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Information on EC 2.3.3.14 - homocitrate synthase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.14 homocitrate synthase
IUBMB Comments
Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36, homoaconitate hydratase. The enzyme also acts with oxaloacetate as substrate, but more slowly [2,3].
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Word Map
  • 2.3.3.14
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  • gyrus
  • frontal
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  • precentral
  • carboxylases
  • dlpfc
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  • tractography
  • biotin-dependent
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  • biotechnology
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  • synthesis
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), acetyl-coenzyme A: 2-ketoglutarate C-transferase, acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase, EC 4.1.3.21, HCS, HcsA, homocitrate synthase, homocitrate synthetase, homocitrate-condensing enzyme, homocondensing enzyme, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
show the reaction diagram
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