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BRENDA support

Information on EC 2.4.1.132 - GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase

for references in articles please use BRENDA:EC2.4.1.132

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IUBMB Comments

The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an α1,3-mannosylation of D-Man-β-(1→4)-D-GlcNAc-β-(1→4)-D-GlcNAc-diphosphodolichol, followed by an α1,6-mannosylation (cf. EC 2.4.1.257), to form the first branched pentasaccharide intermediate of the dolichol pathway [1,2].

The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria

Synonyms
alpha-1,3-mannosyltransferase, mannosyltransferase ii, halg2, scalg2, gdp-man:dol-pp-glcnac2man2 alpha-1,3-mannosyltransferase, gdp-man:man1glcnac2-pp-dolichol mannosyltransferase, asparagine-linked glycosylation 2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-alpha-D-mannose + beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = GDP + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
protein N-glycosylation initial phase (eukaryotic)