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EC Tree
IUBMB Comments This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C-2 of oxaloacetate has not been established [cf. EC 2.3.3.1, citrate (Si)-synthase and EC 2.3.3.3, citrate (Re)-synthase].
The taxonomic range for the selected organisms is: Homo sapiens The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
citrate synthetase, mitochondrial citrate synthase, peroxisomal citrate synthase, si-citrate synthase, type ii citrate synthase, citrate synthase cit1, bifunctional citrate synthase/2-methylcitrate synthase, citrate condensing enzyme,
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citrate condensing enzyme
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citrate oxaloacetate-lyase (CoA-acetylating)
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citrate oxaloacetate-lyase, CoA-acetylating
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citrate synthetase
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citric-condensing enzyme
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oxalacetic transacetase
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oxaloacetate transacetase
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synthase, citrate
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acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C-2 of oxaloacetate has not been established [cf. EC 2.3.3.1, citrate (Si)-synthase and EC 2.3.3.3, citrate (Re)-synthase].
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acetyl-CoA + H2O + oxaloacetate
citrate + CoA
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acetyl-CoA + H2O + oxaloacetate
citrate + CoA
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Acidosis
Carbon flux through tricarboxylic acid cycle in rat renal tubules.
Adenocarcinoma
Pyruvate dehydrogenase, the citrate condensing enzyme and the utilization of 14 C-labeled lactate, pyruvate and alanine by slices of lactating mammary gland and adenocarcinoma of mouse mammary gland.
Amyotrophic Lateral Sclerosis
Enzymatic analysis of individual posterior root ganglion cells in olivopontocerebellar atrophy, amyotrophic lateral sclerosis and Duchenne muscular dystrophy.
Infections
Human skeletal muscle in bacterial infection: enzyme activities and their relationship to age.
Intermittent Claudication
Muscle enzyme adaptation in patients with peripheral arterial insufficiency: spontaneous adaptation, effect of different treatments and consequences on walking performance.
Muscular Diseases
Evidence for metabolic aberrations in asymptomatic persons with type 2 diabetes after initiation of simvastatin therapy.
Muscular Dystrophy, Duchenne
Enzymatic analysis of individual posterior root ganglion cells in olivopontocerebellar atrophy, amyotrophic lateral sclerosis and Duchenne muscular dystrophy.
Mycoplasma Infections
Human skeletal muscle in viral and mycoplasma infections: ultrastructural morphometry and its correlations to enzyme activities.
Obesity
Obesity affects mitochondrial citrate synthase in human omental adipose tissue.
Olivopontocerebellar Atrophies
Enzymatic analysis of individual posterior root ganglion cells in olivopontocerebellar atrophy, amyotrophic lateral sclerosis and Duchenne muscular dystrophy.
Pancreatitis
Cerulein-induced acute pancreatitis diminished vitamin E concentration in plasma and increased in the pancreas.
Phenylketonurias
Effect of phenylpyruvate on enzymes involved in fatty acid synthesis in rat brain.
Rickets
Mode of action of vitamin D; citrogenase and citric acid in dogs in induced rickets.
Sarcopenia
Impact of high-intensity interval training on cardiorespiratory fitness, body composition, physical fitness, and metabolic parameters in older adults: A meta-analysis of randomized controlled trials.
Spinal Cord Injuries
Sixteen weeks of testosterone with or without evoked resistance training on protein expression, fiber hypertrophy and mitochondrial health after spinal cord injury.
Starvation
Increased Fatty Acid beta-Oxidation after Glucose Starvation in Maize Root Tips.
Typhus, Epidemic Louse-Borne
Regulatory properties of citrate synthase from Rickettsia prowazekii.
Vasculitis, Central Nervous System
[Detection of a new species of Rickettsiae in the ticks of Ixodes persulcatus in Russia]
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8.5
calculated from amino acid sequence
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SwissProt
brenda
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brenda
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brenda
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physiological function
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enzymatic activities of citrate synthase and isocitrate dehydrogenase IDH2 are significantly reduced in methyl 4 phenylpyridinium treatment cells, while protein acetylation of citrate synthase and IDH2 increase. Overexpressed sirtuin SIRT3 partially reverses at least, the decline of citrate synthase activity and the increase of citrate synthase protein acetylation
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CISY_HUMAN
466
0
51712
Swiss-Prot
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additional information
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SIRT3 deacetylates and activates citrate synhase activity
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Roy, C.
Insight into sequence, structure and homology modelling of mitochondrial citrate synthase of Homo sapience
Int. J. Pharm. Bio Sci.
6
B1309-B1321
2015
Homo sapiens (O75390)
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brenda
Cui, X.X.; Li, X.; Dong, S.Y.; Guo, Y.J.; Liu, T.; Wu, Y.C.
SIRT3 deacetylated and increased citrate synthase activity in PD model
Biochem. Biophys. Res. Commun.
484
767-773
2017
Homo sapiens
brenda