, 16.1% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
(25R)-5alpha-spirostan-3beta-ol + UDP-glucose
?
-
tigogenin, 2.1% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
(25R)-5alpha-spirostan-3beta-ol-12-one + UDP-glucose
?
-
hecogenin, 6.3% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
(25R)-spirost-5-en-3beta,25beta-diol + UDP-glucose
?
-
isonuatigenin, 13.4% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
(25R)-spirost-5-en-3beta-ol + UDP-glucose
?
-
diosgenin, 3.5% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
(25S)-5alpha,22betaN-spirosolanin-3beta-ol + UDP-glucose
?
-
tomatidine, 2.8% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
24-methylene cholesterol + UDP-glucose
UDP + 24-methylene-cholesterol 3-beta-D-glucoside
-
-
-
-
?
3beta-hydroxy-16,17alpha-epoxypregnenolone + UDP-alpha-D-glucose
3beta-hydroxy-16,17alpha-epoxypregnenolone 3-beta-D-glucoside + UDP
-
-
-
-
?
3beta-hydroxy-pregna-5,16-dien-20-one + UDP-glucose
UDP + 3beta-20-oxopregna-5,16-dien-3-yl beta-D-glucopyranoside
5alpha-cholest-7-en-3beta-ol + UDP-glucose
?
-
14.1% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
5alpha-cholestan-3beta-ol + UDP-glucose
?
-
cholestanol, 12.0% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
5alpha-cholestan-3beta-ol + UDP-glucose
UDP + 3beta,5alpha-cholestan 3-beta-D-glucoside
-
-
-
-
?
androst-5-en-3beta-ol-17-one + UDP-glucose
?
-
androstenolon, 16.0% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
brassicasterol + UDP-glucose
UDP + brassicasterol 3-beta-D-glucoside
-
-
-
-
?
cholest-5-en-22-on-3beta-ol + UDP-glucose
?
-
22-oxycholesterol, 133.1% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
cholest-5-en-3beta,19-diol + UDP-glucose
?
-
9.2% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
cholest-5-en-3beta,20alpha-diol + UDP-glucose
?
-
90.8% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
cholest-5-en-3beta,25-diol + UDP-glucose
?
-
25-hydroxycholesterol, 89.4% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
cholest-5-en-3beta-ol + UDP-glucose
?
-
cholesterol, 98.5% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
cholest-5-en-3beta-ol-7-one + UDP-glucose
?
-
5.6% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
pregn-5-en-3beta-ol-20-one + UDP-glucose
?
-
pregnenolon, 33.1% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
pregnenolene + UDP-glucose
UDP + pregnenolone 3-beta-D-glucoside
-
-
-
-
?
pregnenolone + UDP-glucose
UDP + pregnenolone 3-beta-D-glucoside
-
-
-
-
?
stigmasta-5,22-dien-3beta-ol + UDP-glucose
?
-
stigmasterol, 49.2% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
stigmasta-5,24(28)-dien-3beta-ol + UDP-glucose
?
-
82.4% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
stigmastan-3beta-ol + UDP-glucose
?
-
38.7% of the activity with sitosterol (stigmast-5-en-3beta-ol)
-
-
?
UDP-glucose + 3beta-hydroxy-16,17alpha-epoxypregnenolone
UDP + 3beta-hydroxy-16,17alpha-epoxypregnenolone 3-beta-D-glucoside
-
-
-
-
?
UDP-glucose + 3beta-hydroxy-pregna-5,16-dien-one
UDP + 3beta-20-oxopregna-5,16-dien-3-yl beta-D-glucopyranoside
-
-
-
?
UDP-glucose + 4-demethyl-obtusifoliol
UDP + 4-demethyl-obtusifoliol 3-beta-glucoside
-
58% of the activity with sitosterol
-
?
UDP-glucose + 5-alpha-cholestanol
UDP + 5-alpha-cholestanol 3-beta-D-glucoside
-
8% of the activity with sitosterol
-
?
UDP-glucose + 5-cholestenol
UDP + 5-cholestenol 3-beta-D-glucoside
-
12% of the activity with sitosterol
-
?
UDP-glucose + 7-dehydrocholesterol
UDP + 7-dehydrocholesterol 3-beta-D-glucoside
-
6% of the activity with sitosterol
-
?
UDP-glucose + alpha-spinasterol
UDP + alpha-spinasterol 3-beta-D-glucoside
-
31% of the activity with sitosterol
-
?
UDP-glucose + dehydroepiandrosterone
UDP + dehydroepiandrosterone 3-beta-D-glucoside
-
-
-
?
UDP-glucose + epiandrosterone
UDP + epiandrosterone 3-beta-glucoside
-
best substrate
-
?
