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Information on EC 2.4.1.17 - glucuronosyltransferase and Organism(s) Rattus norvegicus and UniProt Accession Q64550

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.17 glucuronosyltransferase
IUBMB Comments
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
Specify your search results
Select one or more organisms in this record:
This record set is specific for:
Rattus norvegicus
UNIPROT: Q64550
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The taxonomic range for the selected organisms is: Rattus norvegicus
Synonyms
1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17-OH steroid UDPGT, 17beta-hydroxysteroid UDP-glucuronosyltransferase, 1A10, 3,4-catechol estrogen specific UDPGTh-2, 3-OH androgenic UDPGT, 3alpha-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-naphthol glucuronyltransferase
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1-naphthol-UDP-glucuronosyltransferase
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17-OH steroid UDPGT
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17beta-hydroxysteroid UDP-glucuronosyltransferase
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3-OH androgenic UDPGT
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3alpha-hydroxysteroid UDP-glucuronosyltransferase
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4-hydroxybiphenyl UDP-glucuronosyltransferase
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4-methylumbelliferone UDP-glucuronosyltransferase
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4-nitrophenol UDP-glucuronosyltransferase
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4-nitrophenol UDP-glucuronyltransferase
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4-nitrophenol UDPGT
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bile acid uridine 5'-diphosphoglucuronyltransferase
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bilirubin glucuronyltransferase
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bilirubin monoglucuronide glucuronyltransferase
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bilirubin UDP-glucuronosyltransferase
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bilirubin UDPglucuronosyltransferase
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bilirubin UDPGT
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bilirubin uridine diphosphoglucuronyltransferase
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bilirubin-specific UDPGT isozyme 1
281002
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ciramadol UDP-glucuronyltransferase
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estriol UDP-glucuronosyltransferase
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estrone UDP-glucuronosyltransferase
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glucuronosyltransferase, uridine diphospho-
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glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol
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glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl
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glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin
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glucuronosyltransferase, uridine diphosphoglucuronate-estradiol
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glucuronosyltransferase, uridine diphosphoglucuronate-estriol
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glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-
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glucuronyltransferase, uridine diphospho-GT
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HUG-BR1
281002
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morphine glucuronyltransferase
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p-hydroxybiphenyl UDP glucuronyltransferase
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p-nitrophenol UDP-glucuronosyltransferase
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p-nitrophenol UDP-glucuronyltransferase
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p-nitrophenylglucuronosyltransferase
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p-phenylphenol glucuronyltransferase
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phenol-metabolizing UDP-glucuronosyltransferase
281002
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phenyl-UDP-glucuronosyltransferase
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PNP-UDPGT
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UDP glucuronate-estradiol-glucuronosyltransferase
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UDP glucuronate-estriol glucuronosyltransferase
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UDP glucuronic acid transferase
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UDP glucuronosyltransferase
UDP glucuronyltransferase
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UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase
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UDP-glucuronate-bilirubin glucuronyltransferase
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UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1A1
281002
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UDP-glucuronosyltransferase 1A6
281002
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UDP-glucuronyltransferase
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UDPGA transferase
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UDPGA-glucuronyltransferase
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UDPglucuronate beta-D-glucuronosyltransferase
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UDPglucuronosyltransferase
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UDPGT
UGT-1A
281002
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UGT-1F
281002
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UGT1-01
281002
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UGT1-06
281002
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UGT1.1
281002
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UGT1.6
281002
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UGT1A
281002
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UGT1A2
281020
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UGT1A3
281003
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UGT1A5
UGT1A6
UGT1A7
UGT1F
281002
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UGT2B1
281006
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UGT2B12
281008
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UGT2B2
281017
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UGT2B3
281007
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UGT2B8
281018
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uridine 5'-diphosphoglucuronyltransferase
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uridine diphosphate glucuronyltransferase
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uridine diphosphoglucuronate-bilirubin glucuronosyltransferase
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uridine diphosphoglucuronosyltransferase
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uridine diphosphoglucuronyltransferase
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additional information
248
the UGT superfamily is divided into two families, UGT1 and UGT2, the latter is divided into two subfamilies, UGT2A and UGT2B
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
show the reaction diagram
sequential bireactant mechanism
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
CAS REGISTRY NUMBER
COMMENTARY hide
37205-52-0
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37277-52-4
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37277-66-0
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61969-98-0
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62213-43-8
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62213-47-2
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9030-08-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-hydroxy-2',3,3',4',5'-pentachlorobiphenyl + UDPglucuronate
UDP + 2,3,3',4',5'-pentachlorobiphenyl 4-O-glucuronate
show the reaction diagram
-
-
-
?
4-hydroxy-2',3,3',4',5,5'-heptachlorobiphenyl + UDPglucuronate
UDP + 2',3,3',4',5,5'-hexachlorobiphenyl 4-O-glucuronate
show the reaction diagram
-
-
-
?
4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl + UDPglucuronate
UDP + 2',3,4',5,6'-pentachlorobiphenyl 4-O-glucuronate
show the reaction diagram
-
-
-
?
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
show the reaction diagram
-
-
-
?
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
show the reaction diagram
-
-
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?
estradiol + UDP-glucuronate
?
show the reaction diagram
-
-
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?
UDP-glucuronate + p-nitrophenol
UDP + 4-nitrophenyl-alpha-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDPglucuronate + bilirubin
?
show the reaction diagram
-
-
-
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?
(-)-borneol + UDP-glucuronate
UDP + (-)-borneol-O-alpha-D-glucuronide
show the reaction diagram
-
-
-
?
1-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-1-yl-beta-D-glucuronide
show the reaction diagram
-
-
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?
1-naphthol + UDP-alpha-D-glucuronate
1-naphthyl O-glucuronide + UDP
show the reaction diagram
-
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?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
show the reaction diagram
1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
show the reaction diagram
-
-
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?
