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Information on EC 2.4.1.134 - galactosylxylosylprotein 3-beta-galactosyltransferase and Organism(s) Caenorhabditis elegans and UniProt Accession Q9N491

for references in articles please use BRENDA:EC2.4.1.134
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IUBMB Comments
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
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This record set is specific for:
Caenorhabditis elegans
UNIPROT: Q9N491
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The taxonomic range for the selected organisms is: Caenorhabditis elegans
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
galt2, dbeta3galtii, beta3galt i, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
galactosyltransferase II
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-
-
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galactosyltransferase, uridine diphosphogalactose-galactosylxylose
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UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
CAS REGISTRY NUMBER
COMMENTARY hide
56626-19-8
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56626-21-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-galactose + beta-D-galactosyl-1,3-beta-galactosyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-beta-galactosyl-O-naphthalenemethanol
show the reaction diagram
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-
-
?
UDP-galactose + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
show the reaction diagram
-
-
-
?
UDP-galactose + beta-D-galactosyl-1,4-beta-D-xylosyl-O-benzyl
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-xylosyl-O-benzyl
show the reaction diagram
-
-
-
?
UDP-galactose + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
show the reaction diagram
-
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-O-naphthalenemethanol
show the reaction diagram
-
-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1
pmol/h/ml medium, beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol as substrate
2660
pmol/h/ml medium, beta-D-galactosyl-1,4-beta-xylosyl-O-benzyl as substrate
3
pmol/h/ml medium, beta-D-galactosyl-1,3-beta-D-galactosyl-O-naphthalenemethanol as substrate
6
pmol/h/ml medium, N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-O-naphthalenemethanol as substrate
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SQV2_CAEEL
330
1
37973
Swiss-Prot
Secretory Pathway (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Caenorhabditis elegans
transient expression as a fusion protein with protein A in chinese hamster ovary cells COS-1
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hwang, H.Y.; Olson, S.K.; Brown, J.R.; Esko, J.D.; Horvitz, H.R.
The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase
J. Biol. Chem.
278
11735-11738
2003
Caenorhabditis elegans (Q9N491)
Manually annotated by BRENDA team