Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Filter enzyme data
show all tables | show all data
hide all tables
No. of entries

Information on EC 2.4.1.17 - glucuronosyltransferase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC2.4.1.17

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.

The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
ugt1a1, udp-glucuronosyltransferase, ugt2b7, ugt1a9, ugt1a6, ugt1a, ugt2b17, ugt1a4, udp-glucuronyltransferase, udpgt, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-naphthol glucuronyltransferase
-
-
-
-
1-naphthol-UDP-glucuronosyltransferase
-
-
-
-
17-OH steroid UDPGT
-
-
-
-
17beta-hydroxysteroid UDP-glucuronosyltransferase
-
-
-
-
1A10
-
-
3,4-catechol estrogen specific UDPGTh-2
-
3-OH androgenic UDPGT
-
-
-
-
3alpha-hydroxysteroid UDP-glucuronosyltransferase
-
-
-
-
4-hydroxybiphenyl UDP-glucuronosyltransferase
-
-
-
-
4-methylumbelliferone UDP-glucuronosyltransferase
-
-
-
-
4-nitrophenol UDP-glucuronosyltransferase
-
-
-
-
4-nitrophenol UDP-glucuronyltransferase
-
-
-
-
4-nitrophenol UDPGT
-
-
-
-
bile acid uridine 5'-diphosphoglucuronyltransferase
-
-
-
-
bilirubin glucuronyltransferase
-
-
-
-
bilirubin monoglucuronide glucuronyltransferase
-
-
-
-
bilirubin UDP-glucuronosyltransferase
-
-
-
-
bilirubin UDPglucuronosyltransferase
-
-
-
-
bilirubin UDPGT
-
-
-
-
bilirubin uridine diphosphoglucuronyltransferase
-
-
-
-
bilirubin-specific UDPGT isozyme 2
-
ciramadol UDP-glucuronyltransferase
-
-
-
-
DP-glucuronosyltransferase 1A3
-
estriol UDP-glucuronosyltransferase
-
-
-
-
estrone UDP-glucuronosyltransferase
-
-
-
-
GlcAT-P
-
-
GlcAT-S
-
-
glucuronosyltransferase, uridine diphospho-
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estradiol
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estriol
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-
-
-
-
-
glucuronyltransferase
-
-
glucuronyltransferase, uridine diphospho-GT
-
-
-
-
morphine glucuronyltransferase
-
-
-
-
p-hydroxybiphenyl UDP glucuronyltransferase
-
-
-
-
p-nitrophenol UDP-glucuronosyltransferase
-
-
-
-
p-nitrophenol UDP-glucuronyltransferase
-
-
-
-
p-nitrophenylglucuronosyltransferase
-
-
-
-
p-phenylphenol glucuronyltransferase
-
-
-
-
phenyl-UDP-glucuronosyltransferase
-
-
-
-
PNP-UDPGT
-
-
-
-
UDP glucuronate-estradiol-glucuronosyltransferase
-
-
-
-
UDP glucuronate-estriol glucuronosyltransferase
-
-
-
-
UDP glucuronic acid transferase
-
-
-
-
UDP glucuronosyltransferase
UDP glucuronosyltransferase 1A4
-
-
UDP glucuronosyltransferase 2B10
-
UDP glucuronyltransferase
-
-
-
-
UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase
-
-
-
-
UDP-glucuronate-bilirubin glucuronyltransferase
-
-
-
-
UDP-glucuronosyl-transferase 1A1
-
-
UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1A1
UDP-glucuronosyltransferase 1A10
UDP-glucuronosyltransferase 1A3
-
UDP-glucuronosyltransferase 1A4
-
UDP-glucuronosyltransferase 1A5
-
UDP-glucuronosyltransferase 1A6
-
UDP-glucuronosyltransferase 1A7
-
UDP-glucuronosyltransferase 1A8
UDP-glucuronosyltransferase 1A9
-
UDP-glucuronosyltransferase 2A3
-
UDP-glucuronosyltransferase 2B10
-
UDP-glucuronosyltransferase 2B15
-
UDP-glucuronosyltransferase 2B17
-
UDP-glucuronosyltransferase 2B7
UDP-glucuronosyltransferase-1A10
-
UDP-glucuronosyltransferases 2B15
-
UDP-glucuronosyltransferases 2B7
-
UDP-glucuronyltransferase
-
-
-
-
UDPGA transferase
-
-
-
-
UDPGA-glucuronyltransferase
-
-
-
-
UDPglucuronate beta-D-glucuronosyltransferase
-
-
-
-
UDPglucuronosyltransferase
-
-
-
-
UDPGT
UGT 1A10
-
isoform
UGT 1A3
-
isoform
UGT 1A4
UGT 1A6
UGT 1A7
-
isoform
UGT 1A8
-
isoform
UGT 1A9
-
isoform
UGT 2B15
-
isoform
UGT 2B17
-
isoform
UGT 2B4
-
isoform
UGT 2B7
-
isoform
UGT1A1
UGT1A10
UGT1A3
UGT1A4
UGT1A5
UGT1A6
UGT1A7
UGT1A8
UGT1A9
UGT2A1
Q9Y4X1
-
UGT2B10
UGT2B15
UGT2B17
UGT2B4
UGT2B7
uridine 5'-diphospho-glucuronosyltransferase
-
-
uridine 5'-diphosphoglucuronyltransferase
-
-
-
-
uridine diphosphate glucuronosyltransferase
-
-
uridine diphosphate glucuronyltransferase
-
-
-
-
uridine diphosphate-glucuronosyltransferase
-
uridine diphosphate-glucuronosyltransferase 2 B15
-
uridine diphosphate-glucuronosyltransferase 2B10
-
uridine diphosphate-glucuronosyltransferase 2B11
-
uridine diphosphate-glucuronosyltransferase 2B15
-
uridine diphosphate-glucuronosyltransferase 2B17
-
uridine diphosphate-glucuronosyltransferase 2B4
-
uridine diphosphate-glucuronosyltransferase 2B7
-
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase
-
-
-
-
uridine diphosphoglucuronosyltransferase
-
-
-
-
uridine diphosphoglucuronyltransferase
-
-
-
-
additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
heme degradation I, melatonin degradation I, nicotine degradation IV, nicotine degradation V, saponin biosynthesis II, serotonin degradation, thyroid hormone metabolism II (via conjugation and/or degradation)
SYSTEMATIC NAME
IUBMB Comments
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
CAS REGISTRY NUMBER
COMMENTARY hide
37205-52-0
-
37277-52-4
-
37277-66-0
-
61969-98-0
-
62213-43-8
-
62213-47-2
-
9030-08-4
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
Reversibility
r=reversible
ir=irreversible
?=not specified
(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
show the reaction diagram
-
Substrates: substrate for isoforms UGT1A9 and UGT1A10
Products: -
?
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
show the reaction diagram
-
Substrates: substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10
Products: -
?
(R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
(R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
(R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
(R)-propanolol + UDP-glucuronate
UDP + (R)-propanolol O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
(S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
(S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
(S)-naproxen + UDP-alpha-D-glucuronate
beta-D-glucuronosyl (S)-naproxen + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
(S)-naproxen + UDP-alpha-D-glucuronate
UDP + beta-D-glucuronosyl (S)-naproxen
show the reaction diagram
-
Substrates: -
Products: -
?
(S)-oxazepam + UDP-glucuronate
UDP + (S)-oxazepam beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
(S)-propanolol + UDP-glucuronate
UDP + (S)-propanolol O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
1-hydroxy-benzo(a)pyrene + UDP-glucuronate
1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
1-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-1-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
1-hydroxy-pyrene + UDP-D-xylose
pyrene 1-O-D-xyloside + UDP
show the reaction diagram
Substrates: -
Products: -
?
1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
1-hydroxypyrene + UDP-D-glucose
pyrene 1-O-D-glucoside + UDP
show the reaction diagram
Substrates: -
Products: -
?
1-hydroxypyrene + UDP-glucuronate
1-hydroxypyrene 1-O-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
1-hydroxypyrene + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
1-hydroxypyrene + UDP-glucuronate
pyrene 1-O-glucuronide + UDP
show the reaction diagram
Substrates: -
Products: -
?
1-hydroxypyrene + UDP-N-acetylglucosamine
pyrenil-1-O-(N-acetylglucosaminide) + UDP
show the reaction diagram
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
1-hydroxy[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
1-naphthol + UDP-alpha-D-glucuronate
1-naphthyl-O-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
1-naphthol + UDP-D-glucose
naphthyl-1-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
1-naphthol + UDP-glucuronate
1-naphthyl 1-O-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
1-naphthol + UDP-glucuronate
1-naphthyl-O-glucuronide + UDP
show the reaction diagram
Substrates: -
Products: -
?
1-naphthol + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
show the reaction diagram
11alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate
show the reaction diagram
Substrates: -
Products: -
?
12-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
show the reaction diagram
-
Substrates: glucuronidated by UGT1A3, inactive towards benz[a]pyrene trans 4,5 and 7,8 dihydrodiols
Products: -
?
12-hydroxyeicosatetraenoic acid + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
13-hydroxyoctadecadienoic acid + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
16alpha-hydroxyprogesterone + UDP-glucuronate
?
show the reaction diagram
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
show the reaction diagram
17-epiestriol + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
17-epiestriol + UDP-glucuronate
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
17alpha-estradiol + UDP-alpha-D-glucuronate
? + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
17beta-estradiol + UDP-alpha-D-glucuronate
? + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
17beta-estradiol + UDP-glucuronate
?
show the reaction diagram
Substrates: metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
Products: -
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
2',4,4'-trihydroxychalcone + UDP-glucuronate
UDP + 2',4,4'-trihydroxychalcone 4'-O-glucoside + 2',4,4'-trihydroxychalcone 2'-O-glucoside
show the reaction diagram
-
Substrates: i.e. isoliquiritigenin
Products: -
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
show the reaction diagram
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate
?
show the reaction diagram
Substrates: glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans
Products: -
?
2-aminobiphenyl + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
2-hydroxyestradiol + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
2-hydroxyestradiol + UDPglucuronate
UDP + 2-hydroxyestradiol O-glucuronide
show the reaction diagram
2-hydroxyestrone + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
show the reaction diagram
21-hydroxyprogesterone + UDP-glucuronate
UDP + 21-hydroxyprogesterone-21-O-D-glucuronate
show the reaction diagram
Substrates: -
Products: -
?
3 quercetin + 3 UDP-glucuronate
3 UDP + quercetin 7-glucuronide + quercetin 3-glucuronide + quercetin 3'-glucuronide
show the reaction diagram
Substrates: isoform UGT1A9 mainly converts quercetin into three monoglucuronides, including 7-glucuronide, 3-glucuronide, and 3'-glucuronide
Products: -
?
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
show the reaction diagram
-
Substrates: substrate of isoform UGT2B7
Products: -
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
3-azido-4-chlorobenzoic acid + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
3-azidobenzoic acid + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
3-hydroxy-benzo(a)pyrene + UDP-glucuronate
3-hydroxy-benzo(a)pyrene 3-O-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
3-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-3-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
3-hydroxybenzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
3-hydroxydesloratadine + UDP-glucuronate
UDP + 3-hydroxydesloratadinyl-O-glucuronide
show the reaction diagram
4-aminobiphenyl + UDP-glucuronate
UDP + 4-aminobiphenyl N-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
4-aminobiphenyl + UDPglucuronate
UDP + ?
show the reaction diagram
-
Substrates: catalyzed by isozyme 1 but not by isozyme 2
Products: -
?
4-azido-2-hydroxybenzoic acid + UDPglucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
4-azidobenzoic acid + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
show the reaction diagram
4-hydroxyestradiol + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
4-hydroxyestradiol + UDPglucuronate
UDP + 4-hydroxyestradiol O-glucuronide
show the reaction diagram
4-hydroxyestrone + UDP-glucuronate
?
show the reaction diagram
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone 4-O-glucuronide
show the reaction diagram
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
4-methylumbeliferone + UDP-alpha-D-glucuronate
4-methylumbelliferyl-7-O-alpha-D-glucuronide
show the reaction diagram
4-methylumbeliferone + UDP-glucuronate
4-methylumbelliferyl-7-O-beta-D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
show the reaction diagram
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
show the reaction diagram
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-beta-D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
show the reaction diagram
5-diethylaminoethylamino-8-hydroxyimidazoacridinone + UDP-alpha-D-glucuronate
5-{[2-(diethylamino)ethyl]amino}-6-oxo-6H-imidazo[4,5,1-de]acridin-8-yl beta-D-glucuronide + UDP
show the reaction diagram
-
Substrates: i.e. antitumor agent C-1311, NSC-645809
Products: -
?
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone + UDP-alpha-D-glucuronate
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone-8-D-glucuronide + UDP
show the reaction diagram
-
Substrates: i.e. antitumor agent C-1305
Products: -
?
5-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 5-hydroxybenzo[a]pyrene O-glucuronide
show the reaction diagram
-
Substrates: glucuronidated by UGT1A3
Products: -
?
5-hydroxyrofecoxib + UDP-glucuronate
UDP + 5-hydroxyrofecoxib beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
5-methylchrysene-1,2-diol + UDP-D-glucose
1-hydroxy-5-methylchrysene-2-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
5-methylchrysene-1,2-diol + UDP-D-glucose
2-hydroxy-5-methylchrysene-1-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
5-methylchrysene-1,2-diol + UDP-D-xylose
1-hydroxy-5-methylchrysene-2-O-D-xyloside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
5-methylchrysene-1,2-diol + UDP-D-xylose
2-hydroxy-5-methylchrysene-1-O-D-xyloside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
5-methylchrysene-1,2-diol + UDP-glucuronate
? + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
show the reaction diagram
6-hydroxywarfarin + UDP-glucuronate
? + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
6alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate
show the reaction diagram
Substrates: -
Products: -
?
7-ethyl-10-hydroxy-camptothecin + UDP-glucuronate
UDP + 7-ethyl-10-hydroxy-camptothecin beta-D-glucuronide
show the reaction diagram
Substrates: i.e SN-38, substrate for isoform UGT1A1
Products: -
?
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
show the reaction diagram
Substrates: -
Products: -
?
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
show the reaction diagram
Substrates: -
Products: -
?
7-ethyl-10-hydroxycamptothecin + UDP-alpha-D-glucuronate
7-ethyl-10-hydroxycamptothecin 10-O-glucuronate + UDP
show the reaction diagram
Substrates: -
Products: -
?
7-hydroxy benzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
7-hydroxy-4-trifluoromethylcoumarin + UDP-alpha-D-glucuronate
7-hydroxy-4-trifluoromethylcoumarin 7-O-glucuronate + UDP
show the reaction diagram
Substrates: -
Products: -
?