10-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-10-yl-beta-D-glucuronide
show the reaction diagram
-
-
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?
11-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-11-yl-beta-D-glucuronide
show the reaction diagram
-
-
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?
12-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
show the reaction diagram
-
-
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?
17beta-estradiol + UDP-glucuronate
?
show the reaction diagram
-
-
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?
17beta-ethynylestradiol + UDPglucuronate
?
show the reaction diagram
-
-
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?
17beta-hydroxy-5alpha-androstan-3-one + UDPglucuronate
UDP + 17beta-hydroxy-5alpha-androstan-3-one 17O-glucuronide
show the reaction diagram
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
show the reaction diagram
2-hydroxy-2',3',4',5'-tetrachlorobiphenyl + UDPglucuronate
UDP + 2',3',4',5'-tetrachlorobiphenyl 2-O-glucuronate
show the reaction diagram
-
-
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?
2-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-2-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
2-methoxy-4-(2-propenyl)phenol + UDPglucuronate
UDP + 2-methoxy-4-(2-propenyl)phenylglucuronide
show the reaction diagram
-
i.e. eugenol
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
show the reaction diagram
-
-
-
?
3,5-dinitrocatechol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
3-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-3-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
show the reaction diagram
4-hydroxy-2',3,4',6'-tetrachlorobiphenyl + UDP-glucuronate
UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate
show the reaction diagram
-
-
-
?
4-hydroxy-2',4',6'-trichlorobiphenyl + UDP-glucuronate
UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate
show the reaction diagram
-
-
-
?
4-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-4-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
show the reaction diagram
4-hydroxybiphenyl + UDPglucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
show the reaction diagram
-
-
-
?
4-methylumbeliferone + UDP-glucuronate
4-methylumbelliferyl-7-O-alpha-D-glucuronide
show the reaction diagram
-
-
-
?
4-methylumbeliferone + UDP-glucuronate
4-methylumbelliferyl-7-O-beta-D-glucuronide
show the reaction diagram
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
show the reaction diagram
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
show the reaction diagram
4-nitrothiophenol + UDP-glucuronate
4-nitrothiophenyl thio-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
?
5-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-5-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
6-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-6-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
7,7,7-triphenylheptanoic acid + UDPglucuronate
UDP + 7,7,7-triphenylheptanoic acid glucuronide
show the reaction diagram
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
show the reaction diagram
-
-
-
?
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
show the reaction diagram
-
-
-
?
7-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-7-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
7-hydroxycoumarin + UDP-glucuronate
UDP + coumarin-7-yl-alpha-D-glucuronide
show the reaction diagram
-
-
-
?
8-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-8-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
8-hydroxyquinoline + UDPglucuronate
UDP + 8-hydroxyquinoline 8-O-glucuronide
show the reaction diagram
-
-
-
?
9-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-9-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
acetaminophen + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
alpha-naphthylamine + UDPglucuronate
UDP + ?
show the reaction diagram
-
inactive
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-
androsterone + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
show the reaction diagram
anthraflavic acid + UDPglucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
apigenin + UDPglucuronate
UDP + apigenin O-glucuronide
show the reaction diagram
-
-
-
?
benzo[a]pyrene 3,6-diphenol + UDP-glucuronate
?
show the reaction diagram
-
converted readily to mono- and diglucuronides
-
-
?
benzo[a]pyrene 3,6-quinone + UDPglucuronate
benzo[a]pyrene 3,6-quinol glucuronide + UDP
show the reaction diagram
-
-
no information to which positions 3-, 6-, or both the glucuronate is attached
?
benzo[a]pyrene-3,6-quinol + UDPglucuronate
benzo[a]pyrene 3,6-quinol mono- and diglucuronide + UDP
show the reaction diagram
-
-
-
?
benzo[a]pyrene-7,8(+)-diol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
benzo[a]pyrene-7,8(-)diol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
beta-estradiol + UDPglucuronate
beta-estradiol-3-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
show the reaction diagram
bilirubin + UDPglucuronate
UDP + bilirubin O-glucuronide
show the reaction diagram
bilirubin monoglucuronide + UDPglucuronate
bilirubin diglucuronide + UDP
show the reaction diagram
bisphenol A + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
buprenorphine + UDPglucuronate
UDP + buprenorphine O-glucuronide
show the reaction diagram
-
-
-
?
chenodeoxycholic acid + UDP-glucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
chenodeoxycholic acid + UDPgalacturonate
UDP + chenodeoxycholic acid O-galacturonide
show the reaction diagram
-
-
-
?
chloramphenicol + UDPglucuronate
UDP + chloramphenicol O-glucuronide
show the reaction diagram
chrysin + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
diclofenac + UDPalpha-D-glucuronate
UDP + ?
show the reaction diagram
-
recombinant UGT2B1 displays moderate rate
-
-
?
digitoxigenin + UDPglucuronate
UDP + digitoxigenin O-glucuronide
show the reaction diagram
-
-
-
?
epicatechin + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
estradiol-17beta + UDPglucuronate
estradiol-17beta-3-monoglucuronide + UDP
show the reaction diagram
-
-
-
-
?
estriol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
estrone + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
show the reaction diagram
etiocholanone + UDPglucuronate
UDP + etiocholanone O-glucuronide
show the reaction diagram
lithocholic acid + UDPglucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
morphine + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
show the reaction diagram
N-hydroxy-2-naphthylamine + UDPglucuronate
UDP + N-hydroxy-2-naphthylamine-O-glucuronide
show the reaction diagram
phenolphthalein + UDPglucuronate
UDP + phenolphthalein O-glucuronide
show the reaction diagram
planar phenols + UDPglucuronate
UDP + phenylglucuronides
show the reaction diagram
-
expressed before birth
-
-
-
propofol + UDP-glucuronate
UDP + propofyl beta-D-glucuronide
show the reaction diagram
-
-
-
?
quercetin + UDPglucuronate
UDP + quercetin O-glucuronide
show the reaction diagram
-
-
-
?
serotonin + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
serotonin + UDPglucuronate
tryptamine 5-O-beta-D-glucuronide + UDP
show the reaction diagram
testosterone + UDP-glucuronate
UDP + testosterone-17alpha-glucuronide
show the reaction diagram
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
show the reaction diagram
thiophenol + UDPglucuronate
thiophenyl thio-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
?
troglitazone + UDPglucuronate
UDP + troglitazone 6-O-glucuronide
show the reaction diagram
-
Gunn and Wistar strains
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol-3-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + mycophenolate
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
show the reaction diagram
-
-
formation of 1 product metabolite termed G1
-
?
