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Information on EC 2.3.2.36 - RING-type E3 ubiquitin transferase (cysteine targeting)

for references in articles please use BRENDA:EC2.3.2.36
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IUBMB Comments
This relatively rare subpopulation of RING-type E3 ubiquitin transferases (cf. EC 2.3.2.27), found in mammals and herpes viruses, can transfer ubiquitin to a cysteine residue in target proteins. Additional ubiquitin molecules are polymerized on top of the initial ubiquitin molecule by formation of an isopeptide linkage with lysine48 in the pre-attached ubiquitin .
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Word Map
  • 2.3.2.36
  • monoubiquitination
  • nedd8
  • ccr4-not
  • neddylation
  • cereblon
The expected taxonomic range for this enzyme is: Human gammaherpesvirus 8
Reaction Schemes
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[acceptor protein]-L-cysteine
=
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[acceptor protein]-S-ubiquitinyl-L-cysteine
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
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[acceptor protein]-L-cysteine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-S-ubiquitinyl-L-cysteine
Synonyms
E3 ubiquitin ligase MIR1, RING E3 ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine
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