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Disease on EC 2.3.3.10 - hydroxymethylglutaryl-CoA synthase and Organism(s) Homo sapiens and UniProt Accession Q01581

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
abc-type xenobiotic transporter deficiency
Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase--effect of cMOAT deficiency on hepatobiliary excretion in rats and of mdr1a/b gene disruption on tissue distribution in mice.
acetyl-coa c-acyltransferase deficiency
Clinical and biochemical features of fatty acid oxidation disorders.
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency and beta-ketothiolase deficiency: two case reports and reflections of congenital ketone body metabolism disorder.
Acidosis
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Adenocarcinoma
Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression.
Adenoma
Infusion of sodium butyrate promotes rumen papillae growth and enhances expression of genes related to rumen epithelial VFA uptake and metabolism in neonatal twin lambs.
Alzheimer Disease
Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases.
Angina, Stable
Expression of HMG-CoA reductase in human coronary atherosclerotic plaques and relationship to plaque destabilisation.
Angina, Unstable
Carotid intima-media thickness as predictor of secondary events after coronary angioplasty.
Aortic Aneurysm, Abdominal
Inhibitory effect of statins on inflammation-related pathways in human abdominal aortic aneurysm tissue.
Aortic Valve Disease
Deciphering the gene expression profile of peroxisome proliferator-activated receptor signaling pathway in the left atria of patients with mitral regurgitation.
Arthritis
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Arthritis, Rheumatoid
Effect of Atorvastatin on the Disease Activity and Severity of Rheumatoid Arthritis: Double-Blind Randomized Controlled Trial.
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Atherosclerosis
Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits.
Efficacy of Oral Curcuminoid Fraction from Curcuma xanthorrhiza and Curcuminoid Cider in High-cholesterol Fed Rats.
Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages.
Atrial Fibrillation
Perioperative Statin Use May Reduce Postoperative Arrhythmia Rates After Total Joint Arthroplasty.
Blindness
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Brain Diseases
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Brain Ischemia
Coenzyme A and short-chain acyl-CoA species in control and ischemic rat brain.
Breast Neoplasms
Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells.
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.
Influence of DMBA-induced mammary cancer on the liver CPT I, mit HMG-CoA synthase and PPARalpha mRNA expression in rats fed a low or high corn oil diet.
Meta-Analysis of Tumor Stem-Like Breast Cancer Cells Using Gene Set and Network Analysis.
Patients with clinical/radiological hyperplasia of mammary glands show pathological persistence of temperature of skin points.
The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer.
Carcinogenesis
Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis.
HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma.
Carcinoma
A New Survival Model Based on Cholesterol Biosynthesis-Related Genes for Prognostic Prediction in Clear Cell Renal Cell Carcinoma.
FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast.
Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site.
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer.
Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients.
The STAT3-miR-223-TGFBR3/HMGCS1 axis modulates the progression of cervical carcinoma.
Carcinoma, Hepatocellular
ATF6? Stimulates Cholesterogenic Gene Expression and de Novo Cholesterol Synthesis.
Chicken ovalbumin upstream-promoter transcription factor (COUP-TF) could act as a transcriptional activator or repressor of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene.
Co-ordinate regulation of low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase and synthase gene expression in HepG2 cells.
HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study.
HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma.
Involvement of nutrients and nutritional mediators in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression.
miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma.
NMR-based metabolomic profile of hypercholesterolemic human sera: Relationship with in vitro gene expression?
Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes.
Carcinoma, Squamous Cell
The STAT3-miR-223-TGFBR3/HMGCS1 axis modulates the progression of cervical carcinoma.
Cardiomyopathies
Exercise Training Reverses Lipotoxicity-induced Cardiomyopathy by Inhibiting HMGCS2.
Neuro, cardio, and reno protective activities of rosuvastatin in streptozotocin-induced type 2 diabetic rats undergoing treatment with metformin and glimepiride.
Cardiovascular Diseases
Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases.
Enhancement of drug solubility in supramolecular and colloidal systems.
