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L-Gln-2-naphthylamide
5-oxoprolyl-2-naphthylamide + NH3
-
-
-
?
L-Gln-2-naphthylamide
L-pyroglutamyl-2-naphthylamide + NH3
-
-
-
?
L-Gln-7-amido-4-methylcoumarin
5-oxoprolyl-7-amido-4-methylcoumarin + NH3
-
-
-
?
L-Gln-7-amido-4-methylcoumarin
L-pyroglutamyl-4-methylcoumarin-7-amide + NH3
-
-
-
?
L-Gln-Gly
5-oxoprolyl-Gly + NH3
-
-
-
?
L-Gln-Gly
L-pyroglutamyl-Gly + NH3
-
-
-
?
L-Gln-Gly-L-Pro
5-oxoprolyl-Gly-L-Pro + NH3
-
-
-
?
L-Gln-Gly-L-Pro
pyroglutamyl-Gly-L-Pro + NH3
-
-
-
?
L-Gln-L-Ala
L-pyroglutamyl-L-Ala + NH3
-
-
-
?
L-Gln-L-Arg-Gly-L-Ile-NH2
pyroglutamyl-L-Arg-Gly-L-Ile-NH2 + NH3
-
-
-
?
L-Gln-L-Asn-Gly-L-Ile-NH2
L-pyroglutamyl-L-Asn-Gly-L-Ile-NH2 + NH3
-
-
-
?
L-Gln-L-Gln
L-pyroglutamyl-L-Gln + NH3
-
-
-
?
L-Gln-L-Gln-OH
5-oxoprolyl-L-Gln + NH3
-
-
-
?
L-Gln-L-Glu
L-pyroglutamyl-L-Glu + NH3
-
-
-
?
L-Gln-L-Glu-L-Asp-L-Leu-NH2
5-oxoprolyl-L-Glu-L-Asp-L-Leu-NH2 + NH3
-
-
-
?
L-Gln-L-Glu-OH
5-oxoprolyl-L-Glu + NH3
-
-
-
?
L-Gln-L-Lys-L-Arg-L-Leu-NH2
5-oxoprolyl-L-Lys-L-Arg-L-Leu-NH2 + NH3
-
-
-
?
L-Gln-L-Phe-L-Ala-NH2
5-oxoprolyl-L-Phe-L-Ala-NH2 + NH3
-
-
-
?
L-Gln-L-Thr-Gly-L-Ile-NH2
L-pyroglutamyl-L-Thr-Gly-L-Ile-NH2 + NH3
-
-
-
?
L-Gln-L-Trp-L-Ala-NH2
L-pyroglutamyl-L-Trp-L-Ala-NH2 + NH3
-
-
-
?
L-glutaminyl-Abeta(3-42) peptide
5-oxoprolyl-Abeta(3-42) peptide + NH3
L-glutaminyl-peptide
5-oxoprolyl-peptide + NH3
-
-
-
?
EFRH-NH2
pEFRH-NH2 + H2O
-
-
-
-
?
EFRHHDSGYE-NH2
pEFRHHDSGYE-NH2 + H2O
-
-
-
-
?
Gln-Gln
pGlu-Gln + NH3
-
-
-
-
?
Gln-Glu
pGlu-Glu + NH3
-
-
-
-
?
Gln-Gly
pGlu-Gly + NH3
-
-
-
-
?
Gln-Gly-Pro
pGlu-Gly-Pro + NH3
-
-
-
-
?
Gln-Phe-Ala
pGlu-Phe-Ala + NH3
-
-
-
-
?
Gln-Tyr-Ala
pGlu-Tyr-Ala + NH3
-
-
-
-
?
L-Gln(3)-amyloid-beta peptide 3-42
L-pyroglutamyl(3)-amyloid-beta peptide 3-42 + NH3
-
-
-
-
?
L-Gln-2-naphthylamide
5-oxoprolyl-2-naphthylamide + NH3
-
-
-
-
?
L-Gln-2-naphthylamide
L-pyroglutamyl-2-naphthylamide + NH3
-
reaction in cell supernatant is exclusively enzyme-catalyzed
-
-
?
L-Glu(3)-amyloid-beta peptide 3-42
L-pyroglutamyl(3)-amyloid-beta peptide 3-42 + H2O
-
-
-
-
?
L-Glu-2-naphthylamide
5-oxo-L-prolinyl-2-naphthylamide + NH3
-
-
-
-
?
