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(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
-
Substrates: substrate for isoforms UGT1A9 and UGT1A10
Products: -
?
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
-
Substrates: substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10
Products: -
?
(R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
-
Substrates: -
Products: -
?
(R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
-
Substrates: -
Products: -
?
(R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
-
Substrates: -
Products: -
?
(R)-propanolol + UDP-glucuronate
UDP + (R)-propanolol O-glucuronide
-
Substrates: -
Products: -
?
(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
-
Substrates: -
Products: -
?
(S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
-
Substrates: -
Products: -
?
(S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
-
Substrates: -
Products: -
?
(S)-naproxen + UDP-alpha-D-glucuronate
beta-D-glucuronosyl (S)-naproxen + UDP
-
Substrates: -
Products: -
?
(S)-naproxen + UDP-alpha-D-glucuronate
UDP + beta-D-glucuronosyl (S)-naproxen
-
Substrates: -
Products: -
?
(S)-oxazepam + UDP-glucuronate
UDP + (S)-oxazepam beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
?
(S)-propanolol + UDP-glucuronate
UDP + (S)-propanolol O-glucuronide
-
Substrates: -
Products: -
?
1-hydroxy-benzo(a)pyrene + UDP-glucuronate
1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP
-
Substrates: -
Products: -
?
1-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-1-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
1-hydroxy-pyrene + UDP-D-xylose
pyrene 1-O-D-xyloside + UDP
Substrates: -
Products: -
?
1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
1-hydroxypyrene + UDP-D-glucose
pyrene 1-O-D-glucoside + UDP
Substrates: -
Products: -
?
1-hydroxypyrene + UDP-glucuronate
1-hydroxypyrene 1-O-glucuronate + UDP
-
Substrates: -
Products: -
?
1-hydroxypyrene + UDP-glucuronate
?
Substrates: -
Products: -
?
1-hydroxypyrene + UDP-glucuronate
pyrene 1-O-glucuronide + UDP
Substrates: -
Products: -
?
1-hydroxypyrene + UDP-N-acetylglucosamine
pyrenil-1-O-(N-acetylglucosaminide) + UDP
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
1-hydroxy[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide
Substrates: -
Products: -
?
1-naphthol + UDP-alpha-D-glucuronate
1-naphthyl-O-glucuronide + UDP
-
Substrates: -
Products: -
?
1-naphthol + UDP-D-glucose
naphthyl-1-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
1-naphthol + UDP-glucuronate
1-naphthyl 1-O-glucuronate + UDP
-
Substrates: -
Products: -
?
1-naphthol + UDP-glucuronate
1-naphthyl-O-glucuronide + UDP
Substrates: -
Products: -
?
1-naphthol + UDP-glucuronate
?
Substrates: -
Products: -
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
Substrates: -
Products: -
?
1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
11alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate
Substrates: -
Products: -
?
12-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
-
Substrates: glucuronidated by UGT1A3, inactive towards benz[a]pyrene trans 4,5 and 7,8 dihydrodiols
Products: -
?
12-hydroxyeicosatetraenoic acid + UDP-glucuronate
?
Substrates: -
Products: -
?
13-hydroxyoctadecadienoic acid + UDP-glucuronate
?
Substrates: -
Products: -
?
16alpha-hydroxyprogesterone + UDP-glucuronate
?
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
17-epiestriol + UDP-glucuronate
?
Substrates: -
Products: -
?
17-epiestriol + UDP-glucuronate
UDP + ?
-
Substrates: -
Products: -
?
17alpha-estradiol + UDP-alpha-D-glucuronate
? + UDP
-
Substrates: -
Products: -
?
17beta-estradiol + UDP-alpha-D-glucuronate
? + UDP
-
Substrates: -
Products: -
?
17beta-estradiol + UDP-glucuronate
?
Substrates: metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
Products: -
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
2',4,4'-trihydroxychalcone + UDP-glucuronate
UDP + 2',4,4'-trihydroxychalcone 4'-O-glucoside + 2',4,4'-trihydroxychalcone 2'-O-glucoside
-
Substrates: i.e. isoliquiritigenin
Products: -
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate
?
Substrates: glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans
Products: -
?
2-aminobiphenyl + UDP-glucuronate
?
Substrates: -
Products: -
?
2-hydroxyestradiol + UDP-glucuronate
?
Substrates: -
Products: -
?
2-hydroxyestradiol + UDPglucuronate
UDP + 2-hydroxyestradiol O-glucuronide
2-hydroxyestrone + UDP-glucuronate
?
Substrates: -
Products: -
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
21-hydroxyprogesterone + UDP-glucuronate
UDP + 21-hydroxyprogesterone-21-O-D-glucuronate
Substrates: -
Products: -
?
3 quercetin + 3 UDP-glucuronate
3 UDP + quercetin 7-glucuronide + quercetin 3-glucuronide + quercetin 3'-glucuronide
Substrates: isoform UGT1A9 mainly converts quercetin into three monoglucuronides, including 7-glucuronide, 3-glucuronide, and 3'-glucuronide
Products: -
?
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
Substrates: substrate of isoform UGT2B7
Products: -
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
Substrates: -
Products: -
?
3-azido-4-chlorobenzoic acid + UDP-glucuronate
?
Substrates: -
Products: -
?
3-azidobenzoic acid + UDP-glucuronate
?
Substrates: -
Products: -
?
3-hydroxy-benzo(a)pyrene + UDP-glucuronate
3-hydroxy-benzo(a)pyrene 3-O-glucuronate + UDP
-
Substrates: -
Products: -
?
3-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-3-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
3-hydroxybenzo(a)pyrene + UDP-glucuronate
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
-
Substrates: -
Products: -
?
3-hydroxydesloratadine + UDP-glucuronate
UDP + 3-hydroxydesloratadinyl-O-glucuronide
4-aminobiphenyl + UDP-glucuronate
UDP + 4-aminobiphenyl N-glucuronide
-
Substrates: -
Products: -
?
4-aminobiphenyl + UDPglucuronate
UDP + ?
-
Substrates: catalyzed by isozyme 1 but not by isozyme 2
Products: -
?
4-azido-2-hydroxybenzoic acid + UDPglucuronate
?
Substrates: -
Products: -
?
4-azidobenzoic acid + UDP-glucuronate
?
Substrates: -
Products: -
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
4-hydroxyestradiol + UDP-glucuronate
?
Substrates: -
Products: -
?
4-hydroxyestradiol + UDPglucuronate
UDP + 4-hydroxyestradiol O-glucuronide
4-hydroxyestrone + UDP-glucuronate
?
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone 4-O-glucuronide
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide
-
Substrates: -
Products: -
?
4-methylumbeliferone + UDP-alpha-D-glucuronate
4-methylumbelliferyl-7-O-alpha-D-glucuronide
-
Substrates: -
Products: -
?
4-methylumbeliferone + UDP-glucuronate
4-methylumbelliferyl-7-O-beta-D-glucuronide
-
Substrates: -
Products: -
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-beta-D-glucuronide
-
Substrates: -
Products: -
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
5-diethylaminoethylamino-8-hydroxyimidazoacridinone + UDP-alpha-D-glucuronate
5-{[2-(diethylamino)ethyl]amino}-6-oxo-6H-imidazo[4,5,1-de]acridin-8-yl beta-D-glucuronide + UDP
-
Substrates: i.e. antitumor agent C-1311, NSC-645809
Products: -
?
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone + UDP-alpha-D-glucuronate
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone-8-D-glucuronide + UDP
-
Substrates: i.e. antitumor agent C-1305
Products: -
?
5-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 5-hydroxybenzo[a]pyrene O-glucuronide
-
Substrates: glucuronidated by UGT1A3
Products: -
?
5-hydroxyrofecoxib + UDP-glucuronate
UDP + 5-hydroxyrofecoxib beta-D-glucuronide
Substrates: -
Products: -
?
5-methylchrysene-1,2-diol + UDP-D-glucose
1-hydroxy-5-methylchrysene-2-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
5-methylchrysene-1,2-diol + UDP-D-glucose
2-hydroxy-5-methylchrysene-1-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
5-methylchrysene-1,2-diol + UDP-D-xylose
1-hydroxy-5-methylchrysene-2-O-D-xyloside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
5-methylchrysene-1,2-diol + UDP-D-xylose
2-hydroxy-5-methylchrysene-1-O-D-xyloside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
5-methylchrysene-1,2-diol + UDP-glucuronate
? + UDP
-
Substrates: -
Products: -
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
?
Substrates: -
Products: -
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
6-hydroxywarfarin + UDP-glucuronate
? + UDP
-
Substrates: -
Products: -
?
6alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate
Substrates: -
Products: -
?
7-ethyl-10-hydroxy-camptothecin + UDP-glucuronate
UDP + 7-ethyl-10-hydroxy-camptothecin beta-D-glucuronide
Substrates: i.e SN-38, substrate for isoform UGT1A1
Products: -
?
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
Substrates: -
Products: -
?
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
Substrates: -
Products: -
?
7-ethyl-10-hydroxycamptothecin + UDP-alpha-D-glucuronate
7-ethyl-10-hydroxycamptothecin 10-O-glucuronate + UDP
Substrates: -
Products: -
?
