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Disease on EC 2.4.1.122 - N-acetylgalactosaminide beta-1,3-galactosyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
[Developments in the serological diagnosis of malignant diseases]
Adenocarcinoma
C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin ?v.
C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer.
Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice.
Enzyme activities in human breast tumor cells and sera.
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110.
Identification, by a monoclonal antibody, of a 53-kD protein associated with a tubulo-vesicular compartment at the cis-side of the Golgi apparatus.
Increased activity of a beta-galactosyltransferase in tissues of rats bearing prostate and mammary adenocarcinomas.
Quantitative differences in GlcNAc:beta1-->3 and GlcNAc:beta1-->4 galactosyltransferase activities between human colonic adenocarcinomas and normal colonic mucosa.
Treatment and immunodiagnosis of advanced ovarian adenocarcinoma: a preliminary report.
Truncated O-glycans promote epithelial-to-mesenchymal transition and stemness properties of pancreatic cancer cells.
Tumor markers for ovarian cancer.
Uridine 5'-diphosphate-galactose:glycoprotein galactosyltransferase activity in the ovarian cancer patient.
[Localization and modulation of galactosyltransferase during in vitro proliferation of a human ovarian adenocarcinoma cell line]
Adenocarcinoma of Lung
C1GALT1, Negatively Regulated by miR-181d-5p, Promotes Tumor Progression via Upregulating RAC1 in Lung Adenocarcinoma.
Adenoma
A new method for detecting beta 1,4-galactosyltransferase activity in sera of cancer patients.
Adenoma, Pleomorphic
Cell-surface galactosyltransferase acts as a modulator of rat and human acinar cell proliferation.
Alzheimer Disease
COSMC mutations reduce T-synthase activity in advanced Alzheimer's disease.
Anemia
Defective glycosylation of erythrocyte membrane glycoconjugates in a variant of congenital dyserythropoietic anemia type II: association of low level of membrane-bound form of galactosyltransferase.
Identification of the full-length coding sequence for human galactosyltransferase (beta-N-acetylglucosaminide: beta 1,4-galactosyltransferase).
Anemia, Dyserythropoietic, Congenital
Defective glycosylation of erythrocyte membrane glycoconjugates in a variant of congenital dyserythropoietic anemia type II: association of low level of membrane-bound form of galactosyltransferase.
Identification of the full-length coding sequence for human galactosyltransferase (beta-N-acetylglucosaminide: beta 1,4-galactosyltransferase).
Arthritis
Changes in normal glycosylation mechanisms in autoimmune rheumatic disease.
Tissue-specific galactosyltransferase abnormalities in an experimental model of rheumatoid arthritis.
Arthritis, Rheumatoid
Aberrant control of galactosyltransferase in peripheral B lymphocytes and Epstein-Barr virus transformed B lymphoblasts from patients with rheumatoid arthritis.
Agalactosyl IgG in inflammatory bowel disease: correlation with C-reactive protein.
B lymphocyte galactosyltransferase protein levels in normal individuals and in patients with rheumatoid arthritis.
Changes in normal glycosylation mechanisms in autoimmune rheumatic disease.
Decreased B-cell galactosyltransferase activity in rheumatoid arthritis.
Differential B lymphocyte galactosyltransferase activity in the MRL mouse model of rheumatoid arthritis.
Glycosylation and rheumatic disease.
Kinetic study of a galactosyltransferase in the B cells of patients with rheumatoid arthritis.
Polymorphism and expression of the galactosyltransferase-associated protein kinase gene in normal individuals and galactosylation-defective rheumatoid arthritis patients.
Reduced B-cell galactosyltransferase activity in rheumatoid arthritis.
Serum galactosyltransferase as a marker of disease activity in rheumatoid arthritis.
Serum galactosyltransferase isoform changes in rheumatoid arthritis.
Tissue-specific galactosyltransferase abnormalities in an experimental model of rheumatoid arthritis.
Autoimmune Diseases
No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy patients.
Brain Neoplasms
Glycosyltransferase activities in human meningiomas. Preliminary results.
Breast Neoplasms
Alterations in serum glycosyltransferases and 5'-nucleotidase in breast cancer patients.
Conversion of the amphiphilic galactosyltransferase from human mammary carcinoma cells to an active hydrophilic enzyme form by limited proteolysis.
Sequential galactosyltransferase and carcinoembryonic antigen levels in advanced breast carcinoma.
Tn antigen and UDP-Gal:GalNAc alpha-R beta 1-3Galactosyltransferase expression in human breast carcinoma.
Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway.
Carcinogenesis
Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice.
Quantitative differences in GlcNAc:beta1-->3 and GlcNAc:beta1-->4 galactosyltransferase activities between human colonic adenocarcinomas and normal colonic mucosa.
The galactosyltransferase activity of hepatic nodules during rat liver carcinogenesis.
Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway.
Carcinoma
Anti-C1GALT1 Autoantibody Is a Novel Prognostic Biomarker for Patients With Head and Neck Cancer.
Biochemical and immunologic characterization of galactosyltransferase purified from the ascites of ovarian cancer patients.
Biological markers and ovarian carcinomas: galactosyltransferase, CA 125, isoenzymes of amylase and alkaline phosphatase.
Cancer-associated galactosyltransferase acceptor: inhibition of transformed cell and tumor growth.
Cancer-associated galactosyltransferase as a new tumor marker for ovarian clear cell carcinoma.
Carbohydrate receptor-mediated gene transfer to human T leukaemic cells.
Cell-surface galactosyltransferase acts as a modulator of rat and human acinar cell proliferation.
Clinic implication of MUC1 O-glycosylation and C1GALT1 in esophagus squamous cell carcinoma.
Clinical value of serum glycoprotein galactosyltransferase levels in different histological types of ovarian carcinoma.
Comparison of cell-associated and soluble galactosyltransferase isoenzymes from a human bladder transitional cell carcinoma line.
Conversion of the amphiphilic galactosyltransferase from human mammary carcinoma cells to an active hydrophilic enzyme form by limited proteolysis.
Elevation of glycoprotein galactosyltransferase activity in human lung cancer related to histological types.
Expression of alpha-gal epitopes on ovarian carcinoma membranes to be used as a novel autologous tumor vaccine.
Expression of galactosyltransferase in prostatic tumors.
Galactosyltransferase activities in cultured urinary bladder tumor cells.
Galactosyltransferase activity in metastasizing and nonmetastasizing rat mammary carcinomas and its possible relationship with tumor cell surface antigen shedding.
Gastrointestinal tumor markers, other than carcinoembryonic antigen, and alpha fetal protein.
Glycosyltransferase and glycosidase activities in ovarian cancer patients.
Human intestinal epithelial cells express a novel receptor for IgA.
In vitro galactosylation of a 110-kDa glycoprotein by an endogenous cell surface galactosyltransferase correlates with the invasiveness of adrenal carcinoma cells.
Knockdown of Core 1 Beta 1, 3-galactosyltransferase Prolongs Skin Allograft Survival with Induction of Galectin-1 Secretion and Suppression of CD8(+)T Cells : T synthase knockdown effects on galectin-1 and CD8(+)T cells.
[Galactosyltransferase isozyme II (GT-II) as a new tumor marker for ovarian cancers--especially for clear cell carcinoma]
[Preclinical and clinical studies on a tumor marker, galactosyltransferase associated with tumor (GAT), in ovarian cancer (first report)--preclinical study of GAT assay kit and clinical study of normal level]
Carcinoma, Adenoid Cystic
Cell-surface galactosyltransferase acts as a modulator of rat and human acinar cell proliferation.
Carcinoma, Ehrlich Tumor
Comparison of Ehrlich ascites tumour and mouse liver cells by analytical subcellular fractionation combined with a sensitive computational method for data analysis.
Carcinoma, Embryonal
Embryonal carcinoma cell adhesion: the role of surface galactosyltransferase and its 90K lactosaminoglycan substrate.
Evidence that galactosyltransferase is a surface receptor for poly(N)-acetyllactosamine glycoconjugates on embryonal carcinoma cells.
Purification and properties of N-acetylglucosaminide beta 1----4 galactosyltransferase from embryonal carcinoma cells.
Subcellular localization of N-acetylglucosaminide beta 1----4 galactosyltransferase revealed by immunoelectron microscopy.
Temporally specific involvement of cell surface beta-1,4 galactosyltransferase during mouse embryo morula compaction.
Carcinoma, Endometrioid
Biological markers and ovarian carcinomas: galactosyltransferase, CA 125, isoenzymes of amylase and alkaline phosphatase.
Carcinoma, Hepatocellular
C1GALT1 Enhances Proliferation of Hepatocellular Carcinoma Cells via Modulating MET Glycosylation and Dimerization.
C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin ?1 glycosylation and activity.
Characterization of galactosyltransferase released from human hepatoma cells.
Characterization of glycosyltransferases in the Golgi complex from rat ascites hepatoma AH-130 cells: a comparison with those from normal liver.
Comparative studies on the uridine-5'-diphosphate-galactose: glycoprotein galactosyltransferase activity in rat liver and Zajdela ascitic hepatoma.
Distribution of glycosyltransferases among Golgi apparatus subfractions from liver and hepatomas of the rat.
Expression of xenoantigen transformed human cancer cells to be susceptible to antibody-mediated cell killing.
Galactosyltransferase: multiple forms in serum of normal and hepatoma Mc-29 bearing chickens and from liver and hepatoma microsomal and plasma membrane preparations.
Gangliosides of liver tumors induced by N-2 fluorenylacetamide III. Galactosyl and sialyl transferases in single carcinomas and nodules.
