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Information on EC 2.3.2.15 - glutathione gamma-glutamylcysteinyltransferase
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EC Tree
2.3.2.15 glutathione gamma-glutamylcysteinyltransferaseSpecify your search results
Word Map
- 2.3.2.15
- phytochelatins
-
neurogenesis
- cadmium
-
subventricular
-
oligodendrocyte
-
neurospheres
-
hippocampal
- gsh
-
neurogenic
- arsenic
-
self-renewal
-
phytoremediation
- metallothioneins
- nestin
-
multipotent
-
asiii
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subgranular
-
neuroblast
-
metalloid
-
cord-derived
- analysis
- agriculture
- biotechnology
- environmental protection
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
nspcs, cepcs, phytochelatin synthase, atpcs1, ospcs1, ospcs2, atpcs2, atpcs, phytochelatin synthase 1, ljpcs1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AtPCS
AtPCS1
AtPCS2
CaPCS1
CaPCS2
DaPCS1
gamma-glutamylcysteine dipeptidyl transpeptidase
-
-
-
-
NsPCS
OsPCS1
OsPCS2
PC synthase
PCS
PCS1
PCS2
phytochelatin synthase
phytochelatin synthase 1
phytochelatin synthase 2
pseudo-phytochelatin synthase
SrPCS1
isoform 1, produced by alternative splicing of the SrPCS pre-mRNA
SrPCS2
isoform 2, produced by alternative splicing of the SrPCS pre-mRNA
SrPCS3
isoform 3, produced by alternative splicing of the SrPCS pre-mRNA
SrPCS4
isoform 4, produced by alternative splicing of the SrPCS pre-mRNA
TtpsiPCS
phytochelatin synthase
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-
-
-
phytochelatin synthase
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-
pseudo-phytochelatin synthase
biosynthetically inactive enzyme
pseudo-phytochelatin synthase
biosynthetically inactive enzyme
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
glutathione + [Glu(-Cys)]n-Gly = Gly + [Glu(-Cys)]n+1-Gly
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
gamma-glutamylcysteinyl transfer
gamma-glutamylcysteinyl transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
125390-02-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetamido-fluorescein-glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-acetamido-fluorescein-Cys-Gly
-
-
-
-
?
benzyl-glutathione + [Glu(-Cys)]n Gly
Gly + [Glu(-Cys)]n-Glu-S-benzyl-Cys-Gly
-
-
-
-
?
glutathione + Glu-Cys-Gly
Gly + [Glu(-Cys)]2-Gly
-
-
-
?
glutathione + [Glu(-Cys)]2-Gly
Gly + [Glu(-Cys)]3-Gly
-
-
-
?
glutathione + [Glu(-Cys)]3-Gly
Gly + [Glu(-Cys)]4-Gly
-
-
-
?
metal-bis-glutathionate + [Glu(-Cys)]n-Gly
?
Zn2+-bis-glutathionate is the best cosubstrate. The order of preference for the Me-GS2 substrate is Zn2+ > Cd2+ > Mn2+ > As5+ > As3+ > Cu2+ > Ag+
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-
?
monobromobimane-glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-monobromobimane-Cys-Gly
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-
-
-
?
nitrobenzyl-glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-nitrobenzyl-Cys-Gly
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-
-
-
?
S-butylglutathione + [Glu(-Cys)]n Gly
Gly + [Glu(-Cys)]n-Glu-S-butyl-Cys-Gly
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-
-
-
?
S-ethylglutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-ethyl-Cys-Gly
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-
-
-
?
S-hexylglutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-hexyl-Cys-Gly
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-
-
-
?
S-methylglutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-methyl-Cys-Gly
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n = 2,3
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-
?
S-propylglutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-propyl-Cys-Gly
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-
-
-
?
Zn2+-bis-glutathionate + [Glu(-Cys)]n-Gly
?
Zn2+-bis-glutathionate is the best cosubstrate
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-
?
bimane-glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-bimane-Cys-Gly
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-
-
-
?
bimane-glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-bimane-Cys-Gly
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-
-
-
?
bimane-glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-bimane-Cys-Gly
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-
-
-
?
bimane-glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-bimane-Cys-Gly
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-
-
-
?
glutathione + [Glu(-Cys)]n -Gly
Gly + [Glu(-Cys)]n+1 -Gly
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-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
n = 2-11
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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n = 2-11
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?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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cellular functions are formation of heavy-metal binding peptides and degradation of glutathione-S-conjugates
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?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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synthesis of photochelatin
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?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
n = 2-11
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
n = 2-11
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?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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cellular functions are formation of heavy-metal binding peptides and degradation of glutathione-S-conjugates
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
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?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
G5ECE4
critical for heavy metal tolerance
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-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
G5ECE4
critical for heavy metal tolerance
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-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
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?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
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?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
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?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
n = 2-5
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
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?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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critical for heavy metal tolerance
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?
uracil-glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-uracil-Cys-Gly
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?
uracil-glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n-Glu-S-uracil-Cys-Gly
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-
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?
additional information
?
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the presence of VdCl2 activates phytochelatin synthase and induces the synthesis of substantial amounts of phytochelatins
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?
additional information
?
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the PCS enzyme catalyzes transformation of GSH to give phytochelatins (PCs), it can effectively capture and enrich Cd2+ so that the generation and subsequent application process of CdS NPs is greatly improved
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additional information
?
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the PCS enzyme catalyzes transformation of GSH to give phytochelatins (PCs), it can effectively capture and enrich Cd2+ so that the generation and subsequent application process of CdS NPs is greatly improved
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additional information
?
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PC2 is the main polymerization product of PCS1, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS1, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS1, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS1, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS2, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS2, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS2, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS2, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS3, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS3, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS3, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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PC2 is the main polymerization product of PCS3, followed by PC3, low amount of PC4 formation. PCS1 has the highest activity of the three isozymes, PCS3 the lowest
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additional information
?
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despite constitutive expression of the enzyme during most stages of plant development, Brassica juncea may react to prolonged exposure to Cd2+ with an increase of phytochelatin synthase protein in leaves
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?
additional information
?
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the enzyme does not use gamma-glutamylcysteine or phytochelatin2 as substrate
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?
additional information
?
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the enzyme does not use gamma-glutamylcysteine or phytochelatin2 as substrate
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
-
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
n = 2-11
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
cellular functions are formation of heavy-metal binding peptides and degradation of glutathione-S-conjugates
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
n = 2-11
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
cellular functions are formation of heavy-metal binding peptides and degradation of glutathione-S-conjugates
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
G5ECE4
critical for heavy metal tolerance
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
G5ECE4
critical for heavy metal tolerance
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
-
-
-
?
glutathione + [Glu(-Cys)]n-Gly
Gly + [Glu(-Cys)]n+1-Gly
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-
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?