7-hydroxy benzo(a)pyrene + UDP-glucuronate
?
7-hydroxy-4-trifluoromethylcoumarin + UDP-alpha-D-glucuronate
7-hydroxy-4-trifluoromethylcoumarin 7-O-glucuronate + UDP
Substrates: -
Products: -
?
7-hydroxy-4-trifluoromethylcoumarin + UDP-glucuronate
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
7-hydroxy-benzo(a)pyrene + UDP-glucuronate
7-hydroxy-benzo(a)pyrene 7-O-glucuronate + UDP
-
Substrates: -
Products: -
?
7-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-7-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
7-hydroxywarfarin + UDP-glucuronate
? + UDP
-
Substrates: -
Products: -
?
8-hydroxy-benzo(a)pyrene + UDP-glucuronate
8-hydroxy-benzo(a)pyrene 8-O-glucuronate + UDP
-
Substrates: -
Products: -
?
8-hydroxy-benzo[a]pyrene + UDP-glucuronate
benzo[a]pyrenil-8-O-glucuronide + UDP
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
8-hydroxywarfarin + UDP-glucuronate
? + UDP
-
Substrates: -
Products: -
?
9-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-9-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
9-hydroxybenzo(a)pyrene + UDP-glucuronate
?
acetaminophen + UDP-glucuronate
?
acetaminophen + UDP-glucuronate
UDP + ?
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
?
alpha-naphthylamine + UDPglucuronate
UDP + ?
-
Substrates: -
Products: -
?
alprazolam + UDP-alpha-D-glucuronate
alprazolam D-glucuronate + UDP
-
Substrates: -
Products: -
?
amitriptyline + UDP-glucuronate
?
Substrates: -
Products: -
?
anastrozole + UDP-glucuronate
UDP + ?
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
anthraflavic acid + UDPglucuronate
UDP + ?
apigenin + UDPglucuronate
UDP + apigenin O-glucuronide
-
Substrates: -
Products: -
?
bakuchiol + UDP-glucuronate
UDP + bakuchiol beta-D-glucuronide
benzo(a)pyrene-7,8-diol + UDP-glucuronate
? + UDP
-
Substrates: -
Products: -
?
benzo[a]pyrene-7,8-diol + UDP-D-glucose
7-hydroxy-benzo[a]pyrene-8-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-7,8-diol + UDP-D-glucose
8-hydroxy-benzo[a]pyrene-7-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-7,8-diol + UDP-D-xylose
7-hydroxy-benzo[a]pyrene-8-O-D-xyloside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-7,8-diol + UDP-D-xylose
8-hydroxy-benzo[a]pyrene-7-O-D-xyloside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-D-glucose
10-hydroxy-benzo[a]pyrene-9-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-D-glucose
9-hydroxy-benzo[a]pyrene-10-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-D-xylose
10-hydroxy-benzo[a]pyrene-9-O-D-xyloside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-D-xylose
9-hydroxy-benzo[a]pyrene-10-O-D-xyloside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-glucuronate
10-hydroxy-benzo[a]pyrene-9-O-glucuronide + UDP
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-glucuronate
9-hydroxy-benzo[a]pyrene-10-O-glucuronide + UDP
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-N-acetylglucosamine
10-hydroxybenzo[a]pyrene 9-O-(N-acetylglucosaminide) + UDP
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
benzo[a]pyrene-9,10-diol + UDP-N-acetylglucosamine
9-hydroxybenzo[a]pyrene 10-O-(N-acetylglucosaminide) + UDP
Substrates: activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
Products: -
?
beta-estradiol + UDP-alpha-D-glucuronate
beta-estradiol-3-glucuronide + UDP
-
Substrates: -
Products: -
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol 3-O-beta-D-glucuronoside
Substrates: -
Products: -
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol 3-O-glucuronide
A0A0G2JMZ5, D6RH08, O60656, P06133, P16662, P19224, P22309, P22310, P35503, Q9HAW7, Q9HAW8, Q9HAW9 Substrates: -
Products: -
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
beta-estradiol + UDPglucuronate
beta-estradiol-3-glucuronide + UDP
-
Substrates: inactive
Products: -
?
bifonazole + UDP-alpha-D-glucuronate
bifonazole D-glucuronate + UDP
-
Substrates: -
Products: -
?
bilirubin + UDP-glucuronate
?
Substrates: -
Products: -
?
bilirubin + UDP-glucuronate
bilirubin D-glucuronate + UDP
-
Substrates: -
Products: -
?
bilirubin + UDP-glucuronate
bilirubin glucuronoside + UDP
Substrates: UGT1A1 exhibits the highest tranilast glucuronosyltransferase activity (13.5 pmol/min/mg protein)
Products: -
?
bilirubin + UDP-glucuronate
UDP + bilirubin-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
bilirubin + UDPglucuronate
UDP + bilirubin O-glucuronide
-
Substrates: -
Products: -
?
borneol + UDPglucuronate
UDP + borneol O-glucuronide
buprenorphine + UDPglucuronate
UDP + buprenorphine O-glucuronide
-
Substrates: -
Products: -
?
C-1748 + UDP-glucuronate
UDP + C-1748 O-glucuronide
cannabinol + UDP-glucuronate
? + UDP
-
Substrates: substrate for hepatic isoform UGT1A9 and extrahepatic UGT1A7, UGT1A8, and UGT1A10
Products: -
?
carvacrol + UDP-glucuronate
caervcrol O-glucuronate + UDP
-
Substrates: isoform UGT1A9 is the major isozyme responsible for glucuronidation in liver microsomes, and isoform UGT1A7 plays a major role for glucuronidation in intestinal microsomes
Products: -
?
chenodeoxycholic acid + UDP-glucuronate
UDP + ?
chenodeoxycholic acid + UDP-glucuronate
UDP + chenodeoxycholic acid 24-acyl-beta-D-glucuronide
Substrates: -
Products: -
?
chenodeoxycholic acid + UDP-glucuronate
UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
Substrates: -
Products: -
?
cholic acid + UDPglucuronate
cholic acid O-glucuronide
-
Substrates: -
Products: -
?
clofibrate + UDPglucuronate
UDP + ?
-
Substrates: glucuronidated by UGT2B7
Products: -
?
codeine + UDPglucuronate
codeine-6-glucuronide + UDP
-
Substrates: glucuronidated by HGT2B7H and HGT2B7Y
Products: -
?
deferiprone + UDP-glucuronate
deferiprone 3-O-glucuronide + UDP
-
Substrates: -
Products: -
?
deoxycholic acid + UDPglucuronate
UDP + deoxycholic acid O-glucuronide
-
Substrates: -
Products: -
?
dibenzo(a,l)pyrene-11,12-diol + UDP-glucuronate
? + UDP
-
Substrates: -
Products: -
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-glucose
11-hydroxy-benzo[a]pyrene-12-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-glucose
12-hydroxy-benzo[a]pyrene-11-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-xylose
11-hydroxy-benzo[a]pyrene-12-O-D-xyloside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-xylose
12-hydroxy-benzo[a]pyrene-11-O-D-glucoside + UDP
Substrates: UGT3A2-overexpressing microsomes
Products: -
?
diclofenac + UDP-alpha-D-glucuronate
diclofenac D-glucuronide + UDP
-
Substrates: -
Products: -
?
diclofenac + UDPalpha-D-glucuronate
UDP + ?
-
Substrates: UGT2B7 active at high rate, recombinant UGT1A9 active at moderate rate, UGT1A6 and UGT2B15 active at low rates
Products: -
?
dihydrotestosterone + UDP-alpha-D-glucuronate
dihydrotestosterone D-glucuronate + UDP
-
Substrates: -
Products: -
?
econazole + UDP-alpha-D-glucuronate
econazole D-glucuronate + UDP
-
Substrates: -
Products: -
?
edaravone + UDP-alpha-D-glucuronate
edaravone beta-D-glucuronate + UDP
-
Substrates: i.e. 3-methyl-1-phenyl-2-pyrazolin-5-one. Edaravone glucuronidation in liver microsomes and kidney microsomes exhibits biphasic kinetics. UDP glucuronosyltransferases UGT1A1, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B17 produce a significant amount of glucuronide metabolite. Among them, UGT1A9 exhibits the highest activity, followed by UGT2B17 and UGT1A7
Products: -
?
entacapone + UDP-glucuronate
UDP + entacapone-3-O-glucuronide
-
Substrates: -
Products: -
?
epirubicin + UDP-glucuronate
UDP + epirubicin beta-D-glucuronoside
epitestosterone + UDP-glucuronate
UDP + epitestosterone 17-O-glucuronide
epitestosterone + UDP-glucuronate
UDP + epitestosterone O-glucuronide
-
Substrates: glucuronidated by HGT2B7H and HGT2B7Y
Products: -
?
estradiol + UDP-alpha-D-glucuronate
UDP + estradiol 3-O-glucuronide
-
Substrates: substrate of isoform UGT1A1
Products: -
?
estradiol + UDP-glucuronate
?
