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Information on EC 2.4.1.16 - chitin synthase and Organism(s) Neurospora crassa and UniProt Accession Q01285
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2.4.1.16 chitin synthaseIUBMB Comments
Converts UDP-N-acetyl-alpha-D-glucosamine into chitin and UDP.
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Word Map
- 2.4.1.16
- synthases
- candida
- albicans
- nikkomycins
- conidia
- hyphal
- septum
- colletotrichum
- chitinase
-
calcofluor
- cuticle
- polyoxins
- mycelial
- dextrose
-
molt
-
anthracnose
-
hyaline
-
peritrophic
-
weir
- integument
-
exoskeleton
-
echinocandins
- trichophyton
- gloeosporioides
- dermatophytes
- fructicola
- diflubenzuron
- siamense
-
re-isolated
- rouxii
- appressoria
-
rinsed
- caspofungin
-
acervuli
- conidiophore
- dermatitidis
- malassezia
- mentagrophytes
- arthroderma
-
single-spore
-
cottony
- exophiala
-
sunken
-
mother-bud
-
obtuse
- phycomyces
- naclo
-
tetranychus
- dermatophytosis
-
smooth-walled
- analysis
- agriculture
The taxonomic range for the selected organisms is: Neurospora crassa
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
chitin synthase, chitin synthetase, chs3p, chitin synthase 1, chitin synthase iii, chitin synthase 2, csiii, chs4p, chs2p, chitin synthase ii, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acetylglucosaminyltransferase, chitin-uridine diphosphate
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-
-
-
chitin synthetase
-
-
-
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chitin-UDP N-acetylglucosaminyltransferase
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-
-
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chitin-uridine diphosphate acetylglucosaminyltransferase
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-
-
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CHS
Chs1
-
-
-
-
Chs2
-
-
-
-
CSI
-
-
-
-
CSII
-
-
-
-
CSIII
-
-
-
-
trans-N-acetylglucosaminosylase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyltransferase
Converts UDP-N-acetyl-alpha-D-glucosamine into chitin and UDP.
CAS REGISTRY NUMBER
COMMENTARY
9030-18-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-alpha-D-glucosamine + [(1->4)-N-acetyl-beta-D-glucosaminyl]n
UDP + [(1->4)-N-acetyl-beta-D-glucosaminyl]n+1
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
-
-
?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
-
-
?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
-
-
?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
-
-
?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
-
-
?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
existence of a unique secretory pathway based on chitosome microvesicles as the main conveyors of chitin synthetase to the cell surface
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-alpha-D-glucosamine + [(1->4)-N-acetyl-beta-D-glucosaminyl]n
UDP + [(1->4)-N-acetyl-beta-D-glucosaminyl]n+1
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
existence of a unique secretory pathway based on chitosome microvesicles as the main conveyors of chitin synthetase to the cell surface
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
additional information
-
suncellular localization study of CHS-3, CHS proteins are delivered to the cell surface via an alternative route distinct from the classical ER-Golgi body secretory pathway, overview
additional information
suncellular localization study of CHS-3, CHS proteins are delivered to the cell surface via an alternative route distinct from the classical ER-Golgi body secretory pathway, overview
additional information
-
suncellular localization study of CHS-6, CHS proteins are delivered to the cell surface via an alternative route distinct from the classical ER-Golgi body secretory pathway, overview
additional information
suncellular localization study of CHS-6, CHS proteins are delivered to the cell surface via an alternative route distinct from the classical ER-Golgi body secretory pathway, overview
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
developing septa
additional information
developing septa
core, isozyme CHS-2-GFP seems to occupy a smaller area at the Spk than the rest of the CHS isozymes
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
-
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
-
cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and cell septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and cell septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and cell septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and cell septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and cell septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and cell septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
-
isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and cell septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs. Isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs. Isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs. Isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs. Isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs. Isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs. Isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
additional information
-
isozymes CHS-5 and CHS-2 show a different pattern of localization than the other CHSs. Isozyme CHS-1 partially colocalizes with isozymes CHS-2 and CHS-5 at the spitzenkoerper and septa, cellular distribution, analysis using fluorescent-labeled enzyme
-
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
physiological function
malfunction
isozyme mutant DELTAchs-6 strain displays less chitin content, slow colony growth, and apical hyperbranching. Mycelium biomass (dry weight) is reduced in the mutant strain with reduced chitin content
malfunction
mycelium biomass (dry weight) is reduced in the mutant strain with no apparent reduction in chitin content or growth rate, but less production of aerial hyphae and conidia
physiological function
isozyme CHS-6 is important for apical growth and hyphal morphology, it is involved in vegetative growth
