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2 L-tryptophanyl-tRNATrp
2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)
Substrates: -
Products: -
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L-tryptophanyl-tRNATrp + L-alanyl-tRNAAla
tRNATrp + tRNAAla + cyclo(L-tryptophanyl-L-alanyl)
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Substrates: -
Products: -
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L-tryptophanyl-tRNATrp + L-leucyl-tRNALeu
tRNATrp + tRNALeu + cyclo(L-tryptophanyl-L-leucyl)
-
Substrates: -
Products: -
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L-tryptophanyl-tRNATrp + L-phenylalanyl-tRNAPhe
tRNATrp + tRNAPhe + cyclo(L-tryptophanyl-L-phenylalanyl)
L-tryptophanyl-tRNATrp + L-prolyl-tRNAPro
tRNATrp + tRNAPro + cyclo(L-tryptophanyl-L-prolyl)
-
Substrates: -
Products: -
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L-tryptophanyl-tRNATrp + L-tryptophanyl-tRNATrp
2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)
L-tryptophanyl-tRNATrp + L-tyrosyl-tRNATyr
tRNATrp + tRNATyr + cyclo(L-tryptophanyl-L-tyrosyl)
L-tryptophanyl-tRNATrp + L-phenylalanyl-tRNAPhe
tRNATrp + tRNAPhe + cyclo(L-tryptophanyl-L-phenylalanyl)
-
Substrates: -
Products: -
?
L-tryptophanyl-tRNATrp + L-phenylalanyl-tRNAPhe
tRNATrp + tRNAPhe + cyclo(L-tryptophanyl-L-phenylalanyl)
-
Substrates: -
Products: -
?
L-tryptophanyl-tRNATrp + L-phenylalanyl-tRNAPhe
tRNATrp + tRNAPhe + cyclo(L-tryptophanyl-L-phenylalanyl)
-
Substrates: -
Products: -
?
L-tryptophanyl-tRNATrp + L-phenylalanyl-tRNAPhe
tRNATrp + tRNAPhe + cyclo(L-tryptophanyl-L-phenylalanyl)
-
Substrates: -
Products: -
?
L-tryptophanyl-tRNATrp + L-tryptophanyl-tRNATrp
2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)
-
Substrates: -
Products: -
?
L-tryptophanyl-tRNATrp + L-tryptophanyl-tRNATrp
2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)
-
Substrates: -
Products: -
?
L-tryptophanyl-tRNATrp + L-tyrosyl-tRNATyr
tRNATrp + tRNATyr + cyclo(L-tryptophanyl-L-tyrosyl)
-
Substrates: -
Products: -
?
L-tryptophanyl-tRNATrp + L-tyrosyl-tRNATyr
tRNATrp + tRNATyr + cyclo(L-tryptophanyl-L-tyrosyl)
-
Substrates: -
Products: -
?
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physiological function
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expression of CDPS SazA and of SazB harboring fused domains: phytoene synthase-like prenyltransferase and methyltransferase, in Streptomyces albus J1074 leads to the production of four prenylated indole alkaloids, including streptoazines A to C. SazA catalyzes the formation of cyclo(L-Trp-L-Trp)
physiological function
either CDPS NozA or NcdA is responsible for synthesis of the cyclo-L-Trp-L-Trp diketopiperazine precursor of 2,5-diketopiperazines
physiological function
-
expression of CDPS SazA and of SazB harboring fused domains: phytoene synthase-like prenyltransferase and methyltransferase, in Streptomyces albus J1074 leads to the production of four prenylated indole alkaloids, including streptoazines A to C. SazA catalyzes the formation of cyclo(L-Trp-L-Trp)
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synthesis
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expression of CDPS and genes gtmB-gtmE for tailoring enzymes from Streptomyces cinnamoneus enables the synthesis of modified cyclodipeptides
synthesis
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expression of CDPS and genes gtmB-gtmE for tailoring enzymes from Streptomyces cinnamoneus enables the synthesis of modified cyclodipeptides
synthesis
-
expression of CDPS and genes gtmB-gtmE for tailoring enzymes from Streptomyces cinnamoneus enables the synthesis of modified cyclodipeptides
synthesis
-
expression of CDPS and genes gtmB-gtmE for tailoring enzymes from Streptomyces cinnamoneus enables the synthesis of modified cyclodipeptides
synthesis
-
expression of CDPS and genes gtmB-gtmE for tailoring enzymes from Streptomyces cinnamoneus enables the synthesis of modified cyclodipeptides
-
synthesis
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expression of CDPS and genes gtmB-gtmE for tailoring enzymes from Streptomyces cinnamoneus enables the synthesis of modified cyclodipeptides
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Stierle, S.A.; Harken, L.; Li, S.M.
Production of diketopiperazine derivatives by pathway engineering with different cyclodipeptide synthases from various Streptomyces strains
ACS Synth. Biol.
12
1804-1812
2023
Streptomyces monomycini, Streptomyces monomycini NRRL B-24309, Streptomyces sp. NRRL F-5053, Streptomyces sp. NRRL S-1868, Streptomyces varsoviensis, Streptomyces varsoviensis NRRL B-3589
brenda
Zhang, Y.; Yao, T.; Jiang, Y.; Li, H.; Yuan, W.; Li, W.
Deciphering a cyclodipeptide synthase pathway encoding prenylated indole alkaloids in Streptomyces leeuwenhoekii
Appl. Environ. Microbiol.
87
e02525
2021
Streptomyces leeuwenhoekii, Streptomyces leeuwenhoekii NRRL B-24963
brenda
Deletti, G.; Green, S.D.; Weber, C.; Patterson, K.N.; Joshi, S.S.; Khopade, T.M.; Coban, M.; Veek-Wilson, J.; Caulfield, T.R.; Viswanathan, R.; Lane, A.L.
Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase
Nat. Commun.
14
2558
2023
Nocardiopsis sp. CMB-M0232 (A0A0R7QWN6), Nocardiopsis sp. CMB-M0232 (A0A0R7QX11)
brenda
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