UDP-glucose + isofucosterol
UDP + isofucosterol 3-beta-glucoside
-
73% of the activity with sitosterol
-
?
UDP-glucose + poriferasterol
UDP + poriferasterol 3-beta-glucoside
-
synthesis of poriferasterol monoglucoside may be involved in differentiation
-
-
?
UDP-glucose + pregnenolone
UDP + pregnenolone 3-beta-glucoside
-
57% of the activity with epiandrosterone
-
?
UDP-glucose + solasodine
UDP + solasodine 3-beta-D-glucoside
-
-
-
?
3beta-hydroxy-pregna-5,16-dien-20-one + UDP-glucose
UDP + 3beta-20-oxopregna-5,16-dien-3-yl beta-D-glucopyranoside
-
-
-
-
?
3beta-hydroxy-pregna-5,16-dien-20-one + UDP-glucose
UDP + 3beta-20-oxopregna-5,16-dien-3-yl beta-D-glucopyranoside
-
-
-
-
?
beta-sitosterol + UDP-glucose
UDP + beta-sitosterol 3-beta-D-glucoside
-
-
-
-
?
beta-sitosterol + UDP-glucose
UDP + beta-sitosterol 3-beta-D-glucoside
-
-
-
-
?
cholesterol + UDP-glucose
UDP + cholesterol 3-beta-D-glucoside
-
-
-
-
?
cholesterol + UDP-glucose
UDP + cholesterol 3-beta-D-glucoside
-
-
-
-
?
dehydroepiandrosterone + UDP-glucose
UDP + dehydroepiandrosterone 3-beta-D-glucoside
-
-
-
-
?
dehydroepiandrosterone + UDP-glucose
UDP + dehydroepiandrosterone 3-beta-D-glucoside
-
-
-
-
?
stigmasterol + UDP-glucose
UDP + stigmasterol 3-beta-D-glucoside
-
-
-
-
?
stigmasterol + UDP-glucose
UDP + stigmasterol 3-beta-D-glucoside
-
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-alpha-D-glucose + testosterone
UDP + testosterone 17-beta-D-glucoside
-
-
-
?
UDP-glucose + a sterol
UDP + a sterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + a sterol
UDP + a sterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + a sterol
UDP + a sterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + a sterol
UDP + a sterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + a sterol
UDP + a sterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + a sterol
UDP + a sterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + a sterol
UDP + a sterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + a sterol
UDP + a sterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + beta-sitosterol
UDP + beta-sitosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + beta-sitosterol
UDP + beta-sitosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + beta-sitosterol
UDP + beta-sitosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + brassicasterol
UDP + brassicasterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + brassicasterol
UDP + brassicasterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + campesterol
UDP + campesterol 3-beta-D-glucoside
-
-
4% of the products
?
UDP-glucose + campesterol
UDP + campesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + campesterol
UDP + campesterol 3-beta-D-glucoside
-
80% of the activity with poriferasterol
-
?
UDP-glucose + campesterol
UDP + campesterol 3-beta-D-glucoside
-
28% of the activity with sitosterol
-
?
UDP-glucose + campesterol
UDP + campesterol 3-beta-D-glucoside
-
best substrate
-
?
UDP-glucose + campesterol
UDP + campesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + campesterol
UDP + campesterol 3-beta-D-glucoside
-
68% of the activity with sitosterol
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
cloned enzyme exhibits equal activity to the purified protein
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
with sitosterol, best substrates
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
cloned enzyme glucosylates cholesterol
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
cloned enzyme exhibits equal activity to the purified protein
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
cloned enzyme exhibits equal activity to the purified protein
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
cloned enzyme glucosylates cholesterol
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
cloned enzyme glucosylates cholesterol
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
cloned enzyme glucosylates cholesterol
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
best substrate
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
cloned enzyme glucosylates cholesterol
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
cloned enzyme glucosylates cholesterol
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
23% of the activity with sitosterol
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
12% of the activity with poriferasterol
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
cloned enzyme glucosylates cholesterol
-
?
UDP-glucose + cholesterol
UDP + cholesterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
cloned enzyme glucosylates ergosterol
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
69% of the activity with sitosterol
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
cloned enzyme glucosylates ergosterol
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
cloned enzyme glucosylates ergosterol
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
cloned enzyme glucosylates ergosterol
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
cloned enzyme glucosylates ergosterol
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
cloned enzyme glucosylates ergosterol
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
11% of the activity with sitosterol
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
9% of the activity with poriferasterol
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
cloned enzyme glucosylates ergosterol
-
?
UDP-glucose + ergosterol
UDP + ergosterol 3-beta-D-glucoside
-
-
-
?