chitin synthase III from Candida albicans plays an important role in maintaining cell wall integrity, being essential when invading surrounding tissues. Candida albicans strains deficient in CHS7, a key regulator of chitin synthase III, exhibit morphogenetic alterations and attenuated virulence
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
the hyphal-specific chitin synthase gene CHS2 is not essential for growth, dimorphism, or virulence. The class I CaChs2p enzyme is responsible for part of the hyphal chitin
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
chitin synthase III from Candida albicans plays an important role in maintaining cell wall integrity, being essential when invading surrounding tissues. Candida albicans strains deficient in CHS7, a key regulator of chitin synthase III, exhibit morphogenetic alterations and attenuated virulence
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
the hyphal-specific chitin synthase gene CHS2 is not essential for growth, dimorphism, or virulence. The class I CaChs2p enzyme is responsible for part of the hyphal chitin
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
shape and integrity of fungal cells is dependent on the skeletal polysaccharides in their cell walls of which beta-1,3-glucan and chitin are of principle importance, individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall, overview
stereoselective synthesis routes of both the natural (C5'-S) and unnatural (C5'-R) diastereoisomers of uracil polyoxin C methyl ester as specific substrate analogue-inhibitors of chirin synthase, conjugation of the methyl ester of uracil polyoxin C with activated isoxazole carboxylic acids, detailed overview
the architecture of the chitin skeleton of Candida albicans is shaped by the action of more than one chitin synthase at the site of cell wall synthesis
the architecture of the chitin skeleton of Candida albicans is shaped by the action of more than one chitin synthase at the site of cell wall synthesis
the architecture of the chitin skeleton of Candida albicans is shaped by the action of more than one chitin synthase at the site of cell wall synthesis
the architecture of the chitin skeleton of Candida albicans is shaped by the action of more than one chitin synthase at the site of cell wall synthesis
the architecture of the chitin skeleton of Candida albicans is shaped by the action of more than one chitin synthase at the site of cell wall synthesis
the architecture of the chitin skeleton of Candida albicans is shaped by the action of more than one chitin synthase at the site of cell wall synthesis
the architecture of the chitin skeleton of Candida albicans is shaped by the action of more than one chitin synthase at the site of cell wall synthesis
the architecture of the chitin skeleton of Candida albicans is shaped by the action of more than one chitin synthase at the site of cell wall synthesis
the architecture of the chitin skeleton of Candida albicans is shaped by the action of more than one chitin synthase at the site of cell wall synthesis
the architecture of the chitin skeleton of Candida albicans is shaped by the action of more than one chitin synthase at the site of cell wall synthesis
treatment of Candida albicans with low levels of echinocandins such as caspofungin, echinocandin B, cilofungin and anidulafungin stimulates chitin synthase gene expression, increases Chs activity, elevates chitin content and reduced efficacy of these drugs. Elevation of chitin synthesis is mediated via the PKC, HOG, and Ca2+-calcineurin signalling pathways. Stimulation of isoforms Chs2p and Chs8p by activators of these pathways enables cells to survive otherwise lethal concentrations of echinocandins, even in the absence of Chs3p and the normally essential Chs1p, which synthesize the chitinous septal ring and primary septum of the fungus. Under such conditions, a novel proximally offset septum is synthesized that restores the capacity for cell division, sustaines the viability of the cell, and abrogates morphological and growth defects associated with echinocandin treatment and the chs mutations
enzyme exists chiefly in a zymogenic form. Endogenous activation of chitin synthase zymogen is observed over many days in preparations stored in glycerol, 33% w/v at -12°C and over many hours in preparations stored at 30°C The zymogen is preferentially retarded on the column matrices in comparison with the active enzyme
construction of isozyme deficient mutant cells, analysis of chitin ghosts of chs mutant strains by shadow-cast transmission electron microscopy show that the long-chitin microfibrils are absent in chs8 mutants and the short-chitin rodlets are absent in chs3 mutants. The inferred site of chitin microfibril synthesis of these Chs enzymes is corroborated by their localization determined in Chsp-YFP-expressing strains, overview