Substrates: -
Products: -
?
estradiol + UDP-glucuronate
estradiol 3-O-glucuronate + UDP
Substrates: sigmoidal kinetics with n of 1.7
Products: -
?
estriol + UDP-glucuronate
?
estriol + UDPglucuronate
UDP + estriol-16 alpha-glucuronide
estrogen + UDP-glucuronate
?
estrone + UDP-glucuronate
UDP + estrone 3-O-glucuronide
Substrates: -
Products: -
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
etoposide + UDP-glucuronate
?
Substrates: -
Products: -
?
etoposide + UDP-glucuronate
UDP + etoposide glucuronide
eugenol + UDP-glucuronate
?
Substrates: -
Products: -
?
eugenol + UDP-glucuronate
UDP + eugenol-O-alpha-D-glucuronide
Substrates: -
Products: -
?
flavopiridol + UDP-glucuronate
UDP + flavopiridol beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
?
fluconazole + UDP-alpha-D-glucuronate
fluconazole D-glucuronate + UDP
-
Substrates: -
Products: -
?
flurbiprofen + UDP-glucuronate
?
Substrates: metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
Products: -
?
frusemide + UDP-alpha-D-glucuronate
frusemide D-glucuronide
-
Substrates: -
Products: -
?
glycolithocholic acid + UDPglucuronate
UDP + glycolithocholic acid O-glucuronide
-
Substrates: lowest activity among five bile acids studied
Products: -
?
glycyrrhetinic acid + UDP-glucuronate
UDP + glycyrrhetinic acid-3-O-glucuronide
-
Substrates: -
Products: -
?
hyodeoxycholic acid + UDP-glucuronate
?
hyodeoxycholic acid + UDPglucuronate
UDP + hyodeoxycholic acid O-glucuronide
-
Substrates: -
Products: -
?
ibuprofen + UDPglucuronate
UDP + ?
-
Substrates: -
Products: -
?
imipramine + UDP-glucuronate
UDP + ?
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
?
imipramine + UDPglucuronate
UDP + ?
-
Substrates: only UGP1AY shows activity
Products: -
?
itraconazole + UDP-alpha-D-glucuronate
?
-
Substrates: -
Products: -
?
ketoconazole + UDP-alpha-D-glucuronate
?
-
Substrates: -
Products: -
?
lamotrigine + UDP-alpha-D-glucuronate
lamotrigine D-glucuronate + UDP
-
Substrates: -
Products: -
?
lamotrigine + UDP-glucuronate
UDP + ?
-
Substrates: -
Products: -
?
lithocholic acid + UDPglucuronate
UDP + ?
lorazepam + UDP-glucuronate
?
Substrates: -
Products: -
?
miconazole + UDP-alpha-D-glucuronate
miconazole D-glucuronate + UDP
-
Substrates: -
Products: -
?
midazolam + UDP-alpha-D-glucuronate
midazolam D-glucuronide + UDP
-
Substrates: -
Products: -
?
milnacipran + UDP-glucuronate
?
Substrates: -
Products: -
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
morphine + UDP-glucuronate
UDP + morphine 3-beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
?
morphine + UDP-glucuronate
UDP + morphine 3-glucuronide + morphine 6-glucuronide
Substrates: -
Products: -
?
morphine + UDP-glucuronate
UDP + morphine-3-glucuronide
-
Substrates: -
Products: -
?
mycophenolate + UDP-glucuronate
?
Substrates: -
Products: -
?
mycophenolic acid + UDP-alpha-D-glucuronate
mycophenolic acid D-glucuronide
-
Substrates: -
Products: -
?
mycophenolic acid + UDP-glucuronate
UDP + mycophenolic acid beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
?
N-hydroxy-2-acetylaminofluorene + UDPglucuronate
UDP + N-hydroxy-2-acetylaminofluorene O-glucuronide
-
Substrates: glucuronidated by UGT1A3 in preference to the ring-hydroxylated derivatives
Products: -
?
N-hydroxy-2-naphthylamine + UDPglucuronate
UDP + N-hydroxy-2-naphthylamine-O-glucuronide
-
Substrates: -
Products: -
?
naproxen + UDP-glucuronate
naproxen glucuronide + UDP
-
Substrates: -
Products: -
?
octylgallate + UDPglucuronate
?
Substrates: -
Products: -
?
olanzapine + UDP-glucuronate
?
Substrates: -
Products: -
?
opiates + UDPglucuronate
opiates 6-O-glucuronides + UDP
-
Substrates: substrate for UGT2B7
Products: -
?
oxazepam + UDP-glucuronate
?
Substrates: -
Products: -
?
p-ethoxyphenylurea + UDP-glucuronate
?
Substrates: -
Products: -
?
profen + UDPglucuronate
UDP + ?
-
Substrates: glucuronidated by UGT2B7
Products: -
?
propofol + UDP-alpha-D-glucuronate
UDP + propofol D-glucuronide
propofol + UDP-glucuronate
UDP + propofol beta-D-glucuronoside
A0A0G2JMZ5, D6RH08, O60656, P06133, P16662, P19224, P22309, P22310, P35503, Q9HAW7, Q9HAW8, Q9HAW9 Substrates: -
Products: -
?
propofol + UDP-glucuronate
UDP + propofol O-glucuronide
Substrates: -
Products: -
?
quercetin + UDP-glucuronate
UDP + quercetin 7-glucuronide + quercetin 4'-glucuronide + quercetin 3'-glucuronide
Substrates: isoform UGT1A1 mainly converts quercetin into three monoglucuronides, including 7-glucuronide, 4'-glucuronide, and 3'-glucuronide
Products: -
?
quercetin + UDPglucuronate
UDP + quercetin O-glucuronide
-
Substrates: -
Products: -
?
retigabine + UDP-alpha-D-glucuronate
retigabine D-glucuronide
-
Substrates: -
Products: -
?
retigabine + UDP-glucuronate
UDP + retigabine N-glucuronide
-
Substrates: -
Products: -
?
scopoletin + UDP-glucuronate
?
Substrates: -
Products: -
?
scopoletin + UDP-glucuronate
UDP + scopoletin O-glucuronide
scopoletin + UDPglucuronate
UDP + scopoletin O-glucuronide
senecionine + UDP-alpha-D-glucuronate
senecionine N-glucuronide + UDP
-
Substrates: senecionine is a representative of the hepatotoxic pyrrolizidine alkaloids. Glucuronidation is mediated by isofrom UGT1A4 and follows typical Michaelis-Menten kinetics
Products: -
?
serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
serotonin + UDP-glucuronate
UDP + serotonin beta-D-glucuronide
serotonin + UDP-glucuronate
UDP + serotonin O-glucuronide
Substrates: -
Products: -
?
silybin A + UDP-glucuronate
UDP + ?
Substrates: -
Products: -
?
silybin B + UDP-glucuronate
UDP + ?
Substrates: -
Products: -
?
silydianin + UDP-glucuronate
UDP + silydianin beta-D-glucuronide
Substrates: -
Products: -
?
SN-38 + UDP-glucuronate
UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
?
sulconazole + UDP-alpha-D-glucuronate
sulconazole D-glucuronate + UDP
-
Substrates: -
Products: -
?
sulfinpyrazone + UDP-alpha-D-glucuronate
sulfinpyrazone D-glucuronide
-
Substrates: -
Products: -
?
tamoxifen + UDP-alpha-D-glucuronate
tamoxifen-N-glucuronate + UDP
-
Substrates: -
Products: -
?
tamoxifen + UDP-glucuronate
UDP + ?
-
Substrates: -
Products: -
?
testosterone + UDP-glucuronate
UDP + testosterone 17-O-glucuronide
-
Substrates: isoform UGT2B17 is the most active enzyme in testosterone glucuronidation. Isoform UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics
Products: -
?
testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
Substrates: no activity
Products: -
?
thyroxine + UDP-glucuronate
UDP + thyroxine beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
?
tioconazole + UDP-alpha-D-glucuronate
tioconazole D-glucuronate + UDP
-
Substrates: -
Products: -
?
tranilast + UDP-glucuronate
tranilast glucuronoside + UDP
Substrates: -
Products: -
?
trans-4-hydroxytamoxifen + UDP-glucuronate
UDP + ?
-
Substrates: -
Products: -
?
trans-androsterone + UDP-alpha-D-glucuronate
trans-androsterone D-glucuronate + UDP
-
Substrates: -
Products: -
?
trans-endoxifen + UDP-glucuronate
UDP + ?
-
Substrates: -
Products: -
?
trifluoperazine + UDP-glucuronate
UDP + ?
-
Substrates: substrate for isoform UGT1A4 and isoform UGT1A1 mutant H39P
Products: -
?
trifluoperazine + UDP-glucuronate
UDP + trifluoperazine beta-D-glucuronoside
A0A0G2JMZ5, D6RH08, O60656, P06133, P16662, P19224, P22309, P22310, P35503, Q9HAW7, Q9HAW8, Q9HAW9 Substrates: -
Products: -
?
trifluoperazine + UDP-glucuronate
UDP + trifluoperazine N-glucuronide
Substrates: -
Products: -
?
trifluoperazine dihydrochloride + UDP-glucuronate
UDP + ?