7-hydroxy-4-trifluoromethylcoumarin + UDP-glucuronate
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
show the reaction diagram
7-hydroxy-benzo(a)pyrene + UDP-glucuronate
7-hydroxy-benzo(a)pyrene 7-O-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
7-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-7-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
7-hydroxywarfarin + UDP-glucuronate
? + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
8-hydroxy-benzo(a)pyrene + UDP-glucuronate
8-hydroxy-benzo(a)pyrene 8-O-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
8-hydroxy-benzo[a]pyrene + UDP-glucuronate
benzo[a]pyrenil-8-O-glucuronide + UDP
show the reaction diagram
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
8-hydroxywarfarin + UDP-glucuronate
? + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
9-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-9-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
9-hydroxybenzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
acetaminophen + UDP-glucuronate
?
show the reaction diagram
acetaminophen + UDP-glucuronate
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
acetaminophen + UDP-glucuronate
UDP + acetaminophen beta-D-glucuronate
show the reaction diagram
-
Substrates: -
Products: -
?
alpha-naphthylamine + UDPglucuronate
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
alprazolam + UDP-alpha-D-glucuronate
alprazolam D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
amitriptyline + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
anastrozole + UDP-glucuronate
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
show the reaction diagram
anthraflavic acid + UDPglucuronate
UDP + ?
show the reaction diagram
apigenin + UDPglucuronate
UDP + apigenin O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
bakuchiol + UDP-glucuronate
UDP + bakuchiol beta-D-glucuronide
show the reaction diagram
benzo(a)pyrene-7,8-diol + UDP-glucuronate
? + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
benzo[a]pyrene-7,8-diol + UDP-D-glucose
7-hydroxy-benzo[a]pyrene-8-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-7,8-diol + UDP-D-glucose
8-hydroxy-benzo[a]pyrene-7-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-7,8-diol + UDP-D-xylose
7-hydroxy-benzo[a]pyrene-8-O-D-xyloside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-7,8-diol + UDP-D-xylose
8-hydroxy-benzo[a]pyrene-7-O-D-xyloside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-D-glucose
10-hydroxy-benzo[a]pyrene-9-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-D-glucose
9-hydroxy-benzo[a]pyrene-10-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-D-xylose
10-hydroxy-benzo[a]pyrene-9-O-D-xyloside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-D-xylose
9-hydroxy-benzo[a]pyrene-10-O-D-xyloside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-glucuronate
10-hydroxy-benzo[a]pyrene-9-O-glucuronide + UDP
show the reaction diagram
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-glucuronate
9-hydroxy-benzo[a]pyrene-10-O-glucuronide + UDP
show the reaction diagram
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-N-acetylglucosamine
10-hydroxybenzo[a]pyrene 9-O-(N-acetylglucosaminide) + UDP
show the reaction diagram
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-N-acetylglucosamine
9-hydroxybenzo[a]pyrene 10-O-(N-acetylglucosaminide) + UDP
show the reaction diagram
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
beta-estradiol + UDP-alpha-D-glucuronate
beta-estradiol-3-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol 3-O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
show the reaction diagram
beta-estradiol + UDPglucuronate
beta-estradiol-3-glucuronide + UDP
show the reaction diagram
-
Substrates: inactive
Products: -
?
bifonazole + UDP-alpha-D-glucuronate
bifonazole D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
bilirubin + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
bilirubin + UDP-glucuronate
bilirubin D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
bilirubin + UDP-glucuronate
bilirubin glucuronoside + UDP
show the reaction diagram
Substrates: UGT1A1 exhibits the highest tranilast glucuronosyltransferase activity (13.5 pmol/min/mg protein)
Products: -
?
bilirubin + UDP-glucuronate
UDP + bilirubin-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
show the reaction diagram
bilirubin + UDPglucuronate
UDP + bilirubin O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
borneol + UDPglucuronate
UDP + borneol O-glucuronide
show the reaction diagram
buprenorphine + UDPglucuronate
UDP + buprenorphine O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
C-1748 + UDP-glucuronate
UDP + C-1748 O-glucuronide
show the reaction diagram
cannabinol + UDP-glucuronate
? + UDP
show the reaction diagram
-
Substrates: substrate for hepatic isoform UGT1A9 and extrahepatic UGT1A7, UGT1A8, and UGT1A10
Products: -
?
carvacrol + UDP-glucuronate
caervcrol O-glucuronate + UDP
show the reaction diagram
-
Substrates: isoform UGT1A9 is the major isozyme responsible for glucuronidation in liver microsomes, and isoform UGT1A7 plays a major role for glucuronidation in intestinal microsomes
Products: -
?
chenodeoxycholic acid + UDP-glucuronate
UDP + ?
show the reaction diagram
chenodeoxycholic acid + UDP-glucuronate
UDP + chenodeoxycholic acid 24-acyl-beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
chenodeoxycholic acid + UDP-glucuronate
UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
cholic acid + UDPglucuronate
cholic acid O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
clofibrate + UDPglucuronate
UDP + ?
show the reaction diagram
-
Substrates: glucuronidated by UGT2B7
Products: -
?
codeine + UDPglucuronate
codeine-6-glucuronide + UDP
show the reaction diagram
-
Substrates: glucuronidated by HGT2B7H and HGT2B7Y
Products: -
?
deferiprone + UDP-glucuronate
deferiprone 3-O-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
deoxycholic acid + UDPglucuronate
UDP + deoxycholic acid O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
dibenzo(a,l)pyrene-11,12-diol + UDP-glucuronate
? + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-glucose
11-hydroxy-benzo[a]pyrene-12-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-glucose
12-hydroxy-benzo[a]pyrene-11-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-xylose
11-hydroxy-benzo[a]pyrene-12-O-D-xyloside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-xylose
12-hydroxy-benzo[a]pyrene-11-O-D-glucoside + UDP
show the reaction diagram
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
diclofenac + UDP-alpha-D-glucuronate
diclofenac D-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
diclofenac + UDPalpha-D-glucuronate
UDP + ?
show the reaction diagram
-
Substrates: UGT2B7 active at high rate, recombinant UGT1A9 active at moderate rate, UGT1A6 and UGT2B15 active at low rates
Products: -
?
dihydrotestosterone + UDP-alpha-D-glucuronate
dihydrotestosterone D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
econazole + UDP-alpha-D-glucuronate
econazole D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
edaravone + UDP-alpha-D-glucuronate
edaravone beta-D-glucuronate + UDP
show the reaction diagram
-
Substrates: i.e. 3-methyl-1-phenyl-2-pyrazolin-5-one. Edaravone glucuronidation in liver microsomes and kidney microsomes exhibits biphasic kinetics. UDP glucuronosyltransferases UGT1A1, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B17 produce a significant amount of glucuronide metabolite. Among them, UGT1A9 exhibits the highest activity, followed by UGT2B17 and UGT1A7
Products: -
?
entacapone + UDP-glucuronate
UDP + entacapone-3-O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
epirubicin + UDP-glucuronate
UDP + epirubicin beta-D-glucuronoside
show the reaction diagram
epitestosterone + UDP-glucuronate
UDP + epitestosterone 17-O-glucuronide
show the reaction diagram
epitestosterone + UDP-glucuronate
UDP + epitestosterone O-glucuronide
show the reaction diagram
-
Substrates: glucuronidated by HGT2B7H and HGT2B7Y
Products: -
?
estradiol + UDP-alpha-D-glucuronate
UDP + estradiol 3-O-glucuronide
show the reaction diagram
-
Substrates: substrate of isoform UGT1A1
Products: -
?
estradiol + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
estradiol + UDP-glucuronate
estradiol 3-O-glucuronate + UDP
show the reaction diagram
Substrates: sigmoidal kinetics with n of 1.7
Products: -
?
estriol + UDP-glucuronate
?
show the reaction diagram
estriol + UDPglucuronate
UDP + estriol-16 alpha-glucuronide
show the reaction diagram
estrogen + UDP-glucuronate
?
show the reaction diagram
estrone + UDP-glucuronate
UDP + estrone 3-O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
show the reaction diagram
etoposide + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
etoposide + UDP-glucuronate
UDP + etoposide glucuronide
show the reaction diagram
eugenol + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
eugenol + UDP-glucuronate
UDP + eugenol-O-alpha-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
flavopiridol + UDP-glucuronate
UDP + flavopiridol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
fluconazole + UDP-alpha-D-glucuronate
fluconazole D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
flurbiprofen + UDP-glucuronate
?
show the reaction diagram
Substrates: metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
Products: -
?
frusemide + UDP-alpha-D-glucuronate
frusemide D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
glycolithocholic acid + UDPglucuronate
UDP + glycolithocholic acid O-glucuronide
show the reaction diagram
-
Substrates: lowest activity among five bile acids studied
Products: -
?
glycyrrhetinic acid + UDP-glucuronate
UDP + glycyrrhetinic acid-3-O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
hyodeoxycholic acid + UDP-glucuronate
?
show the reaction diagram
hyodeoxycholic acid + UDPglucuronate
UDP + hyodeoxycholic acid O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
ibuprofen + UDPglucuronate
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
imipramine + UDP-glucuronate
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
imipramine + UDPglucuronate
UDP + ?
show the reaction diagram
-
Substrates: only UGP1AY shows activity
Products: -
?
itraconazole + UDP-alpha-D-glucuronate
?
show the reaction diagram
-
Substrates: -
Products: -
?
ketoconazole + UDP-alpha-D-glucuronate
?
show the reaction diagram
-
Substrates: -
Products: -
?
lamotrigine + UDP-alpha-D-glucuronate
lamotrigine D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
lamotrigine + UDP-glucuronate
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
lithocholic acid + UDPglucuronate
UDP + ?
show the reaction diagram
lorazepam + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
miconazole + UDP-alpha-D-glucuronate
miconazole D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
midazolam + UDP-alpha-D-glucuronate
midazolam D-glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
milnacipran + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
show the reaction diagram
morphine + UDP-glucuronate
UDP + morphine 3-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
morphine + UDP-glucuronate
UDP + morphine 3-glucuronide + morphine 6-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
morphine + UDP-glucuronate
UDP + morphine-3-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
mycophenolate + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
mycophenolic acid + UDP-alpha-D-glucuronate
mycophenolic acid D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
mycophenolic acid + UDP-glucuronate
UDP + mycophenolic acid beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
N-hydroxy-2-acetylaminofluorene + UDPglucuronate
UDP + N-hydroxy-2-acetylaminofluorene O-glucuronide
show the reaction diagram
-
Substrates: glucuronidated by UGT1A3 in preference to the ring-hydroxylated derivatives
Products: -
?
N-hydroxy-2-naphthylamine + UDPglucuronate
UDP + N-hydroxy-2-naphthylamine-O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
naproxen + UDP-glucuronate
naproxen glucuronide + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
octylgallate + UDPglucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
olanzapine + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
opiates + UDPglucuronate
opiates 6-O-glucuronides + UDP
show the reaction diagram
-
Substrates: substrate for UGT2B7
Products: -
?
oxazepam + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
oxazepam + UDP-glucuronate
UDP + oxazepam beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
p-cresol + UDP-glucuronate
UDP + p-cresyl beta-D-glucuronide
show the reaction diagram
Substrates: among isoforms UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B4, 2B7, 2B10, 2B15, and 2B17 tesed, only UGT1A6 and UGT1A9 show activity with p-cresol
Products: -
?
p-ethoxyphenylurea + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
posaconazole + UDP-glucuronate
UDP + posaconazole beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
profen + UDPglucuronate
UDP + ?
show the reaction diagram
-
Substrates: glucuronidated by UGT2B7
Products: -
?
propofol + UDP-alpha-D-glucuronate
UDP + propofol D-glucuronide
show the reaction diagram
propofol + UDP-glucuronate
UDP + propofol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
propofol + UDP-glucuronate
UDP + propofol O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
quercetin + UDP-glucuronate
UDP + quercetin 7-glucuronide + quercetin 4'-glucuronide + quercetin 3'-glucuronide
show the reaction diagram
Substrates: isoform UGT1A1 mainly converts quercetin into three monoglucuronides, including 7-glucuronide, 4'-glucuronide, and 3'-glucuronide
Products: -
?
quercetin + UDPglucuronate
UDP + quercetin O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
retigabine + UDP-alpha-D-glucuronate
retigabine D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
retigabine + UDP-glucuronate
UDP + retigabine N-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
scopoletin + UDP-glucuronate
?
show the reaction diagram
Substrates: -
Products: -
?
scopoletin + UDP-glucuronate
UDP + scopoletin O-glucuronide
show the reaction diagram
scopoletin + UDPglucuronate
UDP + scopoletin O-glucuronide
show the reaction diagram
senecionine + UDP-alpha-D-glucuronate
senecionine N-glucuronide + UDP
show the reaction diagram
-
Substrates: senecionine is a representative of the hepatotoxic pyrrolizidine alkaloids. Glucuronidation is mediated by isofrom UGT1A4 and follows typical Michaelis-Menten kinetics
Products: -
?
serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
show the reaction diagram
serotonin + UDP-glucuronate
UDP + serotonin beta-D-glucuronide
show the reaction diagram
serotonin + UDP-glucuronate
UDP + serotonin O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
silybin A + UDP-glucuronate
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
silybin B + UDP-glucuronate
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
silydianin + UDP-glucuronate
UDP + silydianin beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
SN-38 + UDP-glucuronate
UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
sulconazole + UDP-alpha-D-glucuronate
sulconazole D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
sulfinpyrazone + UDP-alpha-D-glucuronate
sulfinpyrazone D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
tamoxifen + UDP-alpha-D-glucuronate
tamoxifen-N-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
tamoxifen + UDP-glucuronate
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
testosterone + UDP-glucuronate
UDP + testosterone 17-O-glucuronide
show the reaction diagram
-
Substrates: isoform UGT2B17 is the most active enzyme in testosterone glucuronidation. Isoform UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics
Products: -
?
testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
show the reaction diagram
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
show the reaction diagram
-
Substrates: no activity
Products: -
?
thyroxine + UDP-glucuronate
UDP + thyroxine beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
tioconazole + UDP-alpha-D-glucuronate
tioconazole D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
tranilast + UDP-glucuronate
tranilast glucuronoside + UDP
show the reaction diagram
Substrates: -
Products: -
?
trans-4-hydroxytamoxifen + UDP-glucuronate
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
trans-androsterone + UDP-alpha-D-glucuronate
trans-androsterone D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
trans-endoxifen + UDP-glucuronate
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
trifluoperazine + UDP-glucuronate
UDP + ?
show the reaction diagram
-
Substrates: substrate for isoform UGT1A4 and isoform UGT1A1 mutant H39P
Products: -
?
trifluoperazine + UDP-glucuronate
UDP + trifluoperazine beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
trifluoperazine + UDP-glucuronate
UDP + trifluoperazine N-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
trifluoperazine dihydrochloride + UDP-glucuronate
UDP + ?
show the reaction diagram
Substrates: substrate for isoform UGT1A4
Products: -
?
troglitazone + UDPglucuronate
UDP + troglitazone 6-O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-alpha-D-glucuronate + (R)-propranolol
UDP + (R)-propranolol beta-D-glucuronoside
show the reaction diagram
UDP-alpha-D-glucuronate + (S)-naproxen
UDP + beta-D-glucuronosyl (S)-naproxen
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
show the reaction diagram
UDP-alpha-D-glucuronate + 3-hydroxyflavone
UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone
show the reaction diagram
Substrates: isozyme UGT1A1
Products: -
?
