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Disease on EC 2.3.2.32 - cullin-RING-type E3 NEDD8 transferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma.
Adenocarcinoma, Bronchiolo-Alveolar
SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma.
Adrenocortical Adenoma
Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas.
Adrenocortical Carcinoma
Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas.
Breast Neoplasms
Widespread Alternative Splicing Changes in Metastatic Breast Cancer Cells.
Carcinoma
3q26 Amplifications in Cervical Squamous Carcinomas.
Association of ring box-1 protein overexpression with clinicopathologic prognostic parameters in prostate carcinoma.
Coamplification and Cooperation: Toward Identifying Biologically Relevant Oncogenes.
Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA.
Immunohistochemical Expression of DCUN1D1 in Non-small Cell Lung Carcinoma: Its Relation to Brain Metastasis.
MicroRNA-195 inhibits growth and invasion of laryngeal carcinoma cells by directly targeting DCUN1D1.
SCCRO (DCUN1D1) induces extracellular matrix invasion by activating matrix metalloproteinase 2.
Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A.
The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.
Carcinoma, Non-Small-Cell Lung
Immunohistochemical Expression of DCUN1D1 in Non-small Cell Lung Carcinoma: Its Relation to Brain Metastasis.
Carcinoma, Renal Cell
An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma.
Carcinoma, Squamous Cell
Coamplification and Cooperation: Toward Identifying Biologically Relevant Oncogenes.
Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A.
The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.
Colorectal Neoplasms
MicroRNA-520b Functions as a Tumor Suppressor in Colorectal Cancer by Inhibiting DCUN1D1.
Frontotemporal Lobar Degeneration
DCUN1D1 is a risk factor for frontotemporal lobar degeneration.
Glioma
SCCRO promotes glioma formation and malignant progression in mice.
Infertility
Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization.
Lung Neoplasms
DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer.
Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer.
Lymphatic Metastasis
DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer.
Melanoma
The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer.
Neoplasm Metastasis
DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer.
Immunohistochemical Expression of DCUN1D1 in Non-small Cell Lung Carcinoma: Its Relation to Brain Metastasis.
MicroRNA-302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1.
SCCRO (DCUN1D1) induces extracellular matrix invasion by activating matrix metalloproteinase 2.
The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue.
Neoplasms
3q26 Amplifications in Cervical Squamous Carcinomas.
Association of ring box-1 protein overexpression with clinicopathologic prognostic parameters in prostate carcinoma.
Clinical significance of SCCRO (DCUN1D1) in prostate cancer and its proliferation-inhibiting effect on Lncap cells.
Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function.
DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer.
DCUN1D1 promotes tumour progress in prostate cancer and its effect on DU145 in vitro.
Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer.
Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA.
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer.
Identification of druggable cancer driver genes amplified across TCGA datasets.
Immunohistochemical Expression of DCUN1D1 in Non-small Cell Lung Carcinoma: Its Relation to Brain Metastasis.
MicroRNA-195 inhibits growth and invasion of laryngeal carcinoma cells by directly targeting DCUN1D1.
MicroRNA-520b Functions as a Tumor Suppressor in Colorectal Cancer by Inhibiting DCUN1D1.
Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2.
SCCRO (DCUN1D1) induces extracellular matrix invasion by activating matrix metalloproteinase 2.
SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma.
SCCRO promotes glioma formation and malignant progression in mice.
SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).
Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A.
Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas.
Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas.
The relation between Ring Box-1 protein overexpression and tumor grade and stage in bladder urothelial cell carcinoma.
The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue.
The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer.
The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.
The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2.
Papilloma
MicroRNA?195 inhibits cell proliferation, migration and invasion by targeting defective in cullin neddylation 1 domain containing 1 in cervical cancer.
Prostatic Intraepithelial Neoplasia
Association of ring box-1 protein overexpression with clinicopathologic prognostic parameters in prostate carcinoma.
Prostatic Neoplasms
Clinical significance of SCCRO (DCUN1D1) in prostate cancer and its proliferation-inhibiting effect on Lncap cells.
DCUN1D1 promotes tumour progress in prostate cancer and its effect on DU145 in vitro.
Squamous Cell Carcinoma of Head and Neck
Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA.
The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue.
The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.
Uterine Cervical Neoplasms
MicroRNA-218 inhibits EMT, migration and invasion by targeting SFMBT1 and DCUN1D1 in cervical cancer.
MicroRNA-302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1.
MicroRNA?195 inhibits cell proliferation, migration and invasion by targeting defective in cullin neddylation 1 domain containing 1 in cervical cancer.
von Hippel-Lindau Disease
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.