Substrates: substrate for isoform UGT1A4
Products: -
?
troglitazone + UDPglucuronate
UDP + troglitazone 6-O-glucuronide
-
Substrates: -
Products: -
?
UDP-alpha-D-glucuronate + (R)-propranolol
UDP + (R)-propranolol beta-D-glucuronoside
UDP-alpha-D-glucuronate + (S)-naproxen
UDP + beta-D-glucuronosyl (S)-naproxen
-
Substrates: -
Products: -
?
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
UDP-alpha-D-glucuronate + 3-hydroxyflavone
UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone
Substrates: isozyme UGT1A1
Products: -
?
UDP-alpha-D-glucuronate + chloramphenicol
UDP + chloramphenicol beta-D-glucuronide
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
?
UDP-alpha-D-glucuronate + diclofenac
UDP + diclofenac O-beta-D-glucuronide
Substrates: -
Products: -
?
UDP-alpha-D-glucuronate + dopamine
UDP + dopamine 3-O-beta-D-glucopyranosiduronic acid
-
Substrates: substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested
Products: -
?
UDP-alpha-D-glucuronate + dopamine
UDP + dopamine 4-O-beta-D-glucopyranosiduronic acid
-
Substrates: -
Products: substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested
?
UDP-alpha-D-glucuronate + sorafenib
UDP + ?
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
?
UDP-alpha-glucuronate + diclofenac
UDP + beta-D-glucuronosyl-diclofenac
-
Substrates: -
Products: -
?
UDP-D-glucuronate + 1-naphthol
UDP + 1-naphthyl beta-D-glucuronoside
UDP-D-glucuronate + 11alpha-hydroxyprogesterone
UDP + 11alpha-hydroxyprogesterone 11-O-beta-D-glucuronoside
Substrates: an UGT2B7 substrate
Products: -
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-beta-D-glucuronoside
Substrates: -
Products: -
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol-3-O-beta-D-glucuronoside
-
Substrates: -
Products: -
?
UDP-D-glucuronate + 1alpha,25-dihydroxyvitamin D3
UDP + 1alpha,25-dihydroxyvitamin D3 25-O-beta-D-glucuronoside
Substrates: among 12 different UGT isozymes tested, only UGT1A4, and also UGT2B4 and UGT2B7 support the reaction, the main product by UGT1A4 supersomes and human liver microsomes is the 25-O-glucuronide, product identification and determination by mass spectral and NMR analyses, overview
Products: -
?
UDP-D-glucuronate + 2-hydroxyestradiol
UDP + 2-hydroxyestradiol beta-D-glucuronoside
Substrates: isozyme UGT1A1
Products: -
?
UDP-D-glucuronate + 2-hydroxyestrone
UDP + 2-hydroxyestrone beta-D-glucuronoside
Substrates: isozyme UGT1A1
Products: -
?
UDP-D-glucuronate + 2-naphthol
UDP + 2-naphthyl beta-D-glucuronoside
UDP-D-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine 5'-O-beta-D-glucuronoside
Substrates: model substrate for determination of glucuronidation with respect to specificity, linearity, detection limit, recovery, stability, precision and accuracy, method development and validation for assay and chromatographic determination of reaction products, overview
Products: -
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UDP-D-glucuronate + 3-hydroxydesloratadine
UDP + 3-hydroxydesloratadine beta-O-D-glucuronoside
Substrates: specific substrate of isozyme UGT1A8
Products: -
?
UDP-D-glucuronate + 4'-hydroxy-warfarin
UDP + 4'-hydroxy-warfarin beta-D-glucuronoside
Substrates: substrate of isozyme UGT1A10
Products: -
?
UDP-D-glucuronate + 4-(trifluoromethyl)-umbelliferone
UDP + 4-(trifluoromethyl)-umbelliferone beta-D-glucuronoside
-
Substrates: -
Products: -
?
UDP-D-glucuronate + 4-hydroxy-estrone
UDP + ?
Substrates: -
Products: -
?
UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen
UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronoside
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferonyl beta-D-glucuronoside
Substrates: -
Products: -
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-O-glucuronoside
Substrates: -
Products: -
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronoside
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-O-D-glucuronoside
Substrates: -
Products: -
?
UDP-D-glucuronate + 5alpha-androstane-3alpha,17beta-diol
UDP + ?
-
Substrates: -
Products: -
?
UDP-D-glucuronate + 6-hydroxy-warfarin
UDP + 6-hydroxy-warfarin beta-D-glucuronoside
UDP-D-glucuronate + 7-hydroxy-warfarin
UDP + 7-hydroxy-warfarin beta-D-glucuronoside
UDP-D-glucuronate + 8-hydroxy-warfarin
UDP + 8-hydroxy-warfarin beta-D-glucuronoside
UDP-D-glucuronate + acacetin
UDP + acacetin 7-O-beta-D-glucuronoside
-
Substrates: -
Products: -
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
UDP-D-glucuronate + anthraflavic acid
UDP + ?
-
Substrates: -
Products: -
?
UDP-D-glucuronate + apigenin
UDP + apigenin 7-O-beta-D-glucuronoside
-
Substrates: -
Products: -
?
UDP-D-glucuronate + beta-D-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronoside
Substrates: isozyme UGT1A1
Products: -
?
UDP-D-glucuronate + beta-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronoside
-
Substrates: -
Products: -
?
UDP-D-glucuronate + bilirubin
UDP + ?
-
Substrates: -
Products: -
?
UDP-D-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
Substrates: isozyme UGT1A1
Products: -
?
UDP-D-glucuronate + bisdemethoxy-curcumin
UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide
-
Substrates: -
Products: -
?
UDP-D-glucuronate + candesartan
UDP + candesartan beta-D-glucuronoside
-
Substrates: isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, also isozyme UGT2B7 glucuronidates candesartan at the tetrazole-N2 position, whereas isozymes UGT1A7, UGT1A8, UGT1A9, and UGT1A10 mainly yield candesartan O-glucuronide
Products: -
?
UDP-D-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronoside
-
Substrates: -
Products: -
?
UDP-D-glucuronate + chenodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
Substrates: isozyme UGT2A3
Products: -
?
UDP-D-glucuronate + cis-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
UDP-D-glucuronate + cotinine
UDP + ?
UDP-D-glucuronate + curcumin
UDP + curcumin beta-D-glucuronoside
-
Substrates: low activity, can reverse the inhibitory effect of curcumin on UGTs
Products: -
?
UDP-D-glucuronate + curcumin
UDP + curcumin phenolic beta-D-monoglucuronide
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
UDP-D-glucuronate + demethoxy-curcumin
UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide
-
Substrates: -
Products: -
?
UDP-D-glucuronate + deoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
Substrates: isozyme UGT2A3
Products: -
?
UDP-D-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone 17-O-beta-D-glucuronoside
UDP-D-glucuronate + eriodictyol
UDP + eriodictyol 7-O-beta-D-glucuronoside
-
Substrates: -
Products: -
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
UDP-D-glucuronate + estradiol
UDP + estradiol-3-beta-D-glucuronoside
UDP-D-glucuronate + estriol
UDP + ?
-
Substrates: -
Products: -
?
UDP-D-glucuronate + estriol
UDP + estriol 3-O-beta-D-glucuronoside
-
Substrates: -
Products: -
?
UDP-D-glucuronate + estriol
UDP + estriol glucuronoside
Substrates: -
Products: -
?
UDP-D-glucuronate + eugenol
UDP + eugenol beta-D-glucuronoside
UDP-D-glucuronate + flurbiprofen
UDP + flurbiprofen beta-D-glucuronoside
-
Substrates: isozyme UGT2B7
Products: -
?
UDP-D-glucuronate + frusemide
UDP + frusemide beta-D-glucuronoside
UDP-D-glucuronate + gemfibrozil
UDP + gemfibrozil beta-D-glucuronoside
UDP-D-glucuronate + hesperetin
UDP + hesperetin 7-O-beta-D-glucuronoside
-
Substrates: -
Products: -
?
UDP-D-glucuronate + homoeriodictyol
UDP + homoeriodictyol 7-O-beta-D-glucuronoside
-
Substrates: -
Products: -
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UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 24-carboxy-glucuronoside
Substrates: recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
Products: product formation depends on the isozyme, overview
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UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 3-O-glucuronoside
Substrates: recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
Products: product formation depends on the isozyme, overview
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UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
UDP-D-glucuronate + imipramine
UDP + imipramine N-beta-D-glucuronoside
Substrates: reaction of isozyme UGT1A4
Products: -
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UDP-D-glucuronate + isolongifolol
UDP + isolongifolol beta-D-glucuronoside
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Substrates: the compound is substrate and competitive inhibitor
Products: -
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UDP-D-glucuronate + kaempferol
UDP + kaempferol 7-O-beta-D-glucuronoside
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Substrates: -
Products: -
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UDP-D-glucuronate + labetalol
UDP + ?