UDP-alpha-D-glucuronate + 7-ethyl-10-hydroxycamptothecin
UDP + 7-ethyl-10-hydroxycampothecin 1-O-beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-alpha-D-glucuronate + chloramphenicol
UDP + chloramphenicol beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-alpha-D-glucuronate + diclofenac
UDP + diclofenac O-beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-alpha-D-glucuronate + dopamine
UDP + dopamine 3-O-beta-D-glucopyranosiduronic acid
show the reaction diagram
-
Substrates: substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested
Products: -
?
UDP-alpha-D-glucuronate + dopamine
UDP + dopamine 4-O-beta-D-glucopyranosiduronic acid
show the reaction diagram
-
Substrates: -
Products: substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested
?
UDP-alpha-D-glucuronate + sorafenib
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-alpha-glucuronate + diclofenac
UDP + beta-D-glucuronosyl-diclofenac
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + 1-naphthol
UDP + 1-naphthyl beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 11alpha-hydroxyprogesterone
UDP + 11alpha-hydroxyprogesterone 11-O-beta-D-glucuronoside
show the reaction diagram
Substrates: an UGT2B7 substrate
Products: -
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol-3-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + 1alpha,25-dihydroxyvitamin D3
UDP + 1alpha,25-dihydroxyvitamin D3 25-O-beta-D-glucuronoside
show the reaction diagram
Substrates: among 12 different UGT isozymes tested, only UGT1A4, and also UGT2B4 and UGT2B7 support the reaction, the main product by UGT1A4 supersomes and human liver microsomes is the 25-O-glucuronide, product identification and determination by mass spectral and NMR analyses, overview
Products: -
?
UDP-D-glucuronate + 2-hydroxyestradiol
UDP + 2-hydroxyestradiol beta-D-glucuronoside
show the reaction diagram
Substrates: isozyme UGT1A1
Products: -
?
UDP-D-glucuronate + 2-hydroxyestrone
UDP + 2-hydroxyestrone beta-D-glucuronoside
show the reaction diagram
Substrates: isozyme UGT1A1
Products: -
?
UDP-D-glucuronate + 2-naphthol
UDP + 2-naphthyl beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine 5'-O-beta-D-glucuronoside
show the reaction diagram
Substrates: model substrate for determination of glucuronidation with respect to specificity, linearity, detection limit, recovery, stability, precision and accuracy, method development and validation for assay and chromatographic determination of reaction products, overview
Products: -
?
UDP-D-glucuronate + 3-hydroxydesloratadine
UDP + 3-hydroxydesloratadine beta-O-D-glucuronoside
show the reaction diagram
Substrates: specific substrate of isozyme UGT1A8
Products: -
?
UDP-D-glucuronate + 4'-hydroxy-warfarin
UDP + 4'-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
Substrates: substrate of isozyme UGT1A10
Products: -
?
UDP-D-glucuronate + 4-(trifluoromethyl)-umbelliferone
UDP + 4-(trifluoromethyl)-umbelliferone beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + 4-hydroxy-estrone
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen
UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferonyl beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-O-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-O-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + 5alpha-androstane-3alpha,17beta-diol
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + 6-hydroxy-warfarin
UDP + 6-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 7-hydroxy-warfarin
UDP + 7-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 8-hydroxy-warfarin
UDP + 8-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + acacetin
UDP + acacetin 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
show the reaction diagram
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + anthraflavic acid
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + apigenin
UDP + apigenin 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + beta-D-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
Substrates: isozyme UGT1A1
Products: -
?
UDP-D-glucuronate + beta-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + bilirubin
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
show the reaction diagram
Substrates: isozyme UGT1A1
Products: -
?
UDP-D-glucuronate + bisdemethoxy-curcumin
UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + candesartan
UDP + candesartan beta-D-glucuronoside
show the reaction diagram
-
Substrates: isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, also isozyme UGT2B7 glucuronidates candesartan at the tetrazole-N2 position, whereas isozymes UGT1A7, UGT1A8, UGT1A9, and UGT1A10 mainly yield candesartan O-glucuronide
Products: -
?
UDP-D-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + chenodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
Substrates: isozyme UGT2A3
Products: -
?
UDP-D-glucuronate + cis-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + cotinine
UDP + ?
show the reaction diagram
UDP-D-glucuronate + curcumin
UDP + curcumin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + curcumin
UDP + curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + demethoxy-curcumin
UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + deoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
Substrates: isozyme UGT2A3
Products: -
?
UDP-D-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone 17-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + eriodictyol
UDP + eriodictyol 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + estradiol
UDP + estradiol-3-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + estriol
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + estriol
UDP + estriol 3-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + estriol
UDP + estriol glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + eugenol
UDP + eugenol beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + flurbiprofen
UDP + flurbiprofen beta-D-glucuronoside
show the reaction diagram
-
Substrates: isozyme UGT2B7
Products: -
?
UDP-D-glucuronate + frusemide
UDP + frusemide beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + gemfibrozil
UDP + gemfibrozil beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + hesperetin
UDP + hesperetin 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + homoeriodictyol
UDP + homoeriodictyol 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 24-carboxy-glucuronoside
show the reaction diagram
Substrates: recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
Products: product formation depends on the isozyme, overview
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 3-O-glucuronoside
show the reaction diagram
Substrates: recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
Products: product formation depends on the isozyme, overview
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
UDP-D-glucuronate + imipramine
UDP + imipramine N-beta-D-glucuronoside
show the reaction diagram
Substrates: reaction of isozyme UGT1A4
Products: -
?
UDP-D-glucuronate + isolongifolol
UDP + isolongifolol beta-D-glucuronoside
show the reaction diagram
-
Substrates: the compound is substrate and competitive inhibitor
Products: -
?
UDP-D-glucuronate + kaempferol
UDP + kaempferol 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + labetalol
UDP + ?
show the reaction diagram
UDP-D-glucuronate + longifolol
UDP + longifolol beta-D-glucuronoside
show the reaction diagram
-
Substrates: the compound is substrate and competitive inhibitor
Products: -
?
UDP-D-glucuronate + losartan
UDP + losartan beta-D-glucuronoside
show the reaction diagram
-
Substrates: no O-glucuronide is generated by any isozyme, while isozymes UGT1A1, UGT1A3, 1A10, UGT2B7, and UGT2B17 glucuronidate losartan at the tetrazole-N2, isozyme UGT1A10 also yields the respective N1-glucuronide, isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring
Products: -
?
UDP-D-glucuronate + luteolin
UDP + luteolin 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + menadiol
UDP + mendadiol 1-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + menadiol
UDP + mendadiol 4-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
show the reaction diagram
Substrates: activity of isozyme UGT1A8
Products: -
?
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + morphine
UDP + morphine 6-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + mycophenolic acid
UDP + mycophenolic acid beta-D-glucuronoside
show the reaction diagram
Substrates: K314 and K404m are determined binding sites required for UDP-glcA binding to isozyme UGT1A10, overview
Products: -
?
UDP-D-glucuronate + myricetin
UDP + myricetin 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + naringenin
UDP + naringenin 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + nicotine
UDP + ?
show the reaction diagram
UDP-D-glucuronate + octylgallate
UDP + octylgallate beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + phenolphthalein
UDP + phenolphthalein beta-D-glucuronoside
show the reaction diagram
Substrates: an UGT2B15 substrate
Products: -
?
UDP-D-glucuronate + phenolphthalein
UDP + phenolphthalein beta-D-monoglucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + phloretin
UDP + ?
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + protocatechuic aldehyde
UDP + ?
show the reaction diagram
UDP-D-glucuronate + quercetin
UDP + quercetin 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + rasloxifene
UDP + raloxifene-6-beta-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
show the reaction diagram
Substrates: isozyme UGT1A6
Products: -
?
UDP-D-glucuronate + serotonin
UDP + serotonin O-beta-D-glucuronoside
show the reaction diagram
Substrates: reaction of isozyme UGT1A6
Products: -
?
UDP-D-glucuronate + tamoxifen + H+
UDP + tamoxifen beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + testosterone
UDP + testosterone 17-O-beta-D-glucuronoside
show the reaction diagram
Substrates: an UGT2B15 substrate
Products: -
?
UDP-D-glucuronate + tetrahydrocurcumin
UDP + tetrahydrocurcumin beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + thyroxine
UDP + thyroxine beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + tizoxanide
UDP + tizoxanide beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + trans-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + trifluoperazine
UDP + trifluoperazine beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + umbelliferone
UDP + umbelliferyl beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + ursodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
Substrates: isozyme UGT2A3
Products: -
?
UDP-D-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + zolarsartan
UDP + zolarsartan beta-D-glucuronoside
show the reaction diagram
-
Substrates: isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, the tetrazole-N1 of this aglycone is accessible to other enzymes, including isozyme UGT1A5, zolarsartan O-glucuronide is mainly produced by isozyme UGT1A10 and isozyme UGT2B7
Products: -
?
UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime
UDP + 1-O-[(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime]-beta-D-glucuronate
show the reaction diagram
UDP-glucuronate + (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid
UDP + ?
show the reaction diagram
-
Substrates: i.e. NI-12a, low activity, NI-12a is glucuronidated at both the -COOH and -OH functions. NI-12a is primarily metabolized by the hepatic and renal enzyme UGT1A9
Products: -
?
UDP-glucuronate + (S)-oxazepam
UDP + (S)-oxazepam beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 1,25-dihydroxyergocalciferol
UDP + 1,25-dihydroxyergocalciferol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 1-hydroxypyrene
UDP + 1-hydroxypyrene beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + 1-naphthol
UDP + beta-D-glucuronosyl-(1-naphthol)
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 5-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 12-hydroxyeicosatetraenoic acid
UDP + 12-hydroxyeicosatetraenoyl beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 12-hydroxyeicosatetraenoic acid
UDP + 12-hydroxyeicosatetraenoyl-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 15-hydroxyeicosatetraenoic acid
UDP + 15-hydroxyeicosatetraenoyl beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 15-hydroxyeicosatetraenoic acid
UDP + 15-hydroxyeicosatetraenoyl-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 17beta-estriol
UDP + estriol 17-beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 2',4'-dihydroxychalcone
UDP + 2'-hydroxychalcone 4'-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: glucuronidation at the OH-4' position by UGT1A1 and UGT1A10 isoforms, both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide
Products: -
?
UDP-glucuronate + 2',4'-dihydroxychalcone
UDP + 4'-hydroxychalcone 2'-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: glucuronidation at the OH-2' position with low activity by UGT1A7, UGT1A6, and UGT1A10 isoforms, and with high activity by isozyme UGT1A9. Both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide
Products: -
?
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone
?
show the reaction diagram
UDP-glucuronate + 2'-hydroxychalcone
UDP + chalcone 2'-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: glucuronidation at the OH-2' position by UGT1A9 isoform
Products: -
?
UDP-glucuronate + 2-hydroxyestrone
UDP + 2-hydroxyestrone beta-D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + 2-methoxyestrone
UDP + 2-methoxyestrone beta-D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + 20-hydroxyeicosatetraenoic acid
UDP + 20-hydroxyeicosatetraenoyl beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + 25-hydroxyergocalciferol
UDP + 25-hydroxyergocalciferol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronide
show the reaction diagram
-
Substrates: isozymes UGT2B4, UGT2B7, and UGT2B17
Products: -
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 3,17-estradiol
UDP + 17-estradiol 3-O-glucuronide
show the reaction diagram
-
Substrates: isozyme UGT1A1
Products: -
?
UDP-glucuronate + 3,17-estradiol
UDP + 3-estradiol 17-O-glucuronide
show the reaction diagram
-
Substrates: isozyme UGT1A1
Products: -
?
UDP-glucuronate + 3,2'-dihydroxychalcone
UDP + 3-hydroxychalcone 2'-O-beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + 3-epideacetycinobufagin
UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + 3alpha,5beta-tetrahydroaldosterone
UDP + 3alpha,5beta-tetrahydroaldosterone beta-D-glucuronide
show the reaction diagram
Substrates: high activity
Products: -
?
UDP-glucuronate + 4,2'-dihydroxychalcone
UDP + 4-hydroxychalcone 2'-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: glucuronidation at the OH-2' position by UGT1A8, UGT1A1, and UGT1A3 isoforms. The A-ring OH-4 group promotes glucuronidation at the 2' position for the reaction of the exclusive substrate 4,2'-dihydroxychalcone of UGT1A1 and 1A3
Products: -
?
UDP-glucuronate + 4-aminobiphenyl
?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 4-ethylphenol
UDP + beta-D-glucuronosyl-(4-ethylphenol)
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + 4-hydroxy-estrone
UDP + ?
show the reaction diagram
Substrates: glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy
Products: -
?
UDP-glucuronate + 4-hydroxyestradiol
UDP + 4-hydroxyestradiol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 4-hydroxyretinoic acid
UDP + 4-hydroxyretinoic acid beta-D-glucuronoside
show the reaction diagram
Substrates: mainly conjugated by UGT2B7
Products: -
?
UDP-glucuronate + 4-methoxyestrone
UDP + 4-methoxyestrone beta-D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl-beta-D-glucuronide
show the reaction diagram
-
Substrates: all isozymes, nonselective substrate
Products: -
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 4-methylumbelliferone
UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenol beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronide
show the reaction diagram
Substrates: recombinant isozyme UGT1A6 from lymphoblasts or insect cells
Products: -
?
UDP-glucuronate + 4-nitrophenol
UDP + beta-D-glucuronosyl-(4-nitrophenol)
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxy-tryptophol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxytryptophol beta-D-glucuronide
show the reaction diagram
Substrates: isozymes UGT1A6 and UGT1A9, the latter shows over 20fold lower activity
Products: -
?
UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxytryptophol beta-D-glucuronoside
show the reaction diagram
Substrates: mucosal serotonin and its metabolite 5-hydroxytryptophol are solely conjugated by UGT1A6
Products: -
?