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
-
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
isozyme chitin synthase 1 domain structure, overview
additional information
-
isozyme chitin synthase 1 domain structure, overview
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
construction of a deletion mutant of isozyme CHS-4
additional information
construction of a deletion mutant of isozyme CHS-4
additional information
construction of a deletion mutant of isozyme CHS-4
additional information
construction of a deletion mutant of isozyme CHS-4
additional information
construction of a deletion mutant of isozyme CHS-4
additional information
construction of a deletion mutant of isozyme CHS-4
additional information
-
construction of a deletion mutant of isozyme CHS-4
additional information
construction of a deletion mutant of isozyme CHS-1
additional information
construction of a deletion mutant of isozyme CHS-1
additional information
construction of a deletion mutant of isozyme CHS-1
additional information
construction of a deletion mutant of isozyme CHS-1
additional information
construction of a deletion mutant of isozyme CHS-1
additional information
construction of a deletion mutant of isozyme CHS-1
additional information
-
construction of a deletion mutant of isozyme CHS-1
additional information
construction of a deletion mutant of isozyme CHS-2
additional information
construction of a deletion mutant of isozyme CHS-2
additional information
construction of a deletion mutant of isozyme CHS-2
additional information
construction of a deletion mutant of isozyme CHS-2
additional information
construction of a deletion mutant of isozyme CHS-2
additional information
construction of a deletion mutant of isozyme CHS-2
additional information
-
construction of a deletion mutant of isozyme CHS-2
additional information
construction of a deletion mutant of isozyme CHS-3
additional information
construction of a deletion mutant of isozyme CHS-3
additional information
construction of a deletion mutant of isozyme CHS-3
additional information
construction of a deletion mutant of isozyme CHS-3
additional information
construction of a deletion mutant of isozyme CHS-3
additional information
construction of a deletion mutant of isozyme CHS-3
additional information
-
construction of a deletion mutant of isozyme CHS-3
additional information
construction of a deletion mutant of isozyme CHS-5
additional information
construction of a deletion mutant of isozyme CHS-5
additional information
construction of a deletion mutant of isozyme CHS-5
additional information
construction of a deletion mutant of isozyme CHS-5
additional information
construction of a deletion mutant of isozyme CHS-5
additional information
construction of a deletion mutant of isozyme CHS-5
additional information
-
construction of a deletion mutant of isozyme CHS-5
additional information
construction of a deletion mutant of isozyme CHS-6
additional information
construction of a deletion mutant of isozyme CHS-6
additional information
construction of a deletion mutant of isozyme CHS-6
additional information
construction of a deletion mutant of isozyme CHS-6
additional information
construction of a deletion mutant of isozyme CHS-6
additional information
construction of a deletion mutant of isozyme CHS-6
additional information
-
construction of a deletion mutant of isozyme CHS-6
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene chs-3, DNA and amino acid sequence determination and analysis, expression of GFP-labeled CHS-3 in hyphae and subcellular localization, overview
gene chs-6, DNA and amino acid sequence determination and analysis, expression of GFP-labeled CHS-6 in hyphae and subcellular localization, overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Selitrennikoff, C.P.
Chitin synthetase activity of Neurospora crassa
Exp. Mycol.
9
179-182
1985
Neurospora crassa
-
Selitrennikoff, C.P.
Calcofluor white inhibits Neurospora chitin synthetase activity
Exp. Mycol.
8
269-272
1984
Neurospora crassa
-
Gow, L.A.; Selitrennikoff, C.P.
Chitin synthetase of Neurospora crassa: inhibition by nikkomycin, polyoxin B, and UDP
Curr. Microbiol.
11
211-216
1984
Neurospora crassa
-
Selitrennikoff, C.P.
Chitin synthase activity from the slime variant of Neurospora crassa
Biochim. Biophys. Acta
571
224-232
1979
Neurospora crassa
Leal-Morales, C.A.; Bracker, C.E.; Bartnicki-Garcia, S.
Distribution of chitin synthetase and various membrane marker enzymes in chitosomes and other organelles of the slime mutant of Neurospora crassa
Exp. Mycol.
18
168-179
1994
Neurospora crassa
-
Riquelme, M.; Bartnicki-Garcia, S.; Gonzalez-Prieto, J.M.; Sanchez-Leon, E.; Verdin-Ramos, J.A.; Beltran-Aguilar, A.; Freitag, M.
Spitzenkorper localization and intracellular traffic of green fluorescent protein-labeled CHS-3 and CHS-6 chitin synthases in living hyphae of Neurospora crassa
Eukaryot. Cell
6
1853-1864
2007
Neurospora crassa, Neurospora crassa (P30588), Neurospora crassa N623, Neurospora crassa DSM 1257 (P30588)
Fajardo-Somera, R.A.; Joehnk, B.; Bayram, O.e.; Valerius, O.; Braus, G.H.; Riquelme, M.
Dissecting the function of the different chitin synthases in vegetative growth and sexual development in Neurospora crassa
Fungal Genet. Biol.
75
30-45
2015
Neurospora crassa (P29070), Neurospora crassa (P30588), Neurospora crassa (P30589), Neurospora crassa (Q01285), Neurospora crassa (Q7RVP6), Neurospora crassa (Q7S857), Neurospora crassa, Neurospora crassa DSM 1257 (P29070), Neurospora crassa DSM 1257 (P30588), Neurospora crassa DSM 1257 (P30589), Neurospora crassa DSM 1257 (Q01285), Neurospora crassa DSM 1257 (Q7RVP6), Neurospora crassa DSM 1257 (Q7S857)
Fernandes, C.; Gow, N.; Goncalves, T.
The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi
Fungal Biol. Rev.
30
1-14
2016
Aspergillus fumigatus, Aspergillus nidulans, Aspergillus oryzae, Botrytis cinerea, Yarrowia lipolytica, Colletotrichum graminicola, Cryptococcus neoformans, Fusarium oxysporum, Fusarium verticillioides, Fusarium graminearum, Neurospora crassa, Pyricularia oryzae, Ustilago maydis, Exophiala dermatitidis, Penicillium digitatum
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