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Information on EC 2.4.1.152 - 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase and Organism(s) Mus musculus and UniProt Accession Q11127
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2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferaseIUBMB Comments
Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
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Word Map
- 2.4.1.152
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sialylated
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fucosylated
- selectins
- fuc-tiii
- n-acetyllactosamine
- medicine
- synthesis
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alpha1,3-fucosylation
- lewisx
- fuc-ts
- fuct-iv
- alpha-2-l-fucosyltransferase
- analysis
- drug development
- biotechnology
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
fuc-tv, alpha-3-fucosyltransferase, fucosyltransferase 4, alpha-3-l-fucosyltransferase, alpha1,3 fuct-vii, fut vi, alpha1,3ft, alpha1,3-fuct, fucosyltransferase ix, fuctvii, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alpha(1-3)fucosyltransferase
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alpha-3-fucosyltransferase
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alpha-3-L-fucosyltransferase
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alpha1,3 fucosyltransferase
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alpha1,3FT
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alpha1-3 fucosyltransferase
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alpha1->3fucosyltransferase
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alpha3-fucosyltransferase-V
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alpha3-fucosyltransferase-VI
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Fuc-Tb
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Fuc-TV
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fucosyltransferase, guanosine diphosphofucose-glucoside alpha1-->3-
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FucT-VI
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FUT5
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FUT6
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FUT7
galactoside 3-fucosyltransferase
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GDL-L-fucose:N-acetyl-beta-D-glucosaminyl alpha-3-L-fucosyltransferase
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GDP-Fuc:Galbeta1-4GlcNAc (Fuc to GlcNAc) alpha1-3 fucosyltransferase
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GDP-fucose:beta-D-N-acetylglucosaminide 3-alpha-fucosyltransferase
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GDP-fucose:Galbeta(1-4)GlcNAc-R alpha(1-3)fucosyltransferase
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GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-galactosaminyl-R 3-L-fucosyltransferase
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guanosine diphosphofucose glucoside alpha1->3fucosyltransferase
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lewis-negative alpha-3-fucosyltransferase
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plasma alpha-3-fucosyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
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PATHWAY SOURCE
PATHWAYS
KEGG
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-, -, -
SYSTEMATIC NAME
IUBMB Comments
GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase (configuration-inverting)
Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
CAS REGISTRY NUMBER
COMMENTARY
111310-38-4
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39279-34-0
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GDP-beta-L-fucose + N-acetyl-D-lactosamine
GDP + L-Fuc-alpha-(1->3)-[D-Gal-beta(1->4)]-D-GlcNac
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?
additional information
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Fuc-TVII participates in the generation of alpha(1,3)fucosylated ligands for L-selectin, evidence for a role for this enzyme in E- and P-selectin ligand expression in leukocytes
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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Fuc-TVII participates in the generation of alpha(1,3)fucosylated ligands for L-selectin, evidence for a role for this enzyme in E- and P-selectin ligand expression in leukocytes
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-
?
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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FUT7 mRNA minorly expressed in mouse brain endothelial cell line bEND.3
the enzyme is expressed in endothelial cells lining the high endothelial venules of perpheral lymph nodes, mesenteric lymph nodes and Pevers patches
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FUT7 mRNA remarkably highly expressed in mouse lymphoid tumor cell line TIB-63
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FUT7 mRNA significantly expressed in mouse macrophage cell line TIB-69
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
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suppression of isoform Fut10 expression induces the differentiation of neural stem cells and embryonic stem cells. In addition, knockdown of Fut10 expression in the cortical ventricular zone of the embryonic brain impairs the radial migration of neural precursor cells
physiological function
physiological function
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synthesis of E- and P-selectin ligands, as mediated by the rate-limiting enzyme FucT-VII, plays an important role in the pathogenesis of atherosclerosis
physiological function
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overexpression of isoform Fut10 enhances the self-renewal of neural stem cells