UDP-glucuronate + 5alpha-dihydroaldosterone
UDP + 5alpha-dihydroaldosterone beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 5alpha-tetrahydrocortisone
UDP + 5alpha-tetrahydrocortisone beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 5beta-tetrahydrocortisone
UDP + 5beta-tetrahydrocortisone beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 5-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 6-hydroxymelatonin
UDP + 6-hydroxymelatonin beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 7-ethyl-10-hydroxy-camptothecin
UDP + 7-ethyl-10-hydroxy-camptothecin beta-D-glucuronoside
show the reaction diagram
Substrates: i.e. SN-38, an active metabolite of irinotecan
Products: -
?
UDP-glucuronate + 7-ethyl-10-hydroxycampothecin
UDP + 7-ethyl-10-hydroxycampothecin 1-O-beta-D-glucuronide
show the reaction diagram
Substrates: i.e. SN-38, isozymes UGT1A1, UGT1A7, and UGT1A9
Products: -
?
UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin
UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
show the reaction diagram
Substrates: i.e. SN-38, an active metabolite of irinotecan
Products: -
?
UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin
UDP + 4-trifluoromethylcoumarin 7-O-beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 7-hydroxyflavanone
UDP + flavanone 7-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 5-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 8-hydroxyquinoline
UDP + 8-hydroxyquinoline beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + acceptor
UDP + acceptor beta-glucuronoside
show the reaction diagram
UDP-glucuronate + aldosterone
UDP + aldosterone beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + all-trans-retinoic acid
UDP + all-trans-retinoic acid beta-D-glucuronoside
show the reaction diagram
Substrates: mainly conjugated by UGT2B7
Products: -
?
UDP-glucuronate + Aloe-emodin
UDP + Aloe-emodin beta-D-glucuronide
show the reaction diagram
Substrates: isozyme UGT1A7
Products: -
?
UDP-glucuronate + alpinetin
UDP + alpinetin beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + amitriptyline
UDP + amitriptyline beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + amitryptiline
UDP + amitryptiline beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + androstane-3,17-diol
UDP + androstane-3,17-diol 17-O-beta-D-glucuronide
show the reaction diagram
-
Substrates: isozyme UGT2B15
Products: -
?
UDP-glucuronate + androstane-3,17-diol
UDP + beta-D-glucuronosyl-androstane-3,17-diol
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + androstanediol
UDP + androstanediol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-glucuronide
show the reaction diagram
-
Substrates: isozyme UGT1A1
Products: -
?
UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-O-beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + apigenin
UDP + apigenin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + asialo-orosomucoid
UDP + asialo-orosomucoid beta-D-glucuronide
show the reaction diagram
-
Substrates: acceptor is a glycoprotein, preferred substrate
Products: -
?
UDP-glucuronate + beta-estradiol
UDP + estradiol 3-beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + bilirubin
?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + biochanin A
UDP + biochanin A beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + buprenorphine
UDP + buprenorphine glucuronide
show the reaction diagram
-
Substrates: isozyme UGT1A1
Products: -
?
UDP-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + cardamonin
UDP + cardamonin beta-D-glucuronoside
show the reaction diagram
-
Substrates: UGT1A9 is the only isoform to glucuronidate cardamonin at the OH-2' position, lower activity with isozyme UGT1A7
Products: -
?
UDP-glucuronate + carvedilol
UDP + carvedilol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + chenodeoxycholic acid
UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + cholic acid
UDP + cholic acid 24-beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + chrysin
UDP + chrysin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + citronellol
UDP + citronellol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + clozapine
UDP + clozapine beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + codeine
UDP + beta-D-glucuronosyl-codeine
show the reaction diagram
-
Substrates: low activity
Products: -
?
UDP-glucuronate + codeine
UDP + codeine beta-D-glucuronide
show the reaction diagram
-
Substrates: isozymes UGT2B4 and UGT2B7
Products: -
?
UDP-glucuronate + cotinine
UDP + cotinine N-beta-D-glucuronoside
show the reaction diagram
Substrates: cotinine is a highly selective substrate of human liver microsomal UGT2B10
Products: -
?
UDP-glucuronate + curcumin
UDP + curcumin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + cyproheptadine
UDP + cyproheptadine beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + deferiprone
UDP + deferiprone beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: formation of 1 product metabolite termed G2
?
UDP-glucuronate + deoxycholic acid
UDP + deoxycholic acid 24-beta-D-glucuronoside
show the reaction diagram
Q6UWM9, Q9Y4X1
Substrates: -
Products: -
?
UDP-glucuronate + desmethylnaproxen
?
show the reaction diagram
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + diphenhydramine
UDP + diphenhydramine beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + dopamine
UDP + dopamine beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + epirubicin
UDP + epirubicin beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + epitestosterone
UDP + epitestosterone beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + estradiol
UDP + estradiol beta-D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + estradiol
UDP + estradiol beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + estriol
UDP + estriol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + estrone
UDP + estrone beta-D-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + estrone
UDP + estrone beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + ethanol
UDP + ethyl beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol glucuronide
show the reaction diagram
-
Substrates: isozyme UGT1A1
Products: -
?
UDP-glucuronate + etoposide
UDP + etoposide beta-D-glucuronide
show the reaction diagram
Substrates: isozyme UGT1A1 is specific for etoposide
Products: -
?
UDP-glucuronate + etoposide
UDP + etoposide beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + eugenol
UDP + beta-D-glucuronosyl-eugenol
show the reaction diagram
-
Substrates: high activity
Products: -
?
UDP-glucuronate + eugenol
UDP + eugenol beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + flavopiridol
UDP + flavopiridol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + flufenamic acid
?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + gemfibrozil
UDP + beta-D-glucuronosyl-gemfibrozil
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + gingerol
UDP + gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + grepafloxacin
UDP + grepafloxacin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + hydromorphone
UDP + beta-D-glucuronosyl-hydromorphone
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + hyocholic acid
UDP + hyocholic acid 24-beta-D-glucuronoside
show the reaction diagram
Q6UWM9, Q9Y4X1
Substrates: -
Products: -
?
UDP-glucuronate + hyodeoxycholic acid
UDP + beta-D-glucuronosyl-hyodeoxycholic acid
show the reaction diagram
-
Substrates: high activity
Products: -
?
UDP-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 24G-beta-D-glucuronoside
show the reaction diagram
Q6UWM9, Q9Y4X1
Substrates: -
Products: -
?
UDP-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholoyl beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + ibuprofen
UDP + beta-D-glucuronosyl-ibuprofen
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + imipramine
UDP + imipramine beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + imipramine
UDP + imipramine beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + imipramine
UDP + imipramine N-beta-D-glucuronoside
show the reaction diagram
Substrates: specific substrate of UGT1A4
Products: -
?
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + ketoconazole
UDP + ketoconazole beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + ketoprofen
UDP + beta-D-glucuronosyl-ketoprofen
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + ketotifen
UDP + ketotifen beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + ketotifen
UDP + ketotifenbeta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + L-thyroxine
UDP + L-thyroxyl beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + lamotrigine
UDP + lamotrigine beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + leukotriene B4
UDP + leukotriene B4 beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + levofloxacin
UDP + levofloxacin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + levomedetomidine
UDP + levomedetomidine beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + lithocholic acid
UDP + lithocholic acid 3-beta-D-glucuronoside + lithocholic acid 24-beta-D-glucuronoside
show the reaction diagram
Q6UWM9, Q9Y4X1
Substrates: -
Products: -
?
UDP-glucuronate + lorazepam
UDP + beta-D-glucuronosyl-lorazepam
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + lorazepam
UDP + lorazepam beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + mefenamic acid
?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + midazolam
UDP + midazolam beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + morphine
UDP + morphine-3-beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + morphine
UDP + morphine-6-beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + morphine 3-glucuronide
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + morphine 3-glucuronide
UDP + morphine 3,6-diglucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + moxifloxacin
UDP + moxifloxacin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-acyl-glucuronide
show the reaction diagram
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-phenyl-glucuronide
show the reaction diagram
UDP-glucuronate + mycophenolic acid
UDP + mycophenoloyl beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + N-acetylserotonin
UDP + N-acetylserotonin beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + naphthol
UDP + naphthol glucuronide
show the reaction diagram
-
Substrates: isozyme UGT1A6
Products: -
?
UDP-glucuronate + naproxen
?
show the reaction diagram
UDP-glucuronate + naproxen
UDP + naproxen beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + naringenin
UDP + naringenin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + niflumic acid
?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + olanzapine
UDP + olanzapine beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + paracetamol
UDP + paracetamol beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + paracetamol
UDP + paracetamol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + paragloboside
UDP + paragloboside beta-D-glucuronide
show the reaction diagram
-
Substrates: acceptor is a glycolipid, activity requires phosphatidylinositol
Products: -
?
UDP-glucuronate + phenylbutazone
?
show the reaction diagram
Substrates: among 16 UDP-glucuronosyltransferase isoforms investigated, only UGT1A9 catalyzes PB C-glucuronidation
Products: -
?
UDP-glucuronate + phloretin
UDP + phloretin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + pizotifen
UDP + pizotifen beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + pregnan-3,17-diol
UDP + pregnan-3,17-diol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + quinazarin
UDP + quinazarin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + quinizarin
UDP + quinizarin beta-D-glucuronide
show the reaction diagram
Substrates: isozyme UGT1A7
Products: -
?
UDP-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + serotonin
?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + serotonin
UDP + serotonin beta-glucuronoside
show the reaction diagram
Substrates: isozyme UGT2B7
Products: -
?
UDP-glucuronate + sitafloxacin
UDP + sitafloxacin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + tacrolimus
UDP + tacrolimus beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + tamoxifen
UDP + tamoxifen beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + tamoxifen
UDP + tamoxifen N-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + Telmisartan
UDP + Telmisartan beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + testosterone
UDP + testosterone beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + thymol
UDP + thymol beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + thymol
UDP + thymol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + tigogenin
UDP + tigogenin beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + tolcapone
UDP + tolcapone beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + trans-androsterone
UDP + trans-androsterone beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + trans-resveratrol
UDP + trans-resveratrol beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + trifluoperazine
UDP + trifluoperazine beta-D-glucuronide
show the reaction diagram
Substrates: isozyme UGT1A4
Products: -
?
UDP-glucuronate + trifluoroperazine
UDP + trifluoroperazine beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + trifluperazine
UDP + trifluperazine
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + umbelliferone
UDP + umbelliferone beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + valproic acid
UDP + beta-D-glucuronosyl-valproic acid
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + vorinostat
UDP + vorinostat beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + zidovudine
UDP + zidovudine O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronic acid + 7-hydroxy-4-(trifluoromethyl)-coumarin
UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide
show the reaction diagram
-
Substrates: UGT1A6, UGT1A9, and UGT2B7
Products: -
?
UDP-glucuronic acid + beta-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronide
show the reaction diagram
-
Substrates: UGT1A3
Products: -
?
UDP-glucuronic acid + bilirubin
UDP + bilirubin-glucuronoside
show the reaction diagram
-
Substrates: UGT1A1
Products: -
?
UDP-glucuronic acid + diclofenac
UDP + diclofenac O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronic acid + imipramine
UDP + imipramine N-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronic acid + serotonin
UDP + serotonin O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronic acid + trifluoperazine
UDP + ?
show the reaction diagram
-
Substrates: UGT1A4
Products: -
?
UDP-glucuronic acid + trifluoperazine
UDP + trifluoperazine N-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + 2,3,4,5-tetrachlorophenol
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + 2,3,4-trichlorophenol
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + 2,4,5-trichlorophenol
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + 2,4,6-trichlorophenol
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + 2,4-dichlorophenol
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + 2-chlorophenol
UDP + 2-chlorophenyl beta-D-O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + 3,4,5-trichlorophenol
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + 3-chlorophenol
UDP + 3-chlorophenyl beta-D-O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + 4-chlorophenol
UDP + 4-chlorophenyl beta-D-O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + chlorophenol
UDP + chlorophenyl beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + chlorophenol
UDP + chlorophenyl beta-D-glucuronoide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + chlorophenol
UDP + chlorophenyl beta-D-O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + pentachlorophenol
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + pentachlorophenol
UDP + pentachlorophenyl beta-D-O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDPglucuronate + naproxen
?
show the reaction diagram
Substrates: UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug
Products: -
?
ursodeoxycholic acid + UDPglucuronate
UDP + ursodeoxycholic acid O-glucuronide
show the reaction diagram
valproic acid + UDPglucuronate
UDP + ?
show the reaction diagram
vanillin + UDP-glucuronate
UDP + vanillin O-glucuronide
show the reaction diagram
-
Substrates: other 7 phenolic compounds show substrate activity on hUGT2A1
Products: -
?
voriconazole + UDP-alpha-D-glucuronate
voriconazole D-glucuronate + UDP
show the reaction diagram
-
Substrates: -
Products: -
?
vorinostat + UDP-glucuronate
UDP + vorinostat beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
xanthotoxol + UDP-glucuronate
UDP + xanthotoxol 8-O-glucuronide
show the reaction diagram
zidovudine + UDP-glucuronate
UDP + zidovudine beta-D-glucuronide
show the reaction diagram
Substrates: substrate for isoform UGT2B7
Products: -
?
zidovudine + UDP-glucuronate
UDP + zidovudine O-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
zidovudine + UDP-glucuronate
UDP + zidovudine-5'-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
11alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate
show the reaction diagram
Substrates: -
Products: -
?
16alpha-hydroxyprogesterone + UDP-glucuronate
?
show the reaction diagram
Substrates: UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation
Products: -
?
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
show the reaction diagram
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
Substrates: the major metabolic pathway of dexmedetomidine, i.e. (4S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3- and N1-glucuronides
Products: -
?
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
Substrates: the major metabolic pathway of levomedetomidine, i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3-glucuronide
Products: -
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
show the reaction diagram
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate
?
show the reaction diagram
Substrates: glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans
Products: -
?
21-hydroxyprogesterone + UDP-glucuronate
UDP + 21-hydroxyprogesterone-21-O-D-glucuronate
show the reaction diagram
Substrates: -
Products: -
?
6alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate
show the reaction diagram
Substrates: -
Products: -
?
bilirubin + UDPglucuronate
UDP + bilirubin O-glucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
estrogen + UDP-glucuronate
?
show the reaction diagram
Substrates: UDP-glucuronosyltransferase 1A10 has been identified as the major isoform involved in the biotransformation of a wide range of phenolic substrates, including native estrogens and their oxidized metabolites
Products: -
?
etoposide + UDP-glucuronate
UDP + etoposide glucuronide
show the reaction diagram
Substrates: UGT1A1 is principally responsible for the formation of etoposide glucuronides, mainly in the form of phenolic glucuronide
Products: -
?
testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
show the reaction diagram
Substrates: UGT2B15 and UGT2B17 are the major enzyme forms involved in human liver microsomal testosterone 17beta-glucuronidation
Products: -
?