UDP-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
bilirubin + UDPglucuronate
UDP + bilirubin O-glucuronide
show the reaction diagram
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + mycophenolate
UDP + ?
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Hg2+
-
activation of bilirubin UDP-glucuronyltransferase
additional information
-
slight stimulatory effect with Cd2+ and Fe2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
silibinin-glucuronide
-
cmpetitive; competitive
silymarin
-
competitive
2,2,2-(Triphenyl)ethyl-UDP
-
-
2,2,2-triphenyl-UDP
-
selective inhibitor
2,5-Dichlorophenyl-UDP
-
-
2,6-Dimethoxyphenyl-UDP
-
-
2-(1-Naphthyl)ethyl-UDP
-
-
2-(1-Naphthyl)ethyl-UMP
-
-
2-(2-Naphthyl)ethyl-UDP
-
-
2-(2-Naphthyl)ethyl-UMP
-
-
2-(4-Bromophenyl)ethyl-UDP
-
-
2-(4-Bromophenyl)ethyl-UMP
-
-
2-(4-Nitrophenyl)ethyl-UDP
-
-
2-Bromophenyl-UDP
-
-
2-Chlorophenyl-UDP
-
-
3,3,3-Triphenylpropionic acid
-
competitive to bilirubin
3-Methyl-2-nitrobenzyl-UDP
-
-
4,4,4-Triphenylbutanoic acid
-
competitive to bilirubin
4-Bromophenyl-UDP
-
-
4-Chlorophenyl-UDP
-
-
4-Iodophenyl-UDP
-
-
4-Isopropylphenyl-UDP
-
-
4-nitrophenol glucuronide
-
inhibits 4-nitrophenol glucuronidation
4-tert-Butylphenyl-UDP
-
-
5,5,5-Triphenylpentanoic acid
-
competitive to bilirubin
6,6,6-Triphenylhexanoic acid
-
competitive to bilirubin
7,7,7-Triphenylheptanoic acid
-
competitive to bilirubin
7,7,7-triphenylheptyl-UDP
-
-
8,8,8-Triphenyloctanoic acid
-
competitive to bilirubin
9,9,9-Triphenylnonanoic acid
-
non-competitive to bilirubin
ADP
-
markedly reduces 4-methylumbelliferone UGT activity only when detergent-treated rat liver microsomes are used as the enzyme source, inhibits UGT activity non-competitively without competing with either 4-methylumbelliferone or UDP-D-glucuronic acid
AMP
-
inhibits exclusively the estradiol 17-glucuronidation activity
androsterone
-
Gunn rat strain, competitive inhibition of troglitazone glucuronidation
ATP
-
markedly reduces 4-methylumbelliferone UGT activity only when detergent-treated rat liver microsomes are used as the enzyme source, inhibits UGT activity non-competitively without competing with either 4-methylumbelliferone or UDP-D-glucuronic acid
bilirubin diglucuronides
-
competitive inhibitors
-
bilirubin monoglucuronides
-
competitive inhibitors
-
codeine
-
competitive inhibitor to morphine-UDPGT
CTP
-
no inhibition of UGT by other cytosine-related nucleotides but CTP
cyproheptadine
-
-
desmethylcyproheptadine
-
-
Diethyldithiocarbamic acid sodium salt
-
irreversible inhibitor
dilauroylphosphatidylcholine
-
activity towards 4-methylumbelliferone: decreased kidney enzyme activity
flunitrazepam
-
competitive inhibitor to morphine glucuronidation
GTP
-
weak inhibition, no inhibition of UGT by other guanosine-related nucleotides but GTP
Hg2+
-
inhibition of 4-methylumbelliferone UDP-glucuronyltransferase
lithocholic acid
-
inhibition at high concentration, other bile acids and bile acids glucuronides also inhibit
Lubrol 12A9
-
-
menthol
-
Gunn rat, non-competitive inhibition of troglitazone glucuronidation
morphine 3-glucuronide
-
inhibits morphine glucuronidation
NAD+
-
inhibits UGT activity non-competitively without competing with either 4-methylumbelliferone or UDP-D-glucuronic acid
NADP+
-
markedly reduces 4-methylumbelliferone UGT activity only when detergent-treated rat liver microsomes are used as the enzyme source, inhibits UGT activity non-competitively without competing with either 4-methylumbelliferone or UDP-D-glucuronic acid
omega,omega,omega-triphenylalkyl-UDP derivatives
-
e.g. 7,7,7-triphenylheptyl-UDP
-
p-[di-n-Propylsulfamoyl]benzoic acid
-
i.e. probenecid
Phenolphthalein
-
strong end product inhibition
testosterone
-
Gunn rat, non-competitive inhibition of troglitazone glucuronidation
Triphenylacetic acid
-
competitive to bilirubin
UDP-N-acetylglucosamine
UDPgalactose
-
inhibition or chenodeoxycholic acid and testosterone glucuronidation
UDPgalacturonic acid
UDPglucose
-
slight effect
UDPxylose
-
inhibition or chenodeoxycholic acid and testosterone glucuronidation
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-methylcholanthrene
Alkyl ketones
-
activation
bilirubin
-
stimulates the glucoronidation of 4-nitrophenol and morphine
cholate
-
activation
Clofibrate
-
induces activity of bilirubin-UDPGT
Diethylnitrosamine
Digitonin
dilauroylphosphatidylcholine
-
activity towards 4-methylumbelliferone: increased liver enzyme activity
lysophosphatidylcholine
Phenobarbital
phosphatidylcholine
-
required by purified preparations for optimal activity
Phospholipase A
-
in presence of Ca2+ activation of glucuronidation of 4-nitrophenol, effect can be stimulated by addition of lysophosphatidylcholine, linoleic acid or arachidonic acid or equimolar mixtures of them
-
Phospholipids
-
effect of various phospholipids
polycyclic aromatic hydrocarbons
-
induce activity towards simple phenols such as 1-naphthol, 2-aminophenol and mitoxantrone
-
Triton X-100
-
activation
UDP-N-acetylglucosamine