Protein kinase C mu is located at the Golgi compartment.
Serum galactosyltransferase isoenzyme patterns of cancer patients with liver involvement.
Carcinoma, Ovarian Epithelial
Correlation of UDP-galactose glycoprotein:galactosyltransferase levels in the sera with the clinical status of ovarian cancer patients.
Determination of serum galactosyltransferase levels in ovarian cancer patients for the evaluation of the effectiveness of therapeutic programs.
Carcinoma, Squamous Cell
Anti-C1GALT1 Autoantibody Is a Novel Prognostic Biomarker for Patients With Head and Neck Cancer.
Clinic implication of MUC1 O-glycosylation and C1GALT1 in esophagus squamous cell carcinoma.
Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1.
Carcinoma, Transitional Cell
Comparison of cell-associated and soluble galactosyltransferase isoenzymes from a human bladder transitional cell carcinoma line.
Galactosyltransferase activities in cultured urinary bladder tumor cells.
Cataract
Cataract development in the GalKO mouse.
Cholera
A radioimmune assay of ganglioside GM1 synthase using cholera toxin.
Chondrosarcoma
Solubilization of murine melanoma xylosyltransferase and galactosyltransferase activities and their inactivation by dialdehyde nucleosides.
Colitis
Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture.
Elevated miR-124-3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T-synthase.
Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.
Colonic Neoplasms
C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2.
CA19.9 antigen circulating in the serum of colon cancer patients: Where is it from?
Colonic cancer cell (HT29) adhesion to laminin is altered by differentiation: adhesion may involve galactosyltransferase.
Complementary Use of Carbohydrate Antigens Lewis a, Lewis b, and Sialyl-Lewis a (CA19.9 Epitope) in Gastrointestinal Cancers: Biological Rationale Towards A Personalized Clinical Application.
Enzymatic basis for sialyl-Tn expression in human colon cancer cells.
Evaluation of galactosyltransferase isoenzyme II in a human colon carcinoma-derived cell line, HCT-8.
Pathways of mucin O-glycosylation in normal and malignant rat colonic epithelial cells reveal a mechanism for cancer-associated Sialyl-Tn antigen expression.
Serum galactosyltransferase isoenzymes as markers for solid tumours in humans.
Suppression of Core 1 Gal-Transferase Is Associated with Reduction of TF and Reciprocal Increase of Tn, sialyl-Tn and Core 3 Glycans in Human Colon Cancer Cells.
Colorectal Neoplasms
A new method for detecting beta 1,4-galactosyltransferase activity in sera of cancer patients.
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2.
Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers.
T-Synthase Deficiency Enhances Oncogenic Features in Human Colorectal Cancer Cells via Activation of Epithelial-Mesenchymal Transition.
Crohn Disease
Agalactosyl IgG in inflammatory bowel disease: correlation with C-reactive protein.
Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.
Cystic Fibrosis
Properties of microsomal glycoprotein galactosyltransferase of cultured human fibroblasts in relation to cystic fibrosis.
Serum factor in cystic fibrosis: correlation with clinical parameters.
The levels of galactosyltransferase activity in sera from normal children and patients with cystic fibrosis.
Cysts
N-acetyl-D-glucosamine is present in cysts and trophozoites of Giardia lamblia and serves as receptor for wheatgerm agglutinin.
[Applications of tumor markers to the screening of endometrial and ovarian cancers]
Demyelinating Diseases
Upregulation of ?-1,4-Galactosyltransferase I in Rat Spinal Cord with Experimental Autoimmune Encephalomyelitis.
Diabetes Mellitus, Experimental
Influence of bis(maltolato)oxovanadium(IV) on activity of galactosyltransferase (GalT) and morphology of rat liver Golgi apparatus in control and streptozotocin diabetes.
Ehlers-Danlos Syndrome
Broadening the phenotypic spectrum of Beta3GalT6-associated phenotypes.
Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene.
Endometriosis
[Clinical significance of galactosyltransferase associated with tumor (GAT), a new tumor marker for ovarian cancer--with special reference to the discrimination between ovarian cancer and endometriosis]
Esophageal Neoplasms
Knockdown of C1GalT1 inhibits radioresistance of human esophageal cancer cells through modifying ?1-integrin glycosylation.
Fatty Liver
Collagen ?(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice.
Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice.
Glomerulonephritis, IGA
A Novel Fluorescent Assay for T-synthase Activity.
Abnormal miR-148b Expression Promotes Aberrant Glycosylation of IgA1 in IgA Nephropathy.
Association between C1GALT1 variants and genetic susceptibility to IgA nephropathy in Uygur.
C1GALT1 expression is associated with galactosylation of IgA1 in peripheral B lymphocyte in immunoglobulin a nephropathy.
Downregulation of the beta1,3- galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy.