High-dose statin therapy for secondary prevention of stroke: stroke prevention by aggressive reduction in cholesterol levels study review.
Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors.
MDR reversal and pro-apoptotic effects of statins and statins combined with flavonoids in colon cancer cells.
Statins and clinical outcomes in heart failure.
Statins: HMG-CoA Reductase Inhibitors as Potential Anticancer Agents against Malignant Neoplasms in Women.
Cerebral Infarction
[Role of HMG-CoA inhibitor (statin) in prevention of cerebral infarction]
Cholestasis
Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: characterization and mechanism.
Choroideremia
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Clostridium Infections
Statin Effects on Incidence, Treatment Success, and Mortality of Clostridium difficile Infections.
Coinfection
Validation of a High-Throughput Multiplex Genetic Detection System for Helicobacter pylori Identification, Quantification, Virulence, and Resistance Analysis.
Colitis
Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism.
Colitis, Ulcerative
Ketogenesis alleviates TNF?-induced apoptosis and inflammatory responses in intestinal cells.
Colonic Neoplasms
Cholesterol metabolism and colon cancer.
Dipyridamole Enhances the Cytotoxicities of Trametinib against Colon Cancer Cells through Combined Targeting of HMGCS1 and MEK Pathway.
HMG-CoA synthase 1 is a synthetic lethal partner of BRAF(V600E) in human cancers.
Ketogenesis alleviates TNF?-induced apoptosis and inflammatory responses in intestinal cells.
Ketogenesis contributes to intestinal cell differentiation.
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer.
Regulation of Ketogenic Enzyme HMGCS2 by Wnt/?-catenin/PPAR? Pathway in Intestinal Cells.
The bioinformatics aspects of gene screening of HT-29, human colon cell line treated with caffeic acid.
Colorectal Neoplasms
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
Hydroxymethylglutaryl-coenzyme a synthase 2 expression is associated with chemoradiotherapy responses in colorectal cancer.
Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker.
Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients.
Coma
Fasting hypoketotic coma in a child with deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.
Genetic basis of mitochondrial HMG-CoA synthase deficiency.
Novel HMGCS2 pathogenic variants in a Chinese family with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.
Coronary Artery Disease
Increased expression of interleukin-1 in coronary artery disease with downregulatory effects of HMG-CoA reductase inhibitors.
Coronary Disease
Cost-effectiveness of HMG-CoA reductase inhibition for primary and secondary prevention of coronary heart disease.
Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.
Guinea pigs as models to study the hypocholesterolemic effects of drugs.
High-dose statin therapy for secondary prevention of stroke: stroke prevention by aggressive reduction in cholesterol levels study review.
Rosuvastatin for the treatment of patients with hypercholesterolemia.
Statin use and cancer risk: a comprehensive review.
[Pharmacoeconomic evaluation of pravastatin in the secondary prevention of coronary heart disease in patients with average cholesterol levels. An analysis for Germany based on the CARE study]
Craniofacial Abnormalities
Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development.
Crohn Disease
Ketogenesis alleviates TNF?-induced apoptosis and inflammatory responses in intestinal cells.
Cysts
FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast.
Dehydration
Mitochondrial dysfunction, AMPK activation and peroxisomal metabolism: A coherent scenario for non-canonical 3-methylglutaconic acidurias.
Diabetes Mellitus
HMG-CoA reductase inhibitors suppress the development and progression of carotid artery intimal-medial thickening in hypercholesterolemic type 2 diabetic patients.
Diabetes Mellitus, Type 1
HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk.
Diabetes Mellitus, Type 2
HMG-CoA reductase inhibitors suppress the development and progression of carotid artery intimal-medial thickening in hypercholesterolemic type 2 diabetic patients.
Diabetic Cardiomyopathies
Silencing of peroxisome proliferator-activated receptor-alpha alleviates myocardial injury in diabetic cardiomyopathy by downregulating 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 expression.
Diabetic Neuropathies
RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice.
Diabetic Retinopathy
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Down Syndrome
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Drug Eruptions
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Drug-Related Side Effects and Adverse Reactions
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Dyslipidemias
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases.