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00246 - 0.067
1-naphthol
0.26
4-Hydroxybiphenyl
-
-
0.416
4-Methylumbelliferone
-
pH 7.4, 37°C
0.494 - 2
4-nitrophenol
0.006 - 0.12
androsterone
0.0137 - 0.064
bilirubin
0.0022
denopamine
-
liver microsomes, substrate denopamine, pH 7.5, 37°C
0.007 - 0.016
diclofenac
0.035
estradiol
-
pH 7.4, 37°C
0.32
morphine
-
pH 7.4, 37°C
0.34
mycophenolate
-
pH 7.4, 37°C
0.012 - 0.02
testosterone
0.136
troglitazone
-
-
0.26
UDP-glucuronic acid
-
apparent Km for UGT1A6, 50mM 1-naphthol, mutants that retained activity shows similar Km values
0.3 - 1.06
UDPglucuronate
5.4
UDPglucuronic acid
-
-
additional information
additional information
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.03
7,7,7-triphenylheptyl-UDP
-
apparent Ki for the inhibition of 1-naphthol glucuronidation
0.009
androsterone
-
Gunn rat, inhibition of troglitazone glucuronidation
1.1
codeine
-
competitive with morphine glucuronidation
0.08
cyproheptadine
-
morphine-UDPGT
4
desmethylcyproheptadine
-
-
0.059
testosterone
-
Gunn rat, inhibition of troglitazone glucuronidation
additional information
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0259 - 0.0774
ADP
0.031
AMP
Rattus norvegicus
-
pH 7.1, 37°C, inhibition of estradiol 17-glucuronidation activity
0.0117 - 0.0352
ATP
0.0059 - 0.0558
CTP
0.108 - 0.227
GTP
0.009 - 0.0321
NAD+
0.008 - 0.0252
NADP+
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.028
-
4-nitrophenol as substrate, using Wistar strain liver microsomes
0.075
-
7,7,7-triphenylheptanoic acid as substrate
0.092
-
4-hydroxybiphenyl as substrate, enzyme induced by 3-methylcholanthrene
0.142
-
bilirubin as substrate, non-treated Wistar strain
0.168
-
chenodeoxycholic acid, Sprague-Dawley rat treated with phenobarbital
0.67
-
morphine as substrate, Wistar strain treated with phenobarbital
0.983
-
testosterone, Sprague-Dawley rat treated with phenobarbital
1.7
-
5-hydroxytryptamine, enzyme induced by 3-methylcholanthrene
1.8
-
eugenol as substrate, enzyme induced by 3-methylcholanthrene
4
-
1-naphthol as substrate, Wistar strain treated with 3-methylcholanthrene
5
-
4-nitrophenol as substrate, Wistar strain treated with 3-methylcholanthrene
5.35
-
1-naphthol as substrate, Wistar strain treated with phenobarbital
6.06
-
1-naphthol as substrate, Wistar strain treated with 3-methylcholanthrene
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.1
-
assay at
7.3 - 7.8
-
4-thionitrophenol, thiophenol and 4-nitrophenol as substrates
7.5
-
assay at
7.8
-
bilirubin
8
-
bilirubin
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
-
wide tissue distribution
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
low activity
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
UD11_RAT
535
2
59663
Swiss-Prot
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
41500
-
bilirubin monoglucuronide forming enzyme, monomeric, radiation inactivation
50000
52000
52500
-
x * 52500
53000
54000
56000
57000
-
x * 57000, SDS-polyacrylamide gel electrophoresis
59000
-
x * 59000, SDS-polyacrylamide gel electrophoresis
73500
-
estrone UDP-glucuronyltransferase, dimeric enzyme, radiation inactivation
109000
-
4-nitrophenol UDP-glucuronyltransferase, dimeric or trimeric enzyme, radiation inactivation
142000
-
testosterone UDP-glucuronyltransferase, trimeric or tetrameric enzyme, radiation inactivation
159000
-
phenolphthalein UDP-glucuronyltransferase, tetrameric enzyme, radiation inactivation
175000
-
formation of bilirubin diglucuronide from bilirubin monoglucuronide, tetrameric enzyme, radiation inactivation
316000 - 318000
-
gel filtration, polyacrylamide gradient slab gel electrophoresis
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
by chromatofocusing
tetramer
-
isozyme for conversion of bilirubin monoglucuronide to bilirubin diglucuronide, a + b + c + d, subunits a and b have a low Km for UDPglucuronide, c and d have a high Km for UDP-glucuronide, a and b can catalyze the conversion of bilirubin to bilirubin monoglucuronide, radiation inactivation
additional information
-
the enzyme is composed of an N-terminal domain with an aglycon binding site, a short transmembrane sequence, a C-terminal domain with UDP-glucuronic acid binding site, a transmembrane helix and a cytoplasmic tail, primary to quarternary structure and oligomeric state analysis of several isozymes, detailed overview
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
phospholipoprotein
additional information
-
Gunn rat strain, inducible phenol-UGT synthesized in the truncated form is not the result of a posttranslational modification
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D446A
-
UGT1A6 activity retained for 1-naphthol nor UDP-glucuronic acid
D446E
-
UGT1A6 activity retained for 1-naphthol nor UDP-glucuronic acid
D446G
-
UGT1A6 activity not detected for 1-naphthol nor UDP-glucuronic acid
D446K
-
UGT1A6 activity not detected for 1-naphthol nor UDP-glucuronic acid
D446N
-
UGT1A6 activity retained for 1-naphthol nor UDP-glucuronic acid