Genetic variant of C1GalT1 contributes to the susceptibility to IgA nephropathy.
Interaction between GALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy.
Leucocyte beta 1,3 galactosyltransferase activity in IgA nephropathy.
Relationship between rs1047763 polymorphism of the C1GALT1 gene and susceptibility to immunoglobulin A nephropathy in Xinjiang Uyghur people.
The Association of rs1047763 and rs1008898 of C1GALT1 with IgA Nephropathy Risk: A Global Meta-Analysis.
The genetic susceptibility to IgA nephropathy: a novel functional candidate gene for incomplete O-glycosylation of IgA1.
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy.
Head and Neck Neoplasms
C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer.
Hemoglobinuria
Differences in the regulation of specific glycosylation in the pathogenesis of paroxysmal nocturnal hemoglobinuria and the Tn-syndrome.
Hemoglobinuria, Paroxysmal
Differences in the regulation of specific glycosylation in the pathogenesis of paroxysmal nocturnal hemoglobinuria and the Tn-syndrome.
Herpes Simplex
Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1.
Host cell-induced differences in the O-glycosylation of herpes simplex virus gC-1. II. Demonstration of cell-specific galactosyltransferase essential for formation of O-linked oligosaccharides.
Herpes Zoster
A role for mouse sperm surface galactosyltransferase in sperm binding to the egg zona pellucida.
Binding of caput epididymal mouse sperm to the zona pellucida.
Cell adhesion and fertilization: steps in oocyte transport, sperm-zona pellucida interactions, and sperm-egg fusion.
Cell surface beta 1,4 galactosyltransferase on primary spermatocytes facilitates their initial adhesion to Sertoli cells in vitro.
Further characterization of the mouse sperm surface zona-binding site with galactosyltransferase activity.
Human sperm plasma membranes possess alpha-D-mannosidase activity but no galactosyltransferase activity.
Identification of a deoxyribonucleic acid allelic variant for beta 1-4 galactosyltransferase expression associated with male sperm binding/penetration infertility.
Molecules involved in mammalian sperm-egg interaction.
Plasma membrane association, purification, and partial characterization of mouse sperm beta 1,4-galactosyltransferase.
Receptor function of mouse sperm surface galactosyltransferase during fertilization.
Redistribution of mouse sperm surface galactosyltransferase after the acrosome reaction.
Relationship between two types of mouse sperm surface sites that mediate binding of sperm to the zona pellucida.
Spatial and temporal expression of cell surface galactosyltransferase during mouse spermatogenesis and epididymal maturation.
Stage-specific increase in cell surface galactosyltransferase activity during spermatogenesis in mice bearing t alleles.
The involvement of beta-1,4-Galactosyltransferase and N-Acetylglucosamine residues in fertilization has been lost in the horse.
The receptor function of galactosyltransferase during mammalian fertilization.
Hypersensitivity
Oral feeding with pig peripheral lymphocytes decreases the xenogeneic delayed type hypersensitivity reaction in galactosyltransferase knockout mice.
Infections
Complete protection against experimental visceral leishmaniasis with complete soluble antigen from attenuated Leishmania donovani promastigotes involves Th1-immunity and down-regulation of IL-10.
Electrophoretic analysis of glycoprotein glycans produced by lepidopteran insect cells infected with an immediate early recombinant baculovirus encoding mammalian beta1,4-galactosyltransferase.
Elevated glycosyltransferase activities in infected or traumatized hosts: nonspecific response to inflammation.
The Immunological Regulation Roles of Porcine ?-1, 4 Galactosyltransferase V (B4GALT5) in PRRSV Infection.
Infertility
Identification of a deoxyribonucleic acid allelic variant for beta 1-4 galactosyltransferase expression associated with male sperm binding/penetration infertility.
Infertility, Male
Identification of novel putative causative genes and genetic marker for male sterility in Japanese cedar (Cryptomeria japonica D.Don).
Intracranial Hemorrhages
Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans.
Targeted disruption of the gene encoding core 1 beta1-3-galactosyltransferase (T-synthase) causes embryonic lethality and defective angiogenesis in mice.
Iron Overload
Chronic liver iron overload in the baboon by ferric nitrilotriacetate. Morphologic and functional changes with special reference to collagen synthesis enzymes.
Joint Instability
Broadening the phenotypic spectrum of Beta3GalT6-associated phenotypes.
Kidney Diseases
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Leishmaniasis, Visceral
UDP-Gal: N-acetylglucosamine beta 1-4 galactosyltransferase expressing live attenuated parasites as vaccine for visceral leishmaniasis.
Leukemia
Elevated thymic and serum galactosyltransferase with low-molecular-weight acceptor activity in murine leukemia.
Glycosyltransferase activities in leukemic cells from patients and human leukemic cell lines.
Release of glycosyltransferase and glycosidase activities from normal and transformed cell lines.