L-Glu-2-naphthylamide
5-oxo-L-prolyl-2-naphthylamide + NH3
-
-
-
-
?
L-glutaminyl-7-amido-4-methylcoumarin
pGlu-7-amido-4-methylcoumarin + NH3
-
-
-
-
?
L-glutaminyl-beta-naphthylamide
pGlu-beta-naphthylamide + NH3
-
-
-
-
?
L-glutaminyl-peptide
5-oxoprolyl-peptide + NH3
-
-
-
-
?
QEDL
pEEDL + NH3
-
-
-
-
?
QEYF
pEEYF + NH3
-
-
-
-
?
QFRH-NH2
pEFRH-NH2 + NH3
-
-
-
-
?
thyrotropin-releasing hormone
?
-
-
-
-
?
additional information
?
-
-
enzyme is important during cellular maturation of L-pyroglutamyl-containing peptides
-
-
?
L-glutaminyl-Abeta(3-42) peptide
5-oxoprolyl-Abeta(3-42) peptide + NH3
-
-
-
?
L-glutaminyl-Abeta(3-42) peptide
5-oxoprolyl-Abeta(3-42) peptide + NH3
a glutamate residue (E) is exposed at position 3 of Abeta(3-42) and can be converted by the enzymatic activity of glutaminyl cyclase (QC) to pE resulting in the peptide pE-Abeta(3-42). 5-Oxoproline ring formation under liberation of water. Slow conversion of N-terminal glutamate under slightly acidic pH conditions, as compared with the much faster pE formation from N-terminal glutamine
-
-
?
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0.04
L-Gln-2-naphthylamide
pH 8.0, 30°C
0.048
L-Gln-7-amido-4-methylcoumarin
pH 8.0, 30°C
0.41
L-Gln-Gly
pH 8.0, 30°C
0.17
L-Gln-Gly-L-Pro
pH 8.0, 30°C
0.4
L-Gln-L-Ala
pH 8.0, 30°C
0.32
L-Gln-L-Arg-Gly-L-Ile-NH2
pH 8.0, 30°C
0.36
L-Gln-L-Asn-Gly-L-Ile-NH2
pH 8.0, 30°C
0.15
L-Gln-L-Gln
pH 8.0, 30°C
0.8
L-Gln-L-Glu
pH 8.0, 30°C
0.16
L-Gln-L-Thr-Gly-L-Ile-NH2
pH 8.0, 30°C
0.072
L-Gln-L-Trp-L-Ala-NH2
pH 8.0, 30°C
0.092
Gln-Gln
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
0.47
Gln-Glu
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
0.16
Gln-Gly
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
0.102
Gln-Gly-Pro
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
0.06
Gln-Phe-Ala
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
0.058
Gln-Tyr-Ala
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
0.03
L-glutaminyl-7-amido-4-methylcoumarin
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
0.032
L-glutaminyl-beta-naphthylamide
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
0.16
QEDL
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
0.029
QEYF
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
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22
L-Gln-2-naphthylamide
pH 8.0, 30°C
6
L-Gln-7-amido-4-methylcoumarin
pH 8.0, 30°C
12.4
L-Gln-Gly
pH 8.0, 30°C
21.6
L-Gln-Gly-L-Pro
pH 8.0, 30°C
42
L-Gln-L-Ala
pH 8.0, 30°C
34
L-Gln-L-Arg-Gly-L-Ile-NH2
pH 8.0, 30°C
68
L-Gln-L-Asn-Gly-L-Ile-NH2
pH 8.0, 30°C
32
L-Gln-L-Gln
pH 8.0, 30°C
29
L-Gln-L-Glu
pH 8.0, 30°C
23
L-Gln-L-Thr-Gly-L-Ile-NH2
pH 8.0, 30°C
41
L-Gln-L-Trp-L-Ala-NH2
pH 8.0, 30°C
8.66
Gln-Gln
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
7.79
Gln-Glu
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
4.57
Gln-Gly
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
11.4
Gln-Gly-Pro
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
24.1
Gln-Phe-Ala
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
22.9
Gln-Tyr-Ala
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
6.98
L-glutaminyl-7-amido-4-methylcoumarin
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
17.48
L-glutaminyl-beta-naphthylamide
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
6.4
QEDL
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
11.78
QEYF
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
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0.000019
EFRH-NH2
-
at pH 6.5
95
Gln-Gln
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
16
Gln-Glu
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
28
Gln-Gly
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
111
Gln-Gly-Pro
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
403
Gln-Phe-Ala
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
394
Gln-Tyr-Ala
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
311
L-glutaminyl-7-amido-4-methylcoumarin
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
554
L-glutaminyl-beta-naphthylamide
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
104
QEDL
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
413
QEYF
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
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Schilling, S.; Cynis, H.; von Bohlen, A.; Hoffmann, T.; Wermann, M.; Heiser, U.; Buchholz, M.; Zunkel, K.; Demuth, H.U.
Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase
Biochemistry
44
13415-13424
2005
Mus musculus (Q9CYK2), Mus musculus
brenda
Cynis, H.; Schilling, S.; Bodnar, M.; Hoffmann, T.; Heiser, U.; Saido, T.C.; Demuth, H.
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells
Biochim. Biophys. Acta
1764
1618-1625
2006
Homo sapiens, Mus musculus
brenda
Seifert, F.; Schulz, K.; Koch, B.; Manhart, S.; Demuth, H.U.; Schilling, S.
Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates
Biochemistry
48
11831-11833
2009
Carica papaya, Homo sapiens, Mus musculus, Solanum tuberosum
brenda
Stephan, A.; Wermann, M.; Von Bohlen, A.; Koch, B.; Cynis, H.; Demuth, H.; Schilling, S.
Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics
FEBS J.
276
6522-6536
2009
Homo sapiens, Mus musculus
brenda
Hartlage-Ruebsamen, M.; Staffa, K.; Waniek, A.; Wermann, M.; Hoffmann, T.; Cynis, H.; Schilling, S.; Demuth, H.U.; Rossner, S.
Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain
Int. J. Dev. Neurosci.
27
825-835
2009
Mus musculus
brenda
Hartlage-Ruebsamen, M.; Morawski, M.; Waniek, A.; Jaeger, C.; Zeitschel, U.; Koch, B.; Cynis, H.; Schilling, S.; Schliebs, R.; Demuth, H.U.; Rossner, S.
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Abeta deposits in hippocampus via distinct cellular mechanisms
Acta Neuropathol.
121
705-719
2011
Homo sapiens, Mus musculus
brenda
Ruiz-Carrillo, D.; Koch, B.; Parthier, C.; Wermann, M.; Dambe, T.; Buchholz, M.; Ludwig, H.H.; Heiser, U.; Rahfeld, J.U.; Stubbs, M.T.; Schilling, S.; Demuth, H.U.
Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center
Biochemistry
50
6280-6288
2011
Homo sapiens (Q16769), Mus musculus (Q9CYK2)
brenda
Koch, B.; Buchholz, M.; Wermann, M.; Heiser, U.; Schilling, S.; Demuth, H.U.
Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development
Chem. Biol. Drug Des.
80
937-946
2012
Homo sapiens (Q16769), Mus musculus (Q9CYK2)
brenda
Waniek, A.; Hartlage-Ruebsamen, M.; Hoefling, C.; Kehlen, A.; Schilling, S.; Demuth, H.U.; Rossner, S.
Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes
Biochim. Biophys. Acta
1852
146-155
2015
Mus musculus
brenda
Becker, A.; Eichentopf, R.; Sedlmeier, R.; Waniek, A.; Cynis, H.; Koch, B.; Stephan, A.; Baeuscher, C.; Kohlmann, S.; Hoffmann, T.; Kehlen, A.; Berg, S.; Freyse, E.J.; Osmand, A.; Plank, A.C.; Rossner, S.; von Hoersten, S.; Graubner, S.; Demuth, H.U.; Schilling, S.
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
Biol. Chem.
397
45-55
2016
Mus musculus
brenda
Hoefling, C.; Indrischek, H.; Hoepcke, T.; Waniek, A.; Cynis, H.; Koch, B.; Schilling, S.; Morawski, M.; Demuth, H.U.; Rossner, S.; Hartlage-Ruebsamen, M.
Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC
Int. J. Dev. Neurosci.
36
64-73
2014
Mus musculus
brenda
Hartlage-Ruebsamen, M.; Bluhm, A.; Piechotta, A.; Linnert, M.; Rahfeld, J.U.; Demuth, H.U.; Lues, I.; Kuhn, P.H.; Lichtenthaler, S.F.; Rossner, S.; Hoefling, C.
Immunohistochemical evidence from APP-transgenic mice for glutaminyl cyclase as drug target to diminish pE-Abeta formation
Molecules
23
924
2018
Mus musculus (Q9CYK2)
brenda