UDP-alpha-D-glucuronate + (S)-naproxen
UDP + beta-D-glucuronosyl (S)-naproxen
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-alpha-D-glucuronate + 3-hydroxyflavone
UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone
show the reaction diagram
Substrates: isozyme UGT1A1
Products: -
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + 3-hydroxydesloratadine
UDP + 3-hydroxydesloratadine beta-O-D-glucuronoside
show the reaction diagram
Substrates: specific substrate of isozyme UGT1A8
Products: -
?
UDP-D-glucuronate + 4'-hydroxy-warfarin
UDP + 4'-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
Substrates: substrate of isozyme UGT1A10
Products: -
?
UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen
UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside
show the reaction diagram
Substrates: the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
Products: -
?
UDP-D-glucuronate + 6-hydroxy-warfarin
UDP + 6-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 7-hydroxy-warfarin
UDP + 7-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 8-hydroxy-warfarin
UDP + 8-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
show the reaction diagram
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
show the reaction diagram
Substrates: isozyme UGT1A1
Products: -
?
UDP-D-glucuronate + bisdemethoxy-curcumin
UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + chenodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
Substrates: isozyme UGT2A3
Products: -
?
UDP-D-glucuronate + cis-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
show the reaction diagram
Substrates: the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
Products: -
?
UDP-D-glucuronate + cotinine
UDP + ?
show the reaction diagram
Substrates: isozyme UGT2B10, cotinine is exclusively glucuronized in liver, no activity in intestinal microsomes
Products: -
?
UDP-D-glucuronate + curcumin
UDP + curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
-
Substrates: glucuronidation is an important pathway in the metabolism of curcumin
Products: -
?
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + demethoxy-curcumin
UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + deoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
Substrates: isozyme UGT2A3
Products: -
?
UDP-D-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone 17-O-beta-D-glucuronoside
show the reaction diagram
Substrates: in epithelial cells of the human prostate
Products: -
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
-
Substrates: isozymes UGT1A1 and UGT1A9
Products: -
?
UDP-D-glucuronate + estradiol
UDP + estradiol-3-beta-D-glucuronoside
show the reaction diagram
Substrates: liver microsomes
Products: -
?
UDP-D-glucuronate + flurbiprofen
UDP + flurbiprofen beta-D-glucuronoside
show the reaction diagram
-
Substrates: isozyme UGT2B7
Products: -
?
UDP-D-glucuronate + frusemide
UDP + frusemide beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-D-glucuronate + gemfibrozil
UDP + gemfibrozil beta-D-glucuronoside
show the reaction diagram
-
Substrates: gemfibrozil is a fibrate hypolipidemic agent, isozyme UGT2B7 in the liver
Products: -
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
Substrates: isozyme UGT2A3
Products: -
?
UDP-D-glucuronate + labetalol
UDP + ?
show the reaction diagram
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + morphine
UDP + morphine 6-beta-D-glucuronoside
show the reaction diagram
Substrates: the metabolic conversion of morphine to morphine-6-glucuronide plays a significant role in mediation of the clinical effect of morphine because of the superior analgesic effect of morphine-6-glucuronide
Products: -
?
UDP-D-glucuronate + nicotine
UDP + ?
show the reaction diagram
Substrates: isozyme UGT2B10, nicotine is mainly glucuronized in liver, very low activity in intestinal microsomes
Products: -
?
UDP-D-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
show the reaction diagram
-
Substrates: isozymes UGT1A1 and UGT1A9
Products: -
?
UDP-D-glucuronate + protocatechuic aldehyde
UDP + ?
show the reaction diagram
Substrates: -
Products: -
?
UDP-D-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
show the reaction diagram
Substrates: isozyme UGT1A6
Products: -
?
UDP-D-glucuronate + tamoxifen + H+
UDP + tamoxifen beta-D-glucuronoside
show the reaction diagram
Substrates: the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
Products: -
?
UDP-D-glucuronate + thyroxine
UDP + thyroxine beta-D-glucuronoside
show the reaction diagram
-
Substrates: glucuronidation of the thyroid hormone thyroxine, T4, in the human liver, the T4 glucuronidation activities of recombinant human UGT isoforms and microsomes
Products: -
?
UDP-D-glucuronate + trans-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
show the reaction diagram
Substrates: the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
Products: -
?
UDP-D-glucuronate + ursodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
Substrates: isozyme UGT2A3
Products: -
?
UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime
UDP + 1-O-[(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime]-beta-D-glucuronate
show the reaction diagram
-
Substrates: i.e. NI-ST-05, low activity, NI-ST-05 forms a distinct N-O-glucuronide. NI-ST-05 is primarily metabolized by an extrahepatic enzyme, UGT1A10
Products: -
?
UDP-glucuronate + (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid
UDP + ?
show the reaction diagram
-
Substrates: i.e. NI-12a, low activity, NI-12a is glucuronidated at both the -COOH and -OH functions. NI-12a is primarily metabolized by the hepatic and renal enzyme UGT1A9
Products: -
?
UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 5-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 3-epideacetycinobufagin
UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
show the reaction diagram
Substrates: 3-epideacetycinobufagin is a highly isoform-specific probe substrate for 3-glucuronidation mediated by UDP-glucuronosyltransferase 2B7 determined in recombinant UGT supersomes, overview
Products: -
?
UDP-glucuronate + 4-hydroxy-estrone
UDP + ?
show the reaction diagram
Substrates: glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy
Products: -
?
UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 5-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin
UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
show the reaction diagram
Substrates: i.e. SN-38, an active metabolite of irinotecan
Products: -
?
UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 5-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + acceptor
UDP + acceptor beta-glucuronoside
show the reaction diagram
UDP-glucuronate + estriol
UDP + estriol beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + ethanol
UDP + ethyl beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + gingerol
UDP + gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + morphine
UDP + morphine-3-beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + morphine
UDP + morphine-6-beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-acyl-glucuronide
show the reaction diagram
-
Substrates: mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil
Products: -
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-phenyl-glucuronide
show the reaction diagram
-
Substrates: mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil
Products: -
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + serotonin
UDP + serotonin beta-glucuronoside
show the reaction diagram
Substrates: isozyme UGT2B7
Products: -
?
UDP-glucuronate + tamoxifen
UDP + tamoxifen N-beta-D-glucuronoside
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronate + trans-resveratrol
UDP + trans-resveratrol beta-D-glucuronoside
show the reaction diagram
-
Substrates: -
Products: -
?
UDP-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
show the reaction diagram
UDP-glucuronic acid + bilirubin
UDP + bilirubin-glucuronoside
show the reaction diagram
-
Substrates: UGT1A1
Products: -
?
UDP-glucuronose + chlorophenol
UDP + chlorophenyl beta-D-glucuronide
show the reaction diagram
Substrates: -
Products: -
?
UDP-glucuronose + chlorophenol
UDP + chlorophenyl beta-D-glucuronoide
show the reaction diagram
Substrates: -
Products: -
?
UDPglucuronate + naproxen
?
show the reaction diagram
Substrates: UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug
Products: -
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
((2R)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid
-
-
((2S)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid
-
-
((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid
-
-
((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid
-
-
(+)-longifolol
a tricyclic sesquiterpenol
(-)-nicotine
-
(1R)-1-cyclopropyl-2-methylpropan-1-ol
IC50: 0.0004 mM
(1R)-1-cyclopropylbut-3-en-1-ol
IC50: 0.0004 mM; IC50: 0.0009 mM
(1R)-1-cyclopropylbut-3-ene-1,3-diol
IC50: 0.0004 mM
(1R)-1-cyclopropylethanol
IC50: 0.0005 mM
(1R)-1-cyclopropylprop-2-en-1-ol
IC50: 0.0003 mM
(1R)-1-cyclopropylpropan-1-ol
IC50: 0.0002 mM
(1R)-1-cyclopropylpropane-1,3-diol
IC50: 0.0002 mM
(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol
-
-
(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
-
(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol
-
-
(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
-
(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol
-
-
(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol
-
-
(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethan
-
-
(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol
-
-
(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
-
(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol
-
-
(1R)-2,2-dimethyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
-
(1R)-2-chloro-1-cyclopropylethanol
IC50: 0.0002 mM
(1R)-2-chloro-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
-
(1R)-2-methyl-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
-
(1R)-2-methyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
-
(1S)-1-cyclopropyl-2,2-dimethylpropan-1-ol
IC50: 0.0002 mM
(1S)-1-cyclopropyl-2-methylpropan-1-ol
IC50: 0.0004 mM
(1S)-1-cyclopropylbut-3-en-1-ol
IC50: 0.0002 mM
(1S)-1-cyclopropylethanol
IC50: 0.0007 mM
(1S)-1-cyclopropylprop-2-en-1-ol
IC50: 0.0006 mM
(1S)-1-cyclopropylpropan-1-ol
IC50: 0.0005 mM
(1S)-1-cyclopropylpropane-1,3-diol
IC50: 0.0003 mM
(1S)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol
-
-
(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol
-
-
(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
-
(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol
-
-
(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
-
(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol
-
-
(1S)-2,2-dimethyl-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
-
(1S)-2,2-dimethyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
-
(1S)-2-chloro-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
-
(1S)-2-methyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
-
(2-cyclopropylethyl)phosphonic acid
IC50: 0.012 mM
(2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid
-
-
(2E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-en-1-ol
-
-
(2E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-enoic acid
-
-
(2E)-3-cyclopropylacrylic acid
IC50: 0.003 mM
(2E)-3-cyclopropylprop-2-en-1-ol
IC50: 0.0008 mM
(2R)-3,3-dimethyl-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol
-
-
(2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-2-ol
-
-
(2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol
-
-
(2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]pent-4-en-2-ol
-
-
(2S)-3-methyl-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol
-
-
(2Z)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-en-1-ol
-
-
(2Z)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-enoic acid
-
-
(2Z)-3-cyclopropylacrylic acid
IC50: 0.003 mM
(2Z)-3-cyclopropylprop-2-en-1-ol
IC50: 0.0007 mM
(3-(dimethylamino)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid
-
-
(3-cyclopropylpropyl)phosphonic acid
IC50: 0.032 mM
(3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid
-
-
(3R)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid
-
-
(3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid
-
-
(3S)-3-cyclopropyl-3-hydroxypropanoic acid
IC50: 0.001 mM
(3S)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid
-
-
(3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid
-
-
(4-(dimethylamino)-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butyl)phosphonic acid
-
-
(4aS,8aR,9aS)-9a-hydroxy-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one
