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UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[integrin beta1]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[integrin beta1]
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP-N-acetyl-D-glucosamine + biantennary N-glycan
?
-
the enzyme transfers a N-acetyl-D-glucosamine from UDP-N-acetyl-D-glucosamine to the biantennary oligosaccharide and produces triantennary N-glycans with a beta1,4-N-acetyl-D-glucosamine on the alpha1,3-Man arm
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
UDP + ?
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
i.e. LAMP-2, LAMP-2 has 16 N-glycans which play crucial roles in cell adhesion to ECM and metastasis of cancer cells because N-glycans configure cell surface ligands of cancer cells for galectin-1, galectin-3, and selectins on extracellular matrix or the membranes of the counter cell
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
i.e. LAMP-2
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
GnT-IVa is primarily responsible for the biosynthesis of complex-type N-glycans
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
GnT-IVb might contribute to the basal GnT-IV activity in cells
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
the enzyme is involved in the branch formation of Asn-linked sugar chains
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVa
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVb
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVa
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVb
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVa
-
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
?
-
N-acetylglucosaminyltransferase-IVb
-
-
?
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UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]
i.e. LAMP-2, LAMP-2 has 16 N-glycans which play crucial roles in cell adhesion to ECM and metastasis of cancer cells because N-glycans configure cell surface ligands of cancer cells for galectin-1, galectin-3, and selectins on extracellular matrix or the membranes of the counter cell
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
GnT-IVa is primarily responsible for the biosynthesis of complex-type N-glycans
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
GnT-IVb might contribute to the basal GnT-IV activity in cells
-
-
?
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
the enzyme is involved in the branch formation of Asn-linked sugar chains
-
-
?
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alpha-1,3-mannosyl-glycoprotein 4-beta-n-acetylglucosaminyltransferase deficiency
Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice.
Carcinoma
Alteration of N-acetylglucosaminyltransferases in pancreatic carcinoma.
Carcinoma, Hepatocellular
Determination of N-acetylglucosaminyltransferases III, IV and V in normal and hepatoma tissues of rats.
Choriocarcinoma
High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.
Choriocarcinoma
N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.
Choriocarcinoma
Structural differences found in the asparagine-linked sugar chains of human chorionic gonadotropins purified from the urine of patients with invasive mole and with choriocarcinoma.
Choriocarcinoma
Structure, pathology and function of the N-linked sugar chains of human chorionic gonadotropin.
Choriocarcinoma
Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.
Diabetes Mellitus, Type 2
Targeted genetic inactivation of N-acetylglucosaminyltransferase-IVa impairs insulin secretion from pancreatic beta cells and evokes type 2 diabetes.
Diabetes Mellitus, Type 2
The transcription of MGAT4A glycosyl transferase is increased in white cells of peripheral blood of Type 2 Diabetes patients.
Hydatidiform Mole, Invasive
N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.
Lung Neoplasms
Multiplexed surrogate analysis of glycotransferase activity in whole biospecimens.
Neoplasm Metastasis
N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147.
Neoplasms
Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.
Neoplasms
Glycans and cancer: role of N-glycans in cancer biomarker, progression and metastasis, and therapeutics.
Neoplasms
Identification of hub genes and key pathways associated with the progression of gynecological cancer.
Neoplasms
Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes.
Neoplasms
N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.
Neoplasms
Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.
Pancreatic Neoplasms
Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.
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0.532 - 3.35
GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
1.04 - 6.94
GlcNAcbeta1-2Man1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
0.971 - 5.72
GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
3.19 - 10.5
GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
0.118 - 0.358
UDP-N-acetyl-D-glucosamine
0.532
GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa
3.35
GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb
1.04
GlcNAcbeta1-2Man1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant soluble human flag-GnTIVa
6.94
GlcNAcbeta1-2Man1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant soluble human flag-GnTIVa
0.971
GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa
5.72
GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb
3.19
GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa
10.5
GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb
0.118