UDP-D-glucuronate + longifolol
UDP + longifolol beta-D-glucuronoside
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Substrates: the compound is substrate and competitive inhibitor
Products: -
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UDP-D-glucuronate + losartan
UDP + losartan beta-D-glucuronoside
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Substrates: no O-glucuronide is generated by any isozyme, while isozymes UGT1A1, UGT1A3, 1A10, UGT2B7, and UGT2B17 glucuronidate losartan at the tetrazole-N2, isozyme UGT1A10 also yields the respective N1-glucuronide, isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring
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UDP-D-glucuronate + luteolin
UDP + luteolin 7-O-beta-D-glucuronoside
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Substrates: -
Products: -
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UDP-D-glucuronate + menadiol
UDP + mendadiol 1-O-beta-D-glucuronoside
UDP-D-glucuronate + menadiol
UDP + mendadiol 4-O-beta-D-glucuronoside
UDP-D-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
Substrates: activity of isozyme UGT1A8
Products: -
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UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
UDP-D-glucuronate + morphine
UDP + morphine 6-beta-D-glucuronoside
UDP-D-glucuronate + mycophenolic acid
UDP + mycophenolic acid beta-D-glucuronoside
Substrates: K314 and K404m are determined binding sites required for UDP-glcA binding to isozyme UGT1A10, overview
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UDP-D-glucuronate + myricetin
UDP + myricetin 7-O-beta-D-glucuronoside
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Substrates: -
Products: -
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UDP-D-glucuronate + naringenin
UDP + naringenin 7-O-beta-D-glucuronoside
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Substrates: -
Products: -
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UDP-D-glucuronate + nicotine
UDP + ?
UDP-D-glucuronate + octylgallate
UDP + octylgallate beta-D-glucuronoside
UDP-D-glucuronate + phenolphthalein
UDP + phenolphthalein beta-D-glucuronoside
Substrates: an UGT2B15 substrate
Products: -
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UDP-D-glucuronate + phenolphthalein
UDP + phenolphthalein beta-D-monoglucuronoside
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Substrates: -
Products: -
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UDP-D-glucuronate + phloretin
UDP + ?
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Substrates: -
Products: -
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UDP-D-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
UDP-D-glucuronate + protocatechuic aldehyde
UDP + ?
UDP-D-glucuronate + quercetin
UDP + quercetin 7-O-beta-D-glucuronoside
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Substrates: -
Products: -
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UDP-D-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronoside
UDP-D-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
Substrates: isozyme UGT1A6
Products: -
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UDP-D-glucuronate + serotonin
UDP + serotonin O-beta-D-glucuronoside
Substrates: reaction of isozyme UGT1A6
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UDP-D-glucuronate + tamoxifen + H+
UDP + tamoxifen beta-D-glucuronoside
UDP-D-glucuronate + testosterone
UDP + testosterone 17-O-beta-D-glucuronoside
Substrates: an UGT2B15 substrate
Products: -
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UDP-D-glucuronate + thyroxine
UDP + thyroxine beta-D-glucuronoside
UDP-D-glucuronate + trans-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
UDP-D-glucuronate + trifluoperazine
UDP + trifluoperazine beta-D-glucuronoside
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Substrates: -
Products: -
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UDP-D-glucuronate + umbelliferone
UDP + umbelliferyl beta-D-glucuronoside
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Substrates: -
Products: -
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UDP-D-glucuronate + ursodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
Substrates: isozyme UGT2A3
Products: -
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UDP-D-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
UDP-D-glucuronate + zolarsartan
UDP + zolarsartan beta-D-glucuronoside
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Substrates: isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, the tetrazole-N1 of this aglycone is accessible to other enzymes, including isozyme UGT1A5, zolarsartan O-glucuronide is mainly produced by isozyme UGT1A10 and isozyme UGT2B7
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UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime
UDP + 1-O-[(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime]-beta-D-glucuronate
UDP-glucuronate + (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid
UDP + ?
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Substrates: i.e. NI-12a, low activity, NI-12a is glucuronidated at both the -COOH and -OH functions. NI-12a is primarily metabolized by the hepatic and renal enzyme UGT1A9
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UDP-glucuronate + (S)-oxazepam
UDP + (S)-oxazepam beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
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UDP-glucuronate + 1,25-dihydroxyergocalciferol
UDP + 1,25-dihydroxyergocalciferol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + 1-hydroxypyrene
UDP + 1-hydroxypyrene beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
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UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
UDP-glucuronate + 1-naphthol
UDP + beta-D-glucuronosyl-(1-naphthol)
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Substrates: -
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UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 4'-O-beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P54855, Q9HAW7, Q9HAW8, Q9HAW9 Substrates: -
Products: -
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UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 5-O-beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P54855, Q9HAW7, Q9HAW8, Q9HAW9 Substrates: -
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UDP-glucuronate + 12-hydroxyeicosatetraenoic acid
UDP + 12-hydroxyeicosatetraenoyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + 12-hydroxyeicosatetraenoic acid
UDP + 12-hydroxyeicosatetraenoyl-beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + 15-hydroxyeicosatetraenoic acid
UDP + 15-hydroxyeicosatetraenoyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + 15-hydroxyeicosatetraenoic acid
UDP + 15-hydroxyeicosatetraenoyl-beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
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UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
UDP-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-glucuronide
Substrates: -
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UDP-glucuronate + 17beta-estriol
UDP + estriol 17-beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + 2',4'-dihydroxychalcone
UDP + 2'-hydroxychalcone 4'-O-beta-D-glucuronoside
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Substrates: glucuronidation at the OH-4' position by UGT1A1 and UGT1A10 isoforms, both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide
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UDP-glucuronate + 2',4'-dihydroxychalcone
UDP + 4'-hydroxychalcone 2'-O-beta-D-glucuronoside
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Substrates: glucuronidation at the OH-2' position with low activity by UGT1A7, UGT1A6, and UGT1A10 isoforms, and with high activity by isozyme UGT1A9. Both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide
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UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone
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UDP-glucuronate + 2'-hydroxychalcone
UDP + chalcone 2'-O-beta-D-glucuronoside
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Substrates: glucuronidation at the OH-2' position by UGT1A9 isoform
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UDP-glucuronate + 2-hydroxyestrone
UDP + 2-hydroxyestrone beta-D-glucuronide
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Substrates: -
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UDP-glucuronate + 2-methoxyestrone
UDP + 2-methoxyestrone beta-D-glucuronide
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Substrates: -
Products: -
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UDP-glucuronate + 20-hydroxyeicosatetraenoic acid
UDP + 20-hydroxyeicosatetraenoyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
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UDP-glucuronate + 25-hydroxyergocalciferol
UDP + 25-hydroxyergocalciferol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
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UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronide
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Substrates: isozymes UGT2B4, UGT2B7, and UGT2B17
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UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
Substrates: -
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UDP-glucuronate + 3,17-estradiol
UDP + 17-estradiol 3-O-glucuronide
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Substrates: isozyme UGT1A1
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UDP-glucuronate + 3,17-estradiol
UDP + 3-estradiol 17-O-glucuronide
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Substrates: isozyme UGT1A1
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UDP-glucuronate + 3,2'-dihydroxychalcone
UDP + 3-hydroxychalcone 2'-O-beta-D-glucuronoside
UDP-glucuronate + 3-epideacetycinobufagin
UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
UDP-glucuronate + 3alpha,5beta-tetrahydroaldosterone
UDP + 3alpha,5beta-tetrahydroaldosterone beta-D-glucuronide
Substrates: high activity
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UDP-glucuronate + 4,2'-dihydroxychalcone
UDP + 4-hydroxychalcone 2'-O-beta-D-glucuronoside
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Substrates: glucuronidation at the OH-2' position by UGT1A8, UGT1A1, and UGT1A3 isoforms. The A-ring OH-4 group promotes glucuronidation at the 2' position for the reaction of the exclusive substrate 4,2'-dihydroxychalcone of UGT1A1 and 1A3
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UDP-glucuronate + 4-aminobiphenyl
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Substrates: -
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UDP-glucuronate + 4-ethylphenol
UDP + beta-D-glucuronosyl-(4-ethylphenol)
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Substrates: -
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UDP-glucuronate + 4-hydroxy-estrone
UDP + ?
