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Information on EC 2.4.1.17 - glucuronosyltransferase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC2.4.1.17

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IUBMB Comments

This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.

The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
ugt1a1, udp-glucuronosyltransferase, ugt2b7, ugt1a9, ugt1a6, ugt1a, ugt2b17, ugt1a4, udp-glucuronyltransferase, udpgt, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-naphthol glucuronyltransferase
-
-
-
-
1-naphthol-UDP-glucuronosyltransferase
-
-
-
-
17-OH steroid UDPGT
-
-
-
-
17beta-hydroxysteroid UDP-glucuronosyltransferase
-
-
-
-
1A10
-
-
3,4-catechol estrogen specific UDPGTh-2
-
3-OH androgenic UDPGT
-
-
-
-
3alpha-hydroxysteroid UDP-glucuronosyltransferase
-
-
-
-
4-hydroxybiphenyl UDP-glucuronosyltransferase
-
-
-
-
4-methylumbelliferone UDP-glucuronosyltransferase
-
-
-
-
4-nitrophenol UDP-glucuronosyltransferase
-
-
-
-
4-nitrophenol UDP-glucuronyltransferase
-
-
-
-
4-nitrophenol UDPGT
-
-
-
-
bile acid uridine 5'-diphosphoglucuronyltransferase
-
-
-
-
bilirubin glucuronyltransferase
-
-
-
-
bilirubin monoglucuronide glucuronyltransferase
-
-
-
-
bilirubin UDP-glucuronosyltransferase
-
-
-
-
bilirubin UDPglucuronosyltransferase
-
-
-
-
bilirubin UDPGT
-
-
-
-
bilirubin uridine diphosphoglucuronyltransferase
-
-
-
-
bilirubin-specific UDPGT isozyme 2
-
ciramadol UDP-glucuronyltransferase
-
-
-
-
DP-glucuronosyltransferase 1A3
-
estriol UDP-glucuronosyltransferase
-
-
-
-
estrone UDP-glucuronosyltransferase
-
-
-
-
GlcAT-P
-
-
GlcAT-S
-
-
glucuronosyltransferase, uridine diphospho-
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estradiol
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estriol
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-
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-
-
-
glucuronyltransferase
-
-
glucuronyltransferase, uridine diphospho-GT
-
-
-
-
morphine glucuronyltransferase
-
-
-
-
p-hydroxybiphenyl UDP glucuronyltransferase
-
-
-
-
p-nitrophenol UDP-glucuronosyltransferase
-
-
-
-
p-nitrophenol UDP-glucuronyltransferase
-
-
-
-
p-nitrophenylglucuronosyltransferase
-
-
-
-
p-phenylphenol glucuronyltransferase
-
-
-
-
phenyl-UDP-glucuronosyltransferase
-
-
-
-
PNP-UDPGT
-
-
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-
UDP glucuronate-estradiol-glucuronosyltransferase
-
-
-
-
UDP glucuronate-estriol glucuronosyltransferase
-
-
-
-
UDP glucuronic acid transferase
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-
-
-
UDP glucuronosyltransferase
UDP glucuronosyltransferase 1A4
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-
UDP glucuronosyltransferase 2B10
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UDP glucuronyltransferase
-
-
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-
UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase
-
-
-
-
UDP-glucuronate-bilirubin glucuronyltransferase
-
-
-
-
UDP-glucuronosyl-transferase 1A1
-
-
UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1A1
UDP-glucuronosyltransferase 1A10
UDP-glucuronosyltransferase 1A3
-
UDP-glucuronosyltransferase 1A4
-
UDP-glucuronosyltransferase 1A5
-
UDP-glucuronosyltransferase 1A6
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UDP-glucuronosyltransferase 1A7
-
UDP-glucuronosyltransferase 1A8
UDP-glucuronosyltransferase 1A9
-
UDP-glucuronosyltransferase 2A3
-
UDP-glucuronosyltransferase 2B10
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UDP-glucuronosyltransferase 2B15
-
UDP-glucuronosyltransferase 2B17
-
UDP-glucuronosyltransferase 2B7
UDP-glucuronosyltransferase-1A10
-
UDP-glucuronosyltransferases 2B15
-
UDP-glucuronosyltransferases 2B7
-
UDP-glucuronyltransferase
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-
-
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UDPGA transferase
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-
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UDPGA-glucuronyltransferase
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-
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UDPglucuronate beta-D-glucuronosyltransferase
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-
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-
UDPglucuronosyltransferase
-
-
-
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UDPGT
UGT 1A10
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isoform
UGT 1A3
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isoform
UGT 1A4
UGT 1A6
UGT 1A7
-
isoform
UGT 1A8
-
isoform
UGT 1A9
-
isoform
UGT 2B15
-
isoform
UGT 2B17
-
isoform
UGT 2B4
-
isoform
UGT 2B7
-
isoform
UGT1A1
UGT1A10
UGT1A3
UGT1A4
UGT1A5
UGT1A6
UGT1A7
UGT1A8
UGT1A9
UGT2A1
Q9Y4X1
-
UGT2B10
UGT2B15
UGT2B17
UGT2B4
UGT2B7
uridine 5'-diphospho-glucuronosyltransferase
-
-
uridine 5'-diphosphoglucuronyltransferase
-
-
-
-
uridine diphosphate glucuronosyltransferase
-
-
uridine diphosphate glucuronyltransferase
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-
-
-
uridine diphosphate-glucuronosyltransferase
-
uridine diphosphate-glucuronosyltransferase 2 B15
-
uridine diphosphate-glucuronosyltransferase 2B10
-
uridine diphosphate-glucuronosyltransferase 2B11
-
uridine diphosphate-glucuronosyltransferase 2B15
-
uridine diphosphate-glucuronosyltransferase 2B17
-
uridine diphosphate-glucuronosyltransferase 2B4
-
uridine diphosphate-glucuronosyltransferase 2B7
-
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase
-
-
-
-
uridine diphosphoglucuronosyltransferase
-
-
-
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uridine diphosphoglucuronyltransferase
-
-
-
-
additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
CAS REGISTRY NUMBER
COMMENTARY hide
37205-52-0
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37277-52-4
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37277-66-0