Quantitation of plasma mevalonic acid using gas chromatography-electron capture mass spectrometry.
Encephalomyelitis
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Toward a role for statins in immunomodulation.
Encephalomyelitis, Autoimmune, Experimental
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Toward a role for statins in immunomodulation.
Epilepsy
Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
Epilepsy, Temporal Lobe
Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
Erectile Dysfunction
Correction to: Inactivation of the Ras/MAPK/PPAR? signaling axis alleviates diabetic mellitus-induced erectile dysfunction through suppression of corpus cavernosal endothelial cell apoptosis by inhibiting HMGCS2 expression.
Inactivation of the Ras/MAPK/PPAR? signaling axis alleviates diabetic mellitus-induced erectile dysfunction through suppression of corpus cavernosal endothelial cell apoptosis by inhibiting HMGCS2 expression.
Erythema Multiforme
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Esophageal Squamous Cell Carcinoma
Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients.
Essential Hypertension
[Beneficial effects of statins and angiotensin converting enzyme inhibitors on aggregability of red blood cells in hypertensive patients]
Fatty Liver
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Gastroenteritis
Human milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses.
Glioblastoma
Cellular and tumoural heterogeneity of EGFR gene amplification in human malignant gliomas.
Glioma
Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Gene-nutrient interactions in G6PD-deficient subjects--implications for cardiovascular disease susceptibility.
Glucosephosphate Dehydrogenase Deficiency
Gene-nutrient interactions in G6PD-deficient subjects--implications for cardiovascular disease susceptibility.
Gonadal Dysgenesis
The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice.
Hearing Loss
Genotype-based databases for variants causing rare diseases.
Hepatitis C
Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme a synthase.
Hepatoblastoma
The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells.
Hepatomegaly
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features.
hydroxymethylglutaryl-coa synthase deficiency
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Association of a novel homozygous mutation in the HMGCS2 gene with an HMGCSD in an Iranian patient.
Clinical and biochemical features of fatty acid oxidation disorders.
Clinical, biochemical, molecular and therapeutic characteristics of four new patients of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.
Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
Expanding phenotypic and mutational spectra of mitochondrial HMG-CoA synthase deficiency.
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Genetic basis of mitochondrial HMG-CoA synthase deficiency.
Hepatic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme a synthase deficiency.
Human Mitochondrial HMG-CoA Synthase Deficiency: Role of Enzyme Dimerization Surface and Characterization of Three New Patients.
Hypoglycemia is not a defining feature of metabolic crisis in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: Further evidence of specific biochemical markers which may aid diagnosis.
Japanese patients with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: In vitro functional analysis of five novel HMGCS2 mutations.
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency and beta-ketothiolase deficiency: two case reports and reflections of congenital ketone body metabolism disorder.
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients.
Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features.
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: urinary organic acid profiles and expanded spectrum of mutations.
Mitochondrial HMG-CoA synthase deficiency: identification of two further patients carrying two novel mutations.
MRI and MRS in HMG-CoA lyase deficiency.
New case of mitochondrial HMG-CoA synthase deficiency. Functional analysis of eight mutations.
Novel HMGCS2 pathogenic variants in a Chinese family with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.
Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency.
Severe clinical manifestation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency associated with two novel mutations: a case report.
The diagnosis of mitochondrial HMG-CoA synthase deficiency.
[Mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase deficiency: a case report and literature review].
Hypercholesterolemia
Amiodarone-induced hypercholesterolemia is associated with a decrease in liver LDL receptor mRNA.
CB1-05: Development of Reusable Logic for Calculating Statin Exposure-Time from Electronic Medical Record Notes and Orders.
Experimental lovastatin myopathy.
Exploration of virtual candidates for human HMG-CoA reductase inhibitors using pharmacophore modeling and molecular dynamics simulations.
HMG-CoA reductase inhibitors suppress the development and progression of carotid artery intimal-medial thickening in hypercholesterolemic type 2 diabetic patients.
HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X.
MicroRNA-223 coordinates cholesterol homeostasis.
Potential antitumor effects of statins (Review).
Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.
The effects of the intestinal glucosidase inhibitor acarbose on cholesterogenesis in corpulent rats.
[Beneficial effects of statins and angiotensin converting enzyme inhibitors on aggregability of red blood cells in hypertensive patients]
[Clinical trial of lovastatin versus gemfibrozil in the treatment of primary hypercholesterolemia]
[The use of statins, a new approach to the treatment of autoimmune diseases]
Hyperglycemia
Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia.
Hyperlipidemias
Cassia auriculata flower extract attenuates hyperlipidemia in male Wistar rats by regulating the hepatic cholesterol metabolism.
Hyperlipoproteinemia Type II
Effects of pravastatin sodium and simvastatin on plasma fibrinogen level and blood rheology in type II hyperlipoproteinemia.
Hyperlipoproteinemias
Effect of medication with pravastatin sodium on hemorheological parameters in patients with hyperlipoproteinemia.
Effects of pravastatin sodium and simvastatin on plasma fibrinogen level and blood rheology in type II hyperlipoproteinemia.
Hypertension
Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2.
Hypoglycemia
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Hypoglycemia is not a defining feature of metabolic crisis in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: Further evidence of specific biochemical markers which may aid diagnosis.
Ketone body metabolism and its defects.
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients.
Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features.
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: urinary organic acid profiles and expanded spectrum of mutations.
Novel HMGCS2 pathogenic variants in a Chinese family with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.
Infections
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci.
Increased Rates of Rhabdomyolysis in Male Hematopoietic Cell Transplantation Recipients Taking Sirolimus and Trimethoprim/Sulfamethoxazole.
Lipid Metabolism in Vascular Smooth Muscle Cells Infuenced by HCMV Infection.
Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model.
Statin Effects on Incidence, Treatment Success, and Mortality of Clostridium difficile Infections.
The Impact of Dietary Fucosylated Oligosaccharides and Glycoproteins of Human Milk on Infant Well-Being.
Validation of a High-Throughput Multiplex Genetic Detection System for Helicobacter pylori Identification, Quantification, Virulence, and Resistance Analysis.
Inflammatory Bowel Diseases
Differences between intestinal segments and soybean meal–induced changes in intestinal mucus composition of common carp Cyprinus carpio L.
Influenza, Human
Functional glycomic analysis of human milk glycans reveals the presence of virus receptors and embryonic stem cell biomarkers.
Ischemic Stroke
[Pathogenetic justification of statin use in ischaemic stroke prevention according to inflammatory theory in development of atherosclerosis].
Ketosis
Aspects of ketogenesis: control and mechanism of ketone-body formation in isolated rat-liver mitochondria.
Effect of polyphenols on 3-hydroxy-3-methylglutaryl-coenzyme A lyase activity in human hepatoma HepG2 cell extracts.
Effect of Saccharomyces cerevisiae fermentation product on feed intake parameters, lactation performance, and metabolism of transition dairy cattle.
Fatty acid and ketone body metabolism in the rat: response to diet and exercise.
Momilactone B Inhibits Ketosis In Vitro by Regulating the ANGPTL3-LPL Pathway and Inhibiting HMGCS2.
Novel HMGCS2 pathogenic variants in a Chinese family with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.
Silibinin inhibits in vitro ketosis by regulating HMGCS2 and NF-kB: elucidation of signaling molecule relationship under ketotic conditions.
Leber Congenital Amaurosis
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Lethargy
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features.
Leukemia
Calcium ionophore treatment impairs the sterol-mediated suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, and farnesyl diphosphate synthetase.
Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester.
Leukemia, Erythroblastic, Acute
Isoprenoid synthesis during the cell cycle. Studies of 3-hydroxy-3-methylglutaryl-coenzyme A synthase and reductase and isoprenoid labeling in cells synchronized by centrifugal elutriation.
Leukemia, Myeloid, Acute
HMGCS1 drives drug-resistance in acute myeloid leukemia through endoplasmic reticulum-UPR-mitochondria axis.