Substrates: glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy
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UDP-glucuronate + 4-hydroxyestradiol
UDP + 4-hydroxyestradiol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
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UDP-glucuronate + 4-hydroxyretinoic acid
UDP + 4-hydroxyretinoic acid beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: mainly conjugated by UGT2B7
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UDP-glucuronate + 4-methoxyestrone
UDP + 4-methoxyestrone beta-D-glucuronide
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Substrates: -
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UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl-beta-D-glucuronide
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Substrates: all isozymes, nonselective substrate
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UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl-beta-D-glucuronoside
Substrates: -
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UDP-glucuronate + 4-methylumbelliferone
UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
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Substrates: -
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UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenol beta-D-glucuronide
Substrates: -
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UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronide
Substrates: recombinant isozyme UGT1A6 from lymphoblasts or insect cells
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UDP-glucuronate + 4-nitrophenol
UDP + beta-D-glucuronosyl-(4-nitrophenol)
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Substrates: -
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UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxy-tryptophol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
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UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxytryptophol beta-D-glucuronide
Substrates: isozymes UGT1A6 and UGT1A9, the latter shows over 20fold lower activity
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UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxytryptophol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: mucosal serotonin and its metabolite 5-hydroxytryptophol are solely conjugated by UGT1A6
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UDP-glucuronate + 5alpha-dihydroaldosterone
UDP + 5alpha-dihydroaldosterone beta-D-glucuronide
Substrates: -
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UDP-glucuronate + 5alpha-tetrahydrocortisone
UDP + 5alpha-tetrahydrocortisone beta-D-glucuronide
Substrates: -
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UDP-glucuronate + 5beta-tetrahydrocortisone
UDP + 5beta-tetrahydrocortisone beta-D-glucuronide
Substrates: -
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UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 4'-O-beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P54855, Q9HAW7, Q9HAW8, Q9HAW9 Substrates: -
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UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 5-O-beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P54855, Q9HAW7, Q9HAW8, Q9HAW9 Substrates: -
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UDP-glucuronate + 6-hydroxymelatonin
UDP + 6-hydroxymelatonin beta-D-glucuronide
Substrates: -
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UDP-glucuronate + 7-ethyl-10-hydroxy-camptothecin
UDP + 7-ethyl-10-hydroxy-camptothecin beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: i.e. SN-38, an active metabolite of irinotecan
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UDP-glucuronate + 7-ethyl-10-hydroxycampothecin
UDP + 7-ethyl-10-hydroxycampothecin 1-O-beta-D-glucuronide
Substrates: i.e. SN-38, isozymes UGT1A1, UGT1A7, and UGT1A9
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UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin
UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
Substrates: i.e. SN-38, an active metabolite of irinotecan
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UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin
UDP + 4-trifluoromethylcoumarin 7-O-beta-D-glucuronide
Substrates: -
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UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
Substrates: -
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UDP-glucuronate + 7-hydroxyflavanone
UDP + flavanone 7-O-beta-D-glucuronoside
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Substrates: -
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UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 4'-O-beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P54855, Q9HAW7, Q9HAW8, Q9HAW9 Substrates: -
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UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 5-O-beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P54855, Q9HAW7, Q9HAW8, Q9HAW9 Substrates: -
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UDP-glucuronate + 8-hydroxyquinoline
UDP + 8-hydroxyquinoline beta-D-glucuronide
Substrates: -
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UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
UDP-glucuronate + acceptor
UDP + acceptor beta-glucuronoside
UDP-glucuronate + aldosterone
UDP + aldosterone beta-D-glucuronide
Substrates: -
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UDP-glucuronate + all-trans-retinoic acid
UDP + all-trans-retinoic acid beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: mainly conjugated by UGT2B7
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UDP-glucuronate + Aloe-emodin
UDP + Aloe-emodin beta-D-glucuronide
Substrates: isozyme UGT1A7
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UDP-glucuronate + alpinetin
UDP + alpinetin beta-D-glucuronoside
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Substrates: -
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UDP-glucuronate + amitriptyline
UDP + amitriptyline beta-D-glucuronoside
Substrates: -
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UDP-glucuronate + amitryptiline
UDP + amitryptiline beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
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UDP-glucuronate + androstane-3,17-diol
UDP + androstane-3,17-diol 17-O-beta-D-glucuronide
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Substrates: isozyme UGT2B15
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UDP-glucuronate + androstane-3,17-diol
UDP + beta-D-glucuronosyl-androstane-3,17-diol
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Substrates: -
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UDP-glucuronate + androstanediol
UDP + androstanediol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
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UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-glucuronide
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Substrates: isozyme UGT1A1
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UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-O-beta-D-glucuronide
UDP-glucuronate + apigenin
UDP + apigenin beta-D-glucuronide
UDP-glucuronate + asialo-orosomucoid
UDP + asialo-orosomucoid beta-D-glucuronide
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Substrates: acceptor is a glycoprotein, preferred substrate
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UDP-glucuronate + beta-estradiol
UDP + estradiol 3-beta-D-glucuronide
Substrates: -
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UDP-glucuronate + bilirubin
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Substrates: -
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UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
UDP-glucuronate + biochanin A
UDP + biochanin A beta-D-glucuronide
UDP-glucuronate + buprenorphine
UDP + buprenorphine glucuronide
-
Substrates: isozyme UGT1A1
Products: -
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UDP-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronide
UDP-glucuronate + cardamonin
UDP + cardamonin beta-D-glucuronoside
-
Substrates: UGT1A9 is the only isoform to glucuronidate cardamonin at the OH-2' position, lower activity with isozyme UGT1A7
Products: -
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UDP-glucuronate + carvedilol
UDP + carvedilol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + chenodeoxycholic acid
UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
UDP-glucuronate + cholic acid
UDP + cholic acid 24-beta-D-glucuronoside
UDP-glucuronate + chrysin
UDP + chrysin beta-D-glucuronide
UDP-glucuronate + citronellol
UDP + citronellol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + clozapine
UDP + clozapine beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + codeine
UDP + beta-D-glucuronosyl-codeine
-
Substrates: low activity
Products: -
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UDP-glucuronate + codeine
UDP + codeine beta-D-glucuronide
-
Substrates: isozymes UGT2B4 and UGT2B7
Products: -
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UDP-glucuronate + cotinine
UDP + cotinine N-beta-D-glucuronoside
Substrates: cotinine is a highly selective substrate of human liver microsomal UGT2B10
Products: -
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UDP-glucuronate + curcumin
UDP + curcumin beta-D-glucuronide
UDP-glucuronate + cyproheptadine
UDP + cyproheptadine beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + deferiprone
UDP + deferiprone beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
Substrates: -
Products: formation of 1 product metabolite termed G2
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UDP-glucuronate + deoxycholic acid
UDP + deoxycholic acid 24-beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + desmethylnaproxen
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UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
UDP-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + diphenhydramine
UDP + diphenhydramine beta-D-glucuronoside
UDP-glucuronate + dopamine
UDP + dopamine beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronide
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
UDP-glucuronate + epirubicin
UDP + epirubicin beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + epitestosterone
UDP + epitestosterone beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + estradiol
UDP + estradiol beta-D-glucuronide
-
Substrates: -
Products: -
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UDP-glucuronate + estradiol
UDP + estradiol beta-D-glucuronoside
UDP-glucuronate + estriol
UDP + estriol beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + estrone
UDP + estrone beta-D-glucuronide
-
Substrates: -
Products: -
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UDP-glucuronate + estrone
UDP + estrone beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + ethanol
UDP + ethyl beta-D-glucuronoside
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol glucuronide
-
Substrates: isozyme UGT1A1
Products: -
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UDP-glucuronate + etoposide
UDP + etoposide beta-D-glucuronide
Substrates: isozyme UGT1A1 is specific for etoposide
Products: -
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UDP-glucuronate + etoposide
UDP + etoposide beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + eugenol
UDP + beta-D-glucuronosyl-eugenol
-
Substrates: high activity
Products: -
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UDP-glucuronate + eugenol
UDP + eugenol beta-D-glucuronide
UDP-glucuronate + flavopiridol
UDP + flavopiridol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + flufenamic acid
?
Substrates: -
Products: -
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UDP-glucuronate + gemfibrozil
UDP + beta-D-glucuronosyl-gemfibrozil
-
Substrates: -
Products: -
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UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronide
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + gingerol
UDP + gingerol 4'-O-beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P54855, Q9HAW7, Q9HAW8, Q9HAW9 Substrates: -
Products: -
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UDP-glucuronate + grepafloxacin
UDP + grepafloxacin beta-D-glucuronide
UDP-glucuronate + hydromorphone
UDP + beta-D-glucuronosyl-hydromorphone
-
Substrates: -
Products: -
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UDP-glucuronate + hyocholic acid
UDP + hyocholic acid 24-beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + hyodeoxycholic acid
UDP + beta-D-glucuronosyl-hyodeoxycholic acid
-
Substrates: high activity
Products: -
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UDP-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 24G-beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholoyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + ibuprofen
UDP + beta-D-glucuronosyl-ibuprofen
-
Substrates: -
Products: -
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UDP-glucuronate + imipramine
UDP + imipramine beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + imipramine
UDP + imipramine beta-D-glucuronoside
UDP-glucuronate + imipramine
UDP + imipramine N-beta-D-glucuronoside
Substrates: specific substrate of UGT1A4
Products: -
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UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
UDP-glucuronate + ketoconazole
UDP + ketoconazole beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + ketoprofen
UDP + beta-D-glucuronosyl-ketoprofen
-
Substrates: -
Products: -
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UDP-glucuronate + ketotifen
UDP + ketotifen beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + ketotifen
UDP + ketotifenbeta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + L-thyroxine
UDP + L-thyroxyl beta-D-glucuronoside
UDP-glucuronate + lamotrigine
UDP + lamotrigine beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + leukotriene B4
UDP + leukotriene B4 beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + levofloxacin
UDP + levofloxacin beta-D-glucuronide
UDP-glucuronate + levomedetomidine
UDP + levomedetomidine beta-D-glucuronoside
UDP-glucuronate + lithocholic acid
UDP + lithocholic acid 3-beta-D-glucuronoside + lithocholic acid 24-beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + lorazepam
UDP + lorazepam beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + mefenamic acid
?
