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Information on EC 2.4.1.17 - glucuronosyltransferase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC2.4.1.17

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2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.17 glucuronosyltransferase

This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.

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This record set is specific for:

Homo sapiens

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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Reaction Schemes

UDP-alpha-D-glucuronate

+

=

+

acceptor beta-D-glucuronoside

+

=

+

Synonyms

ugt1a1, udp-glucuronosyltransferase, ugt2b7, ugt1a9, ugt1a6, ugt1a, ugt2b17, ugt1a4, udp-glucuronyltransferase, udpgt, show all synonyms

show all synonyms

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1-naphthol glucuronyltransferase

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1-naphthol-UDP-glucuronosyltransferase

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17-OH steroid UDPGT

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17beta-hydroxysteroid UDP-glucuronosyltransferase

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1A10

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3,4-catechol estrogen specific UDPGTh-2

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3-OH androgenic UDPGT

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3alpha-hydroxysteroid UDP-glucuronosyltransferase

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4-hydroxybiphenyl UDP-glucuronosyltransferase

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4-methylumbelliferone UDP-glucuronosyltransferase

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4-nitrophenol UDP-glucuronosyltransferase

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4-nitrophenol UDP-glucuronyltransferase

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4-nitrophenol UDPGT

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bile acid uridine 5'-diphosphoglucuronyltransferase

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bilirubin glucuronyltransferase

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bilirubin monoglucuronide glucuronyltransferase

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bilirubin UDP-glucuronosyltransferase

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bilirubin UDPglucuronosyltransferase

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bilirubin UDPGT

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bilirubin uridine diphosphoglucuronyltransferase

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bilirubin-specific UDPGT isozyme 2

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ciramadol UDP-glucuronyltransferase

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DP-glucuronosyltransferase 1A3

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estriol UDP-glucuronosyltransferase

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estrone UDP-glucuronosyltransferase

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GlcAT-P

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GlcAT-S

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glucuronosyltransferase, uridine diphospho-

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glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol

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glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl

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glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin

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glucuronosyltransferase, uridine diphosphoglucuronate-estradiol

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glucuronosyltransferase, uridine diphosphoglucuronate-estriol

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glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-

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glucuronyltransferase

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glucuronyltransferase, uridine diphospho-GT

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HUG-BR2

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morphine glucuronyltransferase

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p-hydroxybiphenyl UDP glucuronyltransferase

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p-nitrophenol UDP-glucuronosyltransferase

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p-nitrophenol UDP-glucuronyltransferase

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p-nitrophenylglucuronosyltransferase

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p-phenylphenol glucuronyltransferase

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phenyl-UDP-glucuronosyltransferase

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PNP-UDPGT

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UDP glucuronate-estradiol-glucuronosyltransferase

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UDP glucuronate-estriol glucuronosyltransferase

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UDP glucuronic acid transferase

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UDP glucuronosyltransferase

show

UDP glucuronosyltransferase 1A4

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UDP glucuronosyltransferase 2B10

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UDP glucuronyltransferase

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UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase

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UDP-glucuronate-bilirubin glucuronyltransferase

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UDP-glucuronosyl-transferase 1A1

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UDP-glucuronosyltransferase

show

UDP-glucuronosyltransferase 1A1

show

UDP-glucuronosyltransferase 1A10

show

UDP-glucuronosyltransferase 1A3

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673300, 673305, 736005

UDP-glucuronosyltransferase 1A4

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658530, 674230, 736005

UDP-glucuronosyltransferase 1A5

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UDP-glucuronosyltransferase 1A6

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658518, 658527, 672123, 673033, 692038, 692114

UDP-glucuronosyltransferase 1A7

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UDP-glucuronosyltransferase 1A8

show

UDP-glucuronosyltransferase 1A9

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659783, 672123, 673300, 674230, 692035

UDP-glucuronosyltransferase 2A3

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UDP-glucuronosyltransferase 2B10

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UDP-glucuronosyltransferase 2B15

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UDP-glucuronosyltransferase 2B17

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UDP-glucuronosyltransferase 2B7

show

UDP-glucuronosyltransferase-1A10

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UDP-glucuronosyltransferases 2B15

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UDP-glucuronosyltransferases 2B7

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UDP-glucuronyltransferase

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UDPGA transferase

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UDPGA-glucuronyltransferase

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UDPglucuronate beta-D-glucuronosyltransferase

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UDPglucuronosyltransferase

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UDPGT

show

UFT1A9

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UGT

show

UGT 1A10

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isoform

UGT 1A3

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isoform

UGT 1A4

show

UGT 1A6

show

UGT 1A7

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isoform

UGT 1A8

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isoform

UGT 1A9

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isoform

UGT 2B15

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isoform

UGT 2B17

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isoform

UGT 2B4

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isoform

UGT 2B7

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isoform

UGT-1D

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UGT-1J

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UGT1-03

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UGT1-04

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UGT1-10

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UGT1-9

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UGT1.10

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UGT1.3

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UGT1.4

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UGT1.9

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UGT1A

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UGT1A1

show

UGT1A10

show

UGT1A3

show

UGT1A4

show

UGT1A5

show

UGT1A6

show

UGT1A7

show

UGT1A8

show

UGT1A9

show

UGT1D

-

UGT1J

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UGT2A1

Q9Y4X1

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UGT2A2

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UGT2A3

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694264, 735649, 736006

UGT2B10

show

UGT2B11

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UGT2B15

show

UGT2B17

show

UGT2B28

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UGT2B4

show

UGT2B7

show

UGT3A1

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UGT3A2

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uridine 5'-diphospho-glucuronosyltransferase