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61969-98-0
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62213-43-8
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62213-47-2
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9030-08-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
show the reaction diagram
-
substrate for isoforms UGT1A9 and UGT1A10
-
-
?
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
show the reaction diagram
-
substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10
-
-
?
(R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(R)-propanolol + UDP-glucuronate
UDP + (R)-propanolol O-glucuronide
show the reaction diagram
-
-
-
-
?
(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(S)-naproxen + UDP-alpha-D-glucuronate
beta-D-glucuronosyl (S)-naproxen + UDP
show the reaction diagram
-
-
-
-
?
(S)-naproxen + UDP-alpha-D-glucuronate
UDP + beta-D-glucuronosyl (S)-naproxen
show the reaction diagram
-
-
-
-
?
(S)-oxazepam + UDP-glucuronate
UDP + (S)-oxazepam beta-D-glucuronoside
show the reaction diagram
-
-
-
?
(S)-propanolol + UDP-glucuronate
UDP + (S)-propanolol O-glucuronide
show the reaction diagram
-
-
-
-
?
1-hydroxy-benzo(a)pyrene + UDP-glucuronate
1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
1-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-1-O-D-glucoside + UDP
show the reaction diagram
UGT3A2-overexpressing microsomes
-
-
?
1-hydroxy-pyrene + UDP-D-xylose
pyrene 1-O-D-xyloside + UDP
show the reaction diagram
-
-
-
?
1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
1-hydroxypyrene + UDP-D-glucose
pyrene 1-O-D-glucoside + UDP
show the reaction diagram
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
1-hydroxypyrene 1-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
pyrene 1-O-glucuronide + UDP
show the reaction diagram
-
-
-
?
1-hydroxypyrene + UDP-N-acetylglucosamine
pyrenil-1-O-(N-acetylglucosaminide) + UDP
show the reaction diagram
activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
-
-
?
1-hydroxy[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide
show the reaction diagram
-
-
-
?
1-naphthol + UDP-alpha-D-glucuronate
1-naphthyl-O-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
1-naphthol + UDP-D-glucose
naphthyl-1-O-D-glucoside + UDP
show the reaction diagram
UGT3A2-overexpressing microsomes
-
-
?
1-naphthol + UDP-glucuronate
1-naphthyl 1-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
1-naphthol + UDP-glucuronate
1-naphthyl-O-glucuronide + UDP
show the reaction diagram
-
-
-
?
1-naphthol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
show the reaction diagram
1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
show the reaction diagram
11alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate
show the reaction diagram
-
-
-
?
12-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
show the reaction diagram
-
glucuronidated by UGT1A3, inactive towards benz[a]pyrene trans 4,5 and 7,8 dihydrodiols
-
?
12-hydroxyeicosatetraenoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
13-hydroxyoctadecadienoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
?
show the reaction diagram
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
show the reaction diagram
17-epiestriol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
17-epiestriol + UDP-glucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
17alpha-estradiol + UDP-alpha-D-glucuronate
? + UDP
show the reaction diagram
-
-
-
-
?
17beta-estradiol + UDP-alpha-D-glucuronate
? + UDP
show the reaction diagram
-
-
-
-
?
17beta-estradiol + UDP-glucuronate
?
show the reaction diagram
metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
2',4,4'-trihydroxychalcone + UDP-glucuronate
UDP + 2',4,4'-trihydroxychalcone 4'-O-glucoside + 2',4,4'-trihydroxychalcone 2'-O-glucoside
show the reaction diagram
-
i.e. isoliquiritigenin
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
show the reaction diagram
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate
?
show the reaction diagram
glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans
-
-
?
2-aminobiphenyl + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
2-hydroxyestradiol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
2-hydroxyestradiol + UDPglucuronate
UDP + 2-hydroxyestradiol O-glucuronide
show the reaction diagram
2-hydroxyestrone + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
show the reaction diagram
21-hydroxyprogesterone + UDP-glucuronate
UDP + 21-hydroxyprogesterone-21-O-D-glucuronate
show the reaction diagram
-
-
-
?
3 quercetin + 3 UDP-glucuronate
3 UDP + quercetin 7-glucuronide + quercetin 3-glucuronide + quercetin 3'-glucuronide
show the reaction diagram
isoform UGT1A9 mainly converts quercetin into three monoglucuronides, including 7-glucuronide, 3-glucuronide, and 3'-glucuronide
-
-
?
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
show the reaction diagram
-
substrate of isoform UGT2B7
-
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
show the reaction diagram
-
-
-
?
3-azido-4-chlorobenzoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
3-azidobenzoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
3-hydroxy-benzo(a)pyrene + UDP-glucuronate
3-hydroxy-benzo(a)pyrene 3-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
3-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-3-O-D-glucoside + UDP
show the reaction diagram
UGT3A2-overexpressing microsomes
-
-
?
3-hydroxybenzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
show the reaction diagram
-
-
-
?
3-hydroxydesloratadine + UDP-glucuronate
UDP + 3-hydroxydesloratadinyl-O-glucuronide
show the reaction diagram
4-aminobiphenyl + UDP-glucuronate
UDP + 4-aminobiphenyl N-glucuronide
show the reaction diagram
-
-
-
-
?
4-aminobiphenyl + UDPglucuronate
UDP + ?
show the reaction diagram
-
catalyzed by isozyme 1 but not by isozyme 2