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). FUT4_MOUSE
433
0
49481
Swiss-Prot
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
double knock-out mice deficient for both FT-IV and FT-VII show an essential absence of eosinophil recruitment to the dermis
additional information
double knock-out mice deficient for both FT-IV and FT-VII show an essential absence of eosinophil recruitment to the dermis
additional information
FT-IV deficient mice show a significant decrease in eosinophil recruitment to the skin
additional information
FT-IV deficient mice show a significant decrease in eosinophil recruitment to the skin
additional information
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a marked reduction in formation of metastatic foci is observed in FucT7 deficient mice injected with murine colon carcinoma cells MC-38GFP
additional information
double knock-out mice deficient for both FT-IV and FT-VII show an essential absence of eosinophil recruitment to the dermis
additional information
double knock-out mice deficient for both FT-IV and FT-VII show an essential absence of eosinophil recruitment to the dermis
additional information
FT-VII deficient mice show a decrease in eosinophil recruitment to the skin
additional information
FT-VII deficient mice show a decrease in eosinophil recruitment to the skin
additional information
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O-linked oligosaccharides attached to GlyCAM-1 are analyzed in FucT-VII deficient mice, an 80% reduction in alpha1,3-fucosylated structures in 6-sulfo sialyl Lewis X and a significant increase in 6-sulfo N-acetyllactosamine are found in high-endothelial venules in secondary lymphoid organs of FucT-VII -/- mice, surprisingly, the amount of 6-sulfated galactose (Gal) is also increased in mutant mice, since 6-sulfo galactose can be synthesized by keratin sulfate sulfotransferase (KSST) it could be concluded that FucT-VII and KSST may compete for the same acceptor molecules
additional information
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primary adhesion of Th1 lymphocytes obtained from FucT-VII deficient mice is drastically reduced
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in CHO cells, to confirm the hypothesis that FucT-VII and keratin sulfate sulfotransferase (KSST) may compete for the same acceptor molecules FucT-VII and Core2GlcNAcT-1 are expressed in CHO cells stably expressing KSST, sialyl Lewis X expression is significantly reduced in these cells
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FucT-VII-/-GFP+ bone marrow transplanted into lethally irradiated low-density lipoprotein receptor low density lipoprotein receptor mice or FucT-VII+/+GFP+ bone marrow into FucT-VII-/-, low density lipoprotein receptor double-mutant mice
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
FT-IV and FT-VII are both important contributors to selectin-dependent eosinophil recruitment to the skin and may represent therapeutic targets in which eosinophil recruitment contributes to pathophysiology
drug development
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FucT-VII and the E- and P-selectin pathways may prove a fruitful therapeutic target in the prevention or treatment of atherosclerosis
medicine
medicine
FT-IV and FT-VII are both important contributors to selectin-dependent eosinophil recruitment to the skin and may represent therapeutic targets in which eosinophil recruitment contributes to pathophysiology
medicine
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FucT-VII is critical for the recruitment of Th1 cells in inflamed brain microcirculation
medicine
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FUT7 mRNA is highly over-expressed at the site of inflammation and in tumorigenesis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Smith, P.L.; Gersten, K.M.; Petryniak, B.; Kelly, R.J.; Rogers, C.; Natsuka, Y.; Alford, J.A., 3rd; Scheidegger, E.P.; Natsuka, S.; Lowe, J.B.
Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands
J. Biol. Chem.
271
8250-8259
1996
Mus musculus (Q11131)
Niittymaki, J.; Mattila, P.; Renkonen, R.
Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter and fucosyltransferase VII
APMIS
114
539-548
2006
Mus musculus, Rattus norvegicus
Satoh, T.; Kanai, Y.; Wu, M.; Yokozeki, H.; Kannagi, R.; Lowe, J.B.; Nishioka, K.
Synthesis of alpha(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin
Am. J. Pathol.
167
787-796
2005
Homo sapiens, Mus musculus (Q11127), Mus musculus (Q11131)
Laeubli, H.; Stevenson, J.L.; Varki, A.; Varki, N.M.; Borsig, L.
L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest
Cancer Res.
66
1536-1542
2006
Mus musculus
Hiraoka, N.; Petryniak, B.; Kawashima, H.; Mitoma, J.; Akama, T.O.; Fukuda, M.N.; Lowe, J.B.; Fukuda, M.
Significant decrease in alpha1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing
Glycobiology
17
277-293
2007
Mus musculus
Piccio, L.; Rossi, B.; Colantonio, L.; Grenningloh, R.; Gho, A.; Ottoboni, L.; Homeister, J.W.; Scarpini, E.; Martinello, M.; Laudanna, C.; DAmbrosio, D.; Lowe, J.B.; Constantin, G.
Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII
J. Immunol.
174
5805-5813
2005
Mus musculus
Gitlin, J.M.; Homeister, J.W.; Bulgrien, J.; Counselman, J.; Curtiss, L.K.; Lowe, J.B.; Boisvert, W.A.
Disruption of tissue-specific fucosyltransferase VII, an enzyme necessary for selectin ligand synthesis, suppresses atherosclerosis in mice
Am. J. Pathol.
174
343-350
2009
Mus musculus
Kumar, A.; Torii, T.; Ishino, Y.; Muraoka, D.; Yoshimura, T.; Togayachi, A.; Narimatsu, H.; Ikenaka, K.; Hitoshi, S.
The Lewis X-related alpha1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations
J. Biol. Chem.
288
28859-28868
2013
Mus musculus
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