D446q
-
UGT1A6 activity retained for 1-naphthol nor UDP-glucuronic acid
D446T
-
UGT1A6 activity retained for 1-naphthol nor UDP-glucuronic acid
additional information
-
a truncated mutant of UGT2B1, whose transmembrane helix is deleted, is still associated to the endoplasmic reticulum membrane, overview
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
UGT1A6 mutants activity reduced at acidic pH
488787
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
-60
-
as pellets with a 1.15% KCl overlay, no apparent loss of activity for three months
-20
-
rapid loss of activity
40
-
inactivation above
45
-
3 min, 80% reduced activity
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
phosphatidylcholine stabilizes the detergent treated enzyme
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, 20% w/v glycerol, complete loss of activity
-
-20°C, at least 1 month
-
-20ºC, completely stable for 3.5 months
-
0-4°C, 0.1 mg/ml lysophosphatidylcholine, 1 mM EDTA, 11% loss of activity in 6 days, 20% loss of activity in 12 days
-
0°C, 30 days, 4-nitrophenol UDP-glucuronosyltransferase loses 11% of activity, 2-aminophenol UDP-glucuronosyltransferase loses 19% of activity
-
0°C, half-life 18-20 days
-
22°C, lyophilized microsomes, 15 days
-
4°C, at least 2 days
-
4°C, bilirubin glucuronosyltransferases: isozyme F1 3 weeks stable, isozyme F3 inactivation in 1 week
-
4°C, solubilized enzyme stable for 7 days, concentrated form loses 12% of activity
-
4ºC, purified GT1 with addition of egg lecithin, stable for 4 weeks, with loss of 25% of activity
-
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
chromatofocusing and affinity chromatography on UDP-hexanolamine sepharose, three isoenzymes
-
comparisson between DEAE-Sepharose and chromatofocusing methods
-
native enzyme partially by microsome preparation
-
overview procedures
-
purification of two isozymes inducibles by 3-methylcholanthrene or phenobarbital using sodium cholate solubilization, chromatography on Bio Gel A 1.5 m, DEAE-cellulose and UDP-hexanolamine Sepharose 4B
-
several methods including chromatofocusing, combined with anion exchange chromatography and/or affinity chromatography of UDP-hexanolamine Sepharose
-
two isozymes by a combination of ion-exchange chromatography, gel filtration and affinity chromatography on UDP-hexanolamine Sepharose
-
Wistar strain purified from microsomes by solubilization with CHAPS, and sequential chromatography on Red-Toyopearl, hydroxyapatite, heparin-Toyopearl and UDP-hexanolamine-agarose
-
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
expression in yeast strain AH22
expressed in COS-7 cells
-
expressed in yeast AH22 cells
-
expression in HEK cells
expression in yeast strain AH22
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bock, K.W.; Burchell, B.; Dutton, G.J.; Hänninen, O.; Mulder, G.J.; Owens, I.S.; Siest, G.; Tephly, T.R.
UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions
Biochem. Pharmacol.
32
953-955
1983
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Burchell, B.
Identification and purification of multiple forms of UDP-glucuronosyltransferase
Rev. Biochem. Toxicol.
3
1-32
1981
Homo sapiens, Rattus norvegicus
-
Manually annotated by BRENDA team
Green, M.D.; Falany, C.N.; Kirkpatrick, R.B.; Tephly, T.R.
Strain differences in purified rat hepatic 3alpha-hydroxysteroid UDP-glucuronosyltransferase
Biochem. J.
230
403-409
1985
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Bock, K.W.; Josting, D.; Lilienblum, W.; Pfeil, H.
Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital
Eur. J. Biochem.
98
19-26
1979
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Crawford, J.M.; Ransil, B.J.; Narciso, J.P.; Gollan, J.L.
Hepatic microsomal bilirubin UDP-glucuronosyltransferase. The kinetics of bilirubin mono- and diglucuronide synthesis
J. Biol. Chem.
267
16943-16950
1992
Rattus norvegicus
Manually annotated by BRENDA team
Said, M.; Noort, D.; Magdalou, J.; Ziegler, J.C.; van der Marel, G.A.; van Boom, J.H.; Mulder, G.J.; Siest, G.
Selective and potent inhibition of different hepatic UDP-glucuronosyltransferase activities by omega,omega,omega-triphenylalcohols and UDP derivatives
Biochem. Biophys. Res. Commun.
187
140-145
1992
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Clarke, D.J.; Keen, J.N.; Burchell, B.
Isolation and characterisation of a new hepatic bilirubin UDP-glucuronosyltransferase. Absence from Gunn rat liver
FEBS Lett.
299
183-186
1992
Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Yokota, H.; Fukuda, T.; Yuasa, A.
Differential effects of phospholipids on two similar forms of UDP-glucuronyltransferase purified from rat liver and kidney microsomes
J. Biochem.
110
50-53
1991
Rattus norvegicus
Manually annotated by BRENDA team
Noort, D.; Coughtrie, M.W.H.; Burchell, B.; van der Marel, G.A.; van Boom, J.H.; van der Gen, A.; Mulder, G.J.
Inhibition of UDP-glucuronosyltransferase activity by possible transition-state analogues in rat-liver microsomes
Eur. J. Biochem.