Leukemia, Myeloid
Differentiation-associated changes of glycolipid composition and metabolism in mouse myeloid leukemia cells. Induction of globotriaosylceramide and a galactosyltransferase.
Leukodystrophy, Globoid Cell
Biosynthesis of galactosylsphingosine (psychosine) in the twitcher mouse.
Lipodystrophy
Collagen ?(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice.
Liver Diseases
Abnormal isoelectric focusing patterns of serum galactosyltransferase activity in patients with liver neoplasia.
Collagen ?(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice.
Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice.
Glycosyltransferases in human blood. II. Study of serum galactosyltransferase and N-acetylgalactosaminyltransferase in patients with liver diseases.
Lung Neoplasms
C1GALT1, Negatively Regulated by miR-181d-5p, Promotes Tumor Progression via Upregulating RAC1 in Lung Adenocarcinoma.
Elevation of glycoprotein galactosyltransferase activity in human lung cancer related to histological types.
Isolation and characterization of cancer-associated galactosyltransferase isoenzyme.
Lupus Erythematosus, Systemic
Glycosphingolipid-associated ?-1,4 galactosyltransferase is elevated in patients with systemic lupus erythematosus.
Lyme Disease
Functional analysis of a lipid galactosyltransferase synthesizing the major envelope lipid in the Lyme disease spirochete Borrelia burgdorferi.
Identification and functional analysis of a galactosyltransferase capable of cholesterol glycolipid formation in the Lyme disease spirochete Borrelia burgdorferi.
Lymphatic Metastasis
A novel mechanism for C1GALT1 in the regulation of gastric cancer progression.
Clinic implication of MUC1 O-glycosylation and C1GALT1 in esophagus squamous cell carcinoma.
Lymphoma
A comparison of galactosyltransferase activity in mouse ascites lymphoma cells (Ly/Ya), in cultured lymphoma cells, in ascitic fluid and culture medium.
Galactosyltransferase activities in subcellular fractions of two YC8 lymphoma cell variants : does a relationship exist between antigenic determinants and acceptor sites for galactose?
Galactosyltransferase and phosphatase activities in physiological fluids from BALB/c mice bearing the YC8 lymphoma.
Malnutrition
Lactose synthesis in the rat, and the effects of litter size and malnutrition.
Melanoma
AGI-134: a fully synthetic ?-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 antibody in mouse melanoma models.
Alterations of cell surface carbohydrates and inhibition of metastatic property of murine melanomas by alpha 1,3 galactosyltransferase gene transfection.
Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
Human melanoma and Chinese hamster ovary cells galactosylate n-alkyl-beta-glucosides using UDP gal:GlcNAc beta 1,4 galactosyltransferase.
Isolation and characterization of a Golgi-rich fraction from the Harding-Passey mouse melanoma.
Lectin-induced apoptosis of tumour cells.
Metastasis-associated murine melanoma cell surface galactosyltransferase: characterization of enzyme activity and identification of the major surface substrates.
Modulation by all-trans retinoic acid of glycoprotein glycosylation in murine melanoma cells: enhancement of fucosyl- and galactosyltransferase activities.
Solubilization of murine melanoma xylosyltransferase and galactosyltransferase activities and their inactivation by dialdehyde nucleosides.
Meningioma
Glycosyltransferase activities in human meningiomas. Preliminary results.
Myasthenia Gravis
Emerging Roles for SSeCKS/Gravin/AKAP12 in the Control of Cell Proliferation, Cancer Malignancy, and Barriergenesis.
n-acetylgalactosaminide beta-1,3-galactosyltransferase deficiency
B4GALT1-congenital disorders of glycosylation presents as a non-neurologic glycosylation disorder with hepatointestinal involvement.
Galactosyltransferase defects in reeler mouse brains.
Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.
New mutations in C1GALT1C1 in individuals with Tn positive phenotype.
Persistent repression of a functional allele can be responsible for galactosyltransferase deficiency in Tn syndrome.
Repressed beta-1,3-galactosyltransferase in the Tn syndrome.
Structural analysis of the N-glycans from human immunoglobulin A1: comparison of normal human serum immunoglobulin A1 with that isolated from patients with rheumatoid arthritis.
T-Synthase Deficiency Enhances Oncogenic Features in Human Colorectal Cancer Cells via Activation of Epithelial-Mesenchymal Transition.
Neoplasm Metastasis
A novel mechanism for C1GALT1 in the regulation of gastric cancer progression.
Anti-C1GALT1 Autoantibody Is a Novel Prognostic Biomarker for Patients With Head and Neck Cancer.
C1GALT1 Enhances Proliferation of Hepatocellular Carcinoma Cells via Modulating MET Glycosylation and Dimerization.
C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin ?v.
C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer.
C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2.
C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin ?1 glycosylation and activity.