i.e. atractylenolide II, one of two important efficient herbal ingredients isolated from Atractylodes macrocepha exhibits specific inhibition towards UGT2B7, with negligible influence towards other UGT isoforms
(5alpha)-17-allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one
IC50 for morphine 3-glucuronide formation: 0.412 mM (noncompetitive), IC50 for morphine 3-glucuronide formation: 0.429 mM (competitive)
(8aS)-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one
i.e. atractylenolide I, one of two important efficient herbal ingredients isolated from Atractylodes macrocephala, exhibits specific competitive inhibition towards UGT2B7, with negligible influence towards other UGT isoforms
(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulene-9-carboxylic acid
-
-
(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulene-9-carboxylic acid
-
-
(R)-7-hydroxywarfarin
-
substrate (S)-7-hydroxywarfarin, noncompetitive
(R)-8-hydroxywarfarin
-
substrate (S)-6-hydroxywarfarin, noncompetitive
(R)-chloro(cyclopropyl)methanol
IC50: 0.0002 mM
(R)-cyclopropyl(phenyl)methanol
IC50: 0.00007 mM
(R)-phenyl[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol
-
-
(S)-8-hydroxywarfarin
-
substrate (R)-8-hydroxywarfarin, noncompetitive
(S)-cyclopropyl(phenyl)methanol
IC50: 0.0009 mM
(S)-phenyl[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol
-
-
(S)-phenyl[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol
-
-
1-(4-methyl-1,4-diazepan-1-yl)-2-(6-(trifluoromethyl)-1H-indol-3-yl)ethane-1,2-dione
selective for isoform UGT1A1. About 50% inhibition at 0.005 mM
1-cyclopropyl-2,2-dimethylpropan-1-ol
IC50: 0.0008 mM
1-hydroxypyrene
-
1-naphthol
1-naphthol O-glucuronide
inhibitory effects on different isozymes with different substrates, overview; inhibitory effects on different isozymes with different substrates, overview; inhibitory effects on different isozymes with different substrates, overview
17alpha-ethinylestradiol
strongly inhibits the formation of etoposide alcoholic glucuronide EAG2 (IC50: 0.0 42 mM) but shows very similar and moderate inhibition on etoposide phenolic glucuronide (IC50: 0.2 mM) and etoposide alcoholic glucuronide EAG1 (IC50: 0.21 mM)
17alpha-ethynylestradiol
slightly activates the 3-beta-glucuronidation of estradiol to 116% at 0.005 mM, but inhibits it at 0.1 mM by 23%, inhibits glucuronidation of 4-methylumbelliferone at all concentration of 0.1 mM
17beta-estradiol
-
-
2'-OH-PCB106
-
2'-hydroxy metabolite of polychlorinated biphenyl 106, competitive inhibition
2,3,4,5-Tetrachlorophenol
substrate inhibition; substrate inhibition
2,3,4,6-tetrachlorophenol
substrate inhibition
2,3,4-Trichlorophenol
substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition
2,3,5,6-Tetrachlorophenol
substrate inhibition
2,4,5-Trichlorophenol
substrate inhibition; substrate inhibition
2,4,6-tribromophenol
competitive inhibition; competitive inhibition; competitive inhibition; noncompetitive inhibition
2,4,6-Trichlorophenol
substrate inhibition; substrate inhibition
2,4-Dibromophenol
2,4-Dichlorophenol
substrate inhibition; substrate inhibition
2,5-dibromophenol
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid
-
2-bromophenol
competitive inhibition; competitive inhibition
2-chlorophenol
substrate inhibition
2-cyclopropyl-N,N-dimethylethanamine
IC50: 0.005 mM
2-cyclopropylethanol
IC50: 0.0005 mM
2-hydroxy-estradiol
-
38.5% inhibition at 0.1 mM, UGT1A3
2-hydroxyestradiol
-
inhibits 4-hydroxyestradiol glucuronidation catalyzed by UGT2B7Y
2-oxo-N-(3-(2-oxopyrrolidin-1-yl)propyl)-2-(6-(trifluoromethyl)-1H-indol-3-yl)acetamide
compound resensitizes FRII cells to ribavirin treatment by about 2 times; compound resensitizes FRII cells to ribavirin treatment by about 2 times
2-phenyl-4H-benzo[h]chromen-4-one
-
-
2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
-
2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-2-ol
-
-
2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
-
20(R)-ginsenoside Rg2
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(R)-ginsenoside Rg3
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(R)-ginsenoside Rh1
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(R)-ginsenoside Rh2
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(R)-protopanaxadiol
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(R)-protopanaxatriol
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(S)-ginsenoside Rg2
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(S)-ginsenoside Rg3
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(S)-ginsenoside Rh1
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(S)-ginsenoside Rh2
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(S)-protopanaxadiol
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
20(S)-protopanaxatriol
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
3'-azido-3'-deoxythymidin
slight inhibition
3,4,5-trichlorophenol
substrate inhibition; substrate inhibition
3,5-dibromophenol
competitive inhibition; competitive inhibition; competitive inhibition; competitive inhibition
3-chlorophenol
substrate inhibition
3-cyclopropylpropan-1-ol
IC50: 0.0009 mM
3-cyclopropylpropanoic acid
IC50: 0.002 mM
3-demethyltranilast
-
3-hydroxyflavone
three-dimensional QSAR-model of UGT1A1 substrate inhibition, binding structure and modelling, overview
3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
-
4'-OH-PCB106
-
4'-hydroxy metabolite of polychlorinated biphenyl 106, competitive inhibition
4-azido-2-hydroxybenzoic acid
inhibition of UGT1A10 catalyzed glucuronidation of 4-nitrophenol
4-Chlorophenol
substrate inhibition
4-cyclopropylbutan-1-ol
IC50: 0.003 mM
4-cyclopropylbutanoic acid
IC50: 0.016 mM
4-demethyltranilast
bilirubin glucuronosyltransferase activity, tranilast glucuronosyltransferase activity
4-hydroxyestradiol
-
inhibits 2-hydroxyestradiol glucuronidation catalyzed by UGT1A1
4-hydroxyphenanthrene
-
-
4-Methylumbelliferone
4-nitrophenol
4-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-1-ol
-
-
4-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butanoic acid
-
-
4-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-1-ol
-
-
4-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butanoic acid
-
-
5-diethylaminoethylamino-8-hydroxyimidazoacridinone
-
substrate inhibition with isoform UGT1A9
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone
-
substrate inhibition with isoform UGT1A9
5-hydroxytryptophol
competitive inhibition of serotonin glucuronidation
6-hydroxywarfarin
-
competitive
7-hydroxy-4-trifluoromethylcoumarin
substrate inhibition
7-hydroxywarfarin
-
competitive
9-Hydroxyphenanthrene
-
acalabrutinib
exhibits weak UGT inhibition towards all tested UGT isoforms; exhibits weak UGT inhibition towards all tested UGT isoforms; exhibits weak UGT inhibition towards all tested UGT isoforms
acetaminophen
3 mM, 90% inhibition
acetone
30% and 40% inhibition of isozyme UGT2B15 at 1%, respectively; 30% and 40% inhibition of isozyme UGT2B17 at 1%, respectively
acetonitrile
50% inhibition of isozyme UGT2B15 at 1%
aflatoxin B1
competitive, binding free energy -8.19 kcal/mol; competitive, binding free energy -9.04 kcal/mol
aflatoxin G1
noncompetitive, binding free energy -9.59 kcal/mol
alisol B
-
-
alisol B acetate
-
-
amentoflavone
0.1 mM, 95.3% inhibition
amitriptyline
androsterone
arctigenin
about 20% inhibition at 0.1 mM; about 35% inhibition at 0.1 mM; about 50% inhibition at 0.1 mM; about 50% inhibition at 0.1 mM; about 65% inhibition at 0.1 mM; about 80% inhibition at 0.1 mM; about 82% inhibition at 0.1 mM; about 90% inhibition at 0.1 mM; noncompetitive inhibition toward isoform UGT2B15 with more than 80% inhibition at 0.1 mM
arctiin
about 20% inhibition at 0.1 mM; about 35% inhibition at 0.1 mM; about 50% inhibition at 0.1 mM; about 50% inhibition at 0.1 mM; about 65% inhibition at 0.1 mM; about 80% inhibition at 0.1 mM; about 82% inhibition at 0.1 mM; about 85% inhibition at 0.1 mM; competitive inhibition toward isoform UGT2B15 with more than 80% inhibition at 0.1 mM
aripiprazole
-
asialo-orosomucoid
-
inhibits activity with paragloboside
-
atazanavir
-
a HIV protease inhibitor, linear mixed-type inhibition mechanism, UGT1A1, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7
atractylenolide I
inhibitor of isoform UGT2B7
auriculasin
-
auriculasin inhibits isoforms UGT1A6, UGT1A8, UGT1A10, and UGT2B7 completely at 0.1 mM. Isoforms UGT1A1, UGT1A3, UGT1A7, UGT1A9, UGT2B4, and UGT2B15 show about 60%, 95%, 90%, 96%, 55% and 42% residual activity at 0.1 mM auriculasin, respectively
azidothymidine
-
selective for isozyme UGT2B7
baicalein
0.1 mM, 23.7% inhibition; 0.1 mM, 35.9% inhibition
beta-estradiol
beta-phenyllongifolol
BIBF 1202
about 60% residual activity at 0.05 mM; about 70% residual activity at 0.05 mM; about 75% residual activity at 0.05 mM; about 75% residual activity at 0.05 mM; about 75% residual activity at 0.05 mM; about 85% residual activity at 0.05 mM; about 85% residual activity at 0.05 mM; about 87% residual activity at 0.05 mM; about 90% residual activity at 0.05 mM; about 90% residual activity at 0.05 mM
bilirubin
bisphenol A
i.e. BPA, inhibits glucuronidation of serotonin and 4-methylumbelliferone
bupropion
-
-
C-1748
mixed-type inhibition of isoform UGT1A9
calphostin-C
-
-
canagliflozin
0.1 mM, 42.3% inhibition; 0.1 mM, 49.2% inhibition
-
carbamazepine
IC50 for morphine 3-glucuronide formation: 0.431 mM (mixed type inhibition), IC50 for morphine 3-glucuronide formation: 0.456 mM (mixed type inhibition)
catechin
-
-
celecoxib
significantly inhibits glucuronidation of 20-hydroxyeicosatetraenoic acid
chenodeoxycholic acid
-
inhibits glucuronidation of bilirubin
chlorpromazine
-
citalopram
-
clomipramine
clozapine
-
curcumin
cyclopropanecarboxylic acid
IC50: 0.001 mM
cyclosporine A
-
-
dabrafenib
about 10% residual activity at 0.05 mM; about 17% residual activity at 0.05 mM; about 30% residual activity at 0.05 mM; about 38% residual activity at 0.05 mM; about 40% residual activity at 0.05 mM; about 40% residual activity at 0.05 mM; about 5% residual activity at 0.05 mM; about 55% residual activity at 0.05 mM; about 59% residual activity at 0.05 mM; about 68% residual activity at 0.05 mM; about 8% residual activity at 0.05 mM; about 8% residual activity at 0.05 mM
darolutamide
-
-
desipramine
desloratadine
-
desmethylnortriptyline
-
desvenlafaxine
-
dextromethorphan
-
-
diazepam
IC50 for morphine 3-glucuronide formation: 0.057 mM (noncompetitive), IC50 for morphine 3-glucuronide formation: 0.053 mM (noncompetitive)
diclofenac
dictamine
competitive, strong inhibitor; competitive, strong inhibitor; competitive, strong inhibitor; competitive, strong inhibitor
-
didesmethylimipramine
-
diethyl ((2R)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonate
-
-
diethyl ((2S)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonate
-
-
diethyl ((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate
-
-
diethyl ((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate
-
-
diethyl [(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonate
IC50: 0.01 mM
diethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate
IC50: 0.005 mM
diethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate
IC50: 0.004 mM
diethyl [(R)-cyclopropyl(hydroxy)methyl]phosphonate
IC50: 0.01 mM
Digitonin
-
inhibition above 0.6 mg/mg protein; no effect at saturating substrate concentrations
Dihydrocodeine
-
-
dimethyl ((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate
-
-
dimethyl ((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate
-
-
dimethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate
IC50: 0.003 mM
dimethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate
IC50: 0.004 mM
duloxetine
-
efavirenz
emodin
inhibits tizoxanide glucuronidation activities in the human liver and even more in intestinal microsomes; inhibits tizoxanide glucuronidation activities in the human liver and even more in intestinal microsomes
estradiol
ethanol
50% inhibition of isozyme UGT2B17 at 1%
ethyl (3R)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate
-
-
ethyl (3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate
-
-
ethyl (3S)-3-cyclopropyl-3-hydroxypropanoate
IC50: 0.0003 mM
ethyl (3S)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate
-
-
ethyl (3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate
-
-
eugenol
-
UGT2B7, 54.5% inhibition at 0.1 mM
Fe2+
-
-
fluconazole
Flufenamic acid
0.02-0.5 mM, completely inhibits glucuronidation of 4-methylumbelliferone; 0.02-0.5 mM, inhibits glucuronidation of 4-methylumbelliferone
flunitrazepam
-
competitive inhibition of estrogen and buprenorphine catalyzed by UGT1A1 and UGT2B7Y, not inhibition of UGT1A3
fluoxetine
-
