show all | hide all No of entries

Information on EC 2.3.2.29 - aspartate/glutamate leucyltransferase

for references in articles please use BRENDA:EC2.3.2.29
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.29 aspartate/glutamate leucyltransferase
IUBMB Comments
The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-aspartate or L-glutamate residue. Once modified, the proteins are recognized by EC 3.4.21.92, the ClpAP/ClpS endopeptidase system. cf. EC 2.3.2.6, lysine/arginine leucyltransferase, and EC 2.3.2.8, arginyltransferase.
Specify your search results
Select one or more organisms in this record: ?
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
N-terminal L-glutamyl-[protein]
=
+
N-terminal L-leucyl-L-glutamyl-[protein]
+
N-terminal L-aspartyl-[protein]
=
+
N-terminal L-leucyl-L-aspartyl-[protein]
Synonyms
bacterial protein transferase, BPT, LD,E-transferase, Leu-conjugating aa-transferase, leucylD,E-transferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-leucyl-tRNALeu + N-terminal L-aspartyl-[protein] = tRNALeu + N-terminal L-leucyl-L-aspartyl-[protein]
show the reaction diagram
(2)
-
-
-
L-leucyl-tRNALeu + N-terminal L-glutamyl-[protein] = tRNALeu + N-terminal L-leucyl-L-glutamyl-[protein]
show the reaction diagram
(1)
-
-
-
PATHWAY SOURCE
PATHWAYS
Select items on the left to see more content.