C1GALT1, Negatively Regulated by miR-181d-5p, Promotes Tumor Progression via Upregulating RAC1 in Lung Adenocarcinoma.
Clinic implication of MUC1 O-glycosylation and C1GALT1 in esophagus squamous cell carcinoma.
Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice.
Expression of galactosyltransferase in prostatic tumors.
Serum galactosyltransferase isoenzyme patterns of cancer patients with liver involvement.
T-Synthase Deficiency Enhances Oncogenic Features in Human Colorectal Cancer Cells via Activation of Epithelial-Mesenchymal Transition.
Neoplasm, Residual
Ovarian cancer and tumor markers: sialic acid, galactosyltransferase and CA-125.
Neoplasms
A comparison of circulating immune complexes, pregnancy associated beta 1-macroglobulin and galactosyltransferase as tumour markers for ovarian cancer.
A Novel Fluorescent Assay for T-synthase Activity.
A novel mechanism for C1GALT1 in the regulation of gastric cancer progression.
A simple and specific assay of glycosyltransferase and glycosidase activities by an enzyme-linked immunosorbent assay method, and its application to assay of galactosyltransferase activity in sera from patients with cancer.
Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29.
Aberrant O-glycosylation contributes to tumorigenesis in human colorectal cancer.
Abnormal isoelectric focusing patterns of serum galactosyltransferase activity in patients with liver neoplasia.
Adenovirus-mediated expression of pig alpha(1, 3) galactosyltransferase reconstructs Gal alpha(1, 3) gal epitope on the surface of human tumor cells.
Alterations in glycosyltransferase activity in human colon cancer.
Alterations in serum glycosyltransferases and 5'-nucleotidase in breast cancer patients.
An enzyme immunoassay for galactosyltransferase isoenzyme II, and its clinical application to cancer diagnosis.
Analysis of the sequences of human beta-1,4-galactosyltransferase cDNA clones.
Antitumor effect of a liposome-encapsulated ?1,4-galactosyltransferase inhibitor.
C1GALT1 Enhances Proliferation of Hepatocellular Carcinoma Cells via Modulating MET Glycosylation and Dimerization.
C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin ?v.
C1GALT1 in health and disease.
C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer.
C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2.
C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer.
C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin ?1 glycosylation and activity.
C1GALT1 Seems to Promote In Vitro Disease Progression in Ovarian Cancer.
C1GALT1, Negatively Regulated by miR-181d-5p, Promotes Tumor Progression via Upregulating RAC1 in Lung Adenocarcinoma.
Cancer-associated galactosyltransferase acceptor: inhibition of transformed cell and tumor growth.
Cancer-associated galactosyltransferase as a new tumor marker for ovarian clear cell carcinoma.
Cancer-associated isoenzyme of serum galactosyltransferase.
Cancer-associated serum galactosyltransferase activity. Demonstration in an animal model system.
Characterization and immunoassay of human tumor-associated galactosyltransferase isoenzyme II.
Clinical characteristics of a newly developed ovarian tumour marker, galactosyltransferase associated with tumour (GAT).
Clinical value of serum glycoprotein galactosyltransferase levels in different histological types of ovarian carcinoma.
Comparison of Ehrlich ascites tumour and mouse liver cells by analytical subcellular fractionation combined with a sensitive computational method for data analysis.
Complementary DNA cloning for galactosyltransferase associated with tumor and determination of antigenic epitopes recognized by specific monoclonal antibodies.
Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes.
Correlation of UDP-galactose glycoprotein:galactosyltransferase levels in the sera with the clinical status of ovarian cancer patients.
Cosmc overexpression enhances malignancies in human colon cancer.
Critical comments on galactosyltransferase.
Determination of serum galactosyltransferase levels in ovarian cancer patients for the evaluation of the effectiveness of therapeutic programs.
Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers.
DNA methylation and histone modifications modulate the ?1,3 galactosyltransferase ?3Gal-T5 native promoter in cancer cells.
Effect of estradiol and prolactin on galactosyltransferase and alpha-lactalbumin activities in rat mammary gland and mammary tumor.
Elevated thymic and serum galactosyltransferase with low-molecular-weight acceptor activity in murine leukemia.
Elevation of 4 beta-galactosyltransferase activity for paragloboside synthesis in sera of patients with cancer.
Eliciting hyperacute xenograft response to treat human cancer: alpha(1,3) galactosyltransferase gene therapy.
Enzyme activities in human breast tumor cells and sera.
Evidence for new beta1-3 galactosyltransferase activity involved in biosynthesis of unusual N-glycan harboring T-antigen in Apis mellifera.
Expression of alpha-gal epitopes on ovarian carcinoma membranes to be used as a novel autologous tumor vaccine.
Expression of galactosyltransferase in prostatic tumors.
Functional assays for the molecular chaperone cosmc.