188
309-312
1990
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Haumont, M.; Magdalou, J.; Lafaurie, C.; Ziegler, J.M.; Siest, G.; Colin, J.N.
Phenobarbital inducible UDP-glucuronosyltransferase is responsible for glucuronidation of 3-azido-3-deoxythymidine: characterization of the enzyme in human and rat liver microsomes
Arch. Biochem. Biophys.
281
264-270
1990
Homo sapiens, Macaca mulatta, Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Vanstapel, F.; Hammaker, L.; Pua, K.; Blanckaert, N.
Properties of membrane-bound bilirubin UDP-glucuronyltransferase in rough and smooth endoplasmic reticulum and in the nuclear envelope from rat liver
Biochem. J.
259
659-663
1989
Rattus norvegicus, Rattus norvegicus R/A Pfd
Manually annotated by BRENDA team
Fournel-Gigleux, S.; Shepherd, S.R.P.; Carre, M.C.; Burchell, B.; Siest, G.; Caubere, P.
Novel inhibitors and substrates of bilirubin: UDP-glucuronosyltransferase. Arylalkylcarboxylic acids
Eur. J. Biochem.
183
653-659
1989
Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Yokota, H.; Ohgiya, N.; Ishihara, G.; Ohta, K.; Yuasa, A.
Purification and properties of UDP-glucuronyltransferase from kidney microsomes of beta-naphthoflavone-treated rat
J. Biochem.
106
248-252
1989
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Yokota, H.; Yuasa, A.; Sato, R.
Purification and properties of a form of UDP-glucuronyltransferase from liver microsomes of 3-methylcholanthrene-treated rats
J. Biochem.
104
531-536
1988
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Vanstapel, F.; Blanckaert, N.
Topology and regulation of bilirubin UDP-glucuronyltransferase in sealed native microsomes from rat liver
Arch. Biochem. Biophys.
263
216-225
1988
Rattus norvegicus, Rattus norvegicus R/A Pfd
Manually annotated by BRENDA team
Odell, G.; Mogilevsky, W.S.; Siegel, F.L.
Isolation of an activator of bilirubin glucuronyltransferase from normal and jaundiced Gunn rats
Biochem. Biophys. Res. Commun.
154
1212-1221
1988
Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Falany, C.N.; Green, M.D.; Swain, E.; Tephly, T.R.
Substrate specificity and characterization of rat liver p-nitrophenol, 3alpha-hydroxysteroid and 17beta-hydroxysteroid UDP-glucuronosyltransferases
Biochem. J.
238
65-73
1986
Rattus norvegicus
Manually annotated by BRENDA team
Roy Chowdhury, J.; Roy Chowdhury, N.; Falany, C.N.; Tephly, T.R.; Arias, I.M.
Isolation and characterization of multiple forms of rat liver UDP-glucuronate glucuronosyltransferase
Biochem. J.
233
827-837
1986
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Fournel, S.; Gergoire, B.; Magdalou, J.; Carre, M.C.; Lafaurie, C.; Siest, G.; Caubere, P.
Inhibition of bilirubin UDPglucuronosyltransferase activity by triphenylacetic acid and related compounds
Biochim. Biophys. Acta
883
190-196
1986
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Peters, W.H.M.; Jansen, P.L.M.; Nauta, H.
The molecular weights of UDP-glucuronyltransferase determined with radiation-inactivation analysis. A molecular model of bilirubin UDP-glucuronyltransferase
J. Biol. Chem.
259
11701-11706
1984
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Burchell, B.; Blanckaert, N.
Bilirubin mono- and di-glucuronide formation by purified rat liver microsomal bilirubin UDP-glucuronyltransferase
Biochem. J.
223
461-465
1984
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Koster, A.S.; Noordhoek, J.
Kinetic properties of the rat intestinal microsomal 1-naphthol:UDP-glucuronosyl transferase. Inhibition by UDP and UDP-N-acetylglucosamine
Biochim. Biophys. Acta
761
76-85
1983
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Falany, C.N.; Tephly, T.R.
Separation, purification and characterization of three isoenzymes of UDP-glucuronyltransferase from rat liver microsomes
Arch. Biochem. Biophys.
227
248-258
1983
Rattus norvegicus
Manually annotated by BRENDA team
Matern, H.; Matern, S.; Gerok, W.
Isolation and characterization of rat liver microsomal UDP-glucuronosyltransferase activity toward chenodeoxycholic acid and testosterone as a single form of enzyme
J. Biol. Chem.
257
7422-7429
1982
Rattus norvegicus
Manually annotated by BRENDA team
Burchell, B.; Weatherill, P.
4-Nitrophenol UDPglucuronyltransferase (rat liver)
Methods Enzymol.
77
169-177
1981
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Burchell, B.
Bilirubin UDPglucuronyltransferase
Methods Enzymol.
77
188-192
1981
Rattus norvegicus
Manually annotated by BRENDA team
Bock, K.W.; Lilienblum, W.; Pfeil, H.
Conversion of benzo[a]pyrene-3,6-quinone to quinol glucuronides with rat liver microsomes or purified NADPH-cytochrome c reductase and UDP-glucuronosyltransferase
FEBS Lett.
121
269-272
1980
Rattus norvegicus
Manually annotated by BRENDA team
Weatherill, P.J.; Burchell, B.
The separation and purification of rat liver UDP-glucuronyltransferase activities towards testosterone and oestrone
Biochem. J.
189
377-380
1980
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Burchell, B.
Isolation and purification of bilirubin UDP-glucuronyl-transferase from rat liver
FEBS Lett.
111
131-135
1980
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Leakey, J.E.A.
An improved assay technique for uridine diphosphate glucuronosyltransferase activity towards 5-hydroxytryptamine and some properties of the enzyme
Biochem. J.
175
1119-1124
1978
Felis catus, Mus musculus, Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Burchell, B.