fluphenazine
-
fluvoxamine
-
galangin
0.1 mM, 88.5% inhibition; 0.1 mM, 93.6% inhibition; 0.1 mM, 94.8% inhibition; 0.1 mM, 98.7% inhibition
gamma-fagarine
competitive, strong inhibitor; competitive, strong inhibitor; competitive, strong inhibitor; competitive, strong inhibitor
-
gemfibrozil
-
inhibits both UGT and CYP2C8, about 50% inhibition via a non-specific, competitive process in drug distribution to UGT
genistein
0.003 mM, 25.4% inhibition. 0.03 mM, 79.5% inhibition; 0.003 mM, 38.8% inhibition. 0.03 mM, 97.6% inhibition; weak; weak
gomisin J
inhibitor of isoform UGT1A9
gossypol
-
noncompetitive inhibitin of estradiol-3-glucuronidation and propofol O-glucuronidation, competitive inhibition towards 3'-azido-3'-deoxythymidine glucuronidation
haloperidol
-
haplopine
competitive, strong inhibitor; competitive, strong inhibitor; competitive, strong inhibitor; competitive, strong inhibitor
-
hecogenin
hyodeoxycholic acid
-
-
ibrutinib
Ibuprofen
significantly inhibits glucuronidation of 20-hydroxyeicosatetraenoic acid
imipramine
indinavir
-
a HIV protease inhibitor, linear mixed-type inhibition mechanism, UGT1A1, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7
indomethacin
significantly inhibits glucuronidation of 20-hydroxyeicosatetraenoic acid
isoliquiritigenin
-
-
isolongifolol
itraconazole
-
kaempferol
ketoconazole
lacto-N-biose
-
22% inhibition of recombinant GlcAT-P and 77.3% of recombinant GlcAT-S at 5 mM
lactose
-
24.5% inhibition of recombinant GlcAT-S at 5 mM, no inhibition of recombinant GlcAT-P
lamotrigen
-
low-affinity substrate of isoform UGT1A4, noncompetitively inhibits dihydrotestosterone and trans-androsterone glucuronidation
lapatinib
-
-
lithocholic acid
-
long-chain unsaturated fatty acids
selective inhibition of some UGT isozymes
-
longifolol
-
and derivatives of primary alcohol series or carboxylic/phosphonic acids and amines, inhibitory potency, overview
lopinavir
-
a HIV protease inhibitor, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7
loratadine
-
lorazepam
IC50 for morphine 3-glucuronide formation: 0.065 mM (mixed type inhibition), IC50 for morphine 3-glucuronide formation: 0.056 mM (mixed type inhibition)
magnolol
combined treatment decreases IC50 values for 2,4-dibromophenol and vice versa. The 2 inhibitors and UGT1A9 can form a ternary complex
Mefenamic acid
meloxicam
-
mianserin
-
midazolam
-
-
mirtazapine
-
monobenzyl phthalate
-
isoform UGT1A9 shows 92.49% inhibition at 0.1 mM
monobutyl phthalate
-
-
monocyclohexyl phthalate
-
isoform UGT1A9 shows 95.9% inhibition at 0.1 mM
monoethyl phthalate
-
-
monoethylhexyl phthalate
-
isoform UGT1A7 shows 85.26% inhibition at 0.1 mM, isoform UGT1A9 shows 97.61% inhibition at 0.1 mM
monohexyl phthalate
-
isoform UGT1A9 shows 85.83% inhibition at 0.1 mM
monomethyl phthalate
-
-
monooctyl phthalate
-
isoform UGT1A9 shows 91.21% inhibition at 0.1 mM
morin
0.1 mM, 81.6% inhibition; 0.1 mM, 89.2% inhibition; 0.1 mM, 96.1% inhibition; 0.1 mM, 96.8% inhibition
morphine
mycophenolate
IC50 for morphine 3-glucuronide formation: 0.341 mM (noncompetitive), IC50 for morphine 3-glucuronide formation: 0.389 mM (noncompetitive)
myricetin
competitive; mixed type; non-competitive; non-competitive; non-competitive; non-competitive; non-competitive
N-(2-((dimethylamino)methyl)benzyl)-2-oxo-2-(6-(trifluoromethyl)-1H-indol-3-yl)acetamide
0.005 mM, 80% inhibition. Kd value 0.0337 mM. Compound resensitizes FRII cells to ribavirin treatment by about 2 times; compound resensitizes FRII cells to ribavirin treatment by about 2 times
N-(3-(dimethylamino)propyl)-N-methyl-2-oxo-2-(6-(trifluoromethyl)-1H-indol-3-yl)acetamide
compound resensitizes FRII cells to ribavirin treatment by about 2 times; compound resensitizes FRII cells to ribavirin treatment by about 2 times
N-acetyllactosamine
-
87.4% inhibition of recombinant GlcAT-P and 83.7% of recombinant GlcAT-S at 5 mM
naphthol
-
UGT1A6, 87.0% inhibition at 0.05 mM
naproxen
significantly inhibits glucuronidation of 20-hydroxyeicosatetraenoic acid
nelfinavir
-
a HIV protease inhibitor, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7
Ni2+
-
-
niflumic acid
nintedanib
about 1% residual activity at 0.05 mM; about 10% residual activity at 0.05 mM; about 15% residual activity at 0.05 mM; about 18% residual activity at 0.05 mM; about 25% residual activity at 0.05 mM; about 3% residual activity at 0.05 mM; about 38% residual activity at 0.05 mM; about 40% residual activity at 0.05 mM; about 5% residual activity at 0.05 mM; about 5% residual activity at 0.05 mM
niotinib
a selective inhibitor of UGT1A1
-
norclomipramine
-
nordihydroguaiaretic acid
-
nortriptyline
-
olanzapine
oleandomycin
-
-
Omeprazole
-
-
opicabone
IC50 values increase at higher substrate concentrations; IC50 values increase at higher substrate concentrations; IC50 values increase at higher substrate concentrations; IC50 values increase at higher substrate concentrations; IC50 values increase at higher substrate concentrations
-
oxazepam
IC50 for morphine 3-glucuronide formation: 0.109 mM (competitive), IC50 for morphine 3-glucuronide formation: 0.119 mM (mixed type inhibition)
p-[di-n-Propylsulfamoyl]benzoic acid
-
i.e. probenecid
paclitaxel
-
-
paroxetine
-
pazopanib
-
-
Pentachlorophenol
substrate inhibition
perphenazine
-
Phenelzine
-
Phenylbutazone
probenicid
-
-
propofol
protopanaxadiol
-
competitive inhibition
protriptyline
-
quercetin
quetiapine
-
quinidine
-
-
regorafenib
-
-
ritonavir
-
a HIV protease inhibitor, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7
rosmarinic acid
-
-
salvigenin
0.1 mM, 55.2% inhibition; 0.1 mM, 60% inhibition
-
saquinavir
-
a HIV protease inhibitor, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7
sauchinone
noncompetitive inhibition; noncompetitive inhibition
schisandrin A
inhibitor of isoform UGT1A1; inhibitor of isoform UGT1A3
selegiline
-
sertraline
-
skimmianine
competitive, strong inhibitor; competitive, strong inhibitor; competitive, strong inhibitor; competitive, strong inhibitor
-
sorafenib
-
-
sulfinpyrazone
-
a UGT1A selective inhibitor
tacrolimus
IC50 for morphine 3-glucuronide formation: 0.384 mM (mixed type inhibition), IC50 for morphine 3-glucuronide formation: 0.488 mM (mixed type inhibition)
tamoxifen
testosterone
thioridazine
-
Tolbutamide
-
-
trametinib
about 10% residual activity at 0.05 mM; about 2% residual activity at 0.05 mM; about 25% residual activity at 0.05 mM; about 25% residual activity at 0.05 mM; about 25% residual activity at 0.05 mM; about 30% residual activity at 0.05 mM; about 45% residual activity at 0.05 mM; about 45% residual activity at 0.05 mM; about 5% residual activity at 0.05 mM; about 6% residual activity at 0.05 mM; about 60% residual activity at 0.05 mM; about 85% residual activity at 0.05 mM
tranilast
bilirubin glucuronosyltransferase activity, activity in human jejunum microsomes is strongly inhibited (0.0753 mM)
trans-androsterone
-
uncompetitive substrate inhibition
tranylcypromine
-
trimipramine
-
Triphenylacetic acid
-
competitive to bilirubin
Triton X-100
troglitazone
-
inhibition of bilirubin glucuronidation by UGT1A1
UDP-glucose
competitive inhibition, predicted binding sites in isozyme UGT1A10 are sites N292, K314, K315, and K404, overview
UDP-hexanol amine
competitive inhibition, predicted binding sites in isozyme UGT1A10 are sites N292, K314, K315, and K404
venlafaxine
-
wogonin
0.1 mM, 38.4% inhibition; 0.1 mM, 38.8% inhibition
xanthotoxol
substrate inhibition of isoform UGT1A1; substrate inhibition of isoform UGT1A10; substrate inhibition of isoform UGT1A8
zidovudine
-
-
Zn2+
-
-
[(1E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-1-en-1-yl]phosphonic acid
-
-
[(1E)-3-cyclopropylprop-1-en-1-yl]phosphonic acid
IC50: 0.041 mM
[(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonic acid
IC50: 0.013 mM
[(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid
IC50: 0.028 mM
[(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid
IC50: 0.018 mM
[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]acetic acid
-
-
[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol
-
-
[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]acetic acid
-
-
[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol
-
-
[(E)-2-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)ethenyl]phosphonic acid
-
-
[(E)-2-cyclopropylvinyl]phosphonic acid
IC50: 0.008 mM
[(R)-cyclopropyl(hydroxy)methyl]phosphonic acid
IC50: 0.018 mM
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17alpha-ethynylestradiol
slightly activates the 3-beta-glucuronidation of estradiol to 116% at 0.005 mM, but inhibits it at 0.1 mM by 23%
alamethicin
arctigenin
about 210% activity of isoform UGT1A8 at 0.1 mM arctigenin
arctiin
about 225% activity of isoform UGT1A8 at 0.1 mM arctiin
BIBF 1202
bovine serum albumin
activates isozyme UGT1A9 by reducing the Km of the substrates, overview
-
Brij58
-
-
Clofibrate
Digitonin
-
0.6 mg/mg liver protein, 1.8fold activation using non-saturated substrate concentration
fatty acid-free human serum albumin
activates isozyme UGT1A9 by reducing the Km of the substrates, overview
-
galangin
0.1 mM, 248% of initial activity
ibrutinib
about 130% activity at 0.05 mM
Nicotine
slightly activating with substrate amitriptyline
nintedanib
Phenobarbital
phosphate
-
activity in phosphate buffer is higher than in Tris/malate buffer containing 5 mM sucrose
phosphatidylcholine
-
required by purified preparations for optimal activity
phosphatidylinositol
-
highly required for activity of GlcAT-P and GlcAT-S with paraglobosid and other glycolipids
Phospholipids
-
-
propofol
activates the glucuronidation of 4-methylumbelliferone at 0.2 mM leading to 1.5fold increased Vmax and 0.53fold reduced Km, overview
sphingomyelin
-
almost indispensable activator of GlcAT-P as to glycoprotein acceptors
Src
-
overexpression of regular or active Src, but not dominant-negative Src, in UGT2B7-transfected COS-1 cells increases UGT2B7 activity and phospho-Y438-2B7 by 50%. UGT2B7 and regular SrcTK are co-localized in COS-1
-
Triton X-100
UDP-GlcNAc
stimulates
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0073 - 0.072
(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol
0.068 - 0.17
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol
0.0062
(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime
-
pH 7.4, 37°C
0.063 - 0.24
(E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid
-
pH 7.4, 37°C, isozyme-dependent
0.21
(R)-6-hydroxywarfarin
-
isoform UGT1A10, pH 7.6, 37°C
0.044 - 0.13
(R)-7-hydroxywarfarin
0.105
(R)-8-hydroxywarfarin
-
isoform UGT1A10, pH 7.6, 37°C
0.16 - 1.21
(R)-propanolol
0.36
(S)-6-hydroxywarfarin
-
isoform UGT1A10, pH 7.6, 37°C
0.16 - 0.23
(S)-7-hydroxywarfarin
0.139
(S)-8-hydroxywarfarin
-
isoform UGT1A10, pH 7.6, 37°C
0.507 - 1.013
(S)-naproxen
0.135 - 0.515
(S)-propanolol
0.247 - 0.263
1-hydroxy-benzo(a)pyrene
0.0061 - 0.011
1-hydroxy-benzo[a]pyrene
0.0012 - 0.0033
1-hydroxy-pyrene
0.0113 - 2.869
1-hydroxybenzo(a)pyrene
0.091 - 0.111
1-hydroxypyrene
0.03 - 27
1-naphthol
0.0178 - 0.0353
10-gingerol
0.0069 - 0.093
11alpha-hydroxyprogesterone
0.073 - 0.211
16alpha-hydroxyprogesterone
0.042 - 0.159
17-epiestriol
0.00192 - 0.0975
17beta-estradiol
0.0073 - 0.0112
1alpha,25-dihydroxyvitamin D3
0.00298 - 0.0258
2',4,4'-trihydroxychalcone
0.00702 - 0.0804
2,3,4,5-Tetrachlorophenol
0.002 - 0.0648
2,3,4-Trichlorophenol
0.0322 - 0.06982
2,4,5-Trichlorophenol
0.01989 - 0.109
2,4,6-Trichlorophenol
0.05182 - 0.1542
2,4-Dichlorophenol
0.0119 - 0.293
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid
0.1302
2-chlorophenol
pH 7.4, 37°C, recombinant UGT1A6, substrate inhibition model
0.014 - 0.027
2-hydroxyestradiol
0.0102 - 0.291
2-hydroxyestrone
0.551 - 13.4
3'-azido-3'-deoxythymidine
0.00347 - 0.0471
3,4,5-trichlorophenol
0.0738
3-chlorophenol
pH 7.4, 37°C, recombinant UGT1A6, substrate inhibition model
0.0444
3-epideacetycinobufagin
pH and temperature not specified in the publication
0.271 - 0.278
3-hydroxy-benzo(a)pyrene
0.0072 - 0.0075
3-hydroxy-benzo[a]pyrene
0.0097 - 0.583
3-hydroxybenzo(a)pyrene
0.00197 - 0.0047
3alpha,5beta-tetrahydroaldosterone
0.0588 - 0.286
4-aminobiphenyl
0.1286
4-Chlorophenol
pH 7.4, 37°C, recombinant UGT1A6, Michaelis-Menten model
0.006 - 0.292
4-hydroxyestradiol
0.014 - 0.1182
4-hydroxyestrone
0.011 - 1.621
4-methylumbeliferone
0.00012 - 4.204
4-Methylumbelliferone
0.0102 - 1.034
4-nitrophenol
0.0293 - 0.149
5-diethylaminoethylamino-8-hydroxyimidazoacridinone
0.0289 - 0.0706
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone
0.135 - 3.674
5-hydroxytryptophol
0.124 - 1.25
5-methylchrysene-1,2-diol
0.016
5alpha-androstane-3alpha,17beta diol
apparent Km for UGT1A4
0.00023 - 0.00036
