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IUBMB CommentsAlso acts on (R)-2-(n-propyl)-malate. Formerly wrongly included with EC 2.3.3.7 3-ethylmalate synthase.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating), 2-ethylmalate-3-hydroxybutanedioate synthase, EC 4.1.3.33, propylmalate synthase, propylmalic synthase,
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(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating)
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2-ethylmalate-3-hydroxybutanedioate synthase
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EC 4.1.3.33
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formerly
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propylmalate synthase
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propylmalic synthase
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acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA
acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA
also acts on (R)-2-(n-propyl)-malate
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acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA
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Acyl group transfer
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acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Also acts on (R)-2-(n-propyl)-malate. Formerly wrongly included with EC 2.3.3.7 3-ethylmalate synthase.
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acetyl-CoA + H2O + 2-ketoisovalerate
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acetyl-CoA + H2O + 2-ketovalerate
(R)-2-(n-propyl)-malate + CoA
acetyl-CoA + H2O + 2-oxobutanoate
(R)-2-ethylmalate + CoA
acetyl-CoA + H2O + pyruvate
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additional information
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not: 2-ketocaproate and 2-ketoisocaproate
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acetyl-CoA + H2O + 2-ketovalerate
(R)-2-(n-propyl)-malate + CoA
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acetyl-CoA + H2O + 2-ketovalerate
(R)-2-(n-propyl)-malate + CoA
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acetyl-CoA + H2O + 2-oxobutanoate
(R)-2-ethylmalate + CoA
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acetyl-CoA + H2O + 2-oxobutanoate
(R)-2-ethylmalate + CoA
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Mg2+
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in the absence of Mg2+ product is formed to an extent of 64% in the complete reaction
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L-leucine
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50% inhibition
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(NH4)2SO4
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maximum of activity: about 45% (NH4)2SO4 and decrease in activity at higher concentrations
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additional information
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additional information
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product formation doubled between pH 6.0 and 6.5, but there is a broud shoulder of activity between pH 6.5 and 7.5
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brenda
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brenda
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additional information
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heating in boiling water for 1 min results in a total loss of activity
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Strassman, M.; Ceci, L.N.
A study of acetyl-CoA condensation with alpha-keto acids
Arch. Biochem. Biophys.
119
420-428
1967
Saccharomyces cerevisiae
brenda
Rabin, R.; Salomon, I.I.; Bleiweis, A.S.; Carlin, J.; Ajl, S.J.
Metabolism of ethylmalic acids by Pseudomonas aeruginosa
Biochem. J.
7
377-389
1968
Pseudomonas aeruginosa
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