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Information on EC 2.4.1.135 - galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

for references in articles please use BRENDA:EC2.4.1.135
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IUBMB Comments
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
beta-1,3-glucuronyltransferase 1, beta1,3-glucuronosyltransferase I, beta1,3-glucuronosyltransferase-I, beta1,3-glucuronyltransferase I, galactose beta1,3 glucuronosyl transferase-I, galactose beta1,3-glucuronosyltransferase-I, Galbeta1,3-glucuronosyltransferase, GlcAT-1, GlcAT-I, GlcAT-P, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
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