Substrate specificity and properties of uridine diphosphate glucuronyltransferase purified to apparent homogeneity from phenobarbital-treated rat liver
Biochem. J.
173
749-757
1978
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Gorski, J.P.; Kasper, C.B.
Purification and properties of microsomal UDP-glucuronosyltransferase from rat liver
J. Biol. Chem.
252
1336-1343
1977
Rattus norvegicus
Manually annotated by BRENDA team
Burchell, B.
Purification of UDP-glucuronyltransferase from untreated rat liver
FEBS Lett.
78
101-104
1977
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Burchell, B.
Studies on the purification of rat liver uridine diphosphate glucuronyltransferase
Biochem. J.
161
543-549
1977
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Graham, A.B.; Pechey, D.T.; Wood, G.C.; Woodcock, B.G.
The role of the microsomal membrane in control of uridine diphosphate glucuronosyltransferase in vitro and in vivo
Biochem. Soc. Trans.
2
1167-1172
1974
Cavia porcellus, Rattus norvegicus
-
Manually annotated by BRENDA team
Mulder, G.J.
Heterogeneity of hepatic microsomal uridine diphosphate glucuronosyltransferase: a critical evaluation
Biochem. Soc. Trans.
2
1172-1176
1974
Rattus norvegicus
-
Manually annotated by BRENDA team
Illing, H.P.A.; Dutton, G.J.
Some properties of the uridine diphosphate glucuronyltransferase activity synthesizing thio-beta-D-glucuronides
Biochem. J.
131
139-147
1973
Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Zakim, D.; Goldenberg, J.; Vessey, D.A.
Effects of metals on the properties of hepatic microsomal uridine diphosphate glucuronyltransferase
Biochemistry
12
4068-4074
1973
Cavia porcellus, Rattus norvegicus
Manually annotated by BRENDA team
Gregory, D.H.; Strickland, R.D.
Solubilization and characterization of hepatic bilirubin UDP-glucuronyltransferase
Biochim. Biophys. Acta
327
36-45
1973
Rattus norvegicus
Manually annotated by BRENDA team
Winsnes, A.
Kinetic properties of different forms of hepatic UDPglucuronyltransferase
Biochim. Biophys. Acta
284
394-405
1972
Cavia porcellus, Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Heirwegh, K.P.M.; van de Vijver, M.; Fevery, J.
Assay and properties of dititonin-activated bilirubin uridine diphosphate glucuronyltransferase from rat liver
Biochem. J.
129
605-618
1972
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Styczynski, P.; Green, M.; Puig, J.; Coffman, B.; Tephly, T.
Purification and properties of a rat liver phenobarbital-inducible 4-hydroxybiphenyl UDP-glucuronosyltransferase
Mol. Pharmacol.
40
80-84
1991
Rattus norvegicus
Manually annotated by BRENDA team
Bock, K.W.; Schirmer, G.; Green, M.D.; Tephly, T.R.
Properties of a 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase from rat liver
Biochem. Pharmacol.
37
1439-1443
1988
Rattus norvegicus
Manually annotated by BRENDA team
Coughtrie, M.W.H.; Burchell, B.; Bend, J.R.
Purification and properties of rat kidney UDP-glucuronosyltransferase
Biochem. Pharmacol.
36
245-251
1987
Rattus norvegicus
Manually annotated by BRENDA team
Puig, J.F.; Tephly, T.R.
Isolation and purification of rat liver morphine UDP-glucuronosyltransferase
Mol. Pharmacol.
30
558-565
1986
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Aitio, A.; Parkki, M.G.
Activation and inhibition of rat hepatic UDP-glucuronyltransferase by mercuric acetate
Xenobiotica
11
97-102
1981
Rattus norvegicus
Manually annotated by BRENDA team
Burchell, B.; Coughtrie, M.W.H.
UDP-glucuronosyltransferases
Pharmacol. Ther.
43
261-289
1989
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Tephly, T.R.
Isolation and purification of UDP-glucuronosyltransferases
Chem. Res. Toxicol.
3
509-516
1990
Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Roy-Chowhury, J.; Huang, T.; Kesari, K.; Lederstein, M.; Arias, I.M.; Roy-Chowhury, N.
Molecular basis for the lack of bilirubin-specific and 3-methylcholanthrene-inducible UDP-glucuronosyltransferase activities in Gunn rats. The two isoforms are encoded by distinct mRNA species that share an identical single base deletion
J. Biol. Chem.
266
18294-18298
1991
Rattus norvegicus, Rattus norvegicus Gunn
Manually annotated by BRENDA team
Hauser, S.C.; Ziurys, J.C.; Gollan, J.L.
Subcellular distribution and regulation of hepatic bilirubin UDP-glucuronyltransferase
J. Biol. Chem.
259
4527-4533
1984
Rattus norvegicus
Manually annotated by BRENDA team
Jansen, P.L.M.; Mulder, G.J.; Burchell, B.; Bock, K.W.
New developments in glucuronidation research: report of a workshop on 'glucuronidation, its role in health and disease'
Hepatology
15
532-544
1992
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Yamashita, A.; Watanabe, M.; Tonegawa, T.; Sugiura, T.; Waku, K.
Acyl-CoA binding and acylation of UDP-glucuronosyltransferase isoforms of rat liver: their effect on enzyme activity
Biochem. J.
312
301-308
1995
Rattus norvegicus
-
Manually annotated by BRENDA team
King, C.D.; Green, M.D.; Rios, G.R.; Coffman, B.L.; Owens, I.S.; Bishop, W.P.; Tephly, T.R.
The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1
Arch. Biochem. Biophys.
332
92-100
1996
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Meech, R.; Mackenzie, P.I.
Structure and function of uridine diphosphate glucuronosyltransferases
Clin. Exp. Pharmacol. Physiol.
24
907-915
1997
Rattus norvegicus
Manually annotated by BRENDA team
Iwano, H.; Yokota, H.; Ohgiya, S.; Yuasa, A.