Substrates: -
Products: -
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UDP-glucuronate + midazolam
UDP + midazolam beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
UDP-glucuronate + morphine
UDP + morphine-3-beta-D-glucuronide
UDP-glucuronate + morphine
UDP + morphine-6-beta-D-glucuronide
UDP-glucuronate + morphine 3-glucuronide
UDP + ?
Substrates: -
Products: -
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UDP-glucuronate + morphine 3-glucuronide
UDP + morphine 3,6-diglucuronide
-
Substrates: -
Products: -
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UDP-glucuronate + moxifloxacin
UDP + moxifloxacin beta-D-glucuronide
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-acyl-glucuronide
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-phenyl-glucuronide
UDP-glucuronate + mycophenolic acid
UDP + mycophenoloyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + N-acetylserotonin
UDP + N-acetylserotonin beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + naphthol
UDP + naphthol glucuronide
-
Substrates: isozyme UGT1A6
Products: -
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UDP-glucuronate + naproxen
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UDP-glucuronate + naproxen
UDP + naproxen beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + naringenin
UDP + naringenin beta-D-glucuronide
UDP-glucuronate + niflumic acid
?
Substrates: -
Products: -
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UDP-glucuronate + olanzapine
UDP + olanzapine beta-D-glucuronoside
UDP-glucuronate + paracetamol
UDP + paracetamol beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + paracetamol
UDP + paracetamol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + paragloboside
UDP + paragloboside beta-D-glucuronide
-
Substrates: acceptor is a glycolipid, activity requires phosphatidylinositol
Products: -
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UDP-glucuronate + phenylbutazone
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Substrates: among 16 UDP-glucuronosyltransferase isoforms investigated, only UGT1A9 catalyzes PB C-glucuronidation
Products: -
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UDP-glucuronate + phloretin
UDP + phloretin beta-D-glucuronide
UDP-glucuronate + pizotifen
UDP + pizotifen beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + pregnan-3,17-diol
UDP + pregnan-3,17-diol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronide
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronide
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + quinazarin
UDP + quinazarin beta-D-glucuronide
UDP-glucuronate + quinizarin
UDP + quinizarin beta-D-glucuronide
Substrates: isozyme UGT1A7
Products: -
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UDP-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + serotonin
?
Substrates: -
Products: -
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UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronide
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
UDP-glucuronate + serotonin
UDP + serotonin beta-glucuronoside
Substrates: isozyme UGT2B7
Products: -
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UDP-glucuronate + sitafloxacin
UDP + sitafloxacin beta-D-glucuronide
UDP-glucuronate + tacrolimus
UDP + tacrolimus beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + tamoxifen
UDP + tamoxifen beta-D-glucuronoside
UDP-glucuronate + tamoxifen
UDP + tamoxifen N-beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronate + Telmisartan
UDP + Telmisartan beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + testosterone
UDP + testosterone beta-D-glucuronoside
UDP-glucuronate + thymol
UDP + thymol beta-D-glucuronide
UDP-glucuronate + thymol
UDP + thymol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + tigogenin
UDP + tigogenin beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + tolcapone
UDP + tolcapone beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + trans-androsterone
UDP + trans-androsterone beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + trans-resveratrol
UDP + trans-resveratrol beta-D-glucuronoside
-
Substrates: -
Products: -
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UDP-glucuronate + trifluoperazine
UDP + trifluoperazine beta-D-glucuronide
Substrates: isozyme UGT1A4
Products: -
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UDP-glucuronate + trifluoroperazine
UDP + trifluoroperazine beta-D-glucuronide
Substrates: -
Products: -
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UDP-glucuronate + trifluperazine
UDP + trifluperazine
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + umbelliferone
UDP + umbelliferone beta-D-glucuronide
UDP-glucuronate + valproic acid
UDP + beta-D-glucuronosyl-valproic acid
-
Substrates: -
Products: -
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UDP-glucuronate + vorinostat
UDP + vorinostat beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 Substrates: -
Products: -
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UDP-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
UDP-glucuronate + zidovudine
UDP + zidovudine O-beta-D-glucuronoside
Substrates: -
Products: -
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UDP-glucuronic acid + 7-hydroxy-4-(trifluoromethyl)-coumarin
UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide
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Substrates: UGT1A6, UGT1A9, and UGT2B7
Products: -
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UDP-glucuronic acid + beta-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronide
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Substrates: UGT1A3
Products: -
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UDP-glucuronic acid + bilirubin
UDP + bilirubin-glucuronoside
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Substrates: UGT1A1
Products: -
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UDP-glucuronic acid + diclofenac
UDP + diclofenac O-glucuronide
Substrates: -
Products: -
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UDP-glucuronic acid + imipramine
UDP + imipramine N-glucuronide
Substrates: -
Products: -
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UDP-glucuronic acid + serotonin
UDP + serotonin O-glucuronide
Substrates: -
Products: -
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UDP-glucuronic acid + trifluoperazine
UDP + ?
-
Substrates: UGT1A4
Products: -
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UDP-glucuronic acid + trifluoperazine
UDP + trifluoperazine N-glucuronide
Substrates: -
Products: -
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UDPglucuronate + naproxen
?
Substrates: UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug
Products: -
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ursodeoxycholic acid + UDPglucuronate
UDP + ursodeoxycholic acid O-glucuronide
valproic acid + UDPglucuronate
UDP + ?
vanillin + UDP-glucuronate
UDP + vanillin O-glucuronide
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Substrates: other 7 phenolic compounds show substrate activity on hUGT2A1
Products: -
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voriconazole + UDP-alpha-D-glucuronate
voriconazole D-glucuronate + UDP
-
Substrates: -
Products: -
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vorinostat + UDP-glucuronate
UDP + vorinostat beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
Products: -
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xanthotoxol + UDP-glucuronate
UDP + xanthotoxol 8-O-glucuronide
zidovudine + UDP-glucuronate
UDP + zidovudine beta-D-glucuronide
Substrates: substrate for isoform UGT2B7
Products: -
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zidovudine + UDP-glucuronate
UDP + zidovudine O-glucuronide
Substrates: -
Products: -
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zidovudine + UDP-glucuronate
UDP + zidovudine-5'-glucuronide
Substrates: -
Products: -
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additional information
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1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
Substrates: -
Products: -
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1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
Substrates: UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member
Products: -
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1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
-
Substrates: -
Products: -
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1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
Substrates: -
Products: -
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1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
Substrates: -
Products: -
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16alpha-hydroxyprogesterone + UDP-glucuronate
?
Substrates: -
Products: -
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16alpha-hydroxyprogesterone + UDP-glucuronate
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Substrates: UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation
Products: -
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16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
Substrates: -
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16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
Substrates: UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation
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2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
Substrates: low activity
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2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
Substrates: the major metabolic pathway of dexmedetomidine, i.e. (4S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3- and N1-glucuronides
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2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
Substrates: i.e. (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT1A4, overview
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2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
Substrates: i.e. (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT2B10, overview
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2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
Substrates: veryl low activity
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2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
Substrates: the major metabolic pathway of levomedetomidine, i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3-glucuronide
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2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
Substrates: i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT1A4, isozyme UGT1A4 shows low activity producing N1- and N3-glucuronides, overview
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2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
Substrates: i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT2B10, isozyme UGT2B10 exclusively produces N3-glucuronides, overview
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2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
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Substrates: -
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2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
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Substrates: glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine
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2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
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Substrates: glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine i humans
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2-hydroxyestradiol + UDPglucuronate
UDP + 2-hydroxyestradiol O-glucuronide
-
Substrates: -
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2-hydroxyestradiol + UDPglucuronate
UDP + 2-hydroxyestradiol O-glucuronide
Substrates: -
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2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
-
Substrates: -
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2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
Substrates: -
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2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
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Substrates: glucuronidated by UGT1A3 and HGT1A9
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3-hydroxybenzo(a)pyrene + UDP-glucuronate
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Substrates: -
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3-hydroxybenzo(a)pyrene + UDP-glucuronate
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Substrates: UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member
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3-hydroxydesloratadine + UDP-glucuronate
UDP + 3-hydroxydesloratadinyl-O-glucuronide
Substrates: specific substrate of isoform UGT1A8
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3-hydroxydesloratadine + UDP-glucuronate
UDP + 3-hydroxydesloratadinyl-O-glucuronide
Substrates: specific substrate of isoform UGT1A8, substrate of isoform UGT1A9 mutant N152A
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4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
Substrates: -
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4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
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Substrates: UGT2B7H and UGT2B7Y inactive
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4-hydroxyestradiol + UDPglucuronate
UDP + 4-hydroxyestradiol O-glucuronide
-
Substrates: -
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4-hydroxyestradiol + UDPglucuronate
UDP + 4-hydroxyestradiol O-glucuronide
Substrates: -
Products: -
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4-hydroxyestrone + UDP-glucuronate
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Substrates: -
Products: -
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4-hydroxyestrone + UDP-glucuronate
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Substrates: -
Products: -
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4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone 4-O-glucuronide
-
Substrates: -
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4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone 4-O-glucuronide
Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
-
Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
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Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
Substrates: -
Products: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
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Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
Substrates: -
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
Substrates: Phe90 and Phe93 are directly involved in the catalytic activity of UGT1A10 towards 4-methylumbelliferone
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4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
Substrates: very low rate of glucuronidation
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4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
Substrates: -
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4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
Substrates: -
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4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
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Substrates: -
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4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
Substrates: -
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4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
Substrates: -
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4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
Substrates: -
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4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
Substrates: Phe90 and Phe93 are directly involved in the catalytic activity of UGT1A10 towards 4-nitrophenol
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5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
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Substrates: -
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5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
Substrates: -
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7-hydroxy benzo(a)pyrene + UDP-glucuronate
?