Liver Diseases
Exercise in mice ameliorates high-fat diet-induced nonalcoholic fatty liver disease by lowering HMGCS2.
HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma.
Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model.
Liver Neoplasms
Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer.
Lupus Erythematosus, Systemic
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Lymphoma
Signalling pathways identified in salivary glands from primary Sjögren's syndrome patients reveal enhanced adipose tissue development.
Lymphoma, B-Cell
Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
Melanoma
HMG-CoA synthase 1 is a synthetic lethal partner of BRAF(V600E) in human cancers.
Metabolic Diseases
Genome-wide Transcriptional Sequencing Identifies Novel Mutations in Metabolic Genes in Human Hepatocellular Carcinoma.
Mouth Neoplasms
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
Multiple Sclerosis
Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination.
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Toward a role for statins in immunomodulation.
Multiple Sclerosis, Chronic Progressive
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Multiple Sclerosis, Relapsing-Remitting
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Muscular Diseases
Evaluation of myopathy risk for HMG-CoA reductase inhibitors by urethane infusion method.
Genotype-based databases for variants causing rare diseases.
Idi1 and Hmgcs2 Are Affected by Stretch in HL-1 Atrial Myocytes.
Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia.
Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors.
Simultaneous analysis of the total plasma concentration of atorvastatin and its five metabolites and the unbound plasma concentration of atorvastatin: Application in a clinical pharmacokinetic study of single oral dose.
Statin-associated immune-mediated necrotizing myopathy: a retrospective analysis of individual case safety reports from VigiBase.
The role of cytochrome P450-mediated drug-drug interactions in determining the safety of statins.
Myotoxicity
Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors.
Neoplasm Metastasis
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
HMGCS2 functions as a tumor suppressor and has a prognostic impact in prostate cancer.
HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma.
Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer.
Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression.
Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker.
Neoplasms
A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer.
Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting.
Arsenic exposure alters expression of cell cycle and lipid metabolism genes in the liver of adult zebrafish (Danio rerio).
Cellular and tumoural heterogeneity of EGFR gene amplification in human malignant gliomas.
Chicken ovalbumin upstream-promoter transcription factor (COUP-TF) could act as a transcriptional activator or repressor of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene.
Contribution of steroidogenic factor 1 to the regulation of cholesterol synthesis.
Correlation between protein accumulation profiles and conventional toxicological findings using a model antiandrogenic compound, flutamide.
Development and validation of a lipogenic genes panel for diagnosis and recurrence of colorectal cancer.
Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial.
FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast.
Genetic variants in the cholesterol biosynthesis pathway genes and risk of prostate cancer.
HMG-CoA synthase 1 is a synthetic lethal partner of BRAF(V600E) in human cancers.
HMGCS1 drives drug-resistance in acute myeloid leukemia through endoplasmic reticulum-UPR-mitochondria axis.
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
HMGCS2 functions as a tumor suppressor and has a prognostic impact in prostate cancer.
HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study.
Influence of DMBA-induced mammary cancer on the liver CPT I, mit HMG-CoA synthase and PPARalpha mRNA expression in rats fed a low or high corn oil diet.
Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data.
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer.
Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer.
Meta-Analysis of Tumor Stem-Like Breast Cancer Cells Using Gene Set and Network Analysis.
Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression.
miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma.
Molecular regulation of cholesterol biosynthesis: implications in carcinogenesis.
NCI-CONNECT: Comprehensive Oncology Network Evaluating Rare CNS Tumors-Histone Mutated Midline Glioma Workshop Proceedings.
Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer.
Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker.
Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients.
Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase synthesis.
Regulation of Ketogenic Enzyme HMGCS2 by Wnt/?-catenin/PPAR? Pathway in Intestinal Cells.
Second hand smoke stimulates tumor angiogenesis and growth.
Tailor-Making Fluorescent Hyaluronic Acid Microgels via Combining Microfluidics and Photoclick Chemistry for Sustained and Localized Delivery of Herceptin in Tumors.