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uridine 5'-diphosphoglucuronyltransferase

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uridine diphosphate glucuronosyltransferase

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uridine diphosphate glucuronyltransferase

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uridine diphosphate-glucuronosyltransferase

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uridine diphosphate-glucuronosyltransferase 2 B15

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uridine diphosphate-glucuronosyltransferase 2B10

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uridine diphosphate-glucuronosyltransferase 2B11

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uridine diphosphate-glucuronosyltransferase 2B15

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uridine diphosphate-glucuronosyltransferase 2B17

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uridine diphosphate-glucuronosyltransferase 2B4

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uridine diphosphate-glucuronosyltransferase 2B7

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uridine diphosphoglucuronate-bilirubin glucuronosyltransferase

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uridine diphosphoglucuronosyltransferase

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uridine diphosphoglucuronyltransferase

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additional information

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UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

show the reaction diagram

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hexosyl group transfer

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UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)

This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.

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37205-52-0

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37277-52-4

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37277-66-0

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61969-98-0

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62213-43-8

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62213-47-2

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9030-08-4

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(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate

? + UDP

show the reaction diagram

-

substrate for isoforms UGT1A9 and UGT1A10

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?

(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate

? + UDP

show the reaction diagram

-

substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10

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?

(R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate

(R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP

show the reaction diagram

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-

?

(R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate

(R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP

show the reaction diagram

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-

?

(R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate

(R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP

show the reaction diagram

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-

-

?

(R)-propanolol + UDP-glucuronate

UDP + (R)-propanolol O-glucuronide

show the reaction diagram

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?

(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate

(S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP

show the reaction diagram

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-

?

(S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate

(S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP

show the reaction diagram

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-

-

-

?

(S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate

(S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP

show the reaction diagram

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-

-

-

?

(S)-naproxen + UDP-alpha-D-glucuronate

beta-D-glucuronosyl (S)-naproxen + UDP

show the reaction diagram

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?

(S)-naproxen + UDP-alpha-D-glucuronate

UDP + beta-D-glucuronosyl (S)-naproxen

show the reaction diagram

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-

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-

?

(S)-oxazepam + UDP-glucuronate

UDP + (S)-oxazepam beta-D-glucuronoside

show the reaction diagram

O60656, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855

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-

?

(S)-propanolol + UDP-glucuronate

UDP + (S)-propanolol O-glucuronide

show the reaction diagram

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-

?

1-hydroxy-benzo(a)pyrene + UDP-glucuronate

1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP

show the reaction diagram

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-

-

-

?

1-hydroxy-benzo[a]pyrene + UDP-D-glucose

benzo[a]pyrenil-1-O-D-glucoside + UDP

show the reaction diagram

UGT3A2-overexpressing microsomes

-

-

?

1-hydroxy-pyrene + UDP-D-xylose

pyrene 1-O-D-xyloside + UDP

show the reaction diagram

-

-

-

?

1-hydroxybenzo(a)pyrene + UDP-glucuronate

?

show the reaction diagram

show

1-hydroxypyrene + UDP-D-glucose

pyrene 1-O-D-glucoside + UDP

show the reaction diagram

-

-

-

?

1-hydroxypyrene + UDP-glucuronate

1-hydroxypyrene 1-O-glucuronate + UDP

show the reaction diagram

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-

-

-

?

1-hydroxypyrene + UDP-glucuronate

?

show the reaction diagram

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-

-

?

1-hydroxypyrene + UDP-glucuronate

pyrene 1-O-glucuronide + UDP

show the reaction diagram

-

-

-

?

1-hydroxypyrene + UDP-N-acetylglucosamine

pyrenil-1-O-(N-acetylglucosaminide) + UDP

show the reaction diagram

activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes

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-

?

1-hydroxy[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide

show the reaction diagram

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-

-

?

1-naphthol + UDP-alpha-D-glucuronate

1-naphthyl-O-glucuronide + UDP

show the reaction diagram

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-

?

1-naphthol + UDP-D-glucose

naphthyl-1-O-D-glucoside + UDP

show the reaction diagram

UGT3A2-overexpressing microsomes

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-

?

1-naphthol + UDP-glucuronate

1-naphthyl 1-O-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

1-naphthol + UDP-glucuronate

1-naphthyl-O-glucuronide + UDP

show the reaction diagram

O60656, O75795, P16662, P22309, P35503, P54855, Q9HAW7, Q9HAW8, Q9HAW9

-

-

-

?

1-naphthol + UDP-glucuronate

?

show the reaction diagram

O60656, P19224, P22309, P22310, P35503, Q9HAW7

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-

?

1-naphthol + UDP-glucuronate

naphth-1-yl-beta-D-glucuronide + UDP

show the reaction diagram

show

1-naphthol + UDP-glucuronate

UDP + naphth-1-yl-beta-D-glucuronide

show the reaction diagram

show

11alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate