Disease on EC 2.3.3.8 - ATP citrate synthase

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DISEASE
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Acidosis
Adenosine triphosphate citrate lyase mediates hypocitraturia in rats.
Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia.
Adenocarcinoma
ATP citrate lyase expression is associated with advanced stage and prognosis in gastric adenocarcinoma.
Alzheimer Disease
Coenzyme A-acetylating enzymes in Alzheimer's disease: possible cholinergic 'compartment' of pyruvate dehydrogenase.
Ataxia Telangiectasia
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.
Atherosclerosis
ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review.
Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.
New Era of Lipid-Lowering Drugs.
Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr(-/-) Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid.
atp citrate synthase deficiency
ATP-citrate lyase deficiency in the mouse.
Brain Diseases
[NADP malate dehydrogenase, acetyl-CoA synthetase and ATP citrate lyase in experimental cyanide encephalopathy]
Breast Neoplasms
ATP citrate lyase is increased in human breast cancer, depletion of which promotes apoptosis.
Cyclin E associates with the lipogenic enzyme ATP-citrate lyase to enable malignant growth of breast cancer cells.
Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast.
MiR-22 down-regulates the proto-oncogene ATP citrate lyase to inhibit the growth and metastasis of breast cancer.
mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer.
Carcinogenesis
A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results.
Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus pre-S2 mutant tumorigenesis.
Carcinoma
Overexpression of ATP citrate lyase in renal cell carcinoma tissues and its effect on the human renal carcinoma cells in vitro.
Carcinoma, Hepatocellular
GTP, a nonsubstrate of ATP citrate lyase, is a phosphodonor for the enzyme histidine autophosphorylation.
Carcinoma, Non-Small-Cell Lung
ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.
Prognostic impact of the combination of glucose transporter 1 and ATP citrate lyase in node-negative patients with non-small lung cancer.
Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly.
Spermidine reduces cancer-related mortality in humans.
Carcinoma, Ovarian Epithelial
Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer.
Carcinoma, Renal Cell
Overexpression of ATP citrate lyase in renal cell carcinoma tissues and its effect on the human renal carcinoma cells in vitro.
Cardiovascular Diseases
Mendelian Randomization Study of ACLY and Cardiovascular Disease.
Colonic Neoplasms
ACLY facilitates colon cancer cell metastasis by CTNNB1.
Colorectal Neoplasms
ATP citrate lyase mediates resistance of colorectal cancer cells to SN38.
Functional polymorphisms of ATP citrate lyase gene predicts clinical outcome of patients with advanced colorectal cancer.
Diabetes Mellitus
The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus.
Diabetes Mellitus, Type 2
Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells.
Dyslipidemias
Adenosine triphosphate citrate lyase: Emerging target in the treatment of dyslipidemia.
ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia.
Fatty Liver
Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.
Some lipogenic enzyme activities in rat livers in which an excessive fat accumulation occurred due to feeding low-level amino acid mixture diets.
Glioblastoma
Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+-NFAT signaling.
Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas.
Glioma
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.
Hepatitis B
Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus pre-S2 mutant tumorigenesis.
Hyperglycemia
Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.
Effects of high sucrose diet on insulin-like effects of vanadate in diabetic rats.
Hyperinsulinism
Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes.
Chronic hyperinsulinemia in the fetal rhesus monkey: effects on hepatic enzymes active in lipogenesis and carbohydrate metabolism.
Hyperlipidemias
Docking study of novel antihyperlipidemic thieno[2,3-d]pyrimidine; LM-1554, with some molecular targets related to hyperlipidemia - an investigation into its mechanism of action.
Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders.
Hypokalemia
Adenosine triphosphate citrate lyase mediates hypocitraturia in rats.
Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia.
Hypothyroidism
A tissue-specific increase in lipogenesis in rat brown adipose tissue in hypothyroidism.
Insulin Resistance
Changes in lipid synthesis in rat adipose tissue during development.
Pyruvate dehydrogenase and ATP citrate (pro-3S)-lyase activities in adipose tissue and liver of the young lean and the older obese rat.
Insulinoma
Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells.
Leukemia
Enzyme activities of NADPH-forming metabolic pathways in normal and leukemic leukocytes.
Leukemia, Myeloid, Acute
Enzyme activities of NADPH-forming metabolic pathways in normal and leukemic leukocytes.
Liver Diseases
ATP Citrate Lyase and LncRNA NONMMUT010685 Play Crucial Role in Nonalcoholic Fatty Liver Disease Based on Analysis of Microarray Data.
Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Diseases, Alcoholic
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Neoplasms
Aberrant lipid metabolism as a therapeutic target in liver cancer.
Lung Neoplasms
ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-actiated protein kinase (MAPK) and phosphatidylinositol-3- kinase (PI3K)/AKT pathways.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Prognostic impact of the combination of glucose transporter 1 and ATP citrate lyase in node-negative patients with non-small lung cancer.
Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly.
Spermidine reduces cancer-related mortality in humans.
Melanoma
Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea.
Myocardial Infarction
Weighted gene co?expression network analysis in identification of key genes and networks for ischemic?reperfusion remodeling myocardium.
Neoplasm Metastasis
Clinical-translational approaches to the Nm23-H1 metastasis suppressor.
MiR-22 down-regulates the proto-oncogene ATP citrate lyase to inhibit the growth and metastasis of breast cancer.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Neoplasms
A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results.
Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.
Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth.
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via ?-ketoglutarate.
Adding a combination of hydroxycitrate and lipoic acid (METABLOC™) to chemotherapy improves effectiveness against tumor development: experimental results and case report.
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.
ATP Citrate Lyase (ACLY): A Promising Target for Cancer Prevention and Treatment.
ATP citrate lyase inhibition can suppress tumor cell growth.
ATP Citrate Lyase Inhibitors as Novel Cancer Therapeutic Agents.
ATP citrate lyase is increased in human breast cancer, depletion of which promotes apoptosis.
ATP citrate lyase knockdown impacts cancer stem cells in vitro.
ATP-Citrate Lyase: A Key Player in Cancer Metabolism.
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.
Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.
Decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer.
Differentiation of human tumors from nonmalignant tissue by natural-abundance 13C NMR spectroscopy.
Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells.
Functional polymorphisms of ATP citrate lyase gene predicts clinical outcome of patients with advanced colorectal cancer.
Hydroxycitrate causes altered pyruvate metabolism by tumorigenic cells.
Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth.
Increased lipogenesis in cancer cells: new players, novel targets.
Inhibition of ATP Citrate Lyase Induces an Anticancer Effect via Reactive Oxygen Species: AMPK as a Predictive Biomarker for Therapeutic Impact.
Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells.
Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer.
Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4.
Leelamine is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo.
Liver fat content and lipid metabolism in dairy cows during early lactation and during a mid-lactation feed restriction.
Mendelian Randomization Study of ACLY and Cardiovascular Disease.
miR-133b acts as a tumor suppressor and negatively regulates ATP citrate lyase via PPAR? in gastric cancer.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Polyamine regulating protein antizyme binds to ATP citrate lyase to accelerate acetyl-CoA production in cancer cells.
Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer.
Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly.
Resveratrol prevents hepatic steatosis and endoplasmic reticulum stress and regulates the expression of genes involved in lipid metabolism, insulin resistance, and inflammation in rats.
Retraction note to: decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer.
Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer.
Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells.
Targeting Mitochondrial Citrate Transport in Breast Cancer Cell Lines.
The metabolic advantage of tumor cells.
The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis.
Weighted gene co?expression network analysis in identification of key genes and networks for ischemic?reperfusion remodeling myocardium.
Neuroblastoma
The enzymes of acetyl-CoA metabolism in differentiating cholinergic (s-20) and noncholinergic (NIE-115) neuroblastoma cells.
Non-alcoholic Fatty Liver Disease
ATP Citrate Lyase and LncRNA NONMMUT010685 Play Crucial Role in Nonalcoholic Fatty Liver Disease Based on Analysis of Microarray Data.
Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Obesity
Changes in hepatic lipogenic enzyme activities in voles and mice treated with monosodium aspartate.
Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial.
The impact of hydroxycitric acid on the lipid metabolism profile under experimental insulin resistance syndrome of Syrian hamsters.
Osteosarcoma
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Ovarian Neoplasms
Regulation of protein metabolism in cancer.
Pancreatic Neoplasms
Decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer.
Retraction note to: decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer.
Prostatic Neoplasms
Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling.
Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.
Retraction: Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling.
Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.
Starvation
Age-dependent hepatic lipogenic enzyme activities in starved-refed rats.
Stomach Neoplasms
miR-133b acts as a tumor suppressor and negatively regulates ATP citrate lyase via PPAR? in gastric cancer.
Uterine Cervical Neoplasms
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Vitamin B 6 Deficiency
Effects of vitamin B6 deficiency on liver, kidney, and adipose tissue enzymes associated with carbohydrate and lipid metabolism, and on glucose uptake by rat epididymal adipose tissue.