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Information on EC 2.4.1.133 - xylosylprotein 4-beta-galactosyltransferase and Organism(s) Bos taurus and UniProt Accession P08037

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.133 xylosylprotein 4-beta-galactosyltransferase
IUBMB Comments
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
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Bos taurus
UNIPROT: P08037
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Synonyms
galt i, b4galt7, galactosyltransferase i, beta-1,4-galt i, beta1,4-galt, beta-1,4-galt v, beta1,4-galt-i, galt-i, beta-1,4-galactosyltransferase i, beta4galt7, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
galactosyltransferase I
-
-
-
-
galactosyltransferase, uridine diphosphogalactose-xylose
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-
-
-
UDP-D-galactose:D-xylose galactosyltransferase
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-
-
-
UDP-D-galactose:xylose galactosyltransferase
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-
-
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UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
CAS REGISTRY NUMBER
COMMENTARY hide
52227-72-2
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cycloheximide
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first order kinetics
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
articular cartilage
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
B4GT1_BOVIN
402
1
44843
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55000
-
gel filtration
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
repeated freezing and thawing, collagenase treatment and sonication result in a significant loss of activity
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gunasekaran, K.; Ma, B.; Ramakrishnan, B.; Qasba, P.K.; Nussinov, R.
Interdependence of backbone flexibility, residue conservation, and enzyme function: a case study on beta1,4-galactosyltransferase-I
Biochemistry
42
3674-3687
2003
Bos taurus (P08037)
Manually annotated by BRENDA team
Parker, G.J.; Handley, C.J.; Robinson, H.C.
An assay for galactosyltransferase-I activity in articular cartilage
Anal. Biochem.
226
154-160
1995
Bos taurus, Gallus gallus
Manually annotated by BRENDA team