Information on EC 2.4.1.160 - pyridoxine 5'-O-beta-D-glucosyltransferase

for references in articles please use BRENDA:EC2.4.1.160
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The expected taxonomic range for this enzyme is: Pisum sativum

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EC NUMBER
COMMENTARY hide
2.4.1.160
-
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RECOMMENDED NAME
GeneOntology No.
pyridoxine 5'-O-beta-D-glucosyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-glucose + pyridoxine = UDP + 5'-O-beta-D-glucosylpyridoxine
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
N-Glycan biosynthesis
-
-
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase
4'-Deoxypyridoxine and pyridoxamine can also act as acceptors, but more slowly.
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CAS REGISTRY NUMBER
COMMENTARY hide
83744-97-2
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
podded pea, L. cv. Kinusaya
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDPglucose + 4'-deoxypyridoxine
UDP + 5'-O-beta-D-glucosyl-4'-deoxypyridoxine
show the reaction diagram
-
-
-
-
?
UDPglucose + pyridoxamine
UDP + 5'-O-beta-D-glucosylpyridoxamine
show the reaction diagram
-
-
-
-
?
UDPglucose + pyridoxine
UDP + 5'-O-beta-D-glucosylpyridoxine
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDPglucose + pyridoxine
UDP + 5'-O-beta-D-glucosylpyridoxine
show the reaction diagram
-
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
required, Km: 1.0 mM
Mn2+
-
can replace Mg2+, 40% as effective as Mg2+
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4'-deoxypyridoxine
-
competitive inhibitor of pyridoxamine and pyridoxine glucosylation
pyridoxamine
-
competitive inhibitor of pyridoxine glucosylation
pyridoxine
-
competitive inhibitor of pyridoxamine glucosylation
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.26
pyridoxamine
-
-
0.25
pyridoxine
-
-
0.67
UDPglucose
-
cosubstrate pyridoxine
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8 - 8.8
-
pyridoxine + UDPglucose
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 9.5
-
about 50% of maximum activity at pH 7 and 9.5
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
assay at
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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LINKS TO OTHER DATABASES (specific for EC-Number 2.4.1.160)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)