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Information on EC 2.4.1.17 - glucuronosyltransferase and Organism(s) Homo sapiens and UniProt Accession P36537

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.17 glucuronosyltransferase
IUBMB Comments
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
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This record set is specific for:
Homo sapiens
UNIPROT: P36537
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
ugt1a1, udp-glucuronosyltransferase, ugt2b7, ugt1a9, ugt1a6, ugt1a, ugt2b17, ugt1a4, udp-glucuronyltransferase, udpgt, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-naphthol glucuronyltransferase
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-
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1-naphthol-UDP-glucuronosyltransferase
-
-
-
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17-OH steroid UDPGT
-
-
-
-
17beta-hydroxysteroid UDP-glucuronosyltransferase
-
-
-
-
1A10
247
-
3,4-catechol estrogen specific UDPGTh-2
277437
-
3-OH androgenic UDPGT
-
-
-
-
3alpha-hydroxysteroid UDP-glucuronosyltransferase
-
-
-
-
4-hydroxybiphenyl UDP-glucuronosyltransferase
-
-
-
-
4-methylumbelliferone UDP-glucuronosyltransferase
-
-
-
-
4-nitrophenol UDP-glucuronosyltransferase
-
-
-
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4-nitrophenol UDP-glucuronyltransferase
-
-
-
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4-nitrophenol UDPGT
-
-
-
-
bile acid uridine 5'-diphosphoglucuronyltransferase
-
-
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-
bilirubin glucuronyltransferase
-
-
-
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bilirubin monoglucuronide glucuronyltransferase
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bilirubin UDP-glucuronosyltransferase
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bilirubin UDPglucuronosyltransferase
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-
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bilirubin UDPGT
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bilirubin uridine diphosphoglucuronyltransferase
-
-
-
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bilirubin-specific UDPGT isozyme 2
277441
-
ciramadol UDP-glucuronyltransferase
-
-
-
-
DP-glucuronosyltransferase 1A3
277444
-
estriol UDP-glucuronosyltransferase
-
-
-
-
estrone UDP-glucuronosyltransferase
-
-
-
-
GlcAT-P
247
-
GlcAT-S
247
-
glucuronosyltransferase, uridine diphospho-
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glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol
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glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl
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glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin
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-
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glucuronosyltransferase, uridine diphosphoglucuronate-estradiol
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glucuronosyltransferase, uridine diphosphoglucuronate-estriol
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-
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glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-
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-
-
-
glucuronyltransferase
247
-
glucuronyltransferase, uridine diphospho-GT
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-
-
-
HUG-BR2
277441
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morphine glucuronyltransferase
-
-
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p-hydroxybiphenyl UDP glucuronyltransferase
-
-
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p-nitrophenol UDP-glucuronosyltransferase
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p-nitrophenol UDP-glucuronyltransferase
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p-nitrophenylglucuronosyltransferase
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p-phenylphenol glucuronyltransferase
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phenyl-UDP-glucuronosyltransferase
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-
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PNP-UDPGT
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UDP glucuronate-estradiol-glucuronosyltransferase
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UDP glucuronate-estriol glucuronosyltransferase
-
-
-
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UDP glucuronic acid transferase
-
-
-
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UDP glucuronosyltransferase
UDP glucuronosyltransferase 1A4
247
-
UDP glucuronosyltransferase 2B10
281015
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UDP glucuronyltransferase
-
-
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UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase
-
-
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UDP-glucuronate-bilirubin glucuronyltransferase
-
-
-
-
UDP-glucuronosyl-transferase 1A1
247
-
UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1A1
UDP-glucuronosyltransferase 1A10
UDP-glucuronosyltransferase 1A3
277444
-
UDP-glucuronosyltransferase 1A4
277441
-
UDP-glucuronosyltransferase 1A5
281016
-
UDP-glucuronosyltransferase 1A6
277438
-
UDP-glucuronosyltransferase 1A7
277442
-
UDP-glucuronosyltransferase 1A8
UDP-glucuronosyltransferase 1A9
277439
-
UDP-glucuronosyltransferase 2A3
285771
-
UDP-glucuronosyltransferase 2B10
281015
-
UDP-glucuronosyltransferase 2B15
277446
-
UDP-glucuronosyltransferase 2B17
277447
-
UDP-glucuronosyltransferase 2B7
UDP-glucuronosyltransferase-1A10
277445
-
UDP-glucuronosyltransferases 2B15
277446
-
UDP-glucuronosyltransferases 2B7
277437
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UDP-glucuronyltransferase
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-
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UDPGA transferase
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UDPGA-glucuronyltransferase
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UDPglucuronate beta-D-glucuronosyltransferase
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UDPglucuronosyltransferase
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UDPGT
UFT1A9
277439
-
UGT 1A10
247
isoform
UGT 1A3
247
isoform
UGT 1A4
UGT 1A6
UGT 1A7
247
isoform
UGT 1A8
247
isoform
UGT 1A9
