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Information on EC 2.4.1.147 - acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

for references in articles please use BRENDA:EC2.4.1.147
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IUBMB Comments
The product of the enzyme is known as core 3, one of the eight core structures of mucin-type O-glycans. O-Linked glycans are polysaccharides or oligosaccharides that are linked to a protein via the oxygen atom in the side chain of an L-serine or L-threonine residue.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
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O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
Synonyms
core 3 synthase, beta3gn-t6, c3gnt, core3 synthase, core 3 beta1,3-n-acetylglucosaminyltransferase, beta3-n-acetylglucosaminyltransferase-6, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] = UDP + O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
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