Substrates: -
Products: -
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7-hydroxy benzo(a)pyrene + UDP-glucuronate
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Substrates: UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member
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7-hydroxy-4-trifluoromethylcoumarin + UDP-glucuronate
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
Substrates: -
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7-hydroxy-4-trifluoromethylcoumarin + UDP-glucuronate
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
Substrates: -
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9-hydroxybenzo(a)pyrene + UDP-glucuronate
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Substrates: -
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9-hydroxybenzo(a)pyrene + UDP-glucuronate
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Substrates: UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member
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acetaminophen + UDP-glucuronate
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Substrates: -
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acetaminophen + UDP-glucuronate
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Substrates: with human UGT1A6, only monoglucuronides are formed, which, however, can be converted to diglucuronides by UGT1A9
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androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
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Substrates: -
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androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
Substrates: -
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androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
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Substrates: glucuronidated by HGT2B7H and HGT2B7Y
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anthraflavic acid + UDPglucuronate
UDP + ?
-
Substrates: -
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anthraflavic acid + UDPglucuronate
UDP + ?
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Substrates: 3 and 7-hydroxyflavone also tested
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bakuchiol + UDP-glucuronate
UDP + bakuchiol beta-D-glucuronide
Substrates: bakuchiol is 1-(4-hydroxyphenyl)-3,7-dimethyl-3-vinyl-1,6-octadiene. Isoform UGT1A1 is a main contributor to glucuronidation of bakuchiol
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bakuchiol + UDP-glucuronate
UDP + bakuchiol beta-D-glucuronide
Substrates: bakuchiol is 1-(4-hydroxyphenyl)-3,7-dimethyl-3-vinyl-1,6-octadiene. Isoform UGT1A3 is a main contributor to glucuronidation of bakuchiol
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bakuchiol + UDP-glucuronate
UDP + bakuchiol beta-D-glucuronide
Substrates: bakuchiol is 1-(4-hydroxyphenyl)-3,7-dimethyl-3-vinyl-1,6-octadiene. Isoform UGT2B15 is a main contributor to glucuronidation of bakuchiol
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beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
Substrates: -
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beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
Substrates: substrate for isoform UGT1A1
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bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
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Substrates: -
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bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
Substrates: -
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borneol + UDPglucuronate
UDP + borneol O-glucuronide
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Substrates: -
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borneol + UDPglucuronate
UDP + borneol O-glucuronide
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Substrates: other 4 monoterpenoid tested on hUGT2A1
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C-1748 + UDP-glucuronate
UDP + C-1748 O-glucuronide
Substrates: C-1748 is 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine. The reaction is selectively catalyzed by isoform UGT2B17
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C-1748 + UDP-glucuronate
UDP + C-1748 O-glucuronide
Substrates: C-1748 is 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine. The reaction is selectively catalyzed by isoform UGT2B7
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chenodeoxycholic acid + UDP-glucuronate
UDP + ?
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Substrates: -
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chenodeoxycholic acid + UDP-glucuronate
UDP + ?
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Substrates: low activity in patients with liver cirrhosis and granulomatous hepatitis
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chenodeoxycholic acid + UDP-glucuronate
UDP + ?
Substrates: substrate for isoform UGT1A3
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epirubicin + UDP-glucuronate
UDP + epirubicin beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
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epirubicin + UDP-glucuronate
UDP + epirubicin beta-D-glucuronoside
Substrates: substrate for isoform UGT2B7
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epitestosterone + UDP-glucuronate
UDP + epitestosterone 17-O-glucuronide
Substrates: -
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epitestosterone + UDP-glucuronate
UDP + epitestosterone 17-O-glucuronide
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Substrates: epitestosterone glucuronidation is catalyzed mainly by UGT2B7. No substrate for isoform UGT2B17, but it binds epitestosterone with affinity similar to that of testosterone. Isoform UGT2A1 catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics
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estriol + UDP-glucuronate
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Substrates: -
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estriol + UDP-glucuronate
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Substrates: metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
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estriol + UDPglucuronate
UDP + estriol-16 alpha-glucuronide
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Substrates: -
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estriol + UDPglucuronate
UDP + estriol-16 alpha-glucuronide
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Substrates: UGT1A3 inactive
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estriol + UDPglucuronate
UDP + estriol-16 alpha-glucuronide
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Substrates: catalyzed by isozyme 1 but not by isozyme 2
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estrogen + UDP-glucuronate
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Substrates: UDP-glucuronosyltransferase 1A10 has been identified as the major isoform involved in the biotransformation of a wide range of phenolic substrates, including native estrogens and their oxidized metabolites
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estrogen + UDP-glucuronate
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Substrates: phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10
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estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
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Substrates: inactive
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estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
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Substrates: glucuronidated by UGT1A3 and HGT1A9
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etoposide + UDP-glucuronate
UDP + etoposide glucuronide
Substrates: -
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etoposide + UDP-glucuronate
UDP + etoposide glucuronide
Substrates: UGT1A1 is principally responsible for the formation of etoposide glucuronides, mainly in the form of phenolic glucuronide
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etoposide + UDP-glucuronate
UDP + etoposide glucuronide
Substrates: activity with UGT1A3 is much lower than activity with UGT1A1
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etoposide + UDP-glucuronate
UDP + etoposide glucuronide
Substrates: activity with UGT1A8 is much lower than activity with UGT1A1
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hyodeoxycholic acid + UDP-glucuronate
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Substrates: -
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hyodeoxycholic acid + UDP-glucuronate
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Substrates: -
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lithocholic acid + UDPglucuronate
UDP + ?
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Substrates: -
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lithocholic acid + UDPglucuronate
UDP + ?
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Substrates: highest activity among five bile acids studied
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morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
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Substrates: -
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morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
Substrates: -
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morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
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Substrates: substrate for UGT2B7
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morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
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Substrates: glucuronidated by HGT2B7H and HGT2B7Y at 3 and 6 hydroxy positions
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propofol + UDP-alpha-D-glucuronate
UDP + propofol D-glucuronide
-
Substrates: -
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propofol + UDP-alpha-D-glucuronate
UDP + propofol D-glucuronide
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Substrates: substrate of isoform UGT1A9
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scopoletin + UDP-glucuronate
UDP + scopoletin O-glucuronide
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Substrates: -
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scopoletin + UDP-glucuronate
UDP + scopoletin O-glucuronide
Substrates: -
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scopoletin + UDP-glucuronate
UDP + scopoletin O-glucuronide
Substrates: very low rate of glucuronidation
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scopoletin + UDPglucuronate
UDP + scopoletin O-glucuronide
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Substrates: -
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scopoletin + UDPglucuronate
UDP + scopoletin O-glucuronide
Substrates: -
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scopoletin + UDPglucuronate
UDP + scopoletin O-glucuronide
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Substrates: other 3 coumarines show substrate activity on hUGT2A1
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serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
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Substrates: -
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serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
Substrates: coexpression of UGT1A6 with UGT2B7 influences wild-type UGT1A6, increasing the normalized activity of UGT1A6
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serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
Substrates: highly selective substrate of UGT1A6 in human liver microsomes, with human UGT1A6, only monoglucuronides are formed, which, however, can be converted to diglucuronides by UGT1A9
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serotonin + UDP-glucuronate
UDP + serotonin beta-D-glucuronide
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
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serotonin + UDP-glucuronate
UDP + serotonin beta-D-glucuronide
Substrates: substrate for isoform UGT1A6
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testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
Substrates: -
Products: -
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testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855 Substrates: -
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testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
Substrates: UGT2B15 and UGT2B17 are the major enzyme forms involved in human liver microsomal testosterone 17beta-glucuronidation
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UDP-alpha-D-glucuronate + (R)-propranolol
UDP + (R)-propranolol beta-D-glucuronoside
Substrates: -
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UDP-alpha-D-glucuronate + (R)-propranolol
UDP + (R)-propranolol beta-D-glucuronoside
Substrates: high activity
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UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
Substrates: -
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UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
Substrates: high activity
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UDP-D-glucuronate + 1-naphthol
UDP + 1-naphthyl beta-D-glucuronoside
-
Substrates: -
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UDP-D-glucuronate + 1-naphthol
UDP + 1-naphthyl beta-D-glucuronoside