247
isoform
UGT 2B15
247
isoform
UGT 2B17
247
isoform
UGT 2B4
247
isoform
UGT 2B7
247
isoform
UGT-1D
277441
-
UGT-1J
277445
-
UGT1-03
277444
-
UGT1-04
277441
-
UGT1-10
277445
-
UGT1-9
277439
-
UGT1.10
277445
-
UGT1.3
277444
-
UGT1.4
277441
-
UGT1.9
277439
-
UGT1A
277440
-
UGT1A1
UGT1A10
UGT1A3
UGT1A4
UGT1A5
UGT1A6
UGT1A7
UGT1A8
UGT1A9
UGT1D
277441
-
UGT1J
277445
-
UGT2A1
305085
-
UGT2A2
247
-
UGT2A3
285771
-
UGT2B10
UGT2B11
281013
-
UGT2B15
UGT2B17
UGT2B28
305086
-
UGT2B4
UGT2B7
UGT3A1
317156
-
UGT3A2
317157
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uridine 5'-diphospho-glucuronosyltransferase
247
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uridine 5'-diphosphoglucuronyltransferase
-
-
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uridine diphosphate glucuronosyltransferase
247
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uridine diphosphate glucuronyltransferase
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uridine diphosphate-glucuronosyltransferase
277437
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uridine diphosphate-glucuronosyltransferase 2 B15
277446
-
uridine diphosphate-glucuronosyltransferase 2B10
281015
-
uridine diphosphate-glucuronosyltransferase 2B11
281013
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uridine diphosphate-glucuronosyltransferase 2B15
277446
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uridine diphosphate-glucuronosyltransferase 2B17
277447
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uridine diphosphate-glucuronosyltransferase 2B4
281014
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uridine diphosphate-glucuronosyltransferase 2B7
277437
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uridine diphosphoglucuronate-bilirubin glucuronosyltransferase
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uridine diphosphoglucuronosyltransferase
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uridine diphosphoglucuronyltransferase
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additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
CAS REGISTRY NUMBER
COMMENTARY hide
9030-08-4
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37277-52-4
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37277-66-0
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37205-52-0
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61969-98-0
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62213-47-2
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62213-43-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
12-hydroxyeicosatetraenoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
13-hydroxyoctadecadienoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
imipramine + UDP-glucuronate
UDP + ?
show the reaction diagram
-
-
-
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-D-glucuronate + 4-hydroxy-estrone
UDP + ?
show the reaction diagram
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + cotinine
UDP + ?
show the reaction diagram
UDP-D-glucuronate + nicotine
UDP + ?
show the reaction diagram
UDP-glucuronate + 12-hydroxyeicosatetraenoic acid
UDP + 12-hydroxyeicosatetraenoyl beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + 15-hydroxyeicosatetraenoic acid
UDP + 15-hydroxyeicosatetraenoyl beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + 20-hydroxyeicosatetraenoic acid
UDP + 20-hydroxyeicosatetraenoyl beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + 4-hydroxy-estrone
UDP + ?
show the reaction diagram
glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + amitriptyline
UDP + amitriptyline beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + cotinine
UDP + cotinine N-beta-D-glucuronoside
show the reaction diagram
cotinine is a highly selective substrate of human liver microsomal UGT2B10
-
-
?
UDP-glucuronate + diphenhydramine
UDP + diphenhydramine beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + ethanol
UDP + ethyl beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + imipramine
UDP + imipramine beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + ketoconazole
UDP + ketoconazole beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + ketotifen
UDP + ketotifen beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + midazolam
UDP + midazolam beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + olanzapine
UDP + olanzapine beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + pizotifen
UDP + pizotifen beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + tamoxifen
UDP + tamoxifen beta-D-glucuronoside
show the reaction diagram
-
-
-
?
(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
show the reaction diagram
-
substrate for isoforms UGT1A9 and UGT1A10
-
-
?
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
show the reaction diagram
-
substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10
-
-
?
(R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(R)-propanolol + UDP-glucuronate
UDP + (R)-propanolol O-glucuronide
show the reaction diagram
-
-
-
-
?
(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(S)-naproxen + UDP-alpha-D-glucuronate
beta-D-glucuronosyl (S)-naproxen + UDP
show the reaction diagram
-
-
-
-
?
(S)-naproxen + UDP-alpha-D-glucuronate
UDP + beta-D-glucuronosyl (S)-naproxen
show the reaction diagram
-
-
-
-
?
(S)-oxazepam + UDP-glucuronate
UDP + (S)-oxazepam beta-D-glucuronoside
show the reaction diagram
-
-
-
?
(S)-propanolol + UDP-glucuronate
UDP + (S)-propanolol O-glucuronide
show the reaction diagram
-
-
-
-
?
1-hydroxy-benzo(a)pyrene + UDP-glucuronate
1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
1-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-1-O-D-glucoside + UDP
show the reaction diagram
UGT3A2-overexpressing microsomes
-
-
?
1-hydroxy-pyrene + UDP-D-xylose
pyrene 1-O-D-xyloside + UDP
show the reaction diagram
-
-
-
?
1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
1-hydroxypyrene + UDP-D-glucose
pyrene 1-O-D-glucoside + UDP
show the reaction diagram
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
1-hydroxypyrene 1-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
pyrene 1-O-glucuronide + UDP
show the reaction diagram
-
-
-
?
1-hydroxypyrene + UDP-N-acetylglucosamine
pyrenil-1-O-(N-acetylglucosaminide) + UDP
show the reaction diagram
activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
-
-
?