UDP-N-acetyl-D-glucosamine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa
0.242
UDP-N-acetyl-D-glucosamine
-
37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb
0.341
UDP-N-acetyl-D-glucosamine
-
37°C, pH 7.5, recombinant soluble human flag-GnTIVa
0.358
UDP-N-acetyl-D-glucosamine
-
37°C, pH 7.5, recombinant soluble human flag-GnTIVa
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metabolism
-
N-acetylglucosaminyltransferase-IV synthesizes the GlcNAcbeta(1-4) branch structure on the Manalpha(1-3) arm of N-glycan core, and is essential for the production of multiantennary N-glycans cooperatively with N-acetylglucosaminyltransferase-V
malfunction
aberrant glycosylation of the cell surface is associated with the malignant transformation of normal cells. Tumor-cell-surface glycans are closely associated with tumor-cell migration, adhesion, and metastasis4, profiling of specific cell surface N-glycans in hepatocellular carcinoma with clinical tissues (88 tumor and adjacent normal tissues) and the corresponding serum samples of hepatocellular carcinoma patients, overview. The level of core-alpha-1,6-fucosylated triantennary glycan (NA3Fb) increases both on the cell surface and in the serum samples of hepatocellular carcinoma patients, and mRNA and protein expression of N-acetylglucosaminyltransferase IVa (GnT-IVa), which is related to the synthesis of the NA3Fb, is substantially increased in hepatocellular carcinoma tissues. Knockdown of GnT-IVa leads to a decreased level of NA3Fb and decreased ability of invasion and migration in HCC cells. The high expression of GnT-IVa is the cause of the abnormal increase of NA3Fb on the HCC cell surface, which regulates cell migration
malfunction
GnT-IVa overexpression increases cell adhesion, migration and invasion abilities of Jar cells. GnT-IVa overexpression increases cellular interaction with ECM as demonstrated by the relative adhesion rates of mock cells and Jar-GnT4a cells on fibronectin, collagen type I and collagen type IV. GnT-IVa knockdown in choriocarcinoma cells suppresses migration and invasion and decreases cellular adhesion to extracellular matrix
physiological function
the enzyme is involved in synthesis of tetra-antennary N-linked glycans. Cell surface glycans play an important role in intercellular and intracellular processes, including cell adhesion and development, cell recognition, and cancer development and metastasis. Changes in cell surface glycosylation modulate cellular activity
physiological function
N-acetylglucosaminyltransferase IV (GnT-IV) is a glycosyltransferase which catalyses the formation of beta1,4GlcNAc branches on the mannose core of N-glycans. beta1,4GlcNAc branches on human chorionic gonadotropin (hCG) are detected in GTN but not in normal pregnancy or hydatidiform mole. N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. Identification of target proteins for GnT-IVa glycosylation which contribute to the malignancy of choriocarcinoma, overview. GnT-IVa overexpression increases highly branched N-glycans on integrin beta1. Highly branched N-glycans resulting from the action of GnT-IVa are strongly detected in invasive mole and choriocarcinoma, in proportion to the GnT-IVa protein expression. GnT-IVa may play an important role in accelerating the malignancy of choriocarcinoma through addition of beta1,4GlcNAc branches to the N-glycans on some proteins
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Zhu, T.Y.; Chen, H.L.; Gu, J.X.; Zhang, Y.F.; Zhang, Y.K.; Zhang, R.A.
Changes in N-acetylglucosaminyltransferase III, IV, and V in renal cell carcinoma
J. Cancer Res. Clin. Oncol.
123
296-299
1997
Homo sapiens
brenda
Yoshida, A.; Minowa, M.T.; Takamatsu, S.; Hara, T.; Ikenaga, H.; Takeuchi, M.
A novel second isoenzyme of the human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment
Glycoconjugate J.
15
1115-1123
1998
Homo sapiens (Q9UQ53), Homo sapiens
brenda
Nan, B.C.; Shao, D.M.; Chen, H.L.; Huang, Y.; Gu, J.X.; Zhang, Y.B.; Wu, Z.G.
Alteration of N-acetylglucosaminyltransferases in pancreatic carcinoma
Glycoconjugate J.
15
1033-1037
1998
Homo sapiens
brenda
Yoshida, A.; Minowa, M.T.; Takamatsu, S.; Hara, T.; Oguri, S.; Ikenaga, H.; Takeuchi, M.
Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase
Glycobiology
9
303-310
1999
Homo sapiens (Q9UM21), Homo sapiens
brenda
Takamatsu, S.; Oguri, S.; Minowa, M.T.; Yoshida, A.; Nakamura, K.; Takeuchi, M.; Kobata, A.
Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain
Cancer Res.
59
3949-3953
1999
Homo sapiens
brenda
Takamatsu, S.; Inoue, N.; Katsumata, T.; Nakamura, K.; Fujibayashi, Y.; Takeuchi, M.
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures
Biochemistry
44
6343-6349
2005
Homo sapiens
brenda
Jin, X.L.; Liu, H.B.; Zhang, Y.; Wang, B.S.; Chen, H.L.
Alteration in N -acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma
Glycoconj. J.
20
399-406
2004
Homo sapiens
brenda
Takamatsu, S.; Katsumata, T.; Inoue, N.; Watanabe, T.; Fujibayashi, Y.; Takeuchi, M.
Abnormal biantennary sugar chains are expressed in human chorionic gonadotropin produced in the choriocarcinoma cell line, JEG-3
Glycoconj. J.
20
473-481
2004
Homo sapiens
brenda
Ide, Y.; Miyoshi, E.; Nakagawa, T.; Gu, J.; Tanemura, M.; Nishida, T.; Ito, T.; Yamamoto, H.; Kozutsumi, Y.; Taniguchi, N.
Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer
Biochem. Biophys. Res. Commun.
341
478-482
2006
Homo sapiens (Q9UM21), Homo sapiens (Q9UQ53)
brenda
Oguri, S.; Yoshida, A.; Minowa, M.T.; Takeuchi, M.
Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes
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