Galactosyltransferase activities in human sera of various diseases.
Galactosyltransferase activity in metastasizing and nonmetastasizing rat mammary carcinomas and its possible relationship with tumor cell surface antigen shedding.
Galactosyltransferase associated with tumor in patients with ovarian cancer: factors involved in elevation of serum galactosyltransferase.
Gangliosides of liver tumors induced by N-2 fluorenylacetamide III. Galactosyl and sialyl transferases in single carcinomas and nodules.
Glycosyltransferase and glycosidase activities in ovarian cancer patients.
Glycosyltransferase levels in tumors metastatic to liver and in uninvolved liver tissue.
Immunoassay of serum galactosyltransferase isoenzyme II in cancer patients and control subjects.
In vitro and in vivo growth control of transformed lymphoid cells expressing plasma membrane galactosyltransferase.
Increased activity of a beta-galactosyltransferase in tissues of rats bearing prostate and mammary adenocarcinomas.
Inhibition of growth of transformed cells and tumors by an endogenous acceptor of galactosyltransferase.
Inhibition of primary and metastatic tumor growth in mice by cancer-associated galactosyltransferase acceptor.
Isoenzymatic patterns of human galactosyltransferase from normal and cancer patients.
Isolation of a Golgi-apparatus-enriched fraction from leukaemic cells.
Metastatic Progression of Prostate Cancer Is Mediated by Autonomous Binding of Galectin-4-O-Glycan to Cancer Cells.
MUC1 glycopeptide epitopes predicted by computational glycomics.
Mucin biosynthesis revisited. The enzymatic transfer of Gal in beta 1,3 linkage to the GalNAc moiety of the core structure R1-GlcNAc beta 1,6GalNAc alpha-O-R2.
Ovarian cancer and tumor markers: sialic acid, galactosyltransferase and CA-125.
Overexpression of ?2,3sialyl T-antigen in breast cancer determined by miniaturized glycosyltransferase assays and confirmed using tissue microarray immunohistochemical analysis.
Phosphatidylcholine stimulates the activity of UDP-Gal beta 1-4 galactosyltransferase in normal human kidney proximal tumour cells.
Relevance of ?Gal-?GalNAc-containing glycans and the enzymes involved in their synthesis for invasion and survival in breast cancer patients.
Serum galactosyltransferase as a prognostic marker in patients with solid tumors.
Serum galactosyltransferase isoenzyme patterns of cancer patients with liver involvement.
Serum galactosyltransferase isoenzymes as markers for solid tumours in humans.
Suppression of Lewis lung tumor development in alpha 1,3 galactosyltransferase knock-out mice.
T-Synthase Deficiency Enhances Oncogenic Features in Human Colorectal Cancer Cells via Activation of Epithelial-Mesenchymal Transition.
The Cosmc connection to the Tn antigen in cancer.
The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn.
The Immunological Regulation Roles of Porcine ?-1, 4 Galactosyltransferase V (B4GALT5) in PRRSV Infection.
Tumour-associated antigens for cystadenocarcinoma of the ovary.
Udp-galactose: glycoprotein galactosyltransferase activity in a clonal line of rat brain.
Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway.
Uridine 5'-diphosphate-galactose:glycoprotein galactosyltransferase activity in the ovarian cancer patient.
[A glycoprotein: galactosyltransferase activity in the ascitic fluid and serum of mice with the YC8 tumor]
[cDNA cloning of galactosyltransferase associated with tumor (GAT)]
[Clinical significance of galactosyltransferase associated with tumor (GAT), a new tumor marker for ovarian cancer--with special reference to the discrimination between ovarian cancer and endometriosis]
[Clinical usefulness of tumor markers for the diagnosis of ovarian cancer]
[Galactosyltransferase isozyme II (GT-II) as a new tumor marker for ovarian cancers--especially for clear cell carcinoma]
[Preclinical and clinical studies on a tumor marker, galactosyltransferase associated with tumor (GAT), in ovarian cancer (first report)--preclinical study of GAT assay kit and clinical study of normal level]
[Preclinical and clinical studies on a tumor marker, galactosyltransferase associated with tumor (GAT), in ovarian cancer (second report)--clinical significance of GAT and comparison with other tumor markers]
Nephritis
C1GALT1 polymorphisms are associated with Henoch-Schönlein purpura nephritis.
Non-alcoholic Fatty Liver Disease
Collagen ?(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice.
Ovarian Neoplasms
A comparison of circulating immune complexes, pregnancy associated beta 1-macroglobulin and galactosyltransferase as tumour markers for ovarian cancer.
Alteration in isoenzyme patterns of serum galactosyltransferase activity in ovarian cancer patients: preliminary results.
Analysis of the sequences of human beta-1,4-galactosyltransferase cDNA clones.
Biochemical and immunologic characterization of galactosyltransferase purified from the ascites of ovarian cancer patients.