The bioinformatics aspects of gene screening of HT-29, human colon cell line treated with caffeic acid.
The effects of glycosylation inhibitors on the proliferation of a spontaneously transformed cell line (3T6) in vitro.
The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer.
The prognostic impact of lipid biosynthesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy.
The STAT3-miR-223-TGFBR3/HMGCS1 axis modulates the progression of cervical carcinoma.
[Significance of hydroxymethylglutaryl-CoA synthase 2 on prognosis of esophageal squamous cell carcinoma].
Neuritis
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Neuritis, Autoimmune, Experimental
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Non-alcoholic Fatty Liver Disease
Exercise in mice ameliorates high-fat diet-induced nonalcoholic fatty liver disease by lowering HMGCS2.
Expression of genes encoding mitochondrial proteins can distinguish nonalcoholic steatosis from steatohepatitis.
Obesity
Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases.
Extracting time-dependent obese-diabetic specific networks in hepatic proteome analysis.
Genome-wide Transcriptional Sequencing Identifies Novel Mutations in Metabolic Genes in Human Hepatocellular Carcinoma.
Ovarian Hyperstimulation Syndrome
Effect of prolactin in an experimental model of the ovarian hyperstimulation syndrome.
Overweight
Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population.
Pancreatitis, Chronic
[Inhibition of the stellate cells using lisinopril and lovastatin for prophylaxis of pancreatic stump fibrosis after performance of distal resection in a model of chronic alcoholic pancreatitis].
Peripheral Nerve Injuries
HMG-CoA synthase isoenzymes 1 and 2 localize to satellite glial cells in dorsal root ganglia and are differentially regulated by peripheral nerve injury.
Pheochromocytoma
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Prostatic Neoplasms
HMGCS2 functions as a tumor suppressor and has a prognostic impact in prostate cancer.
Lovastatin-induced E2F-1 modulation and its effect on prostate cancer cell death.
Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients.
Stromal regulation of prostate cancer cell growth by mevalonate pathway enzymes HMGCS1 and HMGCR.
Pulmonary Disease, Chronic Obstructive
Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease.
Rectal Neoplasms
The prognostic impact of lipid biosynthesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy.
Renal Insufficiency, Chronic
Atorvastatin preserves renal function in chronic complete unilateral ureteral obstruction.
Respiratory Tract Infections
Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci.
Retinal Diseases
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Rhabdomyolysis
Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors.
Seizures
Increased Rates of Rhabdomyolysis in Male Hematopoietic Cell Transplantation Recipients Taking Sirolimus and Trimethoprim/Sulfamethoxazole.
Regulation of the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in astrocytes and meningeal fibroblasts. Implications in normal brain development and seizure neuropathologies.
Sleep Deprivation
Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis.
Squamous Cell Carcinoma of Head and Neck
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
Starvation
CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy.
Gene expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in a poorly ketogenic mammal: effect of starvation during the neonatal period of the piglet.
Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21.
Low activity of mitochondrial HMG-CoA synthase in liver of starved piglets is due to low levels of protein despite high mRNA levels.
Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.
Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetes.
Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis.
Status Epilepticus
Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
Stevens-Johnson Syndrome
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Stomach Neoplasms
Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression.
Stroke
High-dose statin therapy for secondary prevention of stroke: stroke prevention by aggressive reduction in cholesterol levels study review.
Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors.
Tuberculosis, Bovine
Genome-Wide Scanning for Signatures of Selection Revealed the Putative Genomic Regions and Candidate Genes Controlling Milk Composition and Coat Color Traits in Sahiwal Cattle.
Vascular Diseases
Pleiotropic Effects and Cholesterol-Lowering Therapy.
Waldenstrom Macroglobulinemia
The HMG-CoA inhibitor, simvastatin, triggers in vitro anti-tumour effect and decreases IgM secretion in Waldenstrom macroglobulinaemia.
Xanthomatosis
Interaction of galectin-7 with HMGCS1 in vitro may facilitate cholesterol deposition in cultured keratinocytes.