construction of isozyme deficient mutant cells, analysis of chitin ghosts of chs mutant strains by shadow-cast transmission electron microscopy show that the long-chitin microfibrils are absent in chs8 mutants and the short-chitin rodlets are absent in chs3 mutants. The inferred site of chitin microfibril synthesis of these Chs enzymes is corroborated by their localization determined in Chsp-YFP-expressing strains, overview
construction of isozyme deficient mutant cells, analysis of chitin ghosts of chs mutant strains by shadow-cast transmission electron microscopy show that the long-chitin microfibrils are absent in chs8 mutants and the short-chitin rodlets are absent in chs3 mutants. The inferred site of chitin microfibril synthesis of these Chs enzymes is corroborated by their localization determined in Chsp-YFP-expressing strains, overview
construction of isozyme deficient mutant cells, analysis of chitin ghosts of chs mutant strains by shadow-cast transmission electron microscopy show that the long-chitin microfibrils are absent in chs8 mutants and the short-chitin rodlets are absent in chs3 mutants. The inferred site of chitin microfibril synthesis of these Chs enzymes is corroborated by their localization determined in Chsp-YFP-expressing strains, overview
construction of isozyme deficient mutant cells, analysis of chitin ghosts of chs mutant strains by shadow-cast transmission electron microscopy show that the long-chitin microfibrils are absent in chs8 mutants and the short-chitin rodlets are absent in chs3 mutants. The inferred site of chitin microfibril synthesis of these Chs enzymes is corroborated by their localization determined in Chsp-YFP-expressing strains, overview
construction of isozyme deficient mutant cells, analysis of chitin ghosts of chs mutant strains by shadow-cast transmission electron microscopy show that the long-chitin microfibrils are absent in chs8 mutants and the short-chitin rodlets are absent in chs3 mutants. The inferred site of chitin microfibril synthesis of these Chs enzymes is corroborated by their localization determined in Chsp-YFP-expressing strains, overview
construction of isozyme deficient mutant cells, analysis of chitin ghosts of chs mutant strains by shadow-cast transmission electron microscopy show that the long-chitin microfibrils are absent in chs8 mutants and the short-chitin rodlets are absent in chs3 mutants. The inferred site of chitin microfibril synthesis of these Chs enzymes is corroborated by their localization determined in Chsp-YFP-expressing strains, overview
construction of isozyme deficient mutant cells, analysis of chitin ghosts of chs mutant strains by shadow-cast transmission electron microscopy show that the long-chitin microfibrils are absent in chs8 mutants and the short-chitin rodlets are absent in chs3 mutants. The inferred site of chitin microfibril synthesis of these Chs enzymes is corroborated by their localization determined in Chsp-YFP-expressing strains, overview
construction of isozyme deficient mutant cells, analysis of chitin ghosts of chs mutant strains by shadow-cast transmission electron microscopy show that the long-chitin microfibrils are absent in chs8 mutants and the short-chitin rodlets are absent in chs3 mutants. The inferred site of chitin microfibril synthesis of these Chs enzymes is corroborated by their localization determined in Chsp-YFP-expressing strains, overview
construction of isozyme deficient mutant cells, analysis of chitin ghosts of chs mutant strains by shadow-cast transmission electron microscopy show that the long-chitin microfibrils are absent in chs8 mutants and the short-chitin rodlets are absent in chs3 mutants. The inferred site of chitin microfibril synthesis of these Chs enzymes is corroborated by their localization determined in Chsp-YFP-expressing strains, overview
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene CHS3, expression of YFP-tagged wild-type and mutant isozymes in strain BWP17, location of the YFP-tagged Chs proteins in yeast and hyphal cells, overview
gene CHS1, expression of YFP-tagged wild-type and mutant isozymes in strain BWP17, location of the YFP-tagged Chs proteins in yeast and hyphal cells, overview
gene CHS2, expression of YFP-tagged wild-type and mutant isozymes in strain BWP17, location of the YFP-tagged Chs proteins in yeast and hyphal cells, overview
gene CHS8, expression of YFP-tagged wild-type and mutant isozymes in strain BWP17, location of the YFP-tagged Chs proteins in yeast and hyphal cells, overview
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
treatment of Candida albicans with low levels of echinocandins such as caspofungin, echinocandin B, cilofungin and anidulafungin stimulates chitin synthase gene expression, increases Chs activity, elevates chitin content and reduced efficacy of these drugs