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Information on EC 2.3.3.5 - 2-methylcitrate synthase

for references in articles please use BRENDA:EC2.3.3.5

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IUBMB Comments

The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1, citrate (Si)-synthase. Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
methylcitrate synthase, 2-methylcitrate synthase, prpc2, 2-mcs, citrate synthase ii, 2-mcs1, rv1131, 2-mc synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
2-methylcitrate cycle I, 2-methylcitrate cycle II