C1GALT1 Seems to Promote In Vitro Disease Progression in Ovarian Cancer.
Characterization of products synthesized by galactosyltransferase purified from the ascites of ovarian cancer patients.
Clinical characteristics of a newly developed ovarian tumour marker, galactosyltransferase associated with tumour (GAT).
Determination of serum galactosyltransferase levels in ovarian cancer patients for the evaluation of the effectiveness of therapeutic programs.
Galactosyltransferase associated with tumor in patients with ovarian cancer: factors involved in elevation of serum galactosyltransferase.
Murine monoclonal antibodies against galactosyltransferase from the ascites of ovarian cancer patients.
Ovarian cancer and tumor markers: sialic acid, galactosyltransferase and CA-125.
Serum galactosyltransferase activity with three acceptors in ovarian cancer patients.
Tumour-associated antigens for cystadenocarcinoma of the ovary.
Uridine 5'-diphosphate-galactose:glycoprotein galactosyltransferase activity in the ovarian cancer patient.
[Clinical significance of galactosyltransferase associated with tumor (GAT), a new tumor marker for ovarian cancer--with special reference to the discrimination between ovarian cancer and endometriosis]
[Localization and modulation of galactosyltransferase during in vitro proliferation of a human ovarian adenocarcinoma cell line]
[Preclinical and clinical studies on a tumor marker, galactosyltransferase associated with tumor (GAT), in ovarian cancer (first report)--preclinical study of GAT assay kit and clinical study of normal level]
[Preclinical and clinical studies on a tumor marker, galactosyltransferase associated with tumor (GAT), in ovarian cancer (second report)--clinical significance of GAT and comparison with other tumor markers]
Pancreatic Neoplasms
Expression of xenoantigen transformed human cancer cells to be susceptible to antibody-mediated cell killing.
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110.
Galactosyltransferase isoenzyme II in the detection of pancreatic cancer: comparison with radiologic, endoscopic, and serologic tests.
Tissue polypeptide antigen, galactosyltransferase isoenzyme II and pancreatic oncofetal antigen serum determination: role in pancreatic cancer diagnosis.
Pleural Effusion
Galactosyltransferase variant in pleural effusion.
Inhibition of galactosyltransferase activity by cacodylate buffer.
Isolation and characterization of cancer-associated galactosyltransferase isoenzyme.
Monoclonal antibodies to bovine UDP-galactosyltransferase. Characterization, cross-reactivity, and utilization as structural probes.
Pleural Effusion, Malignant
Galactosyltransferase variant in pleural effusion.
Pneumococcal Infections
Elevated glycosyltransferase activities in infected or traumatized hosts: nonspecific response to inflammation.
Progeria
Hutchinson-Gilford progeria: faithful DNA maintenance, inheritance and allelic transcription of beta(1-4) galactosyltransferase.
Prostatic Neoplasms
O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer.
Proteinuria
Loss of mucin-type O-glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney.
Search for genetic association between IgA nephropathy and candidate genes selected by function or by gene mapping at loci IGAN2 and IGAN3.
Purpura
A study on the association between C1GALT1 polymorphisms and the risk of Henoch-Schönlein purpura in a Chinese population.
C1GALT1 polymorphisms are associated with Henoch-Schönlein purpura nephritis.
Renal Insufficiency
Cosmc-dependent mucin-type O-linked glycosylation is essential for podocyte function.
Retinitis Pigmentosa
[Sialyltransferase and galactosyltransferase of lymphocyte in retinitis pigmentosa]
Rheumatic Diseases
Glycosylation and rheumatic disease.
Rotavirus Infections
Glycan-modifying bacteria-derived soluble factors from Bacteroides thetaiotaomicron and Lactobacillus casei inhibit rotavirus infection in human intestinal cells.
Squamous Cell Carcinoma of Head and Neck
Anti-C1GALT1 Autoantibody Is a Novel Prognostic Biomarker for Patients With Head and Neck Cancer.
C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer.
Stomach Neoplasms
A novel mechanism for C1GALT1 in the regulation of gastric cancer progression.
C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer.
Teratocarcinoma
Identification of a major poly-N-acetyllactosamine-containing cell-surface glycoprotein of mouse teratocarcinoma cells. Appearance on cells induced to primitive endoderm but not parietal endoderm differentiation.
Secretion of alpha1,3-galactosyltransferase by cultured cells and presence of enzyme in animal sera.
The use of galactosyltransferase to probe nitrocellulose-immobilized glycoproteins for nonreducing terminal N-acetylglucosamine residues.
Thrombocytopenia
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Thrombosis
Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation.
Tuberculosis
Agalactosyl IgG in inflammatory bowel disease: correlation with C-reactive protein.
Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics.
Urinary Bladder Neoplasms
Galactosyltransferase activities in cultured urinary bladder tumor cells.