The significance of amino acid residue Asp446 for enzymic stability of rat UDP-glucuronosyltransferase UGT1A6
Arch. Biochem. Biophys.
363
116-120
1999
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Radominska-Pandya, A.; Czernik, P.J.; Little, J.M.; Battaglia, E.; Mackenzie, P.I.
Structural and functional studies of UDP-Glucuronosyltransferases
Drug Metab. Rev.
31
817-899
1999
Homo sapiens (P19224), Rattus norvegicus
Manually annotated by BRENDA team
Yoshigae, Y.; Konno, K.; Takasaki, W.; Ikeda, T.
Characterization of UDP-glucuronosyltransferases (UGTS) involved in the metabolism of troglitazone in rats and humans
J. Toxicol. Sci.
25
433-441
2000
Homo sapiens, Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Manually annotated by BRENDA team
King, C.; Tang, W.; Ngui, J.; Tephly, T.; Braun, M.
Characterization of rat and human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of diclofenac
Toxicol. Sci.
61
49-53
2001
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Radominska-Pandya, A.; Little, J.M.; Czernik, P.J.
Human UDP-glucuronosyltransferase 2B7
Curr. Drug Metab.
2
283-298
2001
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Mano, N.; Nishimura, K.; Narui, T.; Ikegawa, S.; Goto, J.
Characterization of rat liver bile acid acyl glucuronosyltransferase
Steroids
67
257-262
2002
Rattus norvegicus
Manually annotated by BRENDA team
Nakajima, M.; Tanaka, E.; Kobayashi, T.; Ohashi, N.; Kume, T.; Yokoi, T.
Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms
Drug Metab. Dispos.
30
636-642
2002
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kaji, H.; Kume, T.
Regioselective glucuronidation of denopamine: marked species differences and identification of human UDP-glucuronosyltransferase isoform
Drug Metab. Dispos.
33
403-412
2005
Canis lupus familiaris, Homo sapiens, Homo sapiens (O60656), Homo sapiens (O75795), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Macaca fascicularis, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Daidoji, T.; Gozu, K.; Iwano, H.; Inoue, H.; Yokota, H.
UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat
Drug Metab. Dispos.
33
1466-1476
2005
Rattus norvegicus (P08430), Rattus norvegicus (P08542), Rattus norvegicus (P09875), Rattus norvegicus (P36511), Rattus norvegicus (Q64550), Rattus norvegicus (Q64633), Rattus norvegicus (Q64637), Rattus norvegicus
Manually annotated by BRENDA team
Webb, L.J.; Miles, K.K.; Auyeung, D.J.; Kessler, F.K.; Ritter, J.K.
Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8
Drug Metab. Dispos.
33
77-82
2005
Rattus norvegicus (P70624), Rattus norvegicus (Q64634)
Manually annotated by BRENDA team
Tallman, M.N.; Ritter, J.K.; Smith, P.C.
Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms
Drug Metab. Dispos.
33
977-983
2005
Homo sapiens, Homo sapiens (O60656), Homo sapiens (P22309), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW9), Rattus norvegicus (Q64550), Rattus norvegicus (Q64633), Rattus norvegicus (Q64634)
Manually annotated by BRENDA team
DAndrea, V.; Perez, L.M.; Sanchez Pozzi, E.J.
Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide
Life Sci.
77
683-692
2005
Rattus norvegicus (Q64550)
Manually annotated by BRENDA team
Gardner-Stephen, D.A.; Gregory, P.A.; Mackenzie, P.I.
Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes
Methods Enzymol.
400
22-46
2005
Homo sapiens, Homo sapiens (P19224), Rattus norvegicus (P08430)
Manually annotated by BRENDA team
Tian, H.; Ou, J.; Strom, S.C.; Venkataramanan, R.
Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats
Pharm. Res.
22
2007-2015
2005
Rattus norvegicus (P08541), Rattus norvegicus (P09875), Rattus norvegicus (P20720), Rattus norvegicus (P36511), Rattus norvegicus (Q62789), Rattus norvegicus (Q64550), Rattus norvegicus (Q64634), Rattus norvegicus (Q64637), Rattus norvegicus (Q64638)
Manually annotated by BRENDA team
Nishimura, Y.; Maeda, S.; Ikushiro, S.; Mackenzie, P.I.; Ishii, Y.; Yamada, H.
Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: Structure-effect relationships and evidence for an allosteric mechanism
Biochim. Biophys. Acta
1770
1557-1566
2007
Rattus norvegicus
Manually annotated by BRENDA team
Sorich, M.J.; Smith, P.A.; Miners, J.O.; Mackenzie, P.I.; McKinnon, R.A.
Recent advances in the in silico modelling of UDP glucuronosyltransferase substrates
Curr. Drug Metab.
9
60-69
2008
Homo sapiens (P22309), Rattus norvegicus
Manually annotated by BRENDA team
Finel, M.; Kurkela, M.
The UDP-glucuronosyltransferases as oligomeric enzymes
Curr. Drug Metab.
9
70-76
2008
Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22310), Rattus norvegicus
Manually annotated by BRENDA team
Shiratani, H.; Katoh, M.; Nakajima, M.; Yokoi, T.
Species differences in UDP-glucuronosyltransferase activities in mice and rats
Drug Metab. Dispos.
36
1745-1752
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Gradinaru, D.; Minn, A.L.; Artur, Y.; Minn, A.; Heydel, J.M.
Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes
Toxicol. Lett.
213
316-324
2012
Rattus norvegicus
Manually annotated by BRENDA team
Higashi, E.; Ando, A.; Iwano, S.; Murayama, N.; Yamazaki, H.; Miyamoto, Y.
Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig
Biopharm. Drug Dispos.
35
313-320
2014
Canis lupus familiaris, Homo sapiens, Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Macaca fascicularis, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
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