5alpha-dihydroaldosterone
0.0646 - 0.0647
5beta-tetrahydrocortisone
0.0253 - 0.404
6-gingerol
0.48 - 0.72
6-hydroxywarfarin
0.003 - 0.055
6alpha-hydroxyprogesterone
19.3 - 44.4
7-ethyl-10-hydroxycampothecin
0.0098 - 1.588
7-hydroxy benzo(a)pyrene
0.00418 - 0.198
7-hydroxy-4-trifluoromethylcoumarin
0.261 - 0.334
7-hydroxy-benzo(a)pyrene
0.0078 - 0.0085
7-hydroxy-benzo[a]pyrene
0.17 - 0.56
7-hydroxywarfarin
0.0132 - 0.0314
8-gingerol
0.308 - 0.368
8-hydroxy-benzo(a)pyrene
0.00048 - 0.494
8-hydroxyquinoline
0.19 - 0.39
8-hydroxywarfarin
0.0096 - 0.012
9-hydroxy-benzo[a]pyrene
0.0301 - 0.615
9-hydroxybenzo(a)pyrene
2
acetaminophen
-
0.00036 - 0.00076
aldosterone
0.261
alprazolam
-
isoform UGT1A4, pH 7.4, 37°C
0.0075 - 0.49
amitriptyline
0.0175
androstanediol
-
pH 7.4, 37°C
0.0066 - 0.01
androsterone
0.01
anthraflavic acid
0.0035 - 0.01005
bakuchiol
0.397 - 0.426
benzo(a)pyrene-7,8-diol
0.168 - 0.397
Benzo[a]pyrene-7,8-diol
0.12 - 0.19
benzo[a]pyrene-9,10-diol
0.021
beta-estradiol
-
isoform UGT1A1, pH 7.4, 37°C
0.028
bifonazole
-
isoform UGT1A4, pH 7.4, 37°C
0.004 - 0.024
bilirubin
0.0034 - 0.059
cannabinol
0.071 - 0.368
carvacrol
0.083
chenodeoxycholic acid
-
-
0.004 - 0.005
chrysin
0.0074 - 0.193
cis-4-hydroxytamoxifen
0.025 - 0.049
clozapine
0.4
codeine
-
isozyme UGT2B7, pH 7.5, 37°C
0.0278
cotinine
pH 7.4, 37°C, recombinant isozyme UGT2B10
0.00168 - 0.1
curcumin
0.086 - 0.228
cyproheptadine
7.4 - 19.3
deferiprone
1.48 - 2.99
denopamine
3.133 - 7.724
desmethylnaproxen
0.284 - 0.307
dibenzo(a,l)pyrene-11,12-diol
0.096 - 0.143
dibenzo[a,1]pyrene-11,12-diol
0.013 - 0.069
diclofenac
0.0196
dihydrotestosterone
-
isoform UGT1A4, pH 7.4, 37°C
0.037 - 0.47
diphenhydramine
1.89 - 3.11
dopamine
0.115
econazole
-
isoform UGT1A4, pH 7.4, 37°C
0.021 - 0.703
entacapone
0.0017 - 0.0116
Epitestosterone
0.0049 - 0.0138
estradiol
0.0388 - 0.0467
estriol
0.0063 - 0.0421
estrone
8.03 - 40.04
ethanol
0.44 - 0.5
etoposide
0.0084 - 0.0257
eugenol
1.667
fluconazole
-
isoform UGT2B7, pH 7.4, 37°C
0.048
Flufenamic acid
-
0.0209 - 0.229
frusemide
0.0022 - 0.0195
gemfibrozil
2.1 - 5.2
grepafloxacin
0.011 - 0.27
hyodeoxycholic acid
0.0072 - 1.442
imipramine
0.007
ketoconazole
-
isoform UGT1A4, pH 7.4, 37°C
0.48
Ketoprofen
-
pH 7.4, 37°C
0.368 - 0.956
labetalol
0.774 - 3.812
lamotrigine
2.6 - 10
levofloxacin
0.449
Mefenamic acid
-
0.059
miconazole
-
isoform UGT1A4, pH 7.4, 37°C
0.013
midazolam
-
isoform UGT1A4, pH 7.4, 37°C
0.019
Mn2+[side2]
37°C, pH 7.4
0.028 - 0.173
MOCAc-Lys-Arg-Gly-Leu-Tyr-Phe-Ile-Thr-His-Lys(Dnp)
0.012 - 0.081
montanoyl-CoA
0.0355 - 37.4
morphine
1.15
morphine 3-glucuronide
-
pH 7.4, 37°C
1.9 - 3.4
moxifloxacin
0.046 - 0.336
Mycophenolic acid
0.072 - 4.375
naproxen
0.135 - 7.344
niflumic acid
0.0503 - 0.0584
p-Cresol
5.06 - 6.99
p-ethoxyphenylurea
0.00255
Pentachlorophenol
pH 7.4, 37°C, recombinant UGT1A1, substrate inhibition model
0.0198 - 0.1951
Phenylbutazone
0.0068 - 0.0964
phloretin
0.0072 - 1
propofol
0.211 - 0.627
Protocatechuic aldehyde
0.032 - 0.099
retigabine
0.034 - 0.045
S-naproxen
0.061 - 7.64
scopoletin
0.51
senecionine
-
pH 7.4, 37°C
3.7 - 55.9
serotonin
0.023
silybin A
at pH 7.4 and 37°C
0.0087
silybin B
at pH 7.4 and 37°C
0.009
silydianin
at pH 7.4 and 37°C
1.9 - 6.3
Sitafloxacin
0.035
sulconazole
-
isoform UGT1A4, pH 7.4, 37°C
0.014 - 0.053
sulfinpyrazone
0.0009
tamoxifen
-
isoform UGT1A4, pH 7.4, 37°C
0.0038 - 0.0387
testosterone
0.00112
tetrahydrocurcumin
pH 7.4, 37°C
0.007 - 0.008
tigogenin
0.124
tioconazole
-
isoform UGT1A4, pH 7.4, 37°C
0.0056 - 0.0155
tizoxanide
0.0506 - 0.0515
tranilast
0.0037 - 0.319
trans-4-hydroxytamoxifen
0.008 - 0.255
trans-androsterone
0.013 - 0.135
trans-endoxifen
0.0197 - 0.305
Trifluoperazine
0.136
troglitazone
-
-
0.00025
UDP-D-glucuronate
pH 7.4, 37°C, recombinant wild-type isozyme UGT1A6
0.138 - 0.184
UDP-glucuronate
0.229 - 0.704
UDP-glucuronic acid
0.96
UDPglucuronic acid
-
-
0.111 - 0.339
umbelliferone
1.13
voriconazole
-
isoform UGT1A4, pH 7.4, 37°C
0.00579 - 0.4593
xanthotoxol
0.508 - 1.54
zidovudine
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0013 - 0.422
entacapone
0.015 - 0.138
morphine
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00187 - 9.22
entacapone
0.00144 - 0.0188
morphine
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00013 - 0.00274
1-hydroxypyrene
0.00008 - 0.0304
1-naphthol
0.533 - 1.547
17beta-estradiol
0.0004 - 0.0027
2'-OH-PCB106
0.0344 - 0.5437
2,3,4,5-Tetrachlorophenol
0.01473 - 0.3452
2,3,4-Trichlorophenol
0.1783 - 1.011
2,4,5-Trichlorophenol
0.00285 - 0.031
2,4,6-tribromophenol
0.562 - 2.561
2,4,6-Trichlorophenol
0.00146 - 0.00372
2,4-Dibromophenol
0.067 - 0.7256
2,4-Dichlorophenol
0.00002 - 0.00156
2,5-dibromophenol
1.56
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid
-
0.00174
2-bromophenol
isoform UGT1A6, at pH 7.4 and 37°C
0.2033
2-chlorophenol
pH 7.4, 37°C, recombinant UGT1A6, substrate inhibition model
0.06431 - 0.189
3,4,5-trichlorophenol
0.00048 - 0.00246
3,5-dibromophenol
0.4336
3-chlorophenol
pH 7.4, 37°C, recombinant UGT1A6, substrate inhibition model
0.09
3-hydroxyflavone
isozyme UGT1A1
0.0007 - 0.0068
4'-OH-PCB106
0.00001 - 0.0014
4-hydroxyphenanthrene
-
0.23 - 3.73
4-Methylumbelliferone
23.4 - 51.2
4-nitrophenol
1.651
5-diethylaminoethylamino-8-hydroxyimidazoacridinone
-
isoform UGT1A9, pH not specified in the publication, temperature not specified in the publication
0.958
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone
-
isoform UGT1A9, pH not specified in the publication, temperature not specified in the publication
0.2 - 0.29
5-hydroxytryptophol
0.82 - 1.1
6-hydroxywarfarin
0.0996
7-hydroxy-4-trifluoromethylcoumarin
recombinant isoform UGT1A1, pH 7.4, 37°C
1.1
7-hydroxywarfarin
-
mutant V92A, pH 7.4, 37°C
0.00001 - 0.00086
9-Hydroxyphenanthrene
0.02979 - 0.03847
aflatoxin B1
0.01955
aflatoxin G1
pH 7.4, 37°C
0.03 - 0.248
amitriptyline
0.149
androsterone
-
inhibition of troglitazone glucuronidation
0.0767
arctigenin
isoform UGT2B15, at pH 7.4 and 37°C
0.016
arctiin
isoform UGT2B15, at pH 7.4 and 37°C
0.0019
atazanavir
-
pH 7.5, 37°C, UGT1A1
0.00501
auriculasin
-
isoform UGT1A8, at pH 7.4 and 37°C
0.00000091
beta-phenyllongifolol
-
0.0005 - 0.28
bilirubin
0.0723 - 0.085
bisphenol A
0.081 - 0.0946
C-1748
0.047 - 0.243
carbamazepine
0.006 - 0.02
clomipramine
0.00645 - 0.01442
darolutamide
-
0.111 - 0.458
desipramine
0.009 - 0.047
diazepam
0.022 - 0.024
diclofenac
0.0037 - 0.0339
dictamine
-
0.26
estradiol
-
-
0.022 - 0.808
flunitrazepam
0.0164 - 0.0342
gossypol
0.0039
hecogenin
-
pH 7.4, 37°C, substrate senecionine
0.00088 - 0.00252
ibrutinib
0.033 - 0.38
imipramine
0.0479
indinavir
-
pH 7.5, 37°C, UGT1A1
0.000023
isolongifolol
-
-
0.0099 - 0.0623
kaempferol
0.000026
longifolol
-
-
0.017 - 0.239
lorazepam
0.00213
monobenzyl phthalate
-
isoform UGT1A9, at pH 7.4 and 37°C
0.00009
monocyclohexyl phthalate
-
isoform UGT1A9, at pH 7.4 and 37°C
0.00117 - 0.01125
monoethylhexyl phthalate
0.00746
monohexyl phthalate
-
isoform UGT1A9, at pH 7.4 and 37°C
0.00016
monooctyl phthalate
-
isoform UGT1A9, at pH 7.4 and 37°C
0.088 - 9
morphine
0.296 - 0.713
mycophenolate
0.00149 - 0.02946
myricetin
0.518 - 1.298
naloxone
0.196 - 0.266
olanzapine
0.00131 - 0.01058
opicabone
-
0.041 - 0.519
oxazepam
0.0549
Pentachlorophenol
pH 7.4, 37°C, recombinant UGT1A1, substrate inhibition model
0.0359
protopanaxadiol
-
at pH 7.4 and 37°C
0.002 - 0.1132
quercetin
0.000524 - 0.00108
sauchinone
0.046 - 0.347
tacrolimus
0.0046 - 0.081
tamoxifen
0.112 - 2.2
testosterone
0.514
trans-androsterone
-
isoform UGT1A4, pH 7.4, 37°C
0.2639 - 1.8
xanthotoxol
additional information
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.214
(-)-nicotine
Homo sapiens
pH 7.4, 37°C
0.0004
(1R)-1-cyclopropyl-2-methylpropan-1-ol
Homo sapiens
IC50: 0.0004 mM
0.0004 - 0.0009
(1R)-1-cyclopropylbut-3-en-1-ol
0.0004
(1R)-1-cyclopropylbut-3-ene-1,3-diol
Homo sapiens
IC50: 0.0004 mM
0.0005
(1R)-1-cyclopropylethanol
Homo sapiens
IC50: 0.0005 mM
0.0003
(1R)-1-cyclopropylprop-2-en-1-ol
Homo sapiens
IC50: 0.0003 mM
0.0002
(1R)-1-cyclopropylpropan-1-ol
Homo sapiens
IC50: 0.0002 mM
0.0002
(1R)-1-cyclopropylpropane-1,3-diol
Homo sapiens
IC50: 0.0002 mM
0.0002
(1R)-2-chloro-1-cyclopropylethanol
Homo sapiens
IC50: 0.0002 mM
0.0002
(1S)-1-cyclopropyl-2,2-dimethylpropan-1-ol
Homo sapiens
IC50: 0.0002 mM
0.0004
(1S)-1-cyclopropyl-2-methylpropan-1-ol
Homo sapiens
IC50: 0.0004 mM
0.0002
(1S)-1-cyclopropylbut-3-en-1-ol
Homo sapiens
IC50: 0.0002 mM
0.0007
(1S)-1-cyclopropylethanol
Homo sapiens
IC50: 0.0007 mM
0.0006
(1S)-1-cyclopropylprop-2-en-1-ol
Homo sapiens
IC50: 0.0006 mM
0.0005
(1S)-1-cyclopropylpropan-1-ol
Homo sapiens
IC50: 0.0005 mM
0.0003
(1S)-1-cyclopropylpropane-1,3-diol
Homo sapiens
IC50: 0.0003 mM
0.012
(2-cyclopropylethyl)phosphonic acid
Homo sapiens
IC50: 0.012 mM
0.003
(2E)-3-cyclopropylacrylic acid
Homo sapiens
IC50: 0.003 mM
0.0008
(2E)-3-cyclopropylprop-2-en-1-ol
Homo sapiens
IC50: 0.0008 mM
0.003
(2Z)-3-cyclopropylacrylic acid
Homo sapiens
IC50: 0.003 mM
0.0007
(2Z)-3-cyclopropylprop-2-en-1-ol
Homo sapiens
IC50: 0.0007 mM
0.032
(3-cyclopropylpropyl)phosphonic acid
Homo sapiens
IC50: 0.032 mM
0.001
(3S)-3-cyclopropyl-3-hydroxypropanoic acid
Homo sapiens
IC50: 0.001 mM
0.412 - 0.429
(5alpha)-17-allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one
0.333
(R)-7-hydroxywarfarin
Homo sapiens
-
isoform UGT1A10, substrate (S)-7-hydroxywarfarin, pH 7.6, 37°C
0.401
(R)-8-hydroxywarfarin
Homo sapiens
-
isoform UGT1A10, substrate (S)-6-hydroxywarfarin, pH 7.6, 37°C
0.0002
(R)-chloro(cyclopropyl)methanol
Homo sapiens
IC50: 0.0002 mM
0.00007
(R)-cyclopropyl(phenyl)methanol
Homo sapiens
IC50: 0.00007 mM
0.344
(S)-8-hydroxywarfarin
Homo sapiens
-
isoform UGT1A10, substrate (R)-8-hydroxywarfarin, pH 7.6, 37°C
0.0009
(S)-cyclopropyl(phenyl)methanol
Homo sapiens
IC50: 0.0009 mM
0.0008
1-cyclopropyl-2,2-dimethylpropan-1-ol
Homo sapiens
IC50: 0.0008 mM
0.00197 - 0.00606
1-hydroxypyrene
0.00015 - 0.0352
1-naphthol
0.042 - 0.21
17alpha-ethinylestradiol
0.0086
17alpha-ethynylestradiol
Homo sapiens
pH 7.5, 37°C, inhibition of glucuronidation of 4-methylumbelliferone by isozyme UGT1A1
0.0016 - 0.01502
2'-OH-PCB106
0.00064 - 0.00858
2,4,6-tribromophenol
0.00013 - 0.189
2,4-Dibromophenol
0.00014 - 0.00507
2,5-dibromophenol
0.0019
2-bromophenol
Homo sapiens
isoform UGT1A6, at pH 7.4 and 37°C
0.005
2-cyclopropyl-N,N-dimethylethanamine
Homo sapiens
IC50: 0.005 mM
0.0005
2-cyclopropylethanol
Homo sapiens
IC50: 0.0005 mM
0.023 - 0.149
2-phenyl-4H-benzo[h]chromen-4-one
0.0324 - 0.1
20(R)-ginsenoside Rg2
0.0114 - 0.1
20(R)-ginsenoside Rg3
0.1
20(R)-ginsenoside Rh1
0.1
20(R)-ginsenoside Rh2
0.0268 - 0.1
20(R)-protopanaxadiol
0.0135 - 0.1
20(R)-protopanaxatriol
0.1
20(S)-ginsenoside Rg2
0.0117 - 0.1
20(S)-ginsenoside Rg3
0.077 - 0.1
20(S)-ginsenoside Rh1
0.00585 - 0.1
20(S)-ginsenoside Rh2
0.0256 - 0.1
20(S)-protopanaxadiol
0.012 - 0.1
20(S)-protopanaxatriol
0.00018 - 0.01
3,5-dibromophenol
0.0009
3-cyclopropylpropan-1-ol
Homo sapiens
IC50: 0.0009 mM
0.002
3-cyclopropylpropanoic acid
Homo sapiens
IC50: 0.002 mM
0.00156 - 0.03047
4'-OH-PCB106
0.003
4-cyclopropylbutan-1-ol
Homo sapiens
IC50: 0.003 mM
0.016
4-cyclopropylbutanoic acid
Homo sapiens
IC50: 0.016 mM
0.00009 - 0.00798
4-hydroxyphenanthrene
-
0.0001 - 0.00337
9-Hydroxyphenanthrene
0.02235 - 0.07163
aflatoxin B1
0.01511
aflatoxin G1
Homo sapiens
pH 7.4, 37°C
0.16
alisol B
Homo sapiens
-
at pH 7.4 and 37°C
0.163
alisol B acetate
Homo sapiens
-
at pH 7.4 and 37°C
0.00645 - 0.159
amitriptyline
0.0271
androsterone
Homo sapiens
pH 7.5, 37°C, recombinant isozyme UGT1A9
0.0558
aripiprazole
Homo sapiens
pH 7.4, 37°C
0.00829
auriculasin
Homo sapiens
-
isoform UGT1A8, at pH 7.4 and 37°C
0.068 - 0.086
beta-estradiol
Homo sapiens
exhibits strong inhibition on etoposide phenolic glucuronide (IC50: 0.068 mM) and etoposide alcoholic glucuronide EAG2 (IC50: 0.086 mM). The inhibitory effect of beta-estradiol on the formation of etoposide alcoholic glucuronide EAG1 is not so significant
0.1
BIBF 1202
0.054 - 0.14
bilirubin
0.0425 - 0.163
bisphenol A
0.088 - 0.152
bupropion
0.0397 - 0.0845
C-1748
0.431 - 0.456
carbamazepine
0.164
catechin
Homo sapiens
-
at pH 7.4 and 37°C
0.077
celecoxib
Homo sapiens
pooled liver microsomes, pH 7.4, 37°C
0.079
chlorpromazine
Homo sapiens
pH 7.4, 37°C
0.0283
chrysin
Homo sapiens
isoform UGT1A1, at pH 7.6 and 37°C
0.218
citalopram
Homo sapiens
pH 7.4, 37°C
0.026 - 0.04
clomipramine
0.0613
clozapine
Homo sapiens
pH 7.4, 37°C
0.001
cyclopropanecarboxylic acid
Homo sapiens
IC50: 0.001 mM
0.023 - 0.048
cyclosporine A
0.0022 - 0.1
dabrafenib
0.0064
deoxyschizandrin
Homo sapiens
isoform UGT1A3, at pH 7.4 and 37°C
0.0341
desipramine
Homo